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International Journal of Radiation Biology Volume 99, 2023 - Issue 8
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Original Articles

Protective effects of L-carnitine on X irradiation-induced uterus injury via antioxidant and anti-inflammatory pathways

Serkan Karacetina Department of Histology and Embryology, Zonguldak Bulent Ecevit University, Institute of Health Sciences, Zonguldak, TurkeyORCID Iconhttps://orcid.org/0000-0002-8670-4812View further author information
ORCID Icon,
Meryem Akpolatb Department of Histology and Embryology, Zonguldak Bulent Ecevit University, Faculty of Medicine, Zonguldak, TurkeyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3419-1728View further author information
ORCID Icon,
Zehra Safi Ozc Department of Medical Biology, Zonguldak Bulent Ecevit University, Faculty of Medicine, Zonguldak, TurkeyORCID Iconhttps://orcid.org/0000-0003-1359-5026View further author information
ORCID Icon &
Ayse Ceylan Hamamcioglud Department of Biochemistry, Zonguldak Bulent Ecevit University, Faculty of Pharmacy, Zonguldak, TurkeyORCID Iconhttps://orcid.org/0000-0003-3440-4700View further author information
ORCID Icon
Pages 1217-1227 | Received 21 Jul 2022, Accepted 08 Nov 2022, Published online: 04 Jan 2023

References

  • Adeva-Andany MM, Calvo-Castro I, Fernández-Fernández C, Donapetry-García C, Pedre-Piñeiro AM. 2017. Significance of L-carnitine for human health. IUBMB Life. 69(8):578–594.
  • Agarwal A, Sengupta P, Durairajanayagam D. 2018. Role of L-carnitine in female infertility. Reprod Biol Endocrinol. 16(1):5.
  • Akpolat M, Gulle K, Topcu-Tarladacalisir Y, Safi Oz Z, Bakkal BH, Arasli M, Ozel Turkcu U. 2013. Protection by L-carnitine against radiation-induced ileal mucosal injury in the rat: pattern of oxidative stress, apoptosis and cytokines. Int J Radiat Biol. 89(9):732–740.
  • Akpolat M, Oz ZS, Gulle K, Hamamcioglu AC, Bakkal BH, Kececi M. 2020. X irradiation induced colonic mucosal injury and the detection of apoptosis through PARP-1/p53 regulatory pathway. Biomed Pharmacother. 127:110134.
  • Ash P. 1980. The influence of radiation on fertility in man. Br J Radiol. 53(628):271–278.
  • Ashkenazi A, Dixit VM. 1998. Death receptors: signaling and modulation. Science. 281(5381):1305–1308.
  • Bertelli A, Conte A, Ronca G. 1994. L-propionyl carnitine protects erythrocytes and low density lipoproteins against peroxidation. Drugs Exp Clin Res. 20(5):191–197.
  • Can B, Atilgan R, Pala S, Kuloğlu T, Kiray S, Ilhan N. 2018. Examination of the effect of ovarian radiation injury induced by hysterosalpingography on ovarian proliferating cell nuclear antigen and the radioprotective effect of amifostine: an experimental study. Drug Des Devel Ther. 12:1491–1500.
  • Carabajal E, Massari N, Croci M, Martinel Lamas DJ, Prestifilippo JP, Bergoc RM, Rivera ES, Medina VA. 2012. Radioprotective potential of histamine on rat small intestine and uterus. Eur J Histochem. 56(4):e48.
  • Deorukhkar A, Krishnan S. 2010. Targeting inflammatory pathways for tumor radiosensitization. Biochem Pharmacol. 80(12):1904–1914.
  • Elmore S. 2007. Apoptosis: a review of programmed cell death. Toxicol Pathol. 35(4):495–516.
  • Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 38(12):1103–1111.
  • Ferreira GC, McKenna MC. 2017. L-Carnitine and Acetyl-L-carnitine roles and neuroprotection in developing brain. Neurochem Res. 42(6):1661–1675.
  • Fischer N, Seo EJ, Efferth T. 2018. Prevention from radiation damage by natural products. Phytomedicine. 47:192–200.
  • Garg D, Johnstone EB, Lomo L, Fair DB, Rosen MP, Taylor R, Silver B, Letourneau JM. 2020. Looking beyond the ovary for oncofertility care in women: uterine injury as a potential target for fertility-preserving treatments. J Assist Reprod Genet. 37(6):1467–1476.
  • Kececi M, Akpolat M, Gulle K, Gencer E, Sahbaz A. 2016. Evaluation of preventive effect of shilajit on radiation-induced apoptosis on ovaries. Arch Gynecol Obstet. 293(6):1255–1262.
  • Mansour HH. 2006. Protective role of carnitine ester against radiation-induced oxidative stress in rats. Pharmacol Res. 54(3):165–171.
  • Nieman CL, Kazer R, Brannigan RE, Zoloth LS, Chase-Lansdale PL, Kinahan K, Dilley KJ, Roberts D, Shea LD, Woodruff TK. 2006. Cancer survivors and infertility: a review of a new problem and novel answers. J Support Oncol. 4(4):171–178.
  • Pala Ş, Atilgan R, Kuloğlu T, Kara M, Başpinar M, Can B, Artaş G. 2016. Protective effects of vitamin C and vitamin E against hysterosalpingography-induced epithelial degeneration and proliferation in rat endometrium. Drug Des Devel Ther. 10:4079–4089.
  • Prasad KN. 2004. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr. 134(11):3182S–3183S.
  • Said RS, Nada AS, El-Demerdash E. 2012. Sodium selenite improves folliculogenesis in radiation-induced ovarian failure: a mechanistic approach. PLoS One. 7(12):e50928.
  • Sànchez-Hernàndez L, Castro-Puyana M, Garcìa-Ruiz C, Crego AL, Marina ML. 2010. Determination of L- and D- carnitine in dietary food supplements using capillary electrophoresis-tandem mass spectrometry. Food Chem. 120(3):921–928.
  • Topcu-Tarladacalisir Y, Kanter M, Uzal MC. 2009. Role of L-carnitine in the prevention of seminiferous tubules damage induced by gamma radiation: a light and electron microscopic study. Arch Toxicol. 83(8):735–746.
  • Wo JY, Viswanathan AN. 2009. Impact of radiotherapy on fertility, pregnancy, and neonatal outcomes in female cancer patients. Int J Radiat Oncol Biol Phys. 73(5):1304–1312.

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