Hydroxyl Radical-induced Strand Break Formation of Poly(U) in Anoxic Solution. Effect of Dithiothreitol and Tetranitromethane

References

• Akhlaq, M.S., von Sonntag, C. Free-radical-induced elimination of H2S from dithiothreitol. A chain reaction. Journal of the American Chemical Society, in press, 1986
   Google Scholar
• Alexander P., Charlesby A. Physico-chemical methods of protection against ionizing radiations. Radiobiology Symposium 1954, Z.M. Bacq, P. Alexander. Butterworths, London 1955; 49–60, Liège
   Google Scholar
• Al-Sheikhly M., von Sonntag C. γ-Radiolysis of 1,3-dimethyluracil in N2O-saturated aqueous solutions. Zeitschrift für Naturforschung 1983; 38b: 1622–1629
   Google Scholar
• Al-Sheikhly M.I., Hissung A., Schuchmann H.-P., Schuchmann M.N., von Sonntag C., Garner A., Scholes G. Radiolysis of dihydrouracil and dihydrothymine in aqueous solutions containing oxygen; first- and second-order reactions of the organic peroxyl radicals; the role of isopyrimidines as intermediates. Journal of the Chemical Society, Perkins Transactions 1984; II: 601–608
   Google Scholar
• Al-Yamoor K.Y., Garner A., Idriss Ali K.M., Scholes G. Reactions of pyrimidine radicals in irradiated aqueous systems: intermediate role of carbocations. Proceedings of the 4th Tihany Symposium on Radiation Chemistry: Keszthely 1976, P. Hedvig, R. Schiller. Akademiai Kiado, Budapest 1977; 845–852
   Google Scholar
• Asmus K.-D., Henglein A. Die Reaktion des Tetranitromethans mit hydratisierten Elektronen aus der γ-Radiolyse des Wassers. Berichte der Bunsengesellschaft für physikalische Chemie 1964; 68: 348–352
   Google Scholar
• Blok J., Loman H. The effects of γ-radiation in DNA. Current Topics in Radiation Research Quarterly 1973; 9: 165–245
   PubMedGoogle Scholar
• Bothe E., Schulte-Frohlinde D. Release of K+ and H+ from poly U in aqeous solution upon γ and electron irradiation. Rate of strand break formation in poly U. Zeitschrift für Naturforschung 1982; 37c: 1191–1204
   Google Scholar
• Chan P.C., Bielski B.H.J. Pulse radiolysis study of optical absorption and kinetic properties of dithiothreitol free radical. Journal of the American Chemical Society 1973; 95: 5504–5508
   Web of Science ®Google Scholar
• Charlesby A. Molecular-weight changes in the degradation of long-chain polymers. Proceedings of the Royal Society, Series A 1954; 224: 120–128
   Google Scholar
• Cleland W.W. Dithiothreitol, a new protective reagent for SH groups. Biochemistry 1964; 3: 480–482
   PubMed Web of Science ®Google Scholar
• Das S., Deeble D.J., Schuchmann M.N., von Sonntag C. Pulse radiolytic studies on uracil and uracil derivatives. Protonation of their electron adducts at oxygen and carbon. International Journal of Radiation Biology 1984; 46: 7–9
   Web of Science ®Google Scholar
• Das S., Deeble D.J., von Sonntag C. Site of H atom attack on uracil and its derivatives in aqueous solution. Zeitschrift für Naturforschung 1985; 40c: 292–294
   Google Scholar
• Deeble D.J., von Sonntag C. γ-Radiolysis of poly(U) in aqueous solution. The role of primary sugar and base radicals in the release of undamaged uracil. International Journal of Radiation Biology 1984; 46: 247–260
   Web of Science ®Google Scholar
• Deeble D.J., Das S., von Sonntag C. Uracil derivatives: Sites and kinetics of protonation of the radical anions and the UV spectra of the C(5) and C(6) H-atom adducts. Journal of Physical Chemistry 1985; 89: 5784–5788
   Web of Science ®Google Scholar
• Deeble, D.J., Schulz, D., von Sonntag, C.>Reactions of OH radicals with poly(U) in deoxygenated solutions: sites of OH attack and the kinetics of base release. International Journal of Radiation Biology, in the press, 1986
   Google Scholar
• Elliot A.J., Sopchyshyn F.C. The radiolysis of aqueous solutions containing dithiothreitol and oxidized dithiothreitol. Radiation Physics and Chemistry 1982; 19: 417–426
