Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB inductions and conversions induced by therapeutic proton beams

References

• Bajinskis A, Natarajan AT, Erixon K, Harms-Ringdahl M. 2013. DNA double strand breaks induced by the indirect effect of radiation are more efficiently repaired by non-homologous end joining compared to homologous recombination repair. Mutat Res. 756(1-2):21–29.
   PubMed Web of Science ®Google Scholar
• Bajinskis A, Olsson G, Harms-Ringdahl M. 2012. The indirect effect of radiation reduces the repair fidelity of NHEJ as verified in repair deficient CHO cell lines exposed to different radiation qualities and potassium bromate. Mutat Res. 731(1-2):125–132.
   PubMed Web of Science ®Google Scholar
• Belli M, Cera F, Cherubini R, Dalla Vecchia M, Haque AM, Ianzini F, Moschini G, Sapora O, Simone G, Tabocchini MA, et al. 1998. RBE-LET relationships for cell inactivation and mutation induced by low energy protons in V79 cells: further results at the LNL facility. Int J Radiat Biol. 74(4):501–509.
   PubMed Web of Science ®Google Scholar
• Berger MJ, Coursey JS, Zucker MA, Chang J. 2005. ESTAR, PSTAR, and ASTAR: computer programs for calculating stopping-power and range tables for electrons, protons, and helium ions. National Institute of Standards and Technology. http://physics.nist.gov/PhysRefData/Star/Text/contents.html (accessed on Jan 24, 2019)
   Google Scholar
• Bert C, Engenhart-Cabillic R, Durante M. 2012. Particle therapy for noncancer diseases. Med Phys. 39(4):1716–1727.
   PubMed Web of Science ®Google Scholar
• Bettega D, Calzolari P, Chauvel P, Courdi A, Herault J, Iborra N, Marchesini R, Massariello P, Poli GL, Tallone L. 2000. Radiobiological studies on the 65 MeV therapeutic proton beam at Nice using human tumour cells. Int J Radiat Biol. 76(10):1297–1303.
   PubMed Web of Science ®Google Scholar
• Biaggi M, Ballarini F, Burkard W, Egger E, Ferrari A, Ottolenghi A. 1999. Physical and biophysical characteristics of a fully modulated 72 MeV therapeutic proton beam: model predictions and experimental data. Nuclear Instr Methods Phys Res Sec B. 159(1-2):89–100.
   Web of Science ®Google Scholar
• Blaisdell JO, Harrison L, Wallace SS. 2001. Base excision repair processing of radiation-induced clustered DNA lesions. Radiat Protect Dosim. 97:25–31.
   PubMed Web of Science ®Google Scholar
• Blocher D. 1988. DNA double-strand break repair determines the RBE of alpha-particles. Int J Radiat Biol. 54:761–771.
   PubMed Web of Science ®Google Scholar
• Bolderson E, Richard DJ, Zhou BB, Khanna KK. 2009. Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clin Cancer Res. 15(20):6314–6320.
   PubMed Web of Science ®Google Scholar
• Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T. 2005. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature. 434(7035):913–917.
   PubMed Web of Science ®Google Scholar
• Calugaru V, Nauraye C, Noel G, Giocanti N, Favaudon V, Megnin-Chanet F. 2011. Radiobiological characterization of two therapeutic proton beams with different initial energy spectra used at the Institut Curie Proton Therapy Center in Orsay. Int J Radiat Oncol Biol Phys. 81(4):1136–1143.
   PubMed Web of Science ®Google Scholar
• Carlson DJ, Stewart RD, Semenenko VA. 2006. Effects of oxygen on intrinsic radiation sensitivity: a test of the relationship between aerobic and hypoxic linear-quadratic (LQ) model parameters. Med Phys. 33(9):3105–3115.
   PubMed Web of Science ®Google Scholar
• Cedervall B, Källman P, Dewey WC, Kallman P. 1995. Repair of DNA double-strand breaks: errors encountered in the determination of half-life times in pulsed-field gel electrophoresis and neutral filter elution. Radiat Res. 142(1):23–28.
