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Original Articles

NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota

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Pages 823-834 | Received 21 Mar 2022, Accepted 18 Oct 2022, Published online: 16 Nov 2022

References

  • Aßhauer KP, Wemheuer B, Daniel R, Meinicke P. 2015. Tax4Fun: predicting functional profiles from metagenomic 16S rRNA data. Bioinformatics. 31(17):2882–2884.
  • Bai J, Barandouzi ZA, Rowcliffe C, Meador R, Tsementzi D, Bruner DW. 2021. Gut microbiome and its associations with acute and chronic gastrointestinal toxicities in cancer patients with pelvic radiation therapy: a systematic review. Front Oncol. 11:745262.
  • Chelakkot C, Choi Y, Kim D-K, Park HT, Ghim J, Kwon Y, Jeon J, Kim M-S, Jee Y-K, Gho YS, et al. 2018. Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp Mol Med. 50(2):e450.
  • Crawford PA, Gordon JI. 2005. Microbial regulation of intestinal radiosensitivity. Proc Natl Acad Sci U S A. 102(37):13254–13259.
  • Cui M, Xiao H, Li Y, Zhou L, Zhao S, Luo D, Zheng Q, Dong J, Zhao Y, Zhang X, et al. 2017. Faecal microbiota transplantation protects against radiation-induced toxicity. EMBO Mol Med. 9(4):448–461.
  • De Ruysscher D, Niedermann G, Burnet NG, Siva S, Lee AWM, Hegi-Johnson F. 2019. Radiotherapy toxicity. Nat Rev Dis Primers. 5(1):13.
  • Derrien M, Belzer C, de Vos WM. 2017. Akkermansia muciniphila and its role in regulating host functions. Microb Pathog. 106:171–181.
  • Edgar RC. 2013. UPARSE: highly accurate OTU sequences from microbial amplicon reads. Nat Methods. 10(10):996–998.
  • Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, et al. 2013. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 110(22):9066–9071.
  • Fan Y, Pedersen O. 2021. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 19(1):55–71.
  • Gaugg MT, Engler A, Bregy L, Nussbaumer-Ochsner Y, Eiffert L, Bruderer T, Zenobi R, Sinues P, Kohler M. 2019. Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis. Respirology 24(5):437–444.
  • Gong D, Gong X, Wang L, Yu X, Dong Q. 2016. Involvement of reduced microbial diversity in inflammatory bowel disease. Gastroenterol Res Pract. 2016:6951091.
  • Gu Z, Pei W, Shen Y, Wang L, Zhu J, Zhang Y, Fan S, Wu Q, Li L, Zhang Z. 2021. Akkermansia muciniphila and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis. Food Funct. 12(20):10184–10195.
  • Guo H, Chou W-C, Lai Y, Liang K, Tam JW, Brickey WJ, Chen L, Montgomery ND, Li X, Bohannon LM, et al. 2020. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science 370(6516):eaay9097.
  • Hauer-Jensen M, Denham JW, Andreyev HJ. 2014. Radiation enteropathy–pathogenesis, treatment and prevention. Nat Rev Gastroenterol Hepatol. 11(8):470–479.
  • Hong W, Mo F, Zhang Z, Huang M, Wei X. 2020. Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD + metabolism. Front Cell Dev Biol. 8:246.
  • Huang P, Jiang A, Wang X, Zhou Y, Tang W, Ren C, Qian X, Zhou Z, Gong A. 2021. NMN maintains intestinal homeostasis by regulating the gut microbiota. Front Nutr. 8:714604.
  • Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, et al. 2018. Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Mucosal Immunol. 11(5):1466–1476.
  • Jian Y, Zhang D, Liu M, Wang Y, Xu ZX. 2021. The impact of gut microbiota on radiation-induced enteritis. Front Cell Infect Microbiol. 11:586392.
  • Kechin A, Boyarskikh U, Kel A, Filipenko M. 2017. cutPrimers: a new tool for accurate cutting of primers from reads of targeted next generation sequencing. J Comput Biol. 24(11):1138–1143.
  • Kim S, Shin YC, Kim TY, Kim Y, Lee YS, Lee SH, Kim MN, Eunju O, Kim KS, Kweon MN. 2021. Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development. Gut Microbes. 13(1):1–20.
  • Kim YS, Kim J, Park SJ. 2015. High-throughput 16S rRNA gene sequencing reveals alterations of mouse intestinal microbiota after radiotherapy. Anaerobe 33:1–7.
