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International Journal of Radiation Biology Volume 59, 1991 - Issue 5
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Original Article

The Efficacy of DFO-HOPO, DTPA-DX and DTPA for Enhancing the Excretion of Plutonium and Americium from the Rat

G.N. Stradling National Radiological Protection Board, Chilton, Didcot, Oxon, UK
,
S.A. Gray Department of Chemistry, University of California, Berkeley, CA, USA
,
J.C. Moody Lawrence Berkeley Laboratory, University of California, Berkeley, CA, USA
,
A. Hodgson National Radiological Protection Board, Chilton, Didcot, Oxon, UK
,
K.N. Raymond Department of Chemistry, University of California, Berkeley, CA, USA
,
P.W. Durbin Lawrence Berkeley Laboratory, University of California, Berkeley, CA, USA
,
S.J. Rodgers National Radiological Protection Board, Chilton, Didcot, Oxon, UK
,
D.L. White Department of Chemistry, University of California, Berkeley, CA, USA
&
P.N. Turowski Lawrence Berkeley Laboratory, University of California, Berkeley, CA, USA
 show all
Pages 1269-1277 | Received 25 Sep 1990, Accepted 19 Dec 1990, Published online: 03 Jul 2009

References

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  • Durbin P.W., Jeung N., Jones E.S., Weitl F.L., Raymond K.N. Specific sequestering agents for actinides: 10. Enhancement of 238Pu elimination from mice by poly(catechoylamide) ligands. Radiation Research 1984; 99: 85–105
  • Durbin P.W., White D.L., Jeung N., Weitl F.L., Uhlir L.C., Jones S.E., Bruenger F.W., Raymond K.N. Specific sequestering agents for the actinides: 18. In-vivo chelation of 238Pu(IV) by 3,4,3-LICAM(C): effects of ligand methylation and pH. Health Physics 1989a; 56: 839–855
  • Durbin P.W., Jeung N., Rodgers S.J., Turowski P.N., Weitl F.L., White D.L., Raymond K.N. Removal of 238Pu(IV) from mice by polycatechoylate, hydroxamate, or -hydroxypridonate ligands. Radiation Protection Dosimetry 1989b; 26: 351–358
  • Harrison J.D., Smith H., David A.J. Plutonium and americium uptake in rats fed with Cumbrian shellfish—implicatons for estimates of dose to man. Science of the Total Environment 1988; 68: 187–196
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  • International Commission on Radiological Protection. Limits on Intakes of Radionuclides by Workers. ICRP Publication 30, Pergamon Press, Oxford 1979, Part 1
  • International Commission on Radiological Protection. Individual Monitoring for Intakes of Radionuclides by Workers: Design and Interpretation. ICRP Publication 54, Pergamon Press, Oxford 1988
  • Keough R.F., Powers G.J. Determination of plutonium in biological materials by extraction and liquid scintillation counting. Analytical Chemistry 1970; 42: 419–421
  • NCRP. National Council on Radiation Protection and Measurements. Mangement of Persons Accidentally Contaminated with Radionuclides. NCRP Report No. 65, NRCP, Washington, DC 1980
  • Nenot J.C., Stather J.W. The Toxicity of Plutonium, Americium and Curium. Commission of the European Communities Report, EUR 6157, Pergamon Press, Oxford 1979
  • Raymond K.N., Smith W.L. Actinide-specific sequestering agents and decontamination applications. Structure and Bonding, J.B. Goodenough. Springer Verlag, Berlin 1981; 43: 159–186
  • Raymond K.N., Harris W.R., Carrano C.J., Weitl F.L. The synthesis, thermodynamic behaviour and biological properties of metal specific sequestering agents for iron and actinides. Inorganic Chemistry in Biology and Medicine, A.E. Martell. ACS Symposium Series No. 140, American Chemical Society, Washington, DC 1980; 313–332
  • Raymond K.N., Muller G., Matzanke B.F. Complexation of iron by siderophores: a review of their solution and structural chemistry and biological function. Topics in Current Chemistry, F.L. Boschke. Springer-Verlag, Berlin 1984; 123: 49–102
  • Stradling G.N., Stather J.W., Sumner S.A., Strong J.C., Lennox A.M., Ham S.E. Decorporation of inhaled plutonium nitrate from hamsters using ZnDTPA. Health Physics 1984; 46: 919–924
  • Stradling G.N., Stather J.W., Gray S.A., Moody J.C., Ellender M., Hodgson A., Volf D.V., Taylor D.M., Wirth P., Gaskin P.W. The efficacies of pure LICAM(C) and DTPA on the retention of plutonium-238 and americium-241 in rats after their inhalation as nitrate and intravenous injection as citrate. International Journal of Radiation Biology 1989; 56: 503–514
  • Turowski P.N., Rodgers S.J., Scarrow R.C., Raymond K.N. Ferric ion sequestering agents. 18. Two hydroxamic acid derivatives of EDTA and DTPA. Inorganic Chemistry 1988; 27: 474–481
  • Volf V. Plutonium decorporation in rats. Diagnosis and Treatment of Incorporated Radionuclides. IAEA, Vienna 1976; 307–322
  • Volf V. Chelation therapy of incorporated plutonium-238 and americium-