A pooled analysis of nine studies in one institution to assess effects of whole heart irradiation in rat models

References

• Applefeld MM, Wiernik PH. 1983. Cardiac disease after radiation therapy for Hodgkin’s disease: analysis of 48 patients. Am J Cardiol. 51(10):1679–1681.
   PubMed Web of Science ®Google Scholar
• Archie JP. 1981. Mathematic coupling of data: a common source of error. Ann Surg. 193(3):296–303.
   PubMed Web of Science ®Google Scholar
• Boerma M, Roberto KA, Hauer-Jensen M. 2008. Prevention and treatment of functional and structural radiation injury in the rat heart by pentoxifylline and alpha-tocopherol. Int J Radiat Oncol Biol Phys. 72(1):170–177.
   PubMed Web of Science ®Google Scholar
• Boerma M, Wang J, Kulkarni A, Roberto KA, Qiu X, Kennedy RH, Hauer-Jensen M. 2008. Influence of endothelin 1 receptor inhibition on functional, structural and molecular changes in the rat heart after irradiation. Radiat Res. 170(3):275–283.
   PubMed Web of Science ®Google Scholar
• Boerma M, Wang J, Sridharan V, Herbert JM, Hauer-Jensen M. 2013. Pharmacological induction of transforming growth factor-beta1 in rat models enhances radiation injury in the intestine and the heart. PLoS One. 8(7):e70479.
   PubMed Web of Science ®Google Scholar
• Clasen SC, Shou H, Freedman G, Plastaras JP, Taunk NK, Kevin Teo BK, Smith AM, Demissei BG, Ky B. 2021. Early Cardiac Effects of Contemporary Radiation Therapy in Patients With Breast Cancer. Int J Radiat Oncol Biol Phys. 109(5):1301–1310.
   PubMed Web of Science ®Google Scholar
• Cuijpers I, Carai P, Mendes-Ferreira P, Simmonds SJ, Mulder P, Miranda-Silva D, De Giorgio D, Pokreisz P, Heymans S, Jones EAV. 2020. The effect of different anaesthetics on echocardiographic evaluation of diastolic dysfunction in a heart failure with preserved ejection fraction model. Sci Rep. 10(1):15701.
   PubMed Web of Science ®Google Scholar
• Damas J. 1996. The brown Norway rats and the kinin system. Peptides. 17(5):859–872.
   PubMed Web of Science ®Google Scholar
• Darby SC, Ewertz M, McGale P, Bennet AM, Blom-Goldman U, Brønnum D, Correa C, Cutter D, Gagliardi G, Gigante B, et al. 2013. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 368(11):987–998.
   PubMed Web of Science ®Google Scholar
• Dess RT, Sun Y, Matuszak MM, Sun G, Soni PD, Bazzi L, Murthy VL, Hearn JWD, Kong FM, Kalemkerian GP, et al. 2017. Cardiac events after radiation therapy: combined analysis of prospective multicenter trials for locally advanced non-small-cell lung cancer. J Clin Oncol. 35(13):1395–1402.
   PubMed Web of Science ®Google Scholar
• Ghobadi G, Van der Veen S, Bartelds B, De Boer RA, Dickinson MG, De Jong JR, Faber H, Niemandsverdriet M, Brandenburg S, Berger RM, et al. 2012. Physiological interactions between heart and lung in thoracic irradiation. Int J Radiat Oncol Biol Phys. 84(5):e639–e646.
   PubMed Web of Science ®Google Scholar
• Harkness A, Ring L, Augustine DX, Oxborough D, Robinson S, Sharma V, Education Committee of the British Society of Echocardiography. 2020. Normal reference intervals for cardiac dimensions and function for use in echocardiographic practice: a guideline from the British Society of Echocardiography. Echo Res Pract. 7(1):X1.
