Role of mTOR pathway in modulation of radiation induced bystander effects

References

• Anerillas C, Abdelmohsen K, Gorospe M. 2020. Regulation of senescence traits by mapks. Geroscience. 42(2):397–408.
   PubMed Web of Science ®Google Scholar
• Asur R, Balasubramaniam M, Marples B, Thomas RA, Tucker JD. 2010. Involvement of mapk proteins in bystander effects induced by chemicals and ionizing radiation. Mutat Res. 686(1–2):15–29.
   PubMed Web of Science ®Google Scholar
• Barker CA, Kim SK, Budhu S, Matsoukas K, Daniyan AF, D’Angelo SP. 2018. Cytokine release syndrome after radiation therapy: case report and review of the literature. J Immunother Cancer. 6(1):1.
   PubMedGoogle Scholar
• Baskar R. 2010. Emerging role of radiation induced bystander effects: cell communications and carcinogenesis. Genome Integr. 1(1):13.
   PubMedGoogle Scholar
• Baskar R, Balajee AS, Geard CR. 2007. Effects of low and high let radiations on bystander human lung fibroblast cell survival. Int J Radiat Biol. 83(8):551–559.
   PubMed Web of Science ®Google Scholar
• Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira S-M, Kwiatkowski D, Lane HA. 2009. Increased akt s473 phosphorylation after mtorc1 inhibition is rictor dependent and does not predict tumor cell response to pi3k/mtor inhibition. Mol Cancer Ther. 8(4):742–753.
   PubMed Web of Science ®Google Scholar
• Cargnello M, Roux PP. 2011. Activation and function of the mapks and their substrates, the mapk-activated protein kinases. Microbiol Mol Biol Rev. 75(1):50–83.
   PubMed Web of Science ®Google Scholar
• Chen H, Ma Z, Vanderwaal RP, Feng Z, Gonzalez-Suarez I, Wang S, Zhang J, Roti Roti JL, Gonzalo S, Zhang J. 2011. The mtor inhibitor rapamycin suppresses DNA double-strand break repair. Radiat Res. 175(2):214–224.
   PubMed Web of Science ®Google Scholar
• Desai S, Kumar A, Laskar S, Pandey BN. 2013. Cytokine profile of conditioned medium from human tumor cell lines after acute and fractionated doses of gamma radiation and its effect on survival of bystander tumor cells. Cytokine. 61(1):54–62.
   PubMed Web of Science ®Google Scholar
• Duan Z, Su Z, Wang H, Pang X. 2018. Involvement of pro-inflammation signal pathway in inhibitory effects of rapamycin on oxaliplatin-induced neuropathic pain. Mol Pain. 14:1744806918769426.
   Web of Science ®Google Scholar
• Faqihi F, Neshastehriz A, Soleymanifard S, Shabani R, Eivazzadeh N. 2015. Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells. J Radiat Res. 56(5):777–783.
   PubMed Web of Science ®Google Scholar
• Gerashchenko BI, Howell RW. 2003. Flow cytometry as a strategy to study radiation-induced bystander effects in co-culture systems. Cytometry A. 54(1):1–7.
   PubMedGoogle Scholar
• Hassan B, Akcakanat A, Sangai T, Evans KW, Adkins F, Eterovic AK, Zhao H, Chen K, Chen H, Do K-A, et al. 2014. Catalytic mtor inhibitors can overcome intrinsic and acquired resistance to allosteric mtor inhibitors. Oncotarget. 5(18):8544–8557.
   PubMedGoogle Scholar
• He Z, He X, Chen Z, Ke J, He X, Yuan R, Cai Z, Chen X, Wu X, Lan P. 2014. Activation of the mtorc1 and stat3 pathways promotes the malignant transformation of colitis in mice. Oncol Rep. 32(5):1873–1880.
   PubMed Web of Science ®Google Scholar
• Heeran AB, Berrigan HP, O’Sullivan J. 2019. The radiation-induced bystander effect (ribe) and its connections with the hallmarks of cancer. Radiat Res. 192(6):668–679.