   PubMed Web of Science ®Google Scholar
• Chang JY, Komaki R, Wen HY, De Gracia B, Bluett JB, McAleer MF, Swisher SG, Gillin M, Mohan R, Cox JD. 2011. Toxicity and patterns of failure of adaptive/ablative proton therapy for early-stage, medically inoperable non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 80(5):1350–1357.
   PubMed Web of Science ®Google Scholar
• Chaudhary P, Gwynne D, Doria D, Romagnani L, Maiorino C, Padda H, Alejo A, Booth N, Carroll D, Kar S, et al. 2016. Laser accelerated ultra high dose rate protons induced DNA damage under hypoxic conditions. Radiother Oncol. 118:S24–S25.
   PubMedGoogle Scholar
• Chaudhary P, Gwynne D, Doria D, Romagnani L, Maiorino C, Padda H, Alejo A, Booth N, Carroll D, Kar S, et al. 2017. Effectiveness of laser accelerated ultra high dose rate protons. In: A. Bret, M. Fajardo, E. Westerhof, A. Melzer, B. Dromey and C. Riconda, editors. Proceedings of the 44th EPS Conference on Plasma Physics, EPS 2017. vol. 41F. Mulhouse, France: European Physical Society (EPS).
   Google Scholar
• Chaudhary P, Marshall TI, Perozziello FM, Manti L, Currell FJ, Hanton F, McMahon SJ, Kavanagh JN, Cirrone GA, Romano F, et al. 2014. Relative biological effectiveness variation along monoenergetic and modulated Bragg peaks of a 62-MeV therapeuticproton beam: a preclinical assessment. Int J Radiat Oncol Biol Phys. 90(1):27–35.
   PubMed Web of Science ®Google Scholar
• Cui L, Tse K, Zahedi P, Harding SM, Zafarana G, Jaffray DA, Bristow RG, Allen C. 2014. Hypoxia and cellular localization influence the radiosensitizing effect of gold nanoparticles (AuNPs) in breast cancer cells. Radiat Res. 182(5):475–488.
   PubMed Web of Science ®Google Scholar
• deLara CM, Jenner TJ, Townsend KM, Marsden SJ, O'Neill P. 1995. The effect of dimethyl sulfoxide on the induction of DNA double-strand breaks in V79-4 mammalian cells by alpha particles. Radiat Res. 144(1):43–49.
   PubMed Web of Science ®Google Scholar
• Eccles LJ, O’Neill P, Lomax ME. 2011. Delayed repair of radiation induced clustered DNA damage: friend or foe? Mutat Res. 711(1-2):134–141.
   PubMed Web of Science ®Google Scholar
• Ewing D, Walton HL. 1991. Radiation protection of in vitro mammalian cells: effects of hydroxyl radical scavengers on the slopes and shoulders of survival curves. Radiat Res. 126(2):187–197.
   PubMed Web of Science ®Google Scholar
• Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, et al. 2005. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 434(7035):917–921.
   PubMed Web of Science ®Google Scholar
• Forster JC, Douglass MJJ, Phillips WM, Bezak E. 2018. Monte Carlo simulation of the oxygen effect in DNA damage induction by ionizing radiation. Radiat Res. 190(3):248–261.
   PubMed Web of Science ®Google Scholar
• Frankenberg D, Frankenberg-Schwager M, Harbich R. 1993. Mechanisms of oxygen radiosensitization in irradiated yeast. I. DNA double-strand breakage. Int J Radiat Biol. 64(5):511–521.
   PubMed Web of Science ®Google Scholar
• Georgakilas AG. 2008. Processing of DNA damage clusters in human cells: current status of knowledge. Mol BioSyst. 4(1):30–35.
   PubMedGoogle Scholar
• Georgakilas AG, O'Neill P, Stewart RD. 2013. Induction and repair of clustered DNA lesions: what do we know so far? Radiat Res. 180(1):100–109.
