272
Views
1
CrossRef citations to date
0
Altmetric
Original Articles

Radioprotective effect of melatonin against radiotherapy-induced cerebral cortex and cerebellum damage in rat

ORCID Icon, , , , & ORCID Icon
Pages 348-355 | Received 15 Sep 2020, Accepted 08 Dec 2020, Published online: 07 Jan 2021

References

  • Alak G, Yeltekin AÇ, Özgeriş FB, Parlak V, Uçar A, Sait Keleş M, Atamanalp M. 2019. Therapeutic effect of N-acetyl cysteine as an antioxidant on rainbow trout’s brain in cypermethrin toxicity. Chemosphere. 221:30–36.
  • Antolín I, Rodríguez C, Sáinz RM, Mayo JC, Uría H, Kotler ML, Rodríguez-Colunga MJ, Tolivia D, Menéndez-Peláez A. 1996. Neurohormone melatonin prevents cell damage: effect on gene expression for antioxidant enzymes. Faseb J. 10:882–890.
  • Béhin A, Delattre JY. 2004. Complications of radiation therapy on the brain and spinal cord. Semin Neurol. 24:405–417.
  • Beutler E. 1984. Red cell metabolism. A Manual of Biochemical Methods. 3rd ed. Basement Membranes and Cell Movement.
  • Cao X, Yang C, Liu J, Hui X, Yang W, Li S, Tian Y, Cai L. 2014. DNA damage and effects on antioxidative enzymes in earthworm (Eisenia fetida) induced by flumorph. Appl Biochem Biotechnol. 172:2276–2285.
  • Cihan YB, Arsav V, Göcen E. 2012. Royal jelly in the prevention of radiation-induced brain damages. J Neurol Sci. 28:475–486.
  • Durak MA, Parlakpinar H, Polat A, Vardi N, Ekici K, Ucar M, Ozhan O, Yildiz A, Pasahan R. 2017. Protective and therapeutic effects of molsidomine on radiation induced neural injury in rats. Biotech Histochem. 92:68–77.
  • Erol FS, Topsakal C, Ozveren MF, Kaplan M, Ilhan N, Ozercan IH, Yildiz OG. 2004. Protective effects of melatonin and vitamin E in brain damage due to gamma radiation: an experimental study. Neurosurg Rev. 27:65–69.
  • Georg D, Knöös T, McClean B. 2011. Current status and future perspective of flattening filter free photon beams. Med Phys. 38:1280–1293.
  • Steen RG, Spence D, Wu S, Xiong X, Kun LE, Merchant TE. 2001. Effect of therapeutic ionizing radiation on the human brain. Ann Neurol. 50:787–795.
  • Hagar HH, El Medany A, El Eter E, Arafa M. 2007. Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats. Eur J Pharmacol. 554:69–77.
  • Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, Ito M, Miyamoto KI, Tsuji A, Kawai Y, et al. 2011. Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med. 51:1329–1336.
  • Jurma OP, Hom DG, Andersen JK. 1997. Decreased glutathione results in calcium-mediated cell death in PC12. Free Radic Biol Med. 23:1055–1066.
  • Kale A, Piskin Ö, Bas Y, Aydin BG, Can M, Elmas Ö, Büyükuysal Ç. 2018. Neuroprotective effects of quercetin on radiation-induced brain injury in rats. J Radiat Res. 59:404–410.
  • Kaya H, Delibas N, Serteser M, Ulukaya E, Özkaya O. 1999. The effect of melatonin on lipid peroxidation during radiotherapy in female rats. Strahlenther Onkol. 175:285–288.
  • Lohse I, Lang S, Hrbacek J, Scheidegger S, Bodis S, MacEdo NS, Feng J, Lütolf UM, Zaugg K. 2011. Effect of high dose per pulse flattening filter-free beams on cancer cell survival. Radiother Oncol. 101:226–232.
  • Matsuya Y, McMahon SJ, Tsutsumi K, Sasaki K, Okuyama G, Yoshii Y, Mori R, Oikawa J, Prise KM, Date H. 2018. Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates. Sci Rep. 8:1–14.
  • Navarria P, Ascolese AM, Mancosu P, Alongi F, Clerici E, Tozzi A, Iftode C, Reggiori G, Tomatis S, Infante M, et al. 2013. Volumetric modulated arc therapy with flattening filter free (FFF) beams for stereotactic body radiation therapy (SBRT) in patients with medically inoperable early stage non small cell lung cancer (NSCLC). Radiother Oncol. 107:414–418.
  • Ozyurt H, Yildirim Z, Kotuk M, Yilmaz HR, Yağmurca M, Iraz M, Söğüt S, Gergerlioglu S. 2004. Cisplatin-induced acute renal failure is ameliorated by erdosteine in a dose-dependent manner. J Appl Toxicol. 24:269–275.
  • Peker S, Abacioglu U, Sun I, Yuksel M, Pamir MN. 2004. Irradiation after surgically induced brain injury in the rat: Timing in relation to severity of radiation damage. J Neurooncol. 70:17–21.
  • Petragnano F, Pietrantoni I, Di Nisio V, Fasciani I, Del Fattore A, Capalbo C, Cheleschi S, Tini P, Orelli S, Codenotti S, et al. 2020. Modulating the dose-rate differently affects the responsiveness of human epithelial prostate- and mesenchymal rhabdomyosarcoma-cancer cell line to radiation. Int J Radiat Biol. 96:823–835. http://dx.doi.org/10.1080/09553002.2020.1739774.
  • Pikalova LV, Legeza VI, Ivanov MB, Zhakovko EB. 2011. Experimental study of cytoprotective effect of melatonin in radiation exposure. Bull Exp Biol Med. 152:76–78.
  • Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z. 2003. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol. 50:1129–1146.
  • Sørensen BS, Vestergaard A, Overgaard J, Praestegaard LH. 2011. Dependence of cell survival on instantaneous dose rate of a linear accelerator. Radiother Oncol. 101:223–225.
  • Spruijt KH, Dahele M, Cuijpers JP, Jeulink M, Rietveld D, Slotman BJ, Verbakel WFAR. 2013. Flattening filter free vs flattened beams for breast irradiation. Int J Radiat Oncol Biol Phys. 85:506–513.
  • Stieb S, Lang S, Linsenmeier C, Graydon S, Riesterer O. 2015. Safety of high-dose-rate stereotactic body radiotherapy. Radiat Oncol. 10:11–27.
  • Sun Y, Oberley LW, Li Y. 1988. A simple method for clinical assay of superoxide dismutase. Clin Chem. 34:497–500.
  • Takahashi S, Sun XZ, Kubota Y, Takai N, Nojima K. 2002. Histological and elemental changes in the rat brain after local irradiation with carbon ion beams. J Radiat Res. 43:143–152.
  • Terashima S, Hosokawa Y, Tsuruga E, Mariya Y, Nakamura T. 2017. Impact of time interval and dose rate on cell survival following low-dose fractionated exposures. J Radiat Res. 58:782–790.
  • Ündeğer Ü, Giray B, Zorlu AF, Öge K, Baçaran N. 2004. Protective effects of melatonin on the ionizing radiation induced DNA damage in the rat brain. Exp Toxicol Pathol. 55:379–384.
  • Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84.
  • Verbakel WFAR, Van Den Berg J, Slotman BJ, Sminia P. 2013. Comparable cell survival between high dose rate flattening filter free and conventional dose rate irradiation. Acta Oncol. 52:652–657.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.