   Web of Science ®Google Scholar
• Fujita S. Radiolysis of uracil in N2O-saturated aqueous solutions. Dose-rate effects of the pK value for the yield of consumption. International Journal of Radiation Biology 1982; 42: 205–210
   Google Scholar
• Fujita S., Steenken S. Pattern of OH radical addition to uracil and methyl- and carboxyl-substituted uracils. Electron transfer of OH adducts with N,N,N′,N′-tetramethyl-p-phenylenediamine and tetranitromethane. Journal of the American Chemical Society 1981; 103: 2540–2545
   Web of Science ®Google Scholar
• Hagen U. Strahlenwirkung auf Struktur und Funktion der Desoxyribonukleinsäure. Biophysik 1973; 9: 279–289
   PubMedGoogle Scholar
• Hart E.J. Radiation chemistry of aqueous solutions. Radiation Research Reviews 1972; 3: 285–304
   Google Scholar
• Held K.D., Harrop H.A., Michael B.D. Effects of oxygen and sulphydrylcontaining compounds on irradiated transforming DNA. III Reaction rates. International Journal of Radiation Biology 1984; 45: 627–636
   Web of Science ®Google Scholar
• Henglein A., Jaspert J. Die Hydrolyse des Tetranitromethans in wässriger Lösung durch 60Co-Gamma-Strahlen. Zeitschrift für Physikalische Chemie Neue Folge 1957; 12: 324–334
   Google Scholar
• Idriss Ali K.M., Scholes G. Analysis of radiolysis products of aqueous uracil + N2O solutions. Journal of the Chemical Society Faraday Transactions I 1980; 76: 449–456
   Google Scholar
• Infante G.A., Jirathana P., Fendler E.J., Fendler J.H. Radiolysis of pyrimidines in aqueous solutions. Part 2. Product formation in the interaction of e-aq, H, OH and Cl-2 with uracil. Journal of the Chemical Society Faraday Transactions I 1974; 70: 1162–1170
   Google Scholar
• Janata E., Schuler R.H. Rate constant for scavenging e-aq in N2O-saturated solutions. Journal of Physical Chemistry 1982; 86: 2078–2084
   Web of Science ®Google Scholar
• Kaye W. Low-angle laser light scattering. Analytical Chemistry 1973; 45: 221A–225A
   Web of Science ®Google Scholar
• Lal M. Radiolytic oxidation of dithiothreitol in N2-saturated aqueous solutions at pH's 1·0 and 6·0. Radiation Physics and Chemistry 1980; 15: 649–656
   Google Scholar
• Lemaire D.G.E. Untersuchungen zum strahleninduzierten Strangbruch von Poly(U) in wässriger Lösung. Ruhr-Universität Bochum. 1984, PhD thesis
   Google Scholar
• Lemaire D.G.E., Bothe E., Schulte-Frohlinde D. Yields of radiation-induced main chain scission of poly U in aqueous solution: Strand break formation via base radicals. International Journal of Radiation Biology 1984; 45: 351–358
   Web of Science ®Google Scholar
• McConnell M.L. Polymer molecular weights and molecular weight distributions. American Laboratory, May 1978; 10: 63–75
   Web of Science ®Google Scholar
• Matsushige T., Koltzenburg G., Schulte-Frohlinde D. Pulse radiolysis of aqueous solutions of acetic acid 2-hydroxyethyl ester. Fast elimination of acetic acid from a primary radical. Berichte der Bunsengesellschaft für Physikalische Chemie 1975; 79: 657–661
   Google Scholar
• Myers L.S., Jr., Hollis M.L., Theard L.M., Peterson F.C., Warnick A. Pulse radiolysis of nucleic acid constituents and related compounds. III. Optical spectra and reactivity of organic free radicals formed by reaction of hydroxyl free radicals with pyrimidine bases. Journal of the American Chemical Society 1970; 92: 2875–2882
   PubMed Web of Science ®Google Scholar
• Neta P., Schuler R.H. Rate constants for reaction of hydrogen atoms with compounds of biochemical interest. Radiation Research 1971; 47: 612–627
   Web of Science ®Google Scholar
• Novais H.M., Steenken S. ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts. Journal of the American Chemical Society 1986; 108: 1–6
   Web of Science ®Google Scholar
• Patt H.M., Tyree E.B., Straube R.L., Smith D.E. Cysteine protection against X-irradiation. Science 1949; 110: 213–214
