FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions

References

• Alter B P. Radiosensitivity in Fanconi's anemia patients. Radiotherapy and Oncology 2002; 62: 345–347
   PubMed Web of Science ®Google Scholar
• Arlett C F, Harcourt S A. Survey of radiosensitivity in a variety of human cell strains. Cancer Research 1980; 40: 926–932
   PubMed Web of Science ®Google Scholar
• Bagby G C, Alter B P. Fanconi anemia. Seminars in Hematology 2006; 43: 147–156
   PubMed Web of Science ®Google Scholar
• Bigelow S B, Rary J M, Bender M A. G2 chromosomal radiosensitivity in Fanconi's anemia. Mutation Research 1979; 63: 189–199
   PubMedGoogle Scholar
• Bremer M, Schindler D, Gross M, Dork T, Morlot S, Karstens J H. Fanconi's anemia and clinical radiosensitivity report on two adult patients with locally advanced solid tumors treated by radiotherapy. Strahlentherapie und Onkologie 2003; 179: 748–753
   Google Scholar
• Dahm-Daphi J, Hubbe P, Horvath F, El-Awady R A, Bouffard K E, Powell S N, Willers H. Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene 2005; 24: 1663–1672
   PubMed Web of Science ®Google Scholar
• Davies K J. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life 2000; 50: 279–289
   PubMed Web of Science ®Google Scholar
• Digweed M, Rothe S, Demuth I, Scholz R, Schindler D, Stumm M, Grompe M, Jordan A, Sperling K. Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia. Carcinogenesis 2002; 23: 1121–1126
   PubMedGoogle Scholar
• Djuzenova C, Flentje M, Plowman P N. Radiation response in vitro of fibroblasts from a fanconi anemia patient with marked clinical radiosensitivity. Strahlentherapie und Onkologie 2004; 180: 789–797
   Google Scholar
• Duckworth-Rysiecki G, Taylor A M. Effects of ionizing radiation on cells from Fanconi's anemia patients. Cancer Research 1985; 45: 416–420
   PubMed Web of Science ®Google Scholar
• Fornace A J, Jr, Little J B, Weichselbaum R R. DNA repair in a Fanconi's anemia fibroblast cell strain. Biochimica et Biophysica Acta 1979; 561: 99–109
   PubMedGoogle Scholar
• Garcia-Higuera I, Taniguchi T, Ganesan S, Meyn M S, Timmers C, Hejna J, Grompe M, D'Andrea A D. Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Molecular Cell 2001; 7: 249–262
   PubMed Web of Science ®Google Scholar
• Gluckman E. Radiosensitivity in Fanconi anemia: Application to the conditioning for bone marrow transplantation. Radiotherapy and Oncology 1990; 18(Suppl. 1)88–93
   PubMedGoogle Scholar
• Godthelp B C, Wiegant W W, Waisfisz Q, Medhurst A L, Arwert F, Joenje H, Zdzienicka M Z. Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2. Mutation Research 2006; 594: 39–48
   PubMed Web of Science ®Google Scholar
• Held K D. Interactions of radioprotectors and oxygen in cultured mammalian cells. I. Dithiothreitol effects on radiation-induced cell killing. Radiation Research 1985; 101: 424–433
   PubMed Web of Science ®Google Scholar
• Houghtaling S, Timmers C, Noll M, Finegold M J, Jones S N, Meyn M S, Grompe M. Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes and Development 2003; 17: 2021–2035
   PubMedGoogle Scholar
• Howlett N G, Taniguchi T, Olson S, Cox B, Waisfisz Q, De Die-Smulders C, Persky N, Grompe M, Joenje H, Pals G, Ikeda H, Fox E A, D'Andrea A D. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 2002; 297: 606–609
   PubMed Web of Science ®Google Scholar
• Hows J M, Chapple M, Marsh J C, Durrant S, Yin J L, Swirsky D, Gordon-Smith E C. Bone marrow transplantation for Fanconi's anaemia: The Hammersmith experience 1977–89. Bone Marrow Transplantation 1989; 4: 629–634
   Google Scholar
• Jakobs P M, Sahaayaruban P, Saito H, Reifsteck C, Olson S, Joenje H, Moses R E, Grompe M. Immortalization of four new Fanconi anemia fibroblast cell lines by an improved procedure. Somatic Cell and Molecular Genetics 1996; 22: 151–157
   PubMedGoogle Scholar
• Joenje H, Arwert F, Eriksson A W, de Koning H, Oostra A B. Oxygen-dependence of chromosomal aberrations in Fanconi's anaemia. Nature 1981; 290: 142–143
   PubMed Web of Science ®Google Scholar
• Joenje H, Patel K J. The emerging genetic and molecular basis of Fanconi anaemia. Nature Review in Genetics 2001; 2: 446–457
   PubMed Web of Science ®Google Scholar
• Kalb R, Duerr M, Wagner M, Herterich S, Gross M, Digweed M, Joenje H, Hoehn H, Schindler D. Lack of sensitivity of primary Fanconi's anemia fibroblasts to UV and ionizing radiation. Radiation Research 2004; 161: 318–325
   Google Scholar
• Kennedy R D, D'Andrea A D. The Fanconi Anemia/BRCA pathway: New faces in the crowd. Genes and Development 2005; 19: 2925–2940
   PubMed Web of Science ®Google Scholar
• Li X, Heyer W D. Homologous recombination in DNA repair and DNA damage tolerance. Cell Research 2008; 18: 99–113
   PubMed Web of Science ®Google Scholar
• Lyakhovich A, Surralles J. Disruption of the Fanconi anemia/BRCA pathway in sporadic cancer. Cancer Letters 2006; 232: 99–106
   PubMed Web of Science ®Google Scholar
