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Original Articles

Radiofrequency radiation emitted from Wi-Fi (2.4 GHz) causes impaired insulin secretion and increased oxidative stress in rat pancreatic islets

, ORCID Icon, ORCID Icon &
Pages 850-857 | Received 05 Jan 2018, Accepted 31 May 2018, Published online: 10 Aug 2018

References

  • Aebi H. 1983. Catalase. In: Bergemyer HU, editor. Methods of enzymatic analysis. Weinheim, West Germany: Verlag Chemie. 3; p. 273–286.
  • Aynali G, Nazıroğlu M, Çelik Ö, Doğan M, Yarıktaş M, Yasan H. 2013. Modulation of wireless (2.45 GHz)-induced oxidative toxicity in laryngotracheal mucosa of rat by melatonin. Eur Arch Otorhinolaryngol. 270:1695–1700.
  • Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254.
  • Burlaka A, Tsybulin O, Sidorik E, Lukin S, Polishuk V, Tsehmistrenko S, Yakymenko I. 2013. Overproduction of free radical species in embryonal cells exposed to low intensity radiofrequency radiation. Exp Oncol. 35:219–225.
  • Çelik Ö, Kahya MC, Nazıroğlu M. 2016. Oxidative stress of brain and liver is increased by Wi-Fi (2.45GHz) exposure of rats during pregnancy and the development of newborns. J Chem Neuroanat. 75:134–139.
  • Çiğ B, Nazıroğlu M. 2015. Investigation of the effects of distance from sources on apoptosis, oxidative stress and cytosolic calcium accumulation via TRPV1 channels induced by mobile phones and Wi-Fi in breast cancer cells. Biochim Biophys Acta. 1848:2756–2765.
  • Consales C, Merla C, Marino C, Benassi B. 2012. Electromagnetic fields, oxidative stress, and neurodegeneration. Int J Biochem Cell Biol. 2012:1.
  • Dasdag S, Zulkuf Akdag M, Aksen F, Yilmaz F, Bashan M, Mutlu Dasdag M, Salih Celik M. 2003. Whole body exposure of rats to microwaves emitted from a cell phone does not affect the testes. Bioelectromagnetics. 24:182–188.
  • Demirel S, Doganay S, Turkoz Y, Dogan Z, Turan B, Firat PG. 2012. Effects of third generation mobile phone-emitted electromagnetic radiation on oxidative stress parameters in eye tissue and blood of rats. Cutan Ocul Toxicol. 31:89–94.
  • Desai NR, Kesari KK, Agarwal A. 2009. Pathophysiology of cell phone radiation: oxidative stress and carcinogenesis with focus on male reproductive system. Reprod Biol Endocrinol. 7:114.
  • Deshmukh PS, Banerjee BD, Abegaonkar MP, Megha K, Ahmed RS, Tripathi AK, Mediratta PK. 2013. Effect of low level microwave radiation exposure on cognitive function and oxidative stress in rats. Indian J Biochem Biophys. 50:114–119.
  • Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD. 2004. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India. 52:794–804.
  • Fahmy HM, Mohammed FF, Abdelrahman RT, Abu Elfetoh MM, Mohammed YA. 2015. Effect of radiofrequency waves emitted from conventional WIFI devices on some oxidative stress parameters in rat kidney. J Drug Metab Toxicol. 6:
  • Farrokhfall K, Khoshbaten A, Zahediasl S, Mehrani H, Karbalaei N. 2014. Improved islet function is associated with anti-inflammatory, antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic syndrome induced by high tail fat in rats. J Funct Foods. 10:397–406.
  • Forman HJ, Ursini F, Maiorino M. 2014. An overview of mechanisms of redox signaling. J Mol Cell Cardiol. 73:2–9.
  • Fridlyand LE, Philipson LH. 2004. Does the glucose-dependent insulin secretion mechanism itself cause oxidative stress in pancreatic beta-cells?. Diabetes. 53:1942–1948.
  • Friedman J, Kraus S, Hauptman Y, Schiff Y, Seger R. 2007. Mechanism of short-term ERK activation by electromagnetic fields at mobile phone frequencies. Biochem J. 405:559–568.
  • Gokcek-Sarac C, Er H, Kencebay Manas C, Kantar Gok D, Ozen S, Derin N. 2017. Effects of acute and chronic exposure to both 900 MHz and 2100 MHz electromagnetic radiation on glutamate receptor signaling pathway. Int J Radiat Biol. 93:980–989.
  • Guney M, Ozguner F, Oral B, Karahan N, Mungan T. 2007. 900 MHz radiofrequency-induced histopathologic changes and oxidative stress in rat endometrium: protection by vitamins E and C. Toxicol Ind Health. 23:411–420.
  • Hafeman DG, Sunde RA, Hoekstra WG. 1974. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr. 104:580–587.
  • Hagar HH, El Etter E, Arafa M. 2006. Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. Clin Exp Pharmacol Physiol. 33:189–196.
  • Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB. 2008. Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 295:E1287–E1297.
  • Kajimoto Y, Kaneto H. 2004. Role of oxidative stress in pancreatic β-cell dysfunction. In: Lee HK, DiMauro S, Tanaka M, Wei Y.-H, editors. Mitochondrial pathogenesis: from genes and apoptosis to aging and disease. Berlin, Heidelberg: Springer; p. 168–176.
