Accelerator-based boron neutron capture therapy for malignant glioma: a pilot neutron irradiation study using boron phenylalanine, sodium borocaptate and liposomal borocaptate with a heterotopic U87 glioblastoma model in SCID mice

References

• Anderson O, Alpen E, Kwan J, Wells R, DeVries G, Faltens A, Reginato L. 1994. ESQ-focused 2.5 MeV DC accelerator for BNCT. In: Suller VP, Petit-Jean-Genaz C, editors. EPAC 94. Proceedings of the 4th European Particle Accelerator Conference; 27 Jun–1 Jul. London (England): World Scientific Pub; p. 2619–2621.
   Google Scholar
• Barth RF, Mi P, Yang W. 2018. Boron delivery agents for neutron capture therapy of cancer. Cancer Commun (Lond). 38:35.
   PubMed Web of Science ®Google Scholar
• Barth RF, Zhang Z, Liu T. 2018. A realistic appraisal of boron neutron capture therapy as a cancer treatment modality. Cancer Commun (Lond). 38:36.
   PubMed Web of Science ®Google Scholar
• Bayanov B, Belov V, Taskaev S. 2006. Neutron producing target for accelerator based neutron capture therapy. J Phys: Conf Ser. 41:460–465.
   Google Scholar
• Brednikhin SA, Lezhnin SI, Frolov SA, Yurov DM. 2012. [NMC code for statistical modeling of neutron transport in fissionable media. Validation and applications]. Moscow: IBRAE. Russian Academy of Sciences, Institute of Problems of Safety, Development of Atomic Energy. No. IBRAE-2012-04.
   Google Scholar
• Byvaltsev VA, Stepanov IA, Belykh EG, Kanygin VV, Kichigin AI. 2015. Molecular biology of high-grade gliomas. Sib Med J. 133:5–9. Russian.
   Google Scholar
• Carpano M, Perona M, Rodriguez C, Nievas S, Olivera M, Santa Cruz GA, Brandizzi D, Cabrini R, Pisarev M, Juvenal GJ, et al. 2015. Experimental studies of boronophenylalanine ((10)BPA) biodistribution for the individual application of boron neutron capture therapy (BNCT) for malignant melanoma treatment. Int J Radiat Oncol Biol Phys. 93:344–352.
   PubMed Web of Science ®Google Scholar
• Coderre JA, Glass JD, Fairchild RG, Micca PL, Fand I, Joel DD. 1990. Selective delivery of boron by the melanin precursor analogue p-boronophenylalanine to tumors other than melanoma. Cancer Res. 50:138–141.
   PubMed Web of Science ®Google Scholar
• Garefalakis M, Hickey M, Johnson N. 2017. Gynecological morbidity. In: Quah SR, Cockerham WC, editors. International encyclopedia of public health. 2nd ed. Oxford (UK): Academic Press. p. 342–353.
   Google Scholar
• Goorley JT, Kiger WS 3rd, Zamenhof RG. 2002. Reference dosimetry calculations for neutron capture therapy with comparison of analytical and voxel models. Med Phys. 29:145–156.
   PubMed Web of Science ®Google Scholar
• Hiratsuka J, Fukuda H. 2012. Malignant melanoma. In: Sauerwein WAG, Wittig A, Moss R, Nakagawa Y, editors. Neutron capture therapy. principles and applications. Berlin: Springer-Verlag; p. 433–448.
   Google Scholar
• Iarullina AI, Kanygin VV, Kichigin AI, Zhdanova MG, Muhamadiyarov RA, SYu T. 2015. Treatment of brain tumours by the method of boron-neutron capture therapy: difficulties and modern solutions. Pac Med J. 4:4–10. Russian.
   Google Scholar
• Iida-Onishi K, Kawabata S, Miyata S, Masabuchi T, Doi A, Yokoyama K, Kuroiwa T, Ono K, Kumada H, Kirihata M, et al. 2009. Evaluation of the biological effects of boron neutron capture therapy for the humanmalignant meningioma cell line IOMM-Lee. Bull Osaka Med Coll. 55:9–19.
