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Original Article

Bystander signal production and response are independent processes which are cell line dependent

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Pages 83-90 | Received 19 Apr 2007, Accepted 11 Sep 2007, Published online: 03 Jul 2009

References

  • Azzam E I, de Toledo S M, Little J B. Direct evidence for the participation of gap-junction mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to non-irradiated cells. Proceedings of the National Academy of Sciences USA 2001; 98: 473–478
  • Azzam E I, de Toledo S M, Spitz D R, Little J B. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from a particles-irradiated normal human fibroblast cultures. Cancer Research 2002; 62: 5436–5442
  • Azzam E I, de Toledo S M, Little J B. Oxidative metabolism, gap junctions and the ionising radiation-induced bystander effect. Oncogene 2003; 22: 7050–7057
  • Belyakov O V, Folkard M, Mothersill C, Prise K M, Michael B D. Bystander-induced apoptosis and premature differentiation in primary urothelial explants after charged particle microbeam irradiation. Radiation Protection. Dosimetry 2002; 99: 249–251
  • Belyakov O V, Folkard M, Mothersill C, Prise K M, Michael B D. Bystander induced differentiation: A major response to targeted irradiation of a urothelial explant model. Mutation Research 2006; 597: 43–49
  • Belyakov O V, Prise K M, Trott K R, Michael B D. Delayed lethality, apoptosis and micronucleus formation in human fibroblasts irradiated with X-rays or alpha-particles. International Journal of Radiation Biology 1999; 75: 985–993
  • Coates P J, Lorimore S A, Wright E G. Damaging and protective cell signalling in the untargeted effects of ionising radiation. Mutation Research 2004; 568: 5–20
  • Hu B, Wu L, Han W, Zhang L, Chen S, Xu A, Hei T K, Yu Z. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 2006; 27: 245–251
  • Iyer R, Lehnert B E. Low dose, low-LET ionizing radiation-induced radioadaptation and associated early responses in unirradiated cells. Mutation Research 2002; 503: 1–9
  • Kashino G, Prise K M, Schettino G, Folkard M, Vojnovic B, Michael B D, Suzuki K, Kodama S, Watanabe M. Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. Mutation Research 2004; 556: 209–215
  • Lehnert B E, Goodwin E H, Deshpande A. Extracellular factors following exposure to alpha particles can cause sister chromatid exchanges in normal human cells. Cancer Research 1997; 57: 2164–2171
  • Li W G, Miller F J, Zang H J, Jr, Spitz D R, Oberley L W, Weintraub N L. Hydrogen peroxide-induced superoxide production by a non-phagocytic NADPH oxidase causes oxidant injury. Journal of Biological Chemistry 2001; 276: 29251–29256
  • Little J B, Azzam E I, de Toledo S M, Nagasawa H. Bystander effects: Intercellular transmission of radiation damage signals. Radiation Protection Dosimetry 2002; 99: 159–162
  • Little J B. Cellular radiation effects and the bystander response. Mutation Research 2006; 597: 113–118
  • Lyng F M, Seymour C B, Mothersill C. Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis. British Journal of Cancer 2000; 83: 1223–1230
  • Lyng F M, Maguire P, Kilmurrary N, Mothersill C, Shao C, Folkard M, Prise K. Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells. International Journal of Radiobiology 2006; 82: 393–399
  • Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Kano E. Induction of radioresistance by nitric oxide mediated bystander effect. Radiation Research 2001; 155: 387–396
  • Morgan W F. Is there a common mechanism underlying genomic instability, bystander effects and other non-targeted effects of exposure to ionizing radiation. Oncogene 2003; 22: 7094–7099
  • Mothersill C, Seymour C B. Cell to cell contact during gamma radiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium. Radiation Research 1998; 149: 256–262
  • Mothersill C, Stamato T D, Perez M L, Cummins R, Mooney R, Seymour C B. Involvement of energy metabolism in the production of ‘bystander effect’ by radiation. British Journal of Cancer 2000; 82: 1740–1746
  • Mothersill C, Seymour R J, Seymour C B. Bystander effects in repair-deficient cell lines. Radiation Research 2004; 161: 256–263
  • Mothersill C, Seymour C. Radiation induced bystander effects and the DNA paradigm: An ‘out of field’ perspective. Mutation Research 2006; 597: 5–10
  • Nagaswa H, Little J B. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Research 1992; 52: 6394–6396
  • Narayanan P K, Goodwin E H, Lehnert B E. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Research 1997; 57: 3963–3971
  • Pirisi L, Creek K E, Doniger J, DiPaolo J A. Continuous cell lines with altered and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis 1988; 9: 1573–1579
  • Prise K M, Belyakov O V, Folkard M, Michael B D. Studies of bystander effects in human fibroblasts using a charged particle microbeam. International Journal of Radiation Biology 1998; 74: 793–798
  • Prise K M, Folkard M, Michael B D. A review of the bystander effect and its implications for low-dose exposure. Radiation Protection Dosimetry 2003; 104: 347–355
  • Prise K M, Folkard M, Michael B D. New insights on cell death from radiation exposure. Lancet Oncology 2005; 6: 520–528
  • Puck T T, Marcus P I. Action of X-rays on mammalian cells. Journal of Experimental Medicine 1956; 653–666
  • Schettino G, Folkard M, Prise K M, Vojnovic B, Held K D, Michael B D. Low dose studies of bystander cell killing with targeted soft X-rays. Radiation Research 2003; 160: 505–511
  • Seymour C B, Mothersill C. Relative contribution of bystander and targeted cell killing to the low dose region of the radiation dose response curve. Radiation Research 2000; 153: 508–511
  • Shao C, Furuasawa Y, Kobayashi Y, Funayama T, Wada S. Bystander effect induced by counted high LET particles in confluent human fibroblasts: A mechanistic study. FASEB Journal 2003a; 17: 1422–1427
  • Shao C, Stewart V, Folkard M, Michael B D, Prise K M. Nitric oxide mediated signalling in the bystander response of individually targeted glioma cells. Cancer Research 2003b; 63: 8437–8442
  • Stamato T D, Richardson E, Ianacone J, Maclaren R A, Denko N, Giaccia A. Isolation and characterization of glucose-6-phosphate dehydrogenase-deficient Chinese hamster cells derived from pure mutatant colonies. Mutagenesis 1989; 44: 259–264
  • Yang H, Asaad N, Held K D. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 2005; 24: 2096–2103

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