   PubMed Web of Science ®Google Scholar
• Rabani J., Mulac W.A., Matheson M.S. The pulse radiolysis of aqueous tetranitromethane. I. Rate constants and the extinction coefficients of e-aq. II. Oxygenated solutions. Journal of Physical Chemistry 1965; 69: 53–70
   Web of Science ®Google Scholar
• Redpath J.L. Pulse radiolysis of dithiothreitol. Radiation Research 1973a; 54: 364–374
   PubMed Web of Science ®Google Scholar
• Redpath J.L. Radioprotection of enzyme and bacterial systems by dithiothreitol. Radiation Research 1973b; 55: 109–117
   PubMed Web of Science ®Google Scholar
• Richards E.G., Flessel C.P., Fresco J.R. Polynucleotides. VI. Molecular properties and conformation of polyribouridylic acid. Biopolymers 1963; 1: 431–446
   Google Scholar
• Schuchmann M.N., Al-Sheikhly M., von Sonntag C., Garner A., Scholes G. The kinetics of the rearrangement of some isopyrimidines to pyrimidines studied by pulse radiolysis. Journal of the Chemical Society Perkin Transactions 1984a; II: 1777–1780
   Google Scholar
• Schuchmann M.N., Steenken S., Wroblewski J., von Sonntag C. Site of OH radical attack on dihydrouracil and some of its methyl derivatives. International Journal of Radiation Biology 1984b; 46: 225–232
   Google Scholar
• Schuchmann M.N., von Sonntag C. Radiolysis of di- and tri-methyl phosphates in oxygenated aqueous solution: a model system for DNA strand breakage. Journal of the Chemical Society Perkin Transactions 1984; II: 699–704
   Google Scholar
• Schuler R.H., Hartzell A.L., Behar B. Track effects in radiation chemistry. Concentration dependence for the scavenging of OH by ferrocyanide in N2O-saturated aqueous solutions. Journal of Physical Chemistry 1981; 85: 192–199
   Web of Science ®Google Scholar
• Schulte-Frohlinde D., Opitz J., Görner H., Bothe E. Model studies for the direct effect of high-energy irradiation on DNA. Mechanism of strand break formation induced by laser photoionization of poly U in aqueous solution. International Journal of Radiation Biology 1985; 48: 397–408
   Web of Science ®Google Scholar
• Shragge P.C., Hunt J.W. A pulse radiolysis study of the free radical intermediates in the radiolysis of uracil. Radiation Research 1974; 60: 233–249
   Web of Science ®Google Scholar
• Shragge P.C., Varghese A.J., Hunt J.W., Greenstock C.L. Radiolysis of uracil in the absence of oxygen. Radiation Research 1974a; 60: 250–267
   Web of Science ®Google Scholar
• Shragge P.C., Varghese A.J., Hunt J.W., Greenstock C.L. Identification of new products in the γ-radiolysis of deoxygenated solutions of uracil and the effect of pH. Journal of the Chemical Society Chemical Communications 1974b; 736–738
   Google Scholar
• Steiner R., Millar D.B.S. The nucleic acids. Biological Polyelectrolytes, A. Veis. Dekker, New York 1970; 65–129
   Google Scholar
• van Rijn K., Mayer T., Blok J., Verberne J.B., Loman H. Reaction rate of OH radicals with 0X174 DNA: influence of salt and scavenger. International Journal of Radiation Biology 1985; 47: 309–317
   Web of Science ®Google Scholar
• Ward J.F. Deoxynucleotides - models for studying mechanisms of strand breakage in DNA-I. International Journal of Radiation Physics and Chemistry 1971; 239–249
   Google Scholar
• Ward J.F. Molecular mechanisms of radiation-induced damage to nucleic acids. Advances in Radiation Biology 1975; 5: 181–239
   Google Scholar
• Warters R.L., Hofer K.G., Harris C.R., Smith J.M. Radionuclide toxicity in cultured mammalian cells: Elucidation of the primary site of radiation damage. Current Topics in Radiation Research Quarterly 1977; 12: 389–407
   Google Scholar
• Washino K., Denk O., Schnabel W. OH radical-induced main-chain scission of poly(ribonucleic acids) under anoxic conditions. Zeitschrift für Naturforschung 1983; 38c: 100–106
   Google Scholar