   PubMed Web of Science ®Google Scholar
• Hong JH, Chiang CS, Tsao CY, Lin PY, McBride WH, Wu CJ. 1999. Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation. Int J Radiat Biol. 75(11):1421–1427.
   PubMed Web of Science ®Google Scholar
• Iglesias-Bartolome R, Patel V, Cotrim A, Leelahavanichkul K, Molinolo AA, Mitchell JB, Gutkind JS. 2012. Mtor inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. Cell Stem Cell. 11(3):401–414.
   PubMed Web of Science ®Google Scholar
• Iwaya T, Yokobori T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Sawada G, Takahashi Y, Ishibashi M, et al. 2012. Downregulation of mir-144 is associated with colorectal cancer progression via activation of mtor signaling pathway. Carcinogenesis. 33(12):2391–2397.
   PubMed Web of Science ®Google Scholar
• Kim M-K, Kim T-J, Sung CO, Choi CH, Lee J-W, Kim B-G, Bae D-S. 2010. High expression of mtor is associated with radiation resistance in cervical cancer. J Gynecol Oncol. 21(3):181–185.
   PubMed Web of Science ®Google Scholar
• Landskron G, De la Fuente M, Thuwajit P, Thuwajit C, Hermoso MA. 2014. Chronic inflammation and cytokines in the tumor microenvironment. J Immunol Res. 2014:149185.
   PubMed Web of Science ®Google Scholar
• Lewis DA, Mayhugh BM, Qin Y, Trott K, Mendonca MS. 2001. Production of delayed death and neoplastic transformation in cgl1 cells by radiation-induced bystander effects. Radiat Res. 156(3):251–258.
   PubMed Web of Science ®Google Scholar
• Li L, Wang L, Prise KM, Yu KN, Chen G, Chen L, Mei Y, Han W. 2017. Akt/mtor mediated induction of bystander effect signaling in a nucleus independent manner in irradiated human lung adenocarcinoma epithelial cells. Oncotarget. 8(11):18010–18020.
   PubMedGoogle Scholar
• McMasters RA, Saylors RL, Jones KE, Hendrix ME, Moyer MP, Drake RR. 1998. Lack of bystander killing in herpes simplex virus thymidine kinase-transduced colon cell lines due to deficient connexin43 gap junction formation. Hum Gene Ther. 9(15):2253–2261.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour RJ, Seymour CB. 2006. Increased radiosensitivity in cells of two human cell lines treated with bystander medium from irradiated repair-deficient cells. Radiat Res. 165(1):26–34.
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Huo L, Little JB. 2003. Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int J Radiat Biol. 79(1):35–41.
   PubMed Web of Science ®Google Scholar
• Nagasawa H, Little JB. 2002. Bystander effect for chromosomal aberrations induced in wild-type and repair deficient cho cells by low fluences of alpha particles. Mutat Res. 508(1–2):121–129.
   PubMed Web of Science ®Google Scholar
• Park JY, Kang SE, Ahn KS, Um JY, Yang WM, Yun M, Lee SG. 2020. Inhibition of the pi3k-akt-mtor pathway suppresses the adipocyte-mediated proliferation and migration of breast cancer cells. J Cancer. 11(9):2552–2559.
   PubMed Web of Science ®Google Scholar
• Prise KM, O’Sullivan JM. 2009. Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer. 9(5):351–360.
   PubMed Web of Science ®Google Scholar
• Ryan LA, Seymour CB, Joiner MC, Mothersill CE. 2009. Radiation-induced adaptive response is not seen in cell lines showing a bystander effect but is seen in lines showing hrs/irr response. Int J Radiat Biol. 85(1):87–95.
   PubMed Web of Science ®Google Scholar
• Ryan LA, Smith RW, Seymour CB, Mothersill CE. 2008. Dilution of irradiated cell conditioned medium and the bystander effect. Radiat Res. 169(2):188–196.
   PubMed Web of Science ®Google Scholar
• Siva S, MacManus MP, Martin RF, Martin OA. 2015. Abscopal effects of radiation therapy: a clinical review for the radiobiologist. Cancer Lett. 356(1):82–90.
