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International Journal of Radiation Biology Volume 56, 1989 - Issue 1
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Original Article

Rapid Human Chromosome Aberration Analysis Using Fluorescence in Situ Hybridization

J.N. Lucas Biomedical Sciences Division, Lawrence Livermore National Laboratory, University of California, PO Box 5507, Livermore, California, 94550, U.S.A.
,
T. Tenjin Environmental Sciences Division, Lawrence Livermore National Laboratory, University of California, PO Box 5507, Livermore, California, 94550, U.S.A.
,
T. Straume Nippon Medical School, Toyko, Japan
,
D. Pinkel Department of Biochemistry, Oregon Health Sciences University, Portland, Oregon, 97201, U.S.A.
,
D. Moore II Department of Medical Genetics, Oregon Health Sciences University, Portland, Oregon, 97201, U.S.A.
,
M. Litt Biomedical Sciences Division, Lawrence Livermore National Laboratory, University of California, PO Box 5507, Livermore, California, 94550, U.S.A.
&
J.W. Gray Environmental Sciences Division, Lawrence Livermore National Laboratory, University of California, PO Box 5507, Livermore, California, 94550, U.S.A.
 show all
Pages 35-44 | Received 14 Oct 1988, Published online: 03 Jul 2009

References

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  • Fuscoe J., Collins C., Pinkel D., Gray J.W. An efficient method for selecting unique-sequence clones from DNA libraries and its application to fluorescent staining of human chromosome 21 using in situ hybridization. Genomics 1988, in press
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  • Lloyd D., Purrott R., Dolphin G., Bolton D., Edwards A. The relationship between chromosome aberrations and low LET radiation dose to human lymphocytes. International Journal of Radiation Biology 1975; 28: 75–90
  • Lloyd D., Prosser J., Lelliott D., Moquet J. Doses in radiation accidents investigated by chromosome aberration analysis. XII. A review of cases investigated: 1981. UK National Radiological Protection Board Report 1982; R-128: 215–288
  • Mendelsohn M., Mayall B., Bogart E., Moore D., II, Perry B. DNA content of the various radiation-induced chromosomal rearrangements in relation to the dose and sample time. Science 1973; 179: 1126–1129
  • National Bureau of Standards. Physical Aspects of Irradiation. 1964, Handbook 85
  • Pinkel D., Straume T., Gray J.W. Cytogenetic analysis using quantitative high-sensitivity fluorescence hybridization. Proceedings of the National Academy of Sciences (USA) 1986; 83: 2934–2938
  • Pinkel D., Landegent J., Collins C., Fuscoe J., Segraves R., Lucas J., Gray J. Fluorescence in situ hybridization with human chromosome-specific libraries: Detection of trisomy 21 and translocations of chromosome 4. Proceedings of the National Academy of Sciences 1988; 85: 9138–9142
  • Sasaki M., Miyata H. Biological dosimetry in atomic bomb survivors. Nature 1968; 220: 1189–1193

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