History of bystander effects research 1905-present; what is in a name?

References

• Ahmad SB, McNeill FE, Byun SH, Prestwich WV, Mothersill C, Seymour C, Armstrong A, Fernandez C. 2013. Ultra-violet light emission from hpv-g cells irradiated with low let radiation from 90Y; consequences for radiation induced bystander effects. Dose Response. 11:498–516.
   PubMed Web of Science ®Google Scholar
• Al-Mayah AHJ, Irons SL, Pink RC, Carter DRF, Kadhim MA. 2012. Possible role of exosomes containing RNA in mediating nontargeted effect of ionizing radiation. Radiat Res. 177:539–545.
   Google Scholar
• Alper T, Mothersill C, Seymour CB. 1988. Lethal mutations attributable to misrepair of Q-Lesions. Int J Radiat Biol. 54:525–530.
   PubMed Web of Science ®Google Scholar
• Arbetter KR, Prakash UBS, Tazelaar HD, Douglas WW. 1999. Radiation-induced pneumonitis in the “nonirradiated” lung. Mayo Clin Proc. 74:27–36.
   PubMed Web of Science ®Google Scholar
• Audette-Stuart M, Kim SB, McMullin D, Festarini A, Yankovich TL, Carr J, Mulpuru S. 2011. Adaptive response in frogs chronically exposed to low doses of ionizing radiation in the environment. J Environ Radioact. 102:566–573.
   PubMed Web of Science ®Google Scholar
• Autsavapromporn N, Suzuki M, Funayama T, Usami N, Plante I, Yokota Y, Mutou Y, Ikeda H, Kobayashi K, Kobayashi Y. 2013. Gap junction communication and the propagation of bystander effects induced by microbeam irradiation in human fibroblast cultures: the impact of radiation quality. Radiat Res. 180:367–375.
   PubMed Web of Science ®Google Scholar
• Azzam EI, de Toledo SM, Gooding T, Little JB. 1998. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat Res. 150:497–504.
   PubMed Web of Science ®Google Scholar
• Azzam EI, de Toledo SM, Little JB. 2001. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc Natl Acad Sci USA. 98:473–478.
   PubMed Web of Science ®Google Scholar
• Azzam EI, de Toledo SM, Little JB. 2003. Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene. 22:7050–7057.
   PubMed Web of Science ®Google Scholar
• Azzam EI, De Toledo SM, Little JB. 2004. Stress signaling from irradiated to non-irradiated cells. Curr Cancer Drug Targets. 4:53–64.
   PubMed Web of Science ®Google Scholar
• Azzam EI, de Toledo SM, Spitz DR, Little JB. 2002. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Res. 62:5436–5442.
   PubMed Web of Science ®Google Scholar
• Baskar R, Balajee AS, Geard CR, Hande MP. 2008. Isoform-specific activation of protein kinase c in irradiated human fibroblasts and their bystander cells. Int J Biochem Cell Biol. 40:125–134.
   PubMed Web of Science ®Google Scholar
• Beam CA, Mortimer RK, Wolfe RG, Tobias CA. 1954. The relation of radioresistance to budding in saccharomyces cerevisiae. Arch Biochem Biophys. 49:110–122.
   PubMed Web of Science ®Google Scholar
• Bertucci A, Pocock RDJ, Randers-Pehrson G, Brenner DJ. 2009. Microbeam irradiation of the C. elegans nematode. J Radiat Res. 50:A49–A54.
   PubMed Web of Science ®Google Scholar
• Blyth BJ, Sykes PJ. 2011. Radiation-induced bystander effects: what are they, and how relevant are they to human radiation exposures? Radiat Res. 176:139–157.
   PubMed Web of Science ®Google Scholar
• Brooks AL, Retherford JC, McClellan RO. 1974. Effect of239 PuO2 particle number and size on the frequency and distribution of chromosome aberrations in the liver of the Chinese Hamster. Radiat Res. 59:693–709.