• Marcou Y, D'Andrea A, Jeggo P A, Plowman P N. Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity. Radiotherapy and Oncology 2001; 60: 75–79
   PubMed Web of Science ®Google Scholar
• Niedernhofer L J, Lalai A S, Hoeijmakers J H. Fanconi anemia (cross)linked to DNA repair. Cell 2005; 123: 1191–1198
   PubMed Web of Science ®Google Scholar
• Pagano G, Degan P, d'Ischia M, Kelly F J, Nobili B, Pallardo F V, Youssoufian H, Zatterale A. Oxidative stress as a multiple effector in Fanconi anaemia clinical phenotype. European Journal of Haematology 2005; 75: 93–100
   PubMed Web of Science ®Google Scholar
• Palcic B, Skarsgard L D. Reduced oxygen enhancement ratio at low doses of ionizing radiation. Radiation Research 1984; 100: 328–339
   PubMed Web of Science ®Google Scholar
• Parshad R, Sanford K K, Jones G M. Chromatid damage after G2 phase x-irradiation of cells from cancer-prone individuals implicates deficiency in DNA repair. Proceedings of the National Academy of Science of the USA 1983; 80: 5612–5616
   PubMed Web of Science ®Google Scholar
• Purschke M, Kasten-Pisula U, Brammer I, Dikomey E. Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation-induced DNA base damage. International Journal of Radiation Biology 2004; 80: 29–38
   PubMed Web of Science ®Google Scholar
• Ridet A, Guillouf C, Duchaud E, Cundari E, Fiore M, Moustacchi E, Rosselli F. Deregulated apoptosis is a hallmark of the Fanconi anemia syndrome. Cancer Research 1997; 57: 1722–1730
   PubMed Web of Science ®Google Scholar
• Rothfuss A, Grompe M. Repair kinetics of genomic interstrand DNA cross-links: Evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Molecular and Cellular Biology 2004; 24: 123–134
   PubMed Web of Science ®Google Scholar
• Saito H, Hammond A T, Moses R E. Hypersensitivity to oxygen is a uniform and secondary defect in Fanconi anemia cells. Mutation Research 1993; 294: 255–262
   Google Scholar
• Saleh-Gohari N, Bryant H E, Schultz N, Parker K M, Cassel T N, Helleday T. Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks. Molecular and Cellular Biology 2005; 25: 7158–7169
   PubMed Web of Science ®Google Scholar
• Schindler D, Hoehn H. Fanconi anemia mutation causes cellular susceptibility to ambient oxygen. American Journal of Human Genetics 1988; 43: 429–435
   PubMed Web of Science ®Google Scholar
• Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald E R, 3rd, Hurov K E, Luo J, Ballif B A, Gygi S P, Hofmann K, D'Andrea A D, Elledge S J. Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell 2007; 129: 289–301
   PubMed Web of Science ®Google Scholar
• Sprong D, Janssen H L, Vens C, Begg A C. Resistance of hypoxic cells to ionizing radiation is influenced by homologous recombination status. International Journal of Radiation Oncology Biology Physics 2006; 64: 562–572
   PubMedGoogle Scholar
• Taniguchi T, Garcia-Higuera I, Xu B, Andreassen P R, Gregory R C, Kim S T, Lane W S, Kastan M B, D'Andrea A D. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 2002; 109: 459–472
   PubMed Web of Science ®Google Scholar
• Tebbs R S, Hinz J M, Yamada N A, Wilson J B, Salazar E P, Thomas C B, Jones I M, Jones N J, Thompson L H. New insights into the Fanconi anemia pathway from an isogenic FancG hamster CHO mutant. DNA Repair (Amst) 2005; 4: 11–22
   PubMed Web of Science ®Google Scholar
• Thompson L H, Hinz J M, Yamada N A, Jones N J. How Fanconi anemia proteins promote the four Rs: Replication, recombination, repair, and recovery. Environmental and Molecular Mutagenesis 2005; 45: 128–142
   PubMed Web of Science ®Google Scholar
• Wang W. Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins. Nature Review in Genetics 2007; 8: 735–748
   PubMed Web of Science ®Google Scholar
• Wang X, Andreassen P R, D'Andrea A D. Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin. Molecular and Cellular Biology 2004; 24: 5850–5862
   PubMed Web of Science ®Google Scholar
• Weichselbaum R R, Nove J, Little J B. X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders. Cancer Research 1980; 40: 920–925
   PubMed Web of Science ®Google Scholar
• Willers H, Kachnic L A, Luo C M, Li L, Purschke M, Borgmann K, Held K D, Powell S N. Biomarkers and mechanisms of FANCD2 function. Journal of Biomedicine and Biotechnology 2008; 2008: 821529
   Google Scholar
• Wilson J B, Johnson M A, Stuckert A P, Trueman K L, May S, Bryant P E, Meyn R E, D'Andrea A D, Jones N J. The Chinese hamster FANCG/XRCC9 mutant NM3 fails to express the monoubiquitinated form of the FANCD2 protein, is hypersensitive to a range of DNA damaging agents and exhibits a normal level of spontaneous sister chromatid exchange. Carcinogenesis 2001; 22: 1939–1946
   PubMedGoogle Scholar
• Zhang J, Willers H, Feng Z, Ghosh J C, Kim S, Weaver D T, Chung J H, Powell S N, Xia F. Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair. Molecular and Cellular Biology 2004; 24: 708–718
   PubMed Web of Science ®Google Scholar