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Original Articles

Candidate biomarkers and persistent transcriptional responses after low and high dose ionizing radiation at high dose rate

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Pages 1853-1864 | Received 12 Apr 2023, Accepted 10 Jul 2023, Published online: 07 Aug 2023

References

  • Abend M, Blakely WF, Ostheim P, Schuele S, Port M. 2022. Early molecular markers for retrospective biodosimetry and prediction of acute health effects. J Radiol Prot. 42(1):010503. doi:10.1088/1361-6498/ac2434
  • Brackmann LK, Poplawski A, Grandt CL, Schwarz H, Hankeln T, Rapp S, Zahnreich S, Galetzka D, Schmitt I, Grad C, et al. 2020. Comparison of time and dose dependent gene expression and affected pathways in primary human fibroblasts after exposure to ionizing radiation. Mol Med. 26(1):85. doi:10.1186/s10020-020-00203-0
  • Chen J, Liu X, Zeng Z, Li J, Luo Y, Sun W, Gong Y, Zhang J, Wu Q, Xie C. 2020. Immunomodulation of NK cells by ionizing radiation. Front Oncol. 10:874. doi:10.3389/fonc.2020.00874
  • Escalona MB, Ryan TL, Balajee AS. 2022. Current developments in biodosimetry tools for radiological/nuclear mass casualty incidents. Environ Adv. 9:100265. doi:10.1016/j.envadv.2022.100265
  • Garikipati VNS, Arakelyan A, Blakely EA, Chang PY, Truongcao MM, Cimini M, Malaredy V, Bajpai A, Addya S, Bisserier M, et al. 2021. Long-term effects of very low dose particle radiation on gene expression in the heart: degenerative disease risks. Cells. 10(2):387. doi:10.3390/cells10020387
  • Ghosh S, Ghosh A. 2021. Activation of DNA damage response signaling in mammalian cells by ionizing radiation. Free Radic Res. 55(5):581–594.
  • Goeman JJ, Solari A. 2014. Multiple hypothesis testing in genomics. Statist Med. 33(11):1946–1978. doi:10.1002/sim.6082
  • Heylmann D, Ponath V, Kindler T, Kaina B. 2021. Comparison of DNA repair and radiosensitivity of different blood cell populations. Sci Rep. 11(1):2478. doi:10.1038/s41598-021-81058-1
  • Hill MA. 2020. Radiation track structure: how the spatial distribution of energy deposition drives biological response. Clin Oncol (R Coll Radiol). 32(2):75–83. doi:10.1016/j.clon.2019.08.006
  • Hladik D, Bucher M, Endesfelder D, Oestreicher U. 2022. The potential of omics in biological dosimetry. Radiation. 2(1):78–90. doi:10.3390/radiation2010006
  • Huang RX, Zhou PK. 2020. DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer. Signal Transduct Target Ther. 5(1):60.
  • IAEA. 2010. Radiation biology: a handbook for teachers and students. Vienna: IAEA. (Training Course Series No. 42, 2010). Retrieved from https://www.iaea.org/publications/8219/radiation-biology-a-handbook-for-teachers-and-students
  • ICRP. 2007. The Recommendations of the International Commission on Radiological Protection. ICRP publication 103 2007. 0146–6453.
  • Jafer A, Sylvius N, Adewoye AB, Dubrova YE. 2020. The long-term effects of exposure to ionising radiation on gene expression in mice. Mutat Res. 821:111723. doi:10.1016/j.mrfmmm.2020.111723
  • Kamiya K, Ozasa K, Akiba S, Niwa O, Kodama K, Takamura N, Zaharieva EK, Kimura Y, Wakeford R. 2015. Long-term effects of radiation exposure on health. Lancet. 386(9992):469–478. doi:10.1016/S0140-6736(15)61167-9
  • Khan MGM, Wang Y. 2022. Advances in the current understanding of how low-dose radiation affects the cell cycle. Cells. 11(3):356. doi:10.3390/cells11030356
  • Lacombe J, Sima C, Amundson SA, Zenhausern F. 2018. Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: a systematic review. PLoS ONE. 13(6):e0198851. doi:10.1371/journal.pone.0198851
  • Little MP, Azizova TV, Hamada N. 2021. Low- and moderate-dose non-cancer effects of ionizing radiation in directly exposed individuals, especially circulatory and ocular diseases: a review of the epidemiology. Int J Radiat Biol. 97(6):782–803. doi:10.1080/09553002.2021.1876955
  • Lonati L, Barbieri S, Guardamagna I, Ottolenghi A, Baiocco G. 2021. Radiation-induced cell cycle perturbations: a computational tool validated with flow-cytometry data. Sci Rep. 11(1):925. doi:10.1038/s41598-020-79934-3
  • Lumniczky K, Impens N, Armengol G, Candéias S, Georgakilas AG, Hornhardt S, Martin OA, Rödel F, Schaue D. 2021. Low dose ionizing radiation effects on the immune system. Environ Int. 149:106212. doi:10.1016/j.envint.2020.106212