   PubMed Web of Science ®Google Scholar
• Gerelchuluun A, Hong Z, Sun L, Suzuki K, Terunuma T, Yasuoka K, Sakae T, Moritake T, Tsuboi K. 2011. Induction of in situ DNA double-strand breaks and apoptosis by 200 MeV protons and 10 MV X-rays in human tumour cell lines. Int J Radiat Biol. 87(1):57–70.
   PubMed Web of Science ®Google Scholar
• Giedzinski E, Rola R, Fike JR, Limoli CL. 2005. Efficient production of reactive oxygen species in neural precursor cells after exposure to 250 MeV protons. Radiat Res. 164(4):540–544.
   PubMed Web of Science ®Google Scholar
• Gueulette J, Octave-Prignot M, De Coster BM, Wambersie A, Grégoire V. 2004. Intestinal crypt regeneration in mice: a biological system for quality assurance in non-conventional radiation therapy. Radiother Oncol. 73:S148–S154.
   PubMed Web of Science ®Google Scholar
• Hall EJ, Giaccia AJ. 2012. Radiobiology for the radiologist. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins.
   Google Scholar
• Hashimoto S, Sugie C, Iwata H, Ogino H, Omachi C, Yasui K, Mizoe JE, Shibamoto Y. 2018. Recovery from sublethal damage and potentially lethal damage: proton beam irradiation vs. X-ray irradiation. Strahlenther Onkol. 194(4):343–351.
   PubMed Web of Science ®Google Scholar
• Hirayama R, Ito A, Noguchi M, Matsumoto Y, Uzawa A, Kobashi G, Okayasu R, Furusawa Y. 2013. OH radicals from the indirect actions of X-rays induce cell lethality and mediate the majority of the oxygen enhancement effect. Radiat Res. 180(5):514–523.
   PubMed Web of Science ®Google Scholar
• Holliday EB, Frank SJ. 2014. Proton radiation therapy for head and neck cancer: a review of the clinical experience to date. Int J Radiat Oncol Biol Phys. 89(2):292–302.
   PubMed Web of Science ®Google Scholar
• Hsiao Y, Stewart RD. 2008. Monte Carlo simulation of DNA damage induction by x-rays and selected radioisotopes. Phys Med Biol. 53(1):233–244.
   PubMed Web of Science ®Google Scholar
• Huang JC, Hsu DS, Kazantsev A, Sancar A. 1994. Substrate spectrum of human excinuclease: Repair of abasic sites, methylated bases, mismatches, and bulky adducts. Proc Natl Acad Sci USA. 91(25):12213–12217.
   PubMed Web of Science ®Google Scholar
• Jacob SW, de la Torre JC. 2017. Dimethyl sulfoxide (DMSO) in trauma and disease. Boca Raton, FL: CRC press.
   Google Scholar
• Karran P, Brem R. 2016. Protein oxidation, UVA and human DNA repair. DNA Repair. 44:178–185.
   PubMed Web of Science ®Google Scholar
• Kelada OJ, Carlson DJ. 2016. Tumor hypoxia and radiotherapy. In: Yun Z, editor. Tumor hypoxia. New Jersey: World Scientific. pp 1–48.
   Google Scholar
• Lin SH, Komaki R, Liao Z, Wei C, Myles B, Guo X, Palmer M, Mohan R, Swisher SG, Hofstetter WL, et al. 2012. Proton beam therapy and concurrent chemotherapy for esophageal cancer. Int J Radiat Oncol Biol Phys. 83(3):e345–e351.
   PubMed Web of Science ®Google Scholar
• Lipinski B. 2011. Hydroxyl radical and its scavengers in health and disease. Oxid Med Cell Longev. 2011:1.
   Google Scholar
• Lomax ME, Folkes LK, O'Neill P. 2013. Biological consequences of radiation-induced DNA damage: relevance to radiotherapy. Clin Oncol. 25(10):578–585.