   Google Scholar
• Ivanov AA, Kasatov DA, Koshkarev AM, Makarov AN, Ostreinov YM, Sorokin IN, Taskaev SY, Shchudlo IM. 2016. Obtaining a proton beam with 5-mA current in a tandem accelerator with vacuum insulation. Tech Phys Lett. 42:608–611.
   Web of Science ®Google Scholar
• Joel DD, Coderre JA, Micca PL, Nawrocky MM. 1999. Effect of dose and infusion time on the delivery of p-boronophenylalanine for neutron capture therapy. J Neurooncol. 41:213–221.
   PubMed Web of Science ®Google Scholar
• Kanygin V, Kichigin A, Krivoshapkin A, Taskaev S. 2017. Prospectives of boron-neutron capture therapy of malignant brain tumours. AIP Conf Proc. 1882:020030.
   Google Scholar
• Kanygin VV, Kichigin AI, Gubanova NV, SYu T. 2015. Opportunities for boron-neutron capture therapy in the treatment of malignant brain tumours. Herald of Radiology and Radiology. 6:36–42. Russian.
   Google Scholar
• Kanygin VV, Zavyalov EL, Simonovich AE, Kasatova AI, Kichigin AI, Razumov IA, Taskaev S. 2019. [Boron neutron capture therapy of human glioblastoma on in vivo tumour models]. Modern Problems of Science and Education. 1:19. Russian.
   Google Scholar
• Kasatov D, Koshkarev A, Kuznetsov A, Makarov A, Ostreinov Y, Shchudlo I, Sorokin I, Sycheva T, Taskaev S, Zaidi L. 2016. The accelerator neutron source for boron neutron capture therapy. J Phys Conf Ser. 769:012064.
   Google Scholar
• Kobyakov GL, Bekyashev AKh, Golanov AV, Konovalov AN, Naskhletashvili DR, Potapov AA, Rzayev DA, Ryzhova MV, Smolin AV, Trunin YYu. 2016. [Practical recommendations on the medicinal treatment of primary tumours of the central nervous system]. Malignant Tumours. 4:64–84. Russian.
   Google Scholar
• Kueffer PJ, Maitz CA, Khan AA, Schuster SA, Shlyakhtina NI, Jalisatgi SS, Brockman JD, Nigg DW, Hawthorne MF. 2013. Boron neutron capture therapy demonstrated in mice bearing EMT6 tumors following selective delivery of boron by rationally designed liposomes. Proc Natl Acad Sci USA. 110:6512–6517.
   PubMed Web of Science ®Google Scholar
• Locher G. 1936. Biological effects and therapeutic possibilities of neutrons. Am J Roentgenol Radium Ther. 36:1–13.
   Google Scholar
• Luderer MJ, Muz B, Alhallak K, Sun J, Wasden K, Guenthner N, de la Puente P, Federico C, Azab AK. 2019. Thermal sensitive liposomes improve delivery of boronated agents for boron neutron capture therapy. Pharm Res. 36:144.
   PubMed Web of Science ®Google Scholar
• Maruyama K, Ishida O, Kasaoka S, Takizawa T, Utoguchi N, Shinohara A, Chiba M, Kobayashi H, Eriguchi M, Yanagie H. 2004. Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumours by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT). J Control Release. 98:195–207.
   PubMed Web of Science ®Google Scholar
• Nakamura H. 2008. Liposomal boron delivery system for neutron capture therapy. Yakugaku Zasshi. 128:193–208. Japanese)
   PubMed Web of Science ®Google Scholar
• Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, et al. 2014. The epidemiology of glioma in adults: a “state of the science” review. Neuro Oncol. 16:896–913.
   PubMed Web of Science ®Google Scholar
• Rossini AE, Dagrosa MA, Portu A, Saint Martin G, Thorp S, Casal M, Navarro A, Juvenal GJ, Pisarev MA. 2015. Assessment of biological effectiveness of boron neutron capture therapy in primary and metastatic melanoma cell lines. Int J Radiat Biol. 91:81–89.
   PubMed Web of Science ®Google Scholar
• Sato E, Zaboronok A, Yamamoto T, Nakai K, Taskaev S, Volkova O, Mechetina L, Taranin A, Kanygin V, Isobe T, et al. 2018. Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy. J Radiat Res. 59:101–107.