  • Karbalaei N, Noorafshan A, Hoshmandi E. 2016. Impaired glucose-stimulated insulin secretion and reduced β-cell mass in pancreatic islets of hyperthyroid rats . Exp Physiol. 101:1114–1127.
  • Khaki AA, Ali-Hemmati A,RN. 2015. A study of the effects of electromagnetic field on islets of langerhans and insulin release in rats. Crescent J Med Biol Sci. 2:1–5.
  • Kleiber CE. 2017. Radiation from wireless technology elevates blood glucose and body temperature in 40-year-old type 1 diabetic male. Electromagn Biol Med. 36:259–264.
  • Li JH, Jiang DP, Wang YF, Yan JJ, Guo QY, Miao X, Lang HY, Xu SL, Liu JY, Guo GZ. 2017. Influence of electromagnetic pulse on the offspring sex ratio of male BALB/c mice. Environ Toxicol Pharmacol. 54:155–161.
  • Mahmoudi R, Mortazavi SMJ, Safari S, Nikseresht M, Mozdarani H, Jafari M, Zamani A, Haghani M, Davari M, Tabatabaie A. 2015. Effects of microwave electromagnetic radiations emitted from common Wi-Fi routers on rats’ sperm count and motility. Int J Radiat Res. 13:363–368.
  • Marklund S, Marklund G. 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem. 47:469–474.
  • Misa Agustino MJ, Leiro JM, Jorge Mora MT, Rodriguez-Gonzalez JA, Jorge Barreiro FJ, Ares-Pena FJ, Lopez-Martin E. 2012. Electromagnetic fields at 2.45 GHz trigger changes in heat shock proteins 90 and 70 without altering apoptotic activity in rat thyroid gland. Biol Open. 1:831–838.
  • Mortazavi SMJOSM, Shojaie-fard MB, Ghader-Panah M, Mortazavi SAR, Tavakoli-Golpayegani A, Haghani M, Taeb S, Shokrpour N, Koohi O. 2016. GSM 900 MHz microwave radiation-induced alterations of insulin level and histopathological changes of liver and pancreas in rat. J Biomed Phys Eng. 6:1–8.
  • Ozguner F, Bardak Y, Comlekci S. 2006. Protective effects of melatonin and caffeic acid phenethyl ester against retinal oxidative stress in long-term use of mobile phone: a comparative study. Mol Cell Biochem. 282:83–88.
  • Ragy MM. 2015. Effect of exposure and withdrawal of 900-MHz-electromagnetic waves on brain, kidney and liver oxidative stress and some biochemical parameters in male rats. Electromagn Biol Med. 34:279–284.
  • Robertson RP, Harmon JS. 2007. Pancreatic Islet beta-cell and oxidative stress: the importance of glutathione peroxidase. FEBS Lett. 581:3743–3748.
  • Safayee S, Karbalaei N, Noorafshan A, Nadimi E. 2016. Induction of oxidative stress, suppression of glucose-induced insulin release, ATP production, glucokinase activity, and histomorphometric changes in pancreatic islets of hypothyroid rat. Eur J Pharmacol. 791:147–156.
  • Sage C, Carpenter DO. 2009. Public health implications of wireless technologies. Pathophysiology. 16:233–246.
  • Sakurai T, Satake A, Sumi S, Inoue K, Miyakoshi J. 2004. An extremely low frequency magnetic field attenuates insulin secretion from the insulinoma cell line, RIN-m. Bioelectromagnetics. 25:160–166.
  • Salah MB, Abdelmelek H, Abderraba M. 2013. Effects of olive leave extract on metabolic disorders and oxidative stress induced by 2.45 GHz WIFI signals. Environ Toxicol Pharmacol. 36:826–834.
  • Shokri S, Soltani A, Kazemi M, Sardari D, Mofrad FB. 2015. Effects of Wi-Fi (2.45 GHz) exposure on apoptosis, sperm parameters and testicular histomorphometry in rats: a time course study. Cell J. 17:322–331.
  • Sivani S, Sudarsanam D. 2012. Impacts of radio-frequency electromagnetic field (RF-EMF) from cell phone towers and wireless devices on biosystem and ecosystem-a review. Biol Med. 4:
  • Tök L, Nazıroğlu M, Doğan S, Kahya MC, Tök O. 2014. Effects of melatonin on Wi-Fi-induced oxidative stress in lens of rats. Indian J Ophthalmol. 62:12–15.
  • Tsuji Y, Nakagawa M, Suzuki Y. 1996. Five-tesla static magnetic fields suppress food and water consumption and weight gain in mice. Ind Health. 34:347–357.
  • Türedi S, Kerimoğlu G, Mercantepe T, Odacı E. 2017. Biochemical and pathological changes in the male rat kidney and bladder following exposure to continuous 900-MHz electromagnetic field on postnatal days 22-59. Int J Radiat Biol. 93:990–999.
  • Wiederkehr A, Wollheim CB. 2006. Minireview: implication of mitochondria in insulin secretion and action. Endocrinology. 147:2643–2649.
  • Yakymenko I, Tsybulin O, Sidorik E, Henshel D, Kyrylenko O, Kyrylenko S. 2016. Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation. Electromagn Biol Med. 35:186–202.
  • Yin H, Xu L, Porter NA. 2011. Free radical lipid peroxidation: mechanisms and analysis. Chem Rev. 111:5944–5972.

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