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Original Articles

Low-dose-rate ionizing radiation affects innate immunity protein IFITM3 in a mouse model of Alzheimer’s disease

ORCID Icon, , & ORCID Icon
Pages 1649-1659 | Received 08 Dec 2022, Accepted 17 Apr 2023, Published online: 12 May 2023

References

  • Baik SH, Kang S, Son SM, Mook-Jung I. 2016. Microglia contributes to plaque growth by cell death due to uptake of amyloid beta in the brain of Alzheimer’s disease mouse model. Glia. 64(12):2274–2290.
  • Blasko I, Ransmayr G, Veerhuis R, Eikelenboom P, Grubeck-Loebenstein B. 2001. Does IFNgamma play a role in neurodegeneration? J Neuroimmunol. 116(1):1–4.
  • Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. 2012. Galactic cosmic radiation leads to cognitive impairment and increased abeta plaque accumulation in a mouse model of Alzheimer’s disease. PLoS One. 7(12):e53275.
  • Cuttler JM, Moore ER, Hosfeld VD, Nadolski DL. 2016. Treatment of Alzheimer Disease With CT Scans: A Case Report. Dose Response. 14(2):1559325816640073.
  • De Strooper B, Vassar R, Golde T. 2010. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nat Rev Neurol. 6(2):99–107.
  • d‘Errico P, Meyer-Luehmann M. 2020. Mechanisms of Pathogenic Tau and Abeta Protein Spreading in Alzheimer’s Disease. Front Aging Neurosci. 12:265.
  • Fairley LH, Wong JH, Barron AM. 2021. Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease. Front Immunol. 12:624538.
  • Findeis MA. 2000. Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization. Biochim Biophys Acta. 1502(1):76–84.
  • Friedlová N, Zavadil Kokáš F, Hupp TR, Vojtěšek B, Nekulová M. 2022. IFITM protein regulation and functions: Far beyond the fight against viruses. Front Immunol. 13:1042368.
  • Gridley DS, Rizvi A, Luo-Owen X, Makinde AY, Pecaut MJ. 2009. Low dose, low dose rate photon radiation modifies leukocyte distribution and gene expression in CD4(+) T cells. J Radiat Res. 50(2):139–150.
  • Hayley S, Scharf J, Anisman H. 2013. Central administration of murine interferon-alpha induces depressive-like behavioral, brain cytokine and neurochemical alterations in mice: a mini-review and original experiments. Brain Behav Immun. 31:115–127.
  • Hur J-Y, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, et al. 2020. The innate immunity protein IFITM3 modulates gamma-secretase in Alzheimer’s disease. Nature. 586(7831):735–740.,.
  • Jeong YJ, Son Y, Choi HD, Kim N, Lee YS, Ko YG, Lee HJ. 2020. Behavioral changes and gene profile alterations after chronic 1,950-MHz radiofrequency exposure: An observation in C57BL/6 mice. Brain Behav. 10(11):e01815.
  • Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B, Prat A. 2007. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med. 13(10):1173–1175.
  • Kempf SJ, Janik D, Barjaktarovic Z, Braga-Tanaka I, 3rd, Tanaka S, Neff F, Saran A, Larsen MR, Tapio S. 2016. Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer’s mouse model. Oncotarget. 7(44):71817–71832.
  • Kim S, Nam Y, Kim C, Lee H, Hong S, Kim HS, Shin SJ, Park YH, Mai HN, Oh SM, et al. 2020. Neuroprotective and anti-inflammatory effects of low-moderate dose ionizing radiation in models of alzheimer’s disease. Int J Mol Sci. 21:3678.
  • Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, Dong Y, Legeron FP, Leboucher A, Burnouf S, et al. 2017. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 140(1):184–200.
  • Lee SH, Jeong YJ, Park J, Kim HY, Son Y, Kim KS, Lee HJ. 2022. Low-dose radiation affects cardiovascular disease risk in human aortic endothelial cells by altering gene expression under normal and diabetic conditions. Int J Mol Sci. 23:8577.
  • Lee HJ, Kim JS, Moon C, Son Y. 2022. Profiling of gene expression in the brain associated with anxiety-related behaviors in the chronic phase following cranial irradiation. Sci Rep. 12(1):13162.