   PubMed Web of Science ®Google Scholar
• Sauerwein WAG, Wittig A, Moss R, Nakagawa Y, editors. 2012. Neutron capture therapy. Principles and applications. Berlin: Springer-Verlag.
   Google Scholar
• Suliman YA, Bruni C, Johnson SR, Praino E, Alemam M, Borazan N, Cometi L, Myers B, Khanna D, Allanore Y, et al. 2017. Defining skin ulcers in systemic sclerosis: systematic literature review and proposed World Scleroderma Foundation (WSF) definition. J Scleroderma Relat Disord. 2:115–120.
   PubMed Web of Science ®Google Scholar
• Sun T, Li Y, Huang Y, Zhang Z, Yang W, Du Z, Zhou Y. 2016. Targeting glioma stem cells enhances anti-tumor effect of boron neutron capture therapy. Oncotarget. 7:43095–43108.
   PubMedGoogle Scholar
• Tachikawa S, Miyoshi T, Koganei H, El-Zaria ME, Vinas C, Suzuki M, Ono K, Nakamura H. 2014. Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy. Chem Commun. 50:12325–12328.
   PubMed Web of Science ®Google Scholar
• Taskaev S. 2015. Accelerator based epithermal neutron source. Phys Part Nuclei. 46:956–990.
   Web of Science ®Google Scholar
• Taskaev S. 2019. Development of an accelerator-based epithermal neutron source for boron neutron capture therapy. Phys Part Nuclei. 50:569–575.
   Web of Science ®Google Scholar
• Taskaev S, Kanygin V, Byvaltsev V, Zaboronok A, Volkova O, Mechetina L, Taranin A, Kichigin A, Iarullina A, Eliseenko I, et al. 2018. Opportunities for using an accelerator-based epithermal neutron source for boron neutron capture therapy. Biomed Eng. 52:73–76.
   Google Scholar
• Watanabe T, Hattori Y, Ohta Y, Ishimura M, Nakagawa Y, Sanada Y, Tanaka H, Fukutani S, Masunaga SI, Hiraoka M, et al. 2016. Comparison of the pharmacokinetics between L-BPA and L-FBPA using the same administration dose and protocol: a validation study for the theranostic approach using [18F]-L-FBPA positron emission tomography in boron neutron capture therapy. BMC Cancer. 16:859.
   PubMed Web of Science ®Google Scholar
• Yancey KB, Lawley TJ. 2018. Approach to the patient with a skin disorder. In Jameson JL, Fauci A, Kasper D, Hauser S, Longo D, Loscalzo J, editors. Harrison’s principles of internal medicine. 20th ed. New York: McGraw-Hill Education. Part 2, Cardinal Manifestations and Presentation of Diseases. Section 8, Alterations in the Skin; p. 325.
   Google Scholar
• Yardeni T, Eckhaus M, Morris HD, Huizing M, Hoogstraten-Miller S. 2011. Retro-orbital injections in mice. Lab Anim (NY). 40:155–160.
   PubMed Web of Science ®Google Scholar
• Zaboronok A, Yamamoto T, Nakai K, Yoshida F, Uspenskii S, Selyanin M, Zelenetskii A, Matsumura A. 2015. Hyaluronic acid as a potential boron carrier for BNCT: Preliminary evaluation. Appl Radiat Isot. 106:181–184.
   PubMed Web of Science ®Google Scholar
• Zaidi L, Belgaid M, Taskaev S, Khelifi R. 2018. Beam shaping assembly design of 7Li(p,n)7Be neutron source for boron neutron capture therapy of deep-seated tumour. Appl Radiat Isot. 139:316–324.
   PubMed Web of Science ®Google Scholar
• Zaidi L, Kashaeva EA, Lezhnin SI, Malyshkin GN, Samarin SI, Sycheva TV, Taskaev SYu, Frolov SA. 2017. Neutron-beam-shaping assembly for boron neutron-capture therapy. Phys Atom Nuclei. 80:60–66.
   Web of Science ®Google Scholar
• Zanders ED, Svensson F, Bailey DS. 2019. Therapy for glioblastoma: is it working? Drug Discov Today. 24:1193–1201.
   PubMed Web of Science ®Google Scholar