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Protection Against Radiation Damage

Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector

, PhD, , , , , , & show all
Pages 598-606 | Received 16 Dec 2008, Accepted 07 Apr 2009, Published online: 21 Jul 2009

References

  • Baliarsingh S, Beg Z H, Ahmad J. The therapeutic impacts of tocotrienols in type 2 diabetic patients with hyperlipidemia. Atherosclerosis 2005; 182: 367–374
  • Davidson D E, Greenan MM, Sweeney T R. Biological characteristics of some improved radioprotectors. Radiation sensitizers, their use in the clinical management of cancer, L W Brady. Mason, New York 1980; 309–320
  • Davis T A, Clarke T K, Mog S R, Landauer M R. Subcutaneous administration of genistein prior to lethal irradiation supports multilineage, hematopoietic progenitor cell recovery and survival. International Journal of Radiation Biology 2007; 83: 141–151
  • Eitsuka T, Nakagawa K, Miyazawa T. Down-regulation of telomerase activity in DLD-1 human colorectal adenocarcinoma cells by tocotrienol. Biochemical and Biophysical Research Communications 2006; 348: 170–175
  • FDA. Guidance for Industry. Toxicology and pharmacology. US Department of Health and Human Service, Rockville, MD 2005; 1–27, July
  • Galli F, Stabile A M, Betti M, Conte C, Pistilli A, Rende M, Floridi A, Azzi A. The effect of alpha- and gamma-tocopherol and their carboxyethyl hydroxychroman metabolites on prostate cancer cell proliferation. Archives of Biochemistry and Biophysics 2004; 423: 97–102
  • Ghosh S P, Hauer-Jensen M, Kumar K S. Chemistry of tocotrienols. Tocotrienols – vitamin E beyond tocopherols, R R Watson, V R Preedy. CRC Press, Boca Raton 2008; 379–398
  • Ghosh S P, Perkins M W, Hieber K, Kulkarni S, Kao T C, Reddy E P, Reddy M V, Maniar M, Seed T, Kumar K S. Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms. Radiation Research 2009; 171: 173–179
  • Goh S H, Hew N F, Norhanom A W, Yadav M. Inhibition of tumour promotion by various palm-oil tocotrienols. International Journal of Cancer 1994; 57: 529–531
  • Gould M N, Haag J D, Kennan W S, Tanner M A, Elson C E. A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors. American Journal of Clinical Nutrition 1991; 53: 1068S–1070S
  • Guthrie N, Gapor A, Chambers A F, Carroll K K. Inhibition of proliferation of estrogen receptor-negative MDA-MB-435 and -positive MCF-7 human breast cancer cells by palm oil tocotrienols and tamoxifen, alone and in combination. Journal of Nutrition 1997; 127: 544S–548S
  • Hauer-Jensen M, Kumar K S, Wang J, Berbee M, Fu Q, Boerma M. Intestinal toxicity in Radiation and combined injury: Significance, Mechanisms and Countermeasures. R Larche. Nova Science Publishers, Hauppauge 2008; 61–100, Global terrorism issues and developments
  • He L, Mo H, Hadisusilo S, Qureshi A A, Elson C E. Isoprenoids suppress the growth of murine B16 melanomas in vitro and in vivo. Journal of Nutrition 1997; 127(5)668–674
  • Iqbal J, Minhajuddin M, Beg Z H. Suppression of diethylnitrosamine and 2-acetylaminofluorene-induced hepatocarcinogenesis in rats by tocotrienol-rich fraction isolated from rice bran oil. European Journal of Cancer Prevention 2004; 13: 515–520
  • Jain S K, McVie R, Smith T. Vitamin E supplementation restores glutathione and malondialdehyde to normal concentrations in erythrocytes of type 1 diabetic children. Diabetes Care 2000; 23: 1389–1394
  • Kumar K S, Ghosh S P, Hauer-Jensen M. Gamma-tocotrienol: Potential as a countermeasure against radiological threat. R R Watson, V R Preedy. CRC Press, Boca Raton 2008; 379–398, Tocotrienols – vitamin E beyond tocopherols
  • Kumar K S, Raghavan M, Hieber K, Christine E, Mog S, Parra N, Hildabrand A, Singh V, Srinivasan V, Toles R, Karikari P, Petrovics G, Seed T, Srivastava S, Papas A. Preferential radiation sensitization of prostate cancer in nude mice by nutraceutical antioxidant gamma-tocotrienol. Life Sciences 2006; 78: 2099–2104
  • Kumar K S, Srinivasan V, Toles R, Jobe L, Seed T M. Nutritional approaches to radioprotection: Vitamin E. Military Medicine 2002; 167: 57–59
  • Kumar K S, Vaishnav Y N, Weiss J F. Radioprotection by antioxidant enzymes and enzyme mimetics. Pharmacology and Therapeutics 1988; 39: 301–309
  • Landauer M R, Davis H D, Kumar K S, Weiss J F. Behavioral toxicity of selected radioprotectors. Advances in Space Research 1992; 12: 273–283
  • Mettler FA, Jr, Voelz G L. Major radiation exposure – what to expect and how to respond. New England Journal of Medicine 2002; 346: 1554–1561
  • Moulder J E. Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: A review. International Journal of Radiation Biology 2004; 80: 3–10