   PubMed Web of Science ®Google Scholar
• Kenward MG, Roger JH. 2009. An improved approximation to the precision of fixed effects from restricted maximum likelihood. Comput Stat Data Anal. 53(7):2583–2595.
   Web of Science ®Google Scholar
• Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. 2010. Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research. PLoS Biol. 8(6):e1000412.
   PubMed Web of Science ®Google Scholar
• Lairez O, Lonjaret L, Ruiz S, Marchal P, Franchitto N, Calise D, Fourcade O, Mialet-Perez J, Parini A, Minville V. 2013. Anesthetic regimen for cardiac function evaluation by echocardiography in mice: comparison between ketamine, etomidate and isoflurane versus conscious state. Lab Anim. 47(4):284–290.
   PubMedGoogle Scholar
• Lee J, Chang CL, Lin JB, Wu MH, Sun FJ, Wu CJ, Tai HC, Hsu SM, Chen YJ. 2018. The effect of body mass index and weight change on late gastrointestinal toxicity in locally advanced cervical cancer treated with intensity-modulated radiotherapy. Int J Gynecol Cancer. 28(7):1377–1386.
   PubMed Web of Science ®Google Scholar
• Muhlhausler BS, Bloomfield FH, Gillman MW. 2013. Whole Animal Experiments Should Be More Like Human Randomized Controlled Trials. PLoS Biol. 11(2):e1001481.
   PubMed Web of Science ®Google Scholar
• Niska JR, Thorpe CS, Allen SM, Daniels TB, Rule WG, Schild SE, Vargas CE, Mookadam F. 2018. Radiation and the heart: systematic review of dosimetry and cardiac endpoints. Expert Rev Cardiovasc Ther. 16(12):931–950.
   PubMed Web of Science ®Google Scholar
• Patel HN, Miyoshi T, Addetia K, Henry MP, Citro R, Daimon M, Gutierrez Fajardo P, Kasliwal RR, Kirkpatrick JN, Monaghan MJ, WASE Investigators., et al. 2021. Normal values of cardiac output and stroke volume according to measurement technique, age, sex, and ethnicity: results of the world alliance of societies of echocardiography study. J Am Soc Echocardiogr. 34(10):1077–1085.e1.
   PubMed Web of Science ®Google Scholar
• Pelosi A, Rosenstein D, Abood SK, Olivier BN. 2013. Cardiac effect of short-term experimental weight gain and loss in dogs. Vet Rec. 172(6):153.
   PubMed Web of Science ®Google Scholar
• Schaible TF, Scheuer J. 1984. Comparison of heart function in male and female rats. Basic Res Cardiol. 79(4):402–412.
   PubMed Web of Science ®Google Scholar
• Schlaak RA, SenthilKumar G, Boerma M, Bergom C. 2020. Advances in preclinical research models of radiation-induced cardiac toxicity. Cancers. 12:415.
   PubMed Web of Science ®Google Scholar
• Schwarz ER, Pollick C, Meehan WP, Kloner RA. 1998. Evaluation of cardiac structures and function in small experimental animals: transthoracic, transesophageal, and intraventricular echocardiography to assess contractile function in rat heart. Basic Res Cardiol. 93(6):477–486.
   PubMed Web of Science ®Google Scholar
• Sridharan V, Tripathi P, Aykin-Burns N, Krager KJ, Sharma SK, Moros EG, Melnyk SB, Pavliv O, Hauer-Jensen M, Boerma M. 2015. A tocotrienol-enriched formulation protects against radiation-induced changes in cardiac mitochondria without modifying late cardiac function or structure. Radiat Res. 183(3):357–366.
   PubMed Web of Science ®Google Scholar
• Sridharan V, Johnson KA, Landes RD, Cao M, Singh P, Wagoner G, Hayar A, Sprick ED, Eveld KA, Bhattacharyya A, et al. 2021. Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin. PLoS One. 16(5):e0252142.
