Informing CONOPS and medical countermeasure deployment strategies after an improvised nuclear device detonation: the importance of delayed treatment efficacy data

References

• Allen RG, Brown FA, Logie LC, Rovner DR, Wilson SG, Jr, Zellmer RW. 1960. Acute effects of gamma radiation in primates. Radiat Res. 12:532–559.
   PubMed Web of Science ®Google Scholar
• Anno GH, Young RW, Bloom RM, Mercier JR. 2003. Dose response relationships for acute ionizing-radiation lethality. Health Phys. 84:565–575.
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. 2014. What to do during a radiation emergency: stay inside. [accessed 2018 June 1]. https://emergency.cdc.gov/radiation/shelter.asp.
   Google Scholar
• Clayton NP, Charpentier EJ, LaCasse ER, Khan-Malek RC, Keutzer JM. 2016. Sargramostim accelerates leukocyte recovery and improves mortality rate at day 60 in a non-human primate model of hematopoietic acute radiation syndrome when administered 48 h after total body irradiation. Blood 128:2512.
   Web of Science ®Google Scholar
• Coleman CN, Knebel AR, Hick JL, Weinstock DM, Casagrande R, Caro JJ, DeRenzo EG, Dodgen D, Norwood AE, Sherman SE, et al. 2011. Scarce resources for nuclear detonation: project overview and challenges. Disaster Med Public Health Prep. 5(Suppl):S13–S19.
   PubMedGoogle Scholar
• Dalrymple GV, Lindsay IR, Ghidoni JJ. 1965. The effect of 2-Mev whole-body X-irradiation on primates. Radiat Res. 25:377–400.
   PubMed Web of Science ®Google Scholar
• Eldred E, Trowbridge WV. 1954. Radiation sickness in the monkey. Radiology 62:65–73.
   PubMed Web of Science ®Google Scholar
• Farese AM, Brown CR, Smith CP, Gibbs AM, Katz BP, Johnson CS, Prado KL, MacVittie TJ. 2014. The ability of filgrastim to mitigate mortality following LD50/60 total-body irradiation is administration time-dependent. Health Phys. 106:39–47.
   PubMed Web of Science ®Google Scholar
• Farese AM, Cohen MV, Katz BP, Smith CP, Gibbs A, Cohen DM, MacVittie TJ. 2013. Filgrastim improves survival in lethally irradiated nonhuman primates. Radiat Res. 179:89–100.
   PubMed Web of Science ®Google Scholar
• Farese AM, Cohen MV, Katz BP, Smith CP, Jackson W 3rd, Cohen DM, MacVittie TJ. 2012. A nonhuman primate model of the hematopoietic acute radiation syndrome plus medical management. Health Phys. 103:367–382.
   PubMed Web of Science ®Google Scholar
• Haigh MV, Paterson E. 1956. Effects of a single session of whole body irradiation in the rhesus monkey. Br J Radiol. 29:148–157.
   PubMed Web of Science ®Google Scholar
• Hankey KG, Farese AM, Blaauw EC, Gibbs AM, Smith CP, Katz BP, Tong Y, Prado KL, MacVittie TJ. 2015. Pegfilgrastim improves survival of lethally irradiated nonhuman primates. Radiat Res. 183:643–655.
   PubMed Web of Science ®Google Scholar
• Henschke UK, Morton JL. 1957. Mortality of rhesus monkeys after single total body irradiation. Am J Roentgenol Radium Ther Nucl Med. 77:899–909.
   PubMedGoogle Scholar
• Holmberg J. 2011. Blood and tissue elements of national all-hazards responses. [accessed 2018 October 7]. https://wayback.archive-it.org/7993/20170111183045/http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/BloodVaccinesandOtherBiologics/BloodProductsAdvisoryCommittee/UCM306356.ppt.
   Google Scholar
• Hrdina CM, Coleman CN, Bogucki S, Bader JL, Hayhurst RE, Forsha JD, Marcozzi D, Yeskey K, Knebel AR. 2009. The “RTR” medical response system for nuclear and radiological mass-casualty incidents: a functional triage-treatment-transport medical response model. Prehosp Disaster Med. 24:167–178.
   PubMedGoogle Scholar
• Knebel AR, Coleman CN, Cliffer KD, Murrain-Hill P, McNally R, Oancea V, Jacobs J, Buddemeier B, Hick JL, Weinstock DM, et al. 2011. Allocation of scarce resources after a nuclear detonation: setting the context. Disaster Med Public Health Prep. 5(Suppl):S20–S31.
   PubMedGoogle Scholar
• National Security Staff Interagency Policy Coordination Subcommittee for Preparedness & Response to Radiological and Nuclear Threats. 2010. Planning Guidance for Response to a Nuclear Detonation. 2nd ed. [Washington (DC)] [accessed 2018 October 7]. https://www.remm.nlm.gov/PlanningGuidanceNuclearDetonation.pdf
   Google Scholar
• Schlumberger HG, Vazquez JJ. 1954. Pathology of total body irradiation in the monkey. Am J Pathol. 30:1013–1047.
   PubMed Web of Science ®Google Scholar
• Singh VK, Garcia M, Seed TM. 2017. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part II. Countermeasures for limited indications, internalized radionuclides, emesis, late effects, and agents demonstrating efficacy in large animals with or without FDA IND status. Int J Radiat Biol. 93:870–884.
   PubMed Web of Science ®Google Scholar
• Singh VK, Hanlon BK, Santiago PT, Seed TM. 2017. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part III. Countermeasures under early stages of development along with ‘standard of care’ medicinal and procedures not requiring regulatory approval for use. Int J Radiat Biol. 93:885–906.
   PubMed Web of Science ®Google Scholar
• Singh VK, Seed TM. 2017. A review of radiation countermeasures focusing on injury-specific medicinals and regulatory approval status: part I. Radiation sub-syndromes, animal models and FDA-approved countermeasures. Int J Radiat Biol. 93:851–869.
   PubMed Web of Science ®Google Scholar
• Stanley RE, Seigneur LJ, Strike TA. 1966. The acute mortality response of monkeys (Macaca mulatta) to mixed gamma-neutron radiations and 250 kVp X rays. Bethesda (MD): Armed Forces Radiobiology Research Institute.
   Google Scholar
• Taplitz RA, Kennedy EB, Bow EJ, Crews J, Gleason C, Hawley DK, Langston AA, Nastoupil LJ, Rajotte M, Rolston K, et al. 2018. Outpatient management of fever and neutropenia in adults treated for malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update. J Clin Oncol. 36:1443–1453.
   PubMed Web of Science ®Google Scholar