   PubMed Web of Science ®Google Scholar
• Born R, Trott KR. 1988. Clonogenicity of the progeny of surviving cells after irradiation. Int J Radiat Biol Relat Stud Phys Chem Med. 53:319–330.
   PubMedGoogle Scholar
• Brown DC, Trott KR. 1994. Clonal heterogeneity in the progeny of HeLa cells which survive x-irradiation. Int J Radiat Biol. 66:151–155.
   PubMed Web of Science ®Google Scholar
• Camphausen K, Moses MA, Ménard C, Sproull M, Beecken WD, Folkman J, O’Reilly MS. 2003. Radiation abscopal antitumor effect is mediated through p53. Cancer Res. 63:1990–1993.
   PubMed Web of Science ®Google Scholar
• Chang WP, Little JB. 1991. Delayed reproductive death in x-irradiated Chinese Hamster ovary cells. Int J Radiat Biol. 60:483–496.
   PubMed Web of Science ®Google Scholar
• Chang WP, Little JB. 1992a. Evidence that DNA double-strand breaks initiate the phenotype of delayed reproductive death in Chinese Hamster ovary cells. Radiat Res. 131:53–59.
   PubMed Web of Science ®Google Scholar
• Chang WP, Little JB. 1992b. Persistently elevated frequency of spontaneous mutations in progeny of CHO clones surviving X-irradiation: association with delayed reproductive death phenotype. Mutat Res Mol Mech Mutagen. 270:191–199.
   PubMed Web of Science ®Google Scholar
• Coates PJ, Rundle JK, Lorimore SA, Wright EG. 2008. Indirect macrophage responses to ionizing radiation: implications for genotype-dependent bystander signaling. Cancer Res. 68:450–456.
   PubMed Web of Science ®Google Scholar
• Delbruck M. 1940. Radiation and the hereditary mechanism. Am Nat. 74:350–362.
   Google Scholar
• Demoise CF, Conrad RA. 1972. Effects of age and radiation exposure on chromosomes in a Marshall Island population. J Gerontol. 27:197–201.
   PubMedGoogle Scholar
• DeVeaux LC, Durtschi LS, Case JG, Wells DP. 2006. Bystander effects in unicellular organisms. Mutat Res. 597:78–86.
   PubMed Web of Science ®Google Scholar
• Emerit I. 1994. Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesis. Free Radic Biol Med. 16:99–109.
   PubMed Web of Science ®Google Scholar
• Faguet GB, Reichard SM, Welter DA. 1984. Radiation-induced clastogenic plasma factors. Cancer Genet Cytogenet. 12:73–83.
   PubMed Web of Science ®Google Scholar
• Fazzari J, Mersov A, Smith R, Seymour C, Mothersill C. 2012. Effect of 5-hydroxytryptamine (serotonin) receptor inhibitors on the radiation-induced bystander effect. Int J Radiat Biol. 88:786–790.
   PubMed Web of Science ®Google Scholar
• Fernandez-Palomo C, Schültke E, Bräuer-Krisch E, Laissue JA, Blattmann H, Seymour C, Mothersill C. 2016. Investigation of abscopal and bystander effects in immunocompromised mice after exposure to pencilbeam and microbeam synchrotron radiation. Health Phys. 111:149–159.
   PubMed Web of Science ®Google Scholar
• Fernandez-Palomo C, Schültke E, Smith R, Bräuer-Krisch E, Laissue J, Schroll C, Fazzari J, Seymour C, Mothersill C. 2013. Bystander effects in tumor-free and tumor-bearing rat brains following irradiation by synchrotron X-rays. Int J Radiat Biol. 89:445–453.
   PubMed Web of Science ®Google Scholar
• Goh K. 1975. Total-body irradiation and human chromosomes. IV. Cytogenetic follow-up studies 8 and 10 1/2 years after total-body irradiation. Radiat Res. 62:364–373.