  • Leibowitz BJ, Wei L, Zhang L, Ping X, Epperly M, Greenberger J, Cheng T, Yu J. 2014. Ionizing irradiation induces acute haematopoietic syndrome and gastrointestinal syndrome independently in mice. Nat Commun. 5:3494.
  • Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJY, Rajman LA, Qin B, Lou Z, Gorbunova V, et al. 2017. A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. Science 355(6331):1312–1317.
  • Muls A, Andreyev J, Lalondrelle S, Taylor A, Norton C, Hart A. 2017. Systematic review: the impact of cancer treatment on the gut and vaginal microbiome in women with a gynecological malignancy. Int J Gynecol Cancer. 27(7):1550–1559.
  • Nam YD, Kim HJ, Seo JG, Kang SW, Bae JW. 2013. Impact of pelvic radiotherapy on gut microbiota of gynecological cancer patients revealed by massive pyrosequencing. PLoS One. 8(12):e82659.
  • Niu KM, Bao T, Gao L, Ru M, Li Y, Jiang L, Ye C, Wang S, Wu X. 2021. The impacts of short-term NMN supplementation on serum metabolism, fecal microbiota, and telomere length in pre-aging phase. Front Nutr. 8:756243.
  • Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, et al. 2017. A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med. 23(1):107–113.
  • Poddar SK, Sifat AE, Haque S, Nahid NA, Chowdhury S, Mehedi I. 2019. Nicotinamide mononucleotide: exploration of diverse therapeutic applications of a potential molecule. Biomolecules 9(1):34.
  • Quast C, Pruesse E, Yilmaz P, Gerken J, Schweer T, Yarza P, Peplies J, Glockner FO. 2013. The SILVA ribosomal RNA gene database project: improved data processing and web-based tools. Nucleic Acids Res. 41(Database issue):D590–596.
  • Reis Ferreira M, Andreyev HJN, Mohammed K, Truelove L, Gowan SM, Li J, Gulliford SL, Marchesi JR, Dearnaley DP. 2019. Microbiota- and radiotherapy-induced gastrointestinal side-effects (MARS) study: a large pilot study of the microbiome in acute and late-radiation enteropathy. Clin Cancer Res. 25(21):6487–6500.
  • Riehl TE, Alvarado D, Ee X, Zuckerman A, Foster L, Kapoor V, Thotala D, Ciorba MA, Stenson WF. 2019. Lactobacillus rhamnosus GG protects the intestinal epithelium from radiation injury through release of lipoteichoic acid, macrophage activation and the migration of mesenchymal stem cells. Gut 68(6):1003–1013.
  • Rognes T, Flouri T, Nichols B, Quince C, Mahe F. 2016. VSEARCH: a versatile open source tool for metagenomics. PeerJ. 4:e2584.
  • Touchefeu Y, Montassier E, Nieman K, Gastinne T, Potel G, Bruley Des Varannes S, Le Vacon F, de La Cochetiere MF. 2014. Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis - current evidence and potential clinical applications. Aliment Pharmacol Ther. 40(5):409–421.
  • Wang Q, Garrity GM, Tiedje JM, Cole JR. 2007. Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy. Appl Environ Microbiol. 73(16):5261–5267.
  • Wang Z, Wang Q, Wang X, Zhu L, Chen J, Zhang B, Chen Y, Yuan Z. 2019. Gut microbial dysbiosis is associated with development and progression of radiation enteritis during pelvic radiotherapy. J Cell Mol Med. 23(5):3747–3756.
  • Yoshino J, Baur JA, Imai SI. 2018. NAD(+) intermediates: the biology and therapeutic potential of NMN and NR. Cell Metab. 27(3):513–528.
  • Zhang HJ, Zhang YN, Zhou H, Guan L, Li Y, Sun MJ. 2018. IL-17A promotes initiation and development of intestinal fibrosis through EMT. Dig Dis Sci. 63(11):2898–2909.
  • Zhang T, Li Q, Cheng L, Buch H, Zhang F. 2019. Akkermansia muciniphila is a promising probiotic. Microb Biotechnol. 12(6):1109–1125.
  • Zhao Z, Cheng W, Qu W, Shao G, Liu S. 2020. Antibiotic alleviates radiation-induced intestinal injury by remodeling microbiota, reducing inflammation, and inhibiting fibrosis. ACS Omega. 5(6):2967–2977.
  • Zhou Y, Chen L, Sun G, Li Y, Huang R. 2019. Alterations in the gut microbiota of patients with silica-induced pulmonary fibrosis. J Occup Med Toxicol. 14:5.

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