   PubMed Web of Science ®Google Scholar
• Madhusudan S, Hickson ID. 2005. DNA repair inhibition: a selective tumour targeting strategy. Trends Mol Med. 11(11):503–511.
   PubMed Web of Science ®Google Scholar
• McKeown SR. 2014. Defining normoxia, physoxia and hypoxia in tumours-implications for treatment response. Br J Radiol. 87(1035):20130676.
   PubMed Web of Science ®Google Scholar
• Mizumoto M, Oshiro Y, Yamamoto T, Kohzuki H, Sakurai H. 2017. Proton beam therapy for pediatric brain tumor. Neurol Med Chir(Tokyo). 57(7):343–355.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, O'Neill P, Terrissol M, Goodhead DT. 1999. Quantitative modelling of DNA damage using Monte Carlo track structure method. Radiat Environ Biophys. 38(1):31–38.
   PubMed Web of Science ®Google Scholar
• Nikjoo H, Uehara S, Wilson WE, Hoshi M, Goodhead DT. 1998. Track structure in radiation biology: theory and applications. Int J Radiat Biol. 73:355–364.
   PubMed Web of Science ®Google Scholar
• Paganetti H. 2014. Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer. Phys Med Biol. 59(22):R419–R472.
   PubMed Web of Science ®Google Scholar
• Paganetti H. 2018. Proton relative biological effectiveness - uncertainties and opportunities. Int J Part Ther. 5(1):2–14.
   PubMedGoogle Scholar
• Petkovic VD, Keta OD, Vidosavljevic MZ, Incerti S, Ristic Fira AM, Petrovic IM. 2019. Biological outcomes of gamma-radiation induced DNA damages in breast and lung cancer cells pretreated with free radical scavengers. Int J Radiat Biol. 95:274–285.
   PubMed Web of Science ®Google Scholar
• Prise KM, Folkard M, Davies S, Michael BD. 1990. The irradiation of V79 mammalian cells by protons with energies below 2 MeV. Part II. Measurement of oxygen enhancement ratios and DNA damage. Int J Radiat Biol. 58(2):261–277.
   PubMed Web of Science ®Google Scholar
• Pruchniak MP, Aražna M, Demkow U. 2016. Biochemistry of oxidative stress. Adv Exp Med Biol. 878:9–19.
   PubMed Web of Science ®Google Scholar
• Ratnayake RK, Semenenko VA, Stewart RD. 2005. Retrospective analysis of double-strand break rejoining data collected using warm-lysis PFGE protocols. Int J Radiat Biol. 81(6):421–428.
   PubMed Web of Science ®Google Scholar
• Reardon JT, Bessho T, Kung HC, Bolton PH, Sancar A. 1997. In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in Xeroderma pigmentosum patients. Proc Natl Acad Sci USA. 94(17):9463–9468.
   PubMed Web of Science ®Google Scholar
• Romesser PB, Cahlon O, Scher E, Zhou Y, Berry SL, Rybkin A, Sine KM, Tang S, Sherman EJ, Wong R, et al. 2016. Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation. Radiother Oncol. 118(2):286–292.
   PubMed Web of Science ®Google Scholar
• Roots R, Okada S. 1975. Estimation of life times and diffusion distances of radicals involved in X ray induced DNA strand breaks or killing of mammalian cells. Radiat Res. 64(2):306–320.
   PubMed Web of Science ®Google Scholar
• Rothkamm K, Löbrich M. 2003. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA. 100(9):5057–5062.
   PubMed Web of Science ®Google Scholar
• Sage E, Shikazono N. 2017. Radiation-induced clustered DNA lesions: repair and mutagenesis. Free Rad Biol Med. 107:125–135.
   PubMed Web of Science ®Google Scholar
• Semenenko VA, Stewart RD. 2004. A fast Monte Carlo algorithm to simulate the spectrum of DNA damages formed by ionizing radiation. Radiat Res. 161(4):451–457.