   PubMed Web of Science ®Google Scholar
• Goh KO, Sumner H. 1968. Breaks in normal human chromosomes: are they induced by a transferable substance in the plasma of persons exposed to total-body irradiation? Radiat Res. 35:171–181.
   PubMed Web of Science ®Google Scholar
• Guan XJ, Bonney WJ, Ruch RJ. 1995. Changes in gap junction permeability, gap junction number, and Connexin43 expression in Lindane-treated rat liver epithelial cells. Toxicol Appl Pharmacol. 130:79–86.
   PubMed Web of Science ®Google Scholar
• Hamada N, Matsumoto H, Hara T, Kobayashi Y. 2007. Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects. J Radiat Res. 48:87–95.
   PubMed Web of Science ®Google Scholar
• Hatzi VI, Laskaratou DA, Mavragani IV, Nikitaki Z, Mangelis A, Panayiotidis MI, Pantelias GE, Terzoudi GI, Georgakilas AG. 2015. Non-targeted radiation effects in vivo: a critical glance of the future in radiobiology. Cancer Lett. 356:34–42.
   PubMed Web of Science ®Google Scholar
• Hei TK, Zhou H, Ivanov VN. 2008. Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol. 60:943–950.
   PubMed Web of Science ®Google Scholar
• Hei TK, Zhou H, Chai Y, Ponnaiya B, Ivanov VN. 2011. Radiation induced non-targeted response: mechanism and potential clinical implications. Curr Mol Pharmacol. 4:96–105.
   PubMedGoogle Scholar
• Heineke H. 1905. Experimental investigations on the effects of X-rays on the bone marrow, with some remarks on the radiotherapy of leukemia and pseudoleukemia and sarcoms. Deutsche Zeitschrift Für Chirurgie. 78:196–230.
   Google Scholar
• Hevesy G. 1945. On the effect of roentgen rays on cellular division. Rev Mod Phys. 17:102–111.
   Web of Science ®Google Scholar
• Hollowell JG, Littlefield LG. 1968. Chromosome damage induced by plasma of X-rayed patients: an indirect effect of X-ray. Proc Soc Exp Biol Med. 129:240–244.
   PubMed Web of Science ®Google Scholar
• Hollowell JGJ, Littlefield LG. 1967. Chromosome aberrations induced by plasma from irradiated patients: a brief report. J S C Med Assoc. 63:442.
   Google Scholar
• Hu B, Shen B, Su Y, Geard CR, Balajee AS. 2009. Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. Int J Biochem Cell Biol. 41:2413–2421.
   PubMed Web of Science ®Google Scholar
• Iyer R, Lehnert BE. 2000. Effects of ionizing radiation in targeted and nontargeted cells. Arch Biochem Biophys. 376:14–25.
   PubMed Web of Science ®Google Scholar
• Jolles B. 1941. X-ray skin reactions and the protective role of normal tissues. Br J Radiol. 14:110–112.
   Google Scholar
• Jolles B. 1949. A diffusible substance in irradiated tissues? Nature. 164:63–64.
   PubMed Web of Science ®Google Scholar
• Kadhim MA, Macdonald DA, Goodhead DT, Lorimore SA, Marsden SJ, Wright EG. 1992. Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature. 355:738–740.
   PubMed Web of Science ®Google Scholar
• Kashino G, Prise KM, Schettino G, Folkard M, Vojnovic B, Michael BD, Suzuki K, Kodama S, Watanabe M. 2004. Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells. Mutat Res Mol Mech Mutagen. 556:209–215.
   PubMed Web of Science ®Google Scholar
• Khan MA, Hill RP, Van Dyk J. 1998. Partial volume rat lung irradiation: an evaluation of early DNA damage. Int J Radiat Oncol Biol Phys. 40:467–476.