  • Nesaretnam K, Dorasamy S, Darbre P D. Tocotrienols inhibit growth of ZR-75-1 breast cancer cells. International Journal of Food Sciences and Nutrition 2000; 51(Suppl)S95–103
  • Ngah W Z, Jarien Z, San M M, Marzuki A, Top G M, Shamaan N A, Kadir K A. Effect of tocotrienols on hepatocarcinogenesis induced by 2-acetylaminofluorene in rats. American Journal of Clinical Nutrition 1991; 53: 1076S–1081S
  • Pellmar TC, Rockwell S, and the Radiological/Nuclear Countermeasure Threat Working Group. Meeting report: Priority list of research areas for radiological nuclear threat countermeasures. Radiation Research 2005; 163: 115–123
  • Qureshi A A, Burger W C, Peterson D M, Elson C E. The structure of an inhibitor of cholesterol biosynthesis isolated from barley. Journal of Biological Chemistry 1986; 261: 10544–10550
  • Rukmini C, Raghuram T C. Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil. Journal of American College Nutrition 1991; 10: 593–601
  • Seed T, Kumar K S, Whitnall M, Srinivasan M, Singh V, Elliot T, Landauer M, Miller A, Chang C, Inal C, Deen J, Gehlhaus M, Jackson W, III, Hilyard E, Pendergrass J, Toles R, Villa V, Miner V, Stewart M, Benjack J, Danilenko D, Farrell C. New strategies for the prevention of radiation injury: Possible implications for countering radiation. Hazards of Long-term Space Travel 2002; 43: S239–S244
  • Sen C K, Khanna S, Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sciences 2006; 78: 2088–2098
  • Shun M C, Yu W, Gapor A, Parsons R, Atkinson J, Sanders B G, Kline K. Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutrition and Cancer 2004; 48: 95–105
  • Singh V K, Shafran R L, Jackson W, 3rd, Seed T M, Kumar K S. Induction of cytokines by radioprotective tocopherol analogs. Experimental and Molecular Pathology 2006; 81: 55–61
  • Singh V K, Yadav V S. Role of cytokines and growth factors in radioprotection. Experimental and Molecular Pathology 2005; 78: 156–169
  • Srinivasan V, Jacobs A J, Simpson S A, Weiss J F. Radioprotection by vitamin E: Effects on hepatic enzymes, delayed type hypersensitivity and post irradiation survival in mice, F L Meyskens, K N Prasad. S. Krager, Basel 1983
  • Srinivasan V, Weiss J F. Radioprotection by vitamin E: Injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice. International Journal of Radiation Oncology, Biology, Physics 1992; 23: 841–845
  • Srinivasan V, Pendergrass JA Jr, Kumar K S, Landauer M R, Seed T M. Radioprotection, pharmacokinetic and behavioral studies in mouse implanted with biodegradable drug (amifostine) pellets. International Journal of Radiation Biology 2002; 78: 535–543
  • Srivastava J K, Gupta S. Tocotrienol-rich fraction of palm oil induces cell cycle arrest and apoptosis selectively in human prostate cancer cells. Biochemical and Biophysical Research Communications 2006; 346: 447–453
  • Sylvester P W, Shah S. Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells. Asia Pacific Journal of Clinical Nutrition 2005; 14: 366–373
  • Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Letters 2005; 229: 181–191
  • Waddick K G, Song C W, Souza L, Uckun F M. Comparative analysis of the in vivo radioprotective effects of recombinant granulocyte colony-stimulating factor (G-CSF), recombinant granulocyte-macrophage CSF, and their combination. Blood 1991; 77: 2364–2371
  • Wang J, Qiu X, Zheng H, Joseph J, Ponnappan U, Mehta Jl, Fink L M, Hauer-Jensen M. Effect of statins on endothelial thrombomodulin in vitro and the intestinal radiation exposure in vivo. 2004, Radiation Research Society 51
  • Watkins T R, Bierenbaum M L, Giampaolo A. Tocotrienols: Biological and health effects. Antoxidant status, diet, nutrition and health, A M Papas. CRC Press, Boca Raton, FL 1999; 479–496
  • Whitnall M H, Elliott T B, Harding R A, Inal C E, Landauer M R, Wilhelmsen C L, McKinney L, Miner V L, Jackson W ER, Loria R M, Ledney G D, Seed T M. Androstenediol stimulates myelopoiesis and enhances resistance to infection in gamma-irradiated mice. International Journal of Immunopharmacology 2000; 22: 1–14
  • Whitnall M H, Elliott T B, Landauer M R, Jackson W E, 3rd, Wilhelmsen C L, McKinney L, Kumar K S, Srinivasan V, Ledney G D, Seed T M. In vivo protection against gamma-irradiation with 5-androstenediol. Experimental Biology and Medicine (Maywood) 2001; 226: 625–627
  • Yap S P, Yuen K H, Wong J W. Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienols under different food status. Journal of Pharmacy and Pharmacology 2001; 53: 67–71
  • Yu W, Simmons-Menchaca M, Gapor A, Sanders B G, Kline K. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutrition and Cancer 1999; 33: 26–32
  • Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. New England Journal of Medicine 2000; 342: 154–160

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