   PubMed Web of Science ®Google Scholar
• Sokolov M, Neumann R. 2018. Changes in gene expression as one of the key mechanisms involved in radiation-induced bystander effect. Biomed Rep. 9(2):99–111.
   PubMed Web of Science ®Google Scholar
• Soleymanifard S, Bahreyni MTT. 2012. Comparing the level of bystander effect in a couple of tumor and normal cell lines. J Med Phys. 37(2):102–106.
   PubMedGoogle Scholar
• Soliman GA. 2013. The role of mechanistic target of rapamycin (mtor) complexes signaling in the immune responses. Nutrients. 5(6):2231–2257.
   PubMed Web of Science ®Google Scholar
• Stocker H, Radimerski T, Schindelholz B, Wittwer F, Belawat P, Daram P, Breuer S, Thomas G, Hafen E. 2003. Rheb is an essential regulator of s6k in controlling cell growth in drosophila. Nat Cell Biol. 5(6):559–565.
   PubMed Web of Science ®Google Scholar
• Taychasiraprapakul A, Suchowerska N, Rizvi S, Atyeo J, McKenzie D. 2012. Radiation dose and time after exposure mediate two types of bystander expression in a single cell line. Radiographer. 59(3):67–72.
   Google Scholar
• Tian T, Li X, Zhang J. 2019. Mtor signaling in cancer and mtor inhibitors in solid tumor targeting therapy. IJMS. 20(3):755.
   Google Scholar
• Verma N, Tiku AB. 2017. Significance and nature of bystander responses induced by various agents. Mutat Res Rev Mutat Res. 773:104–121.
   PubMed Web of Science ®Google Scholar
• Verma N, Tiku AB. 2021. Polydatin-induced direct and bystander effects in a549 lung cancer cell line. Nutr Cancer. :1–13. doi:https://doi.org/10.1080/01635581.2020.1870705. Online ahead of print.
   Google Scholar
• Wang R, Zhou T, Liu W, Zuo L. 2018. Molecular mechanism of bystander effects and related abscopal/cohort effects in cancer therapy. Oncotarget. 9(26):18637–18647.
   PubMedGoogle Scholar
• Watson GE, Lorimore SA, Macdonald DA, Wright EG. 2000. Chromosomal instability in unirradiated cells induced in vivo by a bystander effect of ionizing radiation. Cancer Research. 60(20):5608.
   PubMed Web of Science ®Google Scholar
• Weichhart T. 2018. Mtor as regulator of lifespan, aging, and cellular senescence: a mini-review. Gerontology. 64(2):127–134.
   PubMed Web of Science ®Google Scholar
• Wersäll PJ, Blomgren H, Pisa P, Lax I, Kälkner KM, Svedman C. 2006. Regression of non-irradiated metastases after extracranial stereotactic radiotherapy in metastatic renal cell carcinoma. Acta Oncol. 45(4):493–497.
   PubMed Web of Science ®Google Scholar
• Wu LJ, Randers-Pehrson G, Xu A, Waldren CA, Geard CR, Yu Z, Hei TK. 1999. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proc Natl Acad Sci USA. 96(9):4959–4964.
   PubMed Web of Science ®Google Scholar
• Yang L, Chiang Y, Lenz HJ, Danenberg KD, Spears CP, Gordon EM, Anderson WF, Parekh D. 1998. Intercellular communication mediates the bystander effect during herpes simplex thymidine kinase/ganciclovir-based gene therapy of human gastrointestinal tumor cells. Hum Gene Ther. 9(5):719–728.
   PubMed Web of Science ®Google Scholar
• Yue J, López JM. 2020. Understanding mapk signaling pathways in apoptosis. Int J Mol Sci. 21(7):2346.
   PubMed Web of Science ®Google Scholar
• Zheng H, Wang M, Wu J, Wang Z-M, Nan H-J, Sun H. 2016. Inhibition of mtor enhances radiosensitivity of lung cancer cells and protects normal lung cells against radiation. Biochem Cell Biol. 94(3):213–220.
   PubMedGoogle Scholar