   PubMed Web of Science ®Google Scholar
• Khan MA, Van Dyk J, Yeung IWT, Hill RP. 2003. Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol. 66:95–102.
   PubMed Web of Science ®Google Scholar
• Koturbash I, Zemp FJ, Kutanzi K, Luzhna L, Loree J, Kolb B, Kovalchuk O. 2008. Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle. 7:1658–1667.
   PubMed Web of Science ®Google Scholar
• Kumar Jella K, Rani S, O’driscoll L, McClean B, Byrne HJ, Lyng FM. 2014. Exosomes are involved in mediating radiation induced bystander signaling in human keratinocyte cells. Radiat Res. 181:138–145.
   PubMed Web of Science ®Google Scholar
• Lacassagne A. 1928. The direct and indirect action of radiation on cancer tissues. Radiology. 11:393–402.
   Google Scholar
• Le M, Fernandez-Palomo C, McNeill FE, Seymour CB, Rainbow AJ, Mothersill CE. 2017. Exosomes are released by bystander cells exposed to radiation-induced biophoton signals: reconciling the mechanisms mediating the bystander effect. PLoS One. 12:e0173685.
   PubMed Web of Science ®Google Scholar
• Le M, Mothersill CE, Seymour CB, Ahmad SB, Armstrong A, Rainbow AJ, McNeill FE. 2015a. Factors affecting ultraviolet-a photon emission from beta-irradiated human keratinocyte cells. Phys Med Biol. 60:6371–6389.
   PubMed Web of Science ®Google Scholar
• Le M, McNeill FE, Seymour C, Rainbow AJ, Mothersill CE. 2015b. An observed effect of ultraviolet radiation emitted from beta-irradiated HaCaT cells upon non-beta-irradiated bystander cells. Radiat Res. 183:279–290.
   PubMed Web of Science ®Google Scholar
• Lea DE. 1947. Actions of radiations on living cells. 1st ed. Cambridge (UK): Cambridge University Press.
   Google Scholar
• Liu ZF, Lyun SH, McNeill FE, Mothersill CE, Seymour CB, Prestwich WV. 2007. Fluence and dose measurements for an accelerator neutron beam. Nucl Instrum Meth B. 263:326–328.
   Web of Science ®Google Scholar
• Liu ZF, Mothersill CE, McNeill FE, Lyng FM, Byun SH, Seymour CB, Prestwich WV. 2006. A dose threshold for a medium transfer bystander effect for a human skin cell line. Radiat Res. 166:19–23.
   PubMed Web of Science ®Google Scholar
• Lorimore SA, Coates PJ, Scobie GE, Milne G, Wright EG. 2001. Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? Oncogene. 20:7085.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Desplanques M, Jella KK, Garcia A, McClean B. 2012. The importance of serum serotonin levels in the measurement of radiation-induced bystander cell death in HaCaT cells. Int J Radiat Biol. 88:770–772.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Maguire P, McClean B, Seymour C, Mothersill C. 2006. The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiat Res. 165:400–409.
   PubMed Web of Science ®Google Scholar
• Lyng FM, OReilly S, Cottell DC, Seymour CB, Mothersill C. 1996. Persistent expression of morphological abnormalities in the distant progeny of irradiated cells. Radiat Environ Biophys. 35:273–283.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Seymour CB, Mothersill C. 2001. Oxidative stress in cells exposed to low levels of ionizing radiation. Biochem Soc Trans. 29:350–353.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Seymour CB, Mothersill C. 2002a. Early events in the apoptotic cascade initiated in cells treated with medium from the progeny of irradiated cells. Radiat Prot Dosimetry. 99:169–172.
   PubMed Web of Science ®Google Scholar
• Lyng FM, Seymour CB, Mothersill C. 2002b. Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: a possible mechanism for bystander-induced genomic instability? Radiat Res. 157:365–370.