   PubMed Web of Science ®Google Scholar
• Sridharan V, Seawright JW, Antonawich FJ, Garnett M, Cao M, Singh P, Boerma M. 2017. Late Administration of a Palladium Lipoic Acid Complex (POLY-MVA) Modifies Cardiac Mitochondria but Not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model. Radiat Res. 187(3):361–366.
   PubMed Web of Science ®Google Scholar
• Sridharan V, Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, Compadre CM, Hauer-Jensen M, Boerma M. 2013. Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. PLoS One. 8(7):e68762.
   PubMed Web of Science ®Google Scholar
• Sridharan V, Tripathi P, Sharma SK, Moros EG, Corry PM, Lieblong BJ, Kaschina E, Unger T, Thöne-Reineke C, Hauer-Jensen M, et al. 2012. Cardiac inflammation after local irradiation is influenced by the kallikrein-kinin system. Cancer Res. 72(19):4984–4992.
   PubMed Web of Science ®Google Scholar
• Sridharan V, Tripathi P, Sharma S, Moros EG, Zheng J, Hauer-Jensen M, Boerma M. 2014. Roles of sensory nerves in the regulation of radiation-induced structural and functional changes in the heart. Int J Radiat Oncol Biol Phys. 88(1):167–174.
   PubMed Web of Science ®Google Scholar
• Stein AB, Tiwari S, Thomas P, Hunt G, Levent C, Stoddard MF, Tang XL, Bolli R, Dawn B. 2007. Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats. Basic Res Cardiol. 102(1):28–41.
   PubMed Web of Science ®Google Scholar
• Thrall KD, Mahendra S, Jackson MK, Jackson W, Farese AM, MacVittie TJ. 2019. A comparative dose-response relationship between sexes for mortality and morbidity of radiation-induced lung injury in the Rhesus Macaque. Health Phys. 116(3):354–365.
   PubMed Web of Science ®Google Scholar
• Van den Bogaard VAB, van Luijk P, Hummel YM, van der Meer P, Schuit E, Boerman LM, Maass Swmc Nauta JF, Steggink LC, Gietema JA, de Bock GH, et al. 2019. Cardiac function after radiation therapy for breast cancer. Int J Radiat Oncol Biol Phys. 104(2):392–400.
   PubMed Web of Science ®Google Scholar
• Van Luijk P, Novakova-Jiresova A, Faber H, Schippers JM, Kampinga HH, Meertens H, Coppes RP. 2005. Radiation damage to the heart enhances early radiation-induced lung function loss. Cancer Res. 65(15):6509–6511.
   PubMed Web of Science ®Google Scholar
• Walls GM, O'Kane R, Ghita M, Kuburas R, McGarry CK, Cole AJ, Jain S, Butterworth KT. 2022. Murine models of radiation cardiotoxicity: a systematic review and recommendations for future studies. Radiother Oncol. 173:19–31.
   PubMed Web of Science ®Google Scholar
• Wang K, Eblan MJ, Deal AM, Lipner M, Zagar TM, Wang Y, Mavroidis P, Lee CB, Jensen BC, Rosenman JG, et al. 2017. Cardiac toxicity after radiotherapy for stage III non–small-cell lung cancer: pooled analysis of dose-escalation trials delivering 70 to 90 Gy. J Clin Oncol. 35(13):1387–1394.
   PubMed Web of Science ®Google Scholar
• Wu J, Bu L, Gong H, Jiang G, Li L, Ma H, Zhou N, Lin L, Chen Z, Ye Y, et al. 2010. Effects of heart rate and anesthetic timing on high-resolution echocardiographic assessment under isoflurane anesthesia in mice. J Ultrasound Med. 29(12):1771–1778.
   PubMed Web of Science ®Google Scholar
• Zhang TY, Zhao BJ, Wang T, Wang J. 2021. Effect of aging and sex on cardiovascular structure and function in wildtype mice assessed with echocardiography. Sci Rep. 11(1):22800.
   PubMed Web of Science ®Google Scholar