  • Liu C, Cui G, Zhu M, Kang X, Guo H. 2014. Neuroinflammation in Alzheimer’s disease: chemokines produced by astrocytes and chemokine receptors. Int J Clin Exp Pathol. 7(12):8342–8355.
  • Long JM, Holtzman DM. 2019. Alzheimer disease: an update on pathobiology and treatment strategies. Cell. 179(2):312–339.
  • Machhi J, Yeapuri P, Lu Y, Foster E, Chikhale R, Herskovitz J, Namminga KL, Olson KE, Abdelmoaty MM, Gao J, et al. 2021. CD4+ effector T cells accelerate Alzheimer’s disease in mice. J Neuroinflammation. 18(1):272.
  • Mastrangelo MA, Sudol KL, Narrow WC, Bowers WJ. 2009. Interferon-gamma differentially affects Alzheimer’s disease pathologies and induces neurogenesis in triple transgenic-AD mice. Am J Pathol. 175(5):2076–2088.
  • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. 1984. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 34(7):939–944.
  • Raber J, Rola R, LeFevour A, Morhardt D, Curley J, Mizumatsu S, VandenBerg SR, Fike JR. 2004. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res. 162(1):39–47.
  • Ritchie KJ, Hahn CS, Kim KI, Yan M, Rosario D, Li L, de la Torre JC, Zhang DE. 2004. Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med. 10(12):1374–1378.
  • Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, et al. 2020. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J Clin Invest. 130(4):1912–1930.
  • Rudobeck E, Bellone JA, Szucs A, Bonnick K, Mehrotra-Carter S, Badaut J, Nelson GA, Hartman RE, Vlkolinsky R. 2017. Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s disease - Implications for space travel. PLoS One. 12(11):e0186168.
  • Schneider WM, Chevillotte MD, Rice CM. 2014. Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol. 32:513–545.
  • Son Y, Kang S, Kim J, Lee S, Kim JC, Kim SH, Kim JS, Jo SK, Jung U, Youn B, et al. 2016. Possible involvement of hippocampal immediate-early genes in contextual fear memory deficit induced by cranial irradiation. Neurobiol Learn Mem. 133:19–29.
  • Son Y, Yang M, Kim JS, Kim J, Kim SH, Kim JC, Shin T, Wang H, Jo SK, Jung U, et al. 2014. Hippocampal dysfunction during the chronic phase following a single exposure to cranial irradiation. Exp Neurol. 254:134–144.
  • van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, Kanekiyo M, Li D, Reyderman L, Cohen S, et al. 2023. Lecanemab in Early Alzheimer’s Disease. N Engl J Med. 388(1):9–21.
  • Wang B, Tanaka K, Ji B, Ono M, Fang Y, Ninomiya Y, Maruyama K, Izumi-Nakajima N, Begum N, Higuchi M, et al. 2014a. Low-dose total-body carbon-ion irradiations induce early transcriptional alteration without late Alzheimer’s disease-like pathogenesis and memory impairment in mice. J Neurosci Res. 92(7):915–926.
  • Wang B, Tanaka K, Ji B, Ono M, Fang Y, Ninomiya Y, Maruyama K, Izumi-Nakajima N, Begum N, Higuchi M, et al. 2014b. Total body 100-mGy X-irradiation does not induce Alzheimer’s disease-like pathogenesis or memory impairment in mice. J Radiat Res. 55(1):84–96.
  • Xiang S, Huang Z, Wang T, Han Z, Yu CY, Ni D, Huang K, Zhang J. 2018. Condition-specific gene co-expression network mining identifies key pathways and regulators in the brain tissue of Alzheimer’s disease patients. BMC Med Genomics. 11(Suppl 6):115.
  • Yang EJ, Kim H, Choi Y, Kim HJ, Kim JH, Yoon J, Seo YS, Kim HS. 2021. Modulation of Neuroinflammation by Low-Dose Radiation Therapy in an Animal Model of Alzheimer’s Disease. Int J Radiat Oncol Biol Phys. 111(3):658–670.
  • Yin E, Nelson DO, Coleman MA, Peterson LE, Wyrobek AJ. 2003. Gene expression changes in mouse brain after exposure to low-dose ionizing radiation. Int J Radiat Biol. 79(10):759–775.
  • Zhao X, Li J, Winkler CA, An P, Guo JT. 2018. IFITM Genes, Variants, and Their Roles in the Control and Pathogenesis of Viral Infections. Front Microbiol. 9:3228.