   PubMed Web of Science ®Google Scholar
• Mancuso M, Pasquali E, Leonardi S, Tanori M, Rebessi S, Di Majo V, Pazzaglia S, Toni MP, Pimpinella M, Covelli V, et al. 2008. Oncogenic bystander radiation effects in patched heterozygous mouse cerebellum. Proc Natl Acad Sci USA. 105:12445–12450.
   PubMed Web of Science ®Google Scholar
• Marozik P, Mothersill C, Seymour CB, Mosse I, Melnov S. 2007. Bystander effects induced by serum from survivors of the chernobyl accident. Exp Hematol. 35:55–63.
   PubMed Web of Science ®Google Scholar
• Martín C, Romero S, Sánchez-Payá J, Massutí B, Arriero JM, Hernández L. 1999. Bilateral lymphocytic alveolitis: a common reaction after unilateral thoracic irradiation. Eur Respir J. 13:727–732.
   PubMed Web of Science ®Google Scholar
• Matsumoto H, Hayashi S, Hatashita M, Ohnishi K, Shioura H, Ohtsubo T, Kitai R, Ohnishi T, Kano E. 2001. Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat Res. 155:387–396.
   PubMed Web of Science ®Google Scholar
• McNaughton SJ. 1930. Radiation and genetics. Am Nat. 64:220–251.
   Google Scholar
• McMahon SJ, McGarry CK, Butterworth KT, Jain S, O’Sullivan JM, Hounsell AR, Prise KM. 2015. Cellular signalling effects in high precision radiotherapy. Phys Med Biol. 60:4551.
   PubMed Web of Science ®Google Scholar
• Mole RH. 1953. Whole body irradiation; radiobiology or medicine? Br J Radiol. 26:234–241.
   PubMed Web of Science ®Google Scholar
• Morgan GW, Pharm B, Breit SN. 1995. Radiation and the lung: a reevaluation of the mechanisms mediating pulmonary injury. Int J Radiat Oncol Biol Phys. 31:361–369.
   PubMed Web of Science ®Google Scholar
• Morgan WF. 2003a. Non-targeted and delayed effects of exposure to ionizing radiation: i. radiation-induced genomic instability and bystander effects in vitro. Radiat Res. 159:567–580.
   PubMed Web of Science ®Google Scholar
• Morgan WF. 2003b. Non-targeted and delayed effects of exposure to ionizing radiation: ii. radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat Res. 159:581–596.
   PubMed Web of Science ®Google Scholar
• Mosse I, Marozik P, Seymour C, Mothersill C. 2006. The effect of melanin on the bystander effect in human keratinocytes. Mutat Res. 597:133–137.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C. 1997. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int J Radiat Biol. 71:421–427.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C. 2001. Radiation-induced bystander effects: past history and future directions. Radiat Res. 155:759–767.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C. 2004. Radiation-induced bystander effects and adaptive responses-the Yin and Yang of low dose radiobiology? Mutat Res. 568:121–128.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour CB. 1998. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium. Radiat Res. 149:256–262.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour CB. 2002. Bystander and delayed effects after fractionated radiation exposure. Radiat Res. 158:626–633.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Bucking C, Smith RW, Agnihotri N, O’Neill A, Kilemade M, Seymour CB. 2006. Communication of radiation-induced stress or bystander signals between fish in vivo. Environ Sci Technol. 40:6859–6864.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Lyng F, Seymour C, Maguire P, Lorimore S, Wright E. 2005. Genetic factors influencing bystander signaling in murine bladder epithelium after low-dose irradiation in vivo. Radiat Res. 163:391–399.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Moran G, McNeill F, Gow MD, Denbeigh J, Prestwich W, Seymour CB. 2007a. A role for bioelectric effects in the induction of bystander signals by ionizing radiation? Dose Response. 5:214–229.