   PubMed Web of Science ®Google Scholar
• Semenenko VA, Stewart RD. 2005. Monte Carlo simulation of base and nucleotide excision repair of clustered DNA damage sites. II. Comparisons of model predictions to measured data. Radiat Res. 164(2):194–201.
   PubMed Web of Science ®Google Scholar
• Semenenko VA, Stewart RD. 2006. Fast Monte Carlo simulation of DNA damage formed by electrons and light ions. Phys Med Biol. 51(7):1693–1706. https://faculty.washington.edu/trawets/mcds/download/how2run.txt
   PubMed Web of Science ®Google Scholar
• Semenenko VA, Stewart RD, Ackerman EJ. 2005. Monte Carlo simulation of base and nucleotide excision repair of clustered DNA damage sites. I. Model properties and predicted trends. Radiat Res. 164(2):180–193.
   PubMed Web of Science ®Google Scholar
• Shikazono N, Noguchi M, Fujii K, Urushibara A, Yokoya A. 2009. The yield, processing, and biological consequences of clustered DNA damage induced by ionizing radiation. J Radiat Res. 50(1):27–36.
   PubMed Web of Science ®Google Scholar
• Stewart RD, Yu VK, Georgakilas AG, Koumenis C, Park JH, Carlson DJ. 2011. Effects of radiation quality and oxygen on clustered DNA lesions and cell death. Radiat Res. 176(5):587–602. http://faculty.washington.edu/trawets/mcds/.
   PubMed Web of Science ®Google Scholar
• Takada A, Nakamura T, Takayama K, Makita C, Suzuki M, Azami Y, Kato T, Tsukiyama I, Hareyama M, Kikuchi Y, et al. 2016. Preliminary treatment results of proton beam therapy with chemoradiotherapy for stage I-III esophageal cancer. Cancer Med. 5(3):506–515.
   PubMed Web of Science ®Google Scholar
• Tang JT, Inoue T, Inoue T, Yamazaki H, Fukushima S, Fournier-Bidoz N, Koizumi M, Ozeki S, Hatanaka K. 1997. Comparison of radiobiological effective depths in 65-MeV modulated proton beams. Br J Cancer. 76(2):220–225.
   PubMed Web of Science ®Google Scholar
• Tsai JY, Chen FH, Hsieh TY, Hsiao YY. 2015. Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB induction and conversion induced by gamma rays and helium ions. J Radiat Res. 56(4):691–699.
   PubMed Web of Science ®Google Scholar
• Van der Schans GP. 1991. Effect of dose modifiers on radiation-induced cellular DNA damage. In: Fielden EM and O'Neill P, editors. The early effects of radiation on DNA. Berlin: Springer. pp 347–362.
   Google Scholar
• Von Sonntag C. 2006. Free-radical-induced DNA damage and its repair. Heidelberg: Springer.
   Google Scholar
• Wallace SS. 1998. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat Res. 150(5):S60–S79.
   PubMed Web of Science ®Google Scholar
• Ward JF. 1994. The complexity of DNA damage: relevance to biological consequences. Int J Radiat Biol. 66(5):427–432.
   PubMed Web of Science ®Google Scholar
• Ward JF. 1999. Ionizing radiation damage to DNA: a challenge to repair system. In: Miral D, Ali EK, editors. Advances in DNA damage & repair: oxygen radical effects, cellular protection and biological consequences. New York: Springer. pp. 431–439.
   Google Scholar
• Yang C, Tang H, Wang L, Peng R, Bai F, Shan Y, Yu Z, Zhou P, Cong Y. 2018. Dimethyl sulfoxide prevents radiation-induced oral mucositis through facilitating DNA double-strand break repair in epithelial stem cell. Int J Radiat Oncol Biol Phys. 102(5):1577–1589.
   PubMed Web of Science ®Google Scholar
• Zhang X, Lin SH, Fang B, Gillin M, Mohan R, Chang JY. 2013. Therapy-resistant cancer stem cells have differing sensitivity to photon versus proton beam radiation. J Thorac Oncol. 8(12):1484–1491.
   PubMed Web of Science ®Google Scholar