International Journal of Radiation Biology, Volume 96, Issue 1 (2020)

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International Journal of Radiation Biology, Volume 96, Issue 1 (2020)

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Non-clinical Radiation Biology and Pharmacology Models: Appraisal of State-of-the-Art and Innovation

Editorial

Editorial
Non-clinical radiation biology and pharmacology models: appraisal of state-of-the-art and innovation
Simon Authier, David Cassatt & Polly Chang
Pages: 1-3
Published online: 09 Aug 2019
First Page PreviewforNon-clinical radiation biology and pharmacology models: appraisal of state-of-the-art and innovation | Full Text | References | PDF (258.2 KB) | EPUB
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Free Access

Scenarios/CONOPS

Review
Informing CONOPS and medical countermeasure deployment strategies after an improvised nuclear device detonation: the importance of delayed treatment efficacy data
N. Yeddanapudi, M. A. Clay, D. P. Durham, C. M. Hoffman, M. J. Homer & J. M. Appler
Pages: 4-11
Published online: 07 Nov 2018
AbstractforInforming CONOPS and medical countermeasure deployment strategies after an improvised nuclear device detonation: the importance of delayed treatment efficacy data | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Impact analysis of age on radiation casualty estimations for nuclear detonation scenarios
Jacob Bellman, Emily Wilkinson, Tyler Dant, Alec Thurman & Daniela Stricklin
Pages: 12-21
Published online: 29 Oct 2018
AbstractforImpact analysis of age on radiation casualty estimations for nuclear detonation scenarios | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Dosimetry

Article
Development of a biodosimeter for radiation triage using novel blood protein biomarker panels in humans and non-human primates
Robert P. Balog, Rowena Bacher, Polly Chang, Michael Greenstein, Songeeta Jammalamadaka, Harold Javitz, Susan J. Knox, Shirley Lee, Hua Lin, Thomas Shaler, Lei Shura, Paul Stein, Kathryn Todd & David E. Cooper
Pages: 22-34
Published online: 03 Jan 2019
AbstractforDevelopment of a biodosimeter for radiation triage using novel blood protein biomarker panels in humans and non-human primates | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Development of a point-of-care radiation biodosimeter: studies using novel protein biomarker panels in non-human primates
Robert P. Balog, Polly Chang, Harold S. Javitz, Shirley Lee, Hua Lin, Thomas Shaler & David E. Cooper
Pages: 35-46
Published online: 05 Nov 2018
AbstractforDevelopment of a point-of-care radiation biodosimeter: studies using novel protein biomarker panels in non-human primates | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Bridging the gaps: using an NHP model to predict single dose radiation absorption in humans
Edwin S. Iversen, Janice M. McCarthy, Kirsten Bell Burdett, Gary Lipton, Gary Phillips, Holly Dressman, Joel Ross & Nelson Chao
Pages: 47-56
Published online: 29 Oct 2018
AbstractforBridging the gaps: using an NHP model to predict single dose radiation absorption in humans | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Models

Article
Role of a high throughput biodosimetry test in treatment prioritization after a nuclear incident
Aviva R. Jacobs, Timothy Guyon, Violetta Headley, Mahalakshmi Nair, William Ricketts, Gerry Gray, Jeffery Y. C. Wong, Nelson Chao & Robert Terbrueggen
Pages: 57-66
Published online: 03 Dec 2018
AbstractforRole of a high throughput biodosimetry test in treatment prioritization after a nuclear incident | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Open Access
Article
Development of age-dependent dose modification factors for acute radiation lethality
Daniela Stricklin, Robert Prins & Jacob Bellman
Pages: 67-80
Published online: 04 Jan 2019
AbstractforDevelopment of age-dependent dose modification factors for acute radiation lethality | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
WAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP)
Brian L. Fish, Thomas J. MacVittie, Aniko Szabo, John E. Moulder & Meetha Medhora
Pages: 81-92
Published online: 14 Jan 2019
AbstractforWAG/RijCmcr rat models for injuries to multiple organs by single high dose ionizing radiation: similarities to nonhuman primates (NHP) | Full Text | References | PDF (1.2 MB) | EPUB
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NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity
Laura E. Ewing, Isabelle R. Miousse, Rupak Pathak, Charles M. Skinner, Stanley Kosanke, Marjan Boerma, Martin Hauer-Jensen & Igor Koturbash
Pages: 93-99
Published online: 14 Jan 2019
AbstractforNZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Original Articles

Article
Characterization of a partial-body irradiation model with oral cavity shielding in nonhuman primates
Michael V. Accardi, Oreola Donini, Adam Rumage, Alexis Ascah, Julius Haruna, Mylène Pouliot, Kim Bujold, Hai Huang, Wieslaw Wierzbicki, John Stamatopoulos, Houman Naraghi, Thomas Measey & Simon Authier
Pages: 100-111
Published online: 03 Apr 2018
AbstractforCharacterization of a partial-body irradiation model with oral cavity shielding in nonhuman primates | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Morphological and functional impairment in the gut in a partial body irradiation minipig model of GI-ARS
Amandeep Kaur, Gabriëlla A.M. ten Have, Bernadette Hritzo, Nicolaas E.P. Deutz, Cara Olsen & Maria Moroni
Pages: 112-128
Published online: 07 Jan 2019
AbstractforMorphological and functional impairment in the gut in a partial body irradiation minipig model of GI-ARS | Full Text | References | PDF (4.5 MB) | EPUB
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Countermeasures

Review
Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation
Tyler A. Beach, Angela M. Groves, Jacqueline P. Williams & Jacob N. Finkelstein
Pages: 129-144
Published online: 25 Oct 2018
AbstractforModeling radiation-induced lung injury: lessons learned from whole thorax irradiation | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Romiplostim (Nplate®) as an effective radiation countermeasure to improve survival and platelet recovery in mice
Deborah I. Bunin, James Bakke, Carol E. Green, Harold S. Javitz, Mark Fielden & Polly Y. Chang
Pages: 145-154
Published online: 29 Apr 2019
AbstractforRomiplostim (Nplate®) as an effective radiation countermeasure to improve survival and platelet recovery in mice | Full Text | References | PDF (1.1 MB) | EPUB
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Open Access
Article
Pharmacodynamics of romiplostim alone and in combination with pegfilgrastim on acute radiation-induced thrombocytopenia and neutropenia in non-human primates
Karen Wong, Polly Y. Chang, Mark Fielden, Anne Marie Downey, Deborah Bunin, James Bakke, Janet Gahagen, Lalitha Iyer, Sameer Doshi, Wieslaw Wierzbicki & Simon Authier
Pages: 155-166
Published online: 21 Jun 2019
AbstractforPharmacodynamics of romiplostim alone and in combination with pegfilgrastim on acute radiation-induced thrombocytopenia and neutropenia in non-human primates | Full Text | References | PDF (1.3 MB) | EPUB
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