   PubMedGoogle Scholar
• Mothersill C, Seymour RJ, Seymour CB. 2006. Increased radiosensitivity in cells of two human cell lines treated with bystander medium from irradiated repair-deficient cells. Radiat Res. 165:26–34.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Smith RW, Agnihotri N, Seymour CB. 2007b. Characterization of a radiation-induced stress response communicated in vivo between zebrafish. Environ Sci Technol. 41:3382–3387.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Saroya R, Smith RW, Singh H, Seymour CB. 2010a. Serum serotonin levels determine the magnitude and type of bystander effects in medium transfer experiments. Radiat Res. 174:119–123.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour C. 2012. Changing paradigms in radiobiology. Mutat Res. 750:85–95.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Smith RW, Saroya R, Denbeigh J, Rowe B, et al. 2010b. Irradiation of rainbow trout at early life stages results in legacy effects in adults. Int J Radiat Biol. 86:817–828.
   PubMed Web of Science ®Google Scholar
• Muller HJ. 1928. The production of mutations by X-rays. Proc Natl Acad Sci USA. 14:714–726.
   PubMedGoogle Scholar
• Murphy JB, Morton JJ. 1915. The effect of roentgen rays on the rate of growth of spontaneous tumors in mice. J Exp Med. 22:800–803.
   PubMedGoogle Scholar
• Murphy JEJ, Nugent S, Seymour C, Mothersill C. 2005. Mitochondrial DNA point mutations and a novel deletion induced by direct low-LET radiation and by medium from irradiated cells. Mutat Res Toxicol Environ Mutagen. 585:127–136.
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Little JB. 1992. Induction of sister chromatid exchanges by extremely low doses of α-particles. Cancer Res. 52:6394–6396.
   PubMed Web of Science ®Google Scholar
• Narayanan PK, Goodwin EH, Lehnert BE. 1997. Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57:3963–3971.
   PubMed Web of Science ®Google Scholar
• Narayanan PK, LaRue KEA, Goodwin EH, Lehnert BE. 1999. Alpha particles induce the production of interleukin-8 by human cells. Radiat Res. 152:57–63.
   PubMed Web of Science ®Google Scholar
• Nickson JJ. 1950. The basic aspects of radiation effects on living systems. 1st ed. In: Morrison P, Burton M, Barron EG, Failla G, Patt HM, editors. New York (NY): Wiley.
   Google Scholar
• O’Dowd C, Mothersill CE, Cairns MT, Austin B, McClean B, Lyng FM, Murphy JEJ. 2006. The release of bystander factor(s) from tissue explant cultures of rainbow trout (Onchorhynchus mykiss) after exposure to gamma radiation. Radiat Res. 166:611–617.
   PubMed Web of Science ®Google Scholar
• O’Leary VB, Ovsepian SV, Carrascosa LG, Buske FA, Radulovic V, Niyazi M, Moertl S, Trau M, Atkinson MJ, Anastasov N. 2015. PARTICLE, a triplex-forming long ncRNA, regulates locus-specific methylation in response to low-dose irradiation. Cell Rep. 11:474–485.
   PubMed Web of Science ®Google Scholar
• Packard C. 1927. Biological effects of irradiation. Science. 69:x–xii.
   Google Scholar
• Pampfer S, Streffer C. 1989. Increased chromosome aberration levels in cells from mouse fetuses after zygote x-irradiation. Int J Radiat Biol. 55:85–92.
   PubMed Web of Science ®Google Scholar
• Pant GS, Kamada N. 1977. Chromosome aberrations in normal leukocytes induced by the plasma of exposed individuals. Hiroshima J Med Sci. 26:149–154.
   PubMed Web of Science ®Google Scholar
• Parsons WB, Watkins CH, Pease GL, Childs DS. 1954. Changes in sternal marrow following roentgen-ray therapy to the spleen in chronic granulocytic leukemia. Cancer. 7:179–189.
