164
Views
14
CrossRef citations to date
0
Altmetric
Radiation-Induced Oxidative Injury and Protection with Melatonin

Comparison of the protective effects of melatonin and amifostine on radiation-induced epiphyseal injury

, MD, , , , , & show all
Pages 796-802 | Received 09 May 2008, Accepted 26 Jul 2008, Published online: 03 Jul 2009

References

  • Alheit H, Baumann M, Thames H D, Geyer P, Kumpf R, Herrmann T. Fractionation effect on radiation-induced growth retardation of tibia in rabbits and rats. Acta Oncologica 1998; 372: 151–158
  • Anwar M M, Moustafa M A. The effect of melatonin on eye lens of rats exposed to ultraviolet irradiation. Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology 2001; 129: 57–63
  • Blumberg A L, Nelson D F, Gramkowski M, Glover D, Glick J H, Juhas J M, Kligerman M M. Clinical trials of WR-2721 with radiation therapy. International Journal of Radiation Oncology Biology Physics 1982; 8: 561–563
  • Cardinali D P, Ladizesky M G, Boggio V, Cutrera R A, Mautalen C. Melatonin effects on bone: experimental facts and clinical perspectives. Journal of Pineal Research 2003; 34: 81–87
  • Damron T A, Spadaro J A, Tamurian R M, Damron L A. Sparing of radiation-induced damage to the physis: Fractionation alone compared to amifostine pretreatment. International Journal of Radiation Oncology Biology Physics 2000; 47: 1067–1071
  • Damron T A, Marguiles B, Biskup D, Spadaro J A. Amifostine before fractionated irradiation protects bone growth in rats better than fractionation alone. International Journal of Radiation Oncology Biology Physics 2001; 50: 479–483
  • Eifel P J, Sampson C M, Tucker S L. Radiation fractionation sensitivity of epiphyseal cartilage in a growing rat model. International Journal of Radiation Oncology Biology Physics 1990; 19: 661–664
  • Eifel P J. Decreased bone growth arrest in growing rats with multiple radiation fractions per day. International Journal of Radiation Oncology Biology Physics 1988; 15: 141–145
  • Gibbs F P, Vriend J. Half-life of melatonin elimination from rat plasma. Endocrinology 1981; 109: 1796–1798
  • Hartsell W F, Hanson W R, Conterato D J, Hendricksen F R. Hyperfractionation decreases the deleterious effects of conventional radiation fractionation on vertebral growth in animals. Cancer 1989; 63: 2452–2455
  • Hinkel C L. The effect of roentgen rays upon the growing long bones of albino rats. II. Histopathological changes involving endochondral growth centers. American Journal of Roentgenology 1943; 49: 321–348
  • Jahnke G, Marr M, Myers C, Wilson R, Travlos G, Price C. Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats. Toxicological Sciences 1999; 50: 271–279
  • Jahovic N, Cevik H, Sehirli A O, Yegen B C, Sener G. Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats. Journal of Pineal Research 2003; 34: 282–287
  • Kaliash M, Ueno M, Kazunori A. AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. Journal of Pineal Research 2007; 42: 386–393
  • Karbownik M, Reiter R J. Antioxidative effects of melatonin in protection against cellular damage caused by ionizing radiation. Proceedings of the Society for Experimental Biology and Medicine 2000; 25: 9–22
  • Kaya H, Delibas N, Serteser M, Ulukaya E, Ozkaya O. The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlentherapie und Onkologie 1999; 175: 285–288
  • Kember N F. Hypoxia and recovery in growth cartilage in vivo. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 1967; 13: 387–390
  • Koyama H, Nakade O, Takada Y, Kaku T, Lau K H. Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation. Journal of Bone and Mineral Research 2002; 17: 1219–1229
  • Masuda K, Reid B O, Hunter N, Withers H R. Bone growth retardation induced by single and multifractionated irradiation. Radiotherapy and Oncology 1990; 18: 137–145
  • Nakade O, Koyama H, Ariji H, Yajima A, Kaku T. Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro. Journal of Pineal Research 1999; 27: 106–110
  • Nordlund J J, Lerner A B. The effects of oral melatonin on skin color and on the release of pituitary hormones. Journal of Clinical Endocrinology and Metabolism 1977; 45: 768–774
  • Purdie J W, Inhaber E R, Schneider H, Labelle J L. Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: Implications for mechanisms of radioprotection. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 1983; 43: 517–527
  • Reiter R J, Melchiorri D, Sewerynek E, Poeggeler B, Barlow-Walden L, Chuang J, Ortiz G G, Acuna-Castroviejo D. A review of the evidence supporting melatonin's role as an antioxidant. Journal of Pineal Research 1995; 1: 1–11
  • Reiter R J, Tan D X, Manchester L C, Qi W. Biochemical reactivity of melatonin with reactive oxygen and nitrogen species: A review of the evidence. Cell Biochemistry and Biophysics 2001; 34: 237–256
  • Robertson J RWW, Butler M W, D'Angio G J, Rate W R. Leg length discrepancy following irradiation for childhood tumors. Journal of Pediatric Orthopaedics 1991; 11: 284–287
  • Roth J A, Kim B G, Lin W L, Cho M I. Melatonin promotes osteoblast differentiation and bone formation. Journal of Biological Chemistry 1999; 274: 22041–22047
  • Seabra M L, Bignotto M, Pinto LR Jr, Tufik S. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment. Journal of Pineal Research 2000; 29: 193–200
  • Shirazi A, Ghobadi G, Ghazi-Khansari M. A radiobiologic review on melatonin: A novel radioprotector. Journal of Radiation Research 2007; 48: 263–272
  • Takahashi S, Sugimoto M, Kotoura Y, Sasai K, Oka M, Yamamuro T. Long-term changes in the haversian systems following high-dose irradiation. An ultrastructural and quantitative histomorphological study. The Journal of Bone and Joint Surgery 1994; 76: 722–738
  • Tan D X, Manchester L C, Terron P, Flores L J, Reiter R J. One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species. Journal of Pineal Research 2007; 42: 28–42
  • Van Der Vijgh W J, Peters G J. Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects. Seminars in Oncology 1994; 21: 2–7
  • Vijayalaxmi, Meltz M L, Reiter R J, Herman T S. Melatonin and protection from genetic damage in blood and bone marrow: whole-body irradiation studies in mice. Journal of Pineal Research 1999; 27: 221–225
  • Vijayalaxmi, Reiter R J, Herman T S, Meltz M L. Melatonin and radioprotection from genetic damage: in vivo/in vitro studies with human volunteers. Mutation Research 1996; 371: 221–228
  • Vijayalaxmi, Reiter R J, Meltz M L, Herman T S. Melatonin: Possible mechanisms involved in its radioprotective effect. Mutation Research 1998; 404: 187–189
  • Wetterberg L, Eriksson O, Friberg Y, Vangbo B. A simplified radioimmunoassay for melatonin and its application to biological fluids. Preliminary observations on the half-life of plasma melatonin in man. Clinica Chimica Acta 1978; 86: 169–177
  • Yavuz M N, Yavuz A A, Ulku C, Sener M, Yaris E, Kosucu P, Karslioglu I. Protective effect of melatonin against fractionated irradiation-induced epiphyseal injury in a growing rat model. Journal of Pineal Research 2003; 35: 288–294
  • Yuhas J M, Proctor J O, Smith L H. Some pharmacologic effects of WR-2721: Their role in toxicity and radioprotection. Radiation Research 1973; 54: 222–233

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.