  • Macaeva E, Mysara M, De Vos WH, Baatout S, Quintens R. 2019. Gene expression-based biodosimetry for radiological incidents: assessment of dose and time after radiation exposure. Int J Radiat Biol. 95(1):64–75. doi:10.1080/09553002.2018.1511926
  • Manning G, Kabacik S, Finnon P, Bouffler S, Badie C. 2013. High and low dose responses of transcriptional biomarkers in ex vivo X-irradiated human blood. Int J Radiat Biol. 89(7):512–522. [Database] doi:10.3109/09553002.2013.769694
  • Milanowska K, Krwawicz J, Papaj G, Kosinski J, Poleszak K, Lesiak J, Osinska E, Rother K, Bujnicki JM. 2011. REPAIRtoire–a database of DNA repair pathways. Nucleic Acids Res. 39(Database issue):D788–92. doi:10.1093/nar/gkq1087
  • Nagane M, Yasui H, Kuppusamy P, Yamashita T, Inanami O. 2021. DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases. J Radiat Res. 62(4):564–573. doi:10.1093/jrr/rrab032
  • Noda A. 2018. Radiation-induced unrepairable DSBs: their role in the late effects of radiation and possible applications to biodosimetry. J Radiat Res. 59(suppl_2):ii114–ii120. doi:10.1093/jrr/rrx074
  • Noda A, Hirai Y, Hamasaki K, Mitani H, Nakamura N, Kodama Y. 2012. Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells. J Cell Sci. 125(Pt 22):5280–5287.
  • Nosel I, Vaurijoux A, Barquinero JF, Gruel G. 2013. Characterization of gene expression profiles at low and very low doses of ionizing radiation. DNA Repair. 12(7):508–517. doi:10.1016/j.dnarep.2013.04.021
  • Ozasa K, Cullings HM, Ohishi W, Hida A, Grant EJ. 2019. Epidemiological studies of atomic bomb radiation at the radiation effects research foundation. Int J Radiat Biol. 95(7):879–891. doi:10.1080/09553002.2019.1569778
  • Ostheim P, Amundson SA, Badie C, Bazyka D, Evans AC, Ghandhi SA, Gomolka M, López Riego M, Rogan PK, Terbrueggen R, et al. 2022. Gene expression for biodosimetry and effect prediction purposes: promises, pitfalls and future directions - key session ConRad 2021. Int J Radiat Biol. 98(5):843–854. doi:10.1080/09553002.2021.1987571
  • Paul S, Amundson SA. 2008. Development of gene expression signatures for practical radiation biodosimetry. Int J Radiat Oncol Biol Phys. 71(4):1236–1244. doi:10.1016/j.ijrobp.2008.03.043
  • Paul S, Amundson SA. 2011. Gene expression signatures of radiation exposure in peripheral white blood cells of smokers and non-smokers. Int J Radiat Biol. 87(8):791–801. doi:10.3109/09553002.2011.568574
  • Paul S, Smilenov LB, Amundson SA. 2013. Widespread decreased expression of immune function genes in human peripheral blood following radiation exposure. Radiat Res. 180(6):575–583. doi:10.1667/RR13343.1
  • Paul S, Barker CA, Turner HC, McLane A, Wolden SL, Amundson SA. 2011. Prediction of in vivo radiation dose status in radiotherapy patients using ex vivo and in vivo gene expression signatures. Radiat Res. 175(3):257–265. doi:10.1667/RR2420.1
  • Riba A, Oravecz A, Durik M, Jiménez S, Alunni V, Cerciat M, Jung M, Keime C, Keyes WM, Molina N. 2022. Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning. Nat Commun. 13(1):2865. doi:10.1038/s41467-022-30545-8
  • Santos A, Wernersson R, Jensen LJ. 2015. Cyclebase 3.0: a multi-organism database on cell-cycle regulation and phenotypes. Nucleic Acids Res. 43(D1):D1140–D1144. doi:10.1093/nar/gku1092
  • Serra A, Fratello M, Del Giudice G, Saarimäki LA, Paci M, Federico A, Greco D. 2020. TinderMIX: Time-dose integrated modelling of toxicogenomics data. Gigascience. 9(5):giaa055. doi:10.1093/gigascience/giaa055
  • Sokolov M, Neumann R. 2015. Global gene expression alterations as a crucial. constituent of human cell response to low doses of ionizing radiation exposure. IJMS. 17(1):55. doi:10.3390/ijms17010055
  • Sproull MT, Camphausen KA, Koblentz GD. 2017. Biodosimetry: a future tool for medical management of radiological emergencies. Health Secur. 15(6):599–610. doi:10.1089/hs.2017.0050
  • Sullivan JM, Prasanna PG, Grace MB, Wathen LK, Wallace RL, Koerner JF, Coleman CN. 2013. Assessment of biodosimetry methods for a mass-casualty radiological incident: medical response and management considerations. Health Phys. 105(6):540–554. [Database] doi:10.1097/HP.0b013e31829cf221
  • UNSCEAR. 2008. Sources, and Effects of Ionizing Radiation: United Nations Scientific Committee on the Effects of Atomic Radiation 2008 Report to the General Assembly, with Scientific Annexes, Volume I, Annex B. United NationsNew York