   PubMed Web of Science ®Google Scholar
• Poncy JL, Walter C, Fritsch P, Masse R, Lafuma J. 1979. Delayed SCE frequency of rat bone marrow cells after radon inhalation. 19. Annual ranford life sciences symposium on pulmonary toxicology of respirable particle; October 22–24; Richland, USA.
   Google Scholar
• Poon RC, Agnihotri N, Seymour C, Mothersill C. 2007. Bystander effects of ionizing radiation can be modulated by signaling amines. Environ Res. 105:200–211.
   PubMed Web of Science ®Google Scholar
• Prise KM, Belyakov OV, Newman HC, Patel S, Schettino G, Folkard M, Michael BD. 2002. Non-targeted effects of radiation: bystander responses in cell and tissue models. Radiat Prot Dosimetry. 99:223–226.
   PubMed Web of Science ®Google Scholar
• Prise KM, O’sullivan JM. 2009. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 9:351–360.
   PubMed Web of Science ®Google Scholar
• Prise KM, Schettino G, Folkard M, Held KD. 2005. New insights on cell death from radiation exposure. Lancet Oncol. 6:520–528.
   PubMed Web of Science ®Google Scholar
• Robertson JA. 1978. The CANDU reactor system: an appropriate technology. Science. 199:657–664.
   PubMed Web of Science ®Google Scholar
• Saroya R, Smith R, Seymour C, Mothersill C. 2010. Injection of reserpine into zebrafish prevents fish to fish communication of radiation induced bystander signals: confirmation in vivo of a role for serotonin in the mechanism. Dose Response. 8:317–330.
   Web of Science ®Google Scholar
• Schettino G, Folkard M, Michael BD, Prise KM. 2005. Low-dose binary behavior of bystander cell killing after microbeam irradiation of a single cell with focused c(k) x rays. Radiat Res. 163:332–336.
   PubMed Web of Science ®Google Scholar
• Schettino G, Folkard M, Prise KM, Vojnovic B, Held KD, Michael BD. 2003. Low-dose studies of bystander cell killing with targeted soft X rays. Radiat Res. 160:505–511.
   PubMed Web of Science ®Google Scholar
• Seymour CB, Mothersill C. 2000. Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat Res. 153:508–511.
   PubMed Web of Science ®Google Scholar
• Seymour CB, Mothersill CE, Alper T. 1986. High yields of lethal mutations in somatic mammalian-cells that survive ionizing-radiation. Int J Radiat Biol. 50:167–179.
   Web of Science ®Google Scholar
• Shao C, Furusawa Y, Aoki M, Matsumoto H, Ando K. 2002. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int J Radiat Biol. 78:837–844.
   PubMed Web of Science ®Google Scholar
• Shao C, Stewart V, Folkard M, Michael BD, Prise KM. 2003. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res. 63:8437–8442.
   PubMed Web of Science ®Google Scholar
• Shao C, Lyng FM, Folkard M, Prise KM. 2006. Calcium fluxes modulate the radiation-induced bystander responses in targeted glioma and fibroblast cells. Radiat Res. 166:479–487.
   PubMed Web of Science ®Google Scholar
• Sharetskiĭ AN, Kharlamov VA, Surinov BP. 2011. Effect of radiation-induced bystander chemosignals of mice on the humoral immune response in spleen and lymph nodes of intact recipients. Radiats Biol Radioecol. 52:229–233.
   Google Scholar
• Shields L, Vega-Carrascal I, Singleton S, Lyng FM, McClean B. 2014. Cell survival and DNA damage in normal prostate cells irradiated out-of-field. Radiat Res. 182:499–506.
   PubMed Web of Science ®Google Scholar
• Smith RW, Wang J, Bucking CP, Mothersill CE, Seymour CB. 2007. Evidence for a protective response by the gill proteome of rainbow trout exposed to X-ray induced bystander signals. Proteomics. 7:4171–4180.
