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International Journal of Radiation Biology Volume 96, 2020 - Issue 7
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Original Articles

The influence of the α/β ratio on treatment time iso-effect relationships in the central nervous system

Bleddyn JonesGray Laboratory, Department of Oncology, University of Oxford, Oxford, UK; ;Green Templeton College, University of Oxford, Oxford, UK; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-6698-1660View further author information
ORCID Icon,
Thomas KlingeWellcome/EPSRC Centre for Interventional and Surgical Sciences, Department Medical Physics and Biomedical Engineering, University College London, London, UK; ;Centre for Medical Image Computing, Department Medical Physics and Biomedical Engineering, University College London, London, UK; ;School of Biomedical Engineering and Imaging Sciences, King’s College London, London, UKORCID Iconhttp://orcid.org/0000-0002-8559-0841View further author information
ORCID Icon &
John W. HopewellGreen Templeton College, University of Oxford, Oxford, UK; ORCID Iconhttp://orcid.org/0000-0001-9751-3109View further author information
ORCID Icon
Pages 903-909 | Received 08 Nov 2019, Accepted 10 Mar 2020, Published online: 28 Apr 2020

References

  • Canney PA, Millar WT. 1997. Biphasic cellular repair and implications for multiple field radiotherapy treatments. Br J Radiol. 70:817–822.
  • Dale RG. 2018. Radiation repair models for clinical application. Br J Radiol. 92:20180070.
  • Dale RG, Jones B. 1998. The clinical radiobiology of brachytherapy. Br J Radiol. 71:465–483.
  • Graffeo CS, Donegan D, Erickson D, Brown PD, Perry A, Link MJ, Young WF Jr, Pollock BE. 2020. The impact of insulin-like growth factor index and biological effective dose on outcomes after stereotactic radiosurgery for acromegaly: cohort study. Neurosurgery.
  • Hopewell JW, Millar WT, Lindquist C, Nordström H, Lidberg P, Gårding J. 2013. Application of the concept of biologically effective dose (BED) to patients with Vestibular Schwannomas treated by radiosurgery. J Radiosurg SBRT. 2:259–271.
  • Hopewell JW, Millar WT, Lindquist C. 2012. Radiobiological principle: their application to Gamma Knife therapy. Prog Neurol Surg. 25:39–54.
  • Hopewell JW, Morris AD, Dixon-Brown A1. 1987. The influence of field size on the late tolerance of the rat spinal cord to single doses of X rays. Br J Radiol. 60:1099–1108.
  • Hopewell JW, van der Kogel AJ. 1988. Volume effects in the spinal cord. Br J Radiol. 61:973–975.
  • Jones B, Hopewell JW. 2014. Alternative models for estimating the radiotherapy re-treatment dose for the spinal cord. Int J Radiat Biol. 90:731–741.
  • Jones B, Hopewell JW. 2019. Spinal cord re-treatments using photon and proton based radiotherapy: LQ-derived tolerance doses. Phys Med. 64:304–310.
  • Jones B, Hopewell JW. 2018. Modelling the influence of treatment time on the biological effectiveness of single radiosurgery treatments: derivation of ‘protective’ dose modification factors. Br J Radiol. 92:20180111.
  • Millar WT, Canney PA. 1993. Derivation and application of equations describing the effects of fractionated protracted irradiation, based on multiple and incomplete repair processes. Part I. Derivation of equations. Int J Radiat Biol. 64:275–291.
  • Millar WT, Hopewell JW, Paddick I, Lindquist C, Nordströn H, Lidberg P, Gårding J. 2015. The role of the concept of biologically effective dose (BED) in treatment planning in radiosurgery. Phys Med. 31:627–633.
  • Pop LA, Millar WT, van der Plas M, van der Kogel AJ. 2000. Radiation tolerance of rat spinal cord to pulsed dose rate (PDR-) brachytherapy: the impact of differences in temporal dose distribution. Radiother Oncol. 55:301–315.
  • Tuleasca C, Paddick I, Hopewell JW, Jones B, Millar WT, Hamdi H, Porcheron D, Levivier M, Régis J. 2020. Establishment of a therapeutic ratio for Gamma Knife Radiosurgery of trigeminal neuralgia: the critical importance of biologically effective dose (BED) versus physical dose. World Neurosurg. 134:e204–e213.
  • Woolley TE, Belmonte-Beitia J, Calvo GF, Hopewell JW, Gaffney EA, Jones B. 2018. Changes in the retreatment radiation tolerance of the spinal cord with time after the initial treatment. Int J Radiat Biol. 94:515–531.

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