   PubMed Web of Science ®Google Scholar
• Smith RW, Seymour CB, Moccia RD, Hinton TG, Mothersill CE. 2013. The induction of a radiation-induced bystander effect in fish transcends taxonomic group and trophic level. Int J Radiat Biol. 89:225–233.
   PubMed Web of Science ®Google Scholar
• Smith RW, Seymour CB, Moccia RD, Mothersill CE. 2016. Irradiation of rainbow trout at early life stages results in trans-generational effects including the induction of a bystander effect in non-irradiated fish. Environ Res. 145:26–38.
   PubMed Web of Science ®Google Scholar
• Souto J. 1962. Tumour development in the rat induced by blood of irradiated animals. Nature. 195:1317–1318.
   PubMed Web of Science ®Google Scholar
• Strangeway TSP, Fell HB. 1927. A study of the direct and indirect action of X-rays upon the tissues of the embryonic fowl. Proc R Soc London Ser B Contain Pap a Biol Character. 102:9–29.
   Google Scholar
• Surinov BP, Isaeva VG, Dukhova NN. 2004a. Communicative multiplication of secondary disorders in blood formula and immunity in groups of intact mice caused by volatile compounds excreted by irradiated animals. Radiats Biol Radioecol. 44:387–391.
   PubMedGoogle Scholar
• Surinov BP, Isaeva VG, Dukhova NN. 2004b. Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects. Bull Exp Biol Med. 138:384–386.
   PubMed Web of Science ®Google Scholar
• Surinov BP, Isaeva VG, Tokarev OI. 2001. Allelopathic activity of volatile secretions in irradiated animals. Radiats Biol Radioecol. 41:645–649.
   PubMedGoogle Scholar
• Surinov BP, Karpova NA, Isaeva VG, Kulish I. 1997. Communicative behavioral effects and disorders of immunity. Zh Vyss Nerv Deiat Im I P Pavlova. 48:1073–1079.
   Google Scholar
• Surinov BP, Karpova NA, Isaeva VG, Kulish IS. 2000. Post-stress state and communicative alterations of immunity and blood. Patol Fiziol Eksp Ter. 4:9–11.
   Google Scholar
• Surinov VP, Karpova NA, Isaeva VG, Kulish I. 1998. Natural excretions of mice in the postradiation period and contact induction of immunodeficiencies. Radiats Biol Radioecol. 38:9.
   PubMedGoogle Scholar
• Tartier L, Gilchrist S, Burdak-Rothkamm S, Folkard M, Prise KM. 2007. Cytoplasmic irradiation induces mitochondrial-dependent 53BP1 protein relocalization in irradiated and bystander cells. Cancer Res. 67:5872–5879.
   PubMed Web of Science ®Google Scholar
• Timofeeff-Ressovsky NW, Delbruck M. 1936. Radiation researches on visible mutations and the mutability of single genes in Drosophila. Z indukt Abstamm-u VererbLehre. 71:322.
   Google Scholar
• Timoféeff-Ressovsky NW, Zimmer KG. 1939. Radiation genetics. Strahlentherapie. 66:684.
   Google Scholar
• Trott KR. 2001. Non-targeted radiation effects in radiotherapy & roles of radiation-induced genomic instability and of the bystander effect in cancer cure by radiotherapy. Acta Oncol. 40:976–980.
   PubMed Web of Science ®Google Scholar
• Xu S, Wang J, Ding N, Hu W, Zhang X, Wang B, Hua J, Wei W, Zhu Q. 2015. Exosome-mediated microRNA transfer plays a role in radiation-induced bystander effect. RNA Biol. 12:1355–1363.
   PubMed Web of Science ®Google Scholar
• Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, Yu Z, Lieberman HB, Hei TK. 2005. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci USA. 102:14641–14646.
   PubMed Web of Science ®Google Scholar
• Zhou H, Ivanov VN, Lien Y-C, Davidson M, Hei TK. 2008. Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res. 68:2233–2240.
   PubMed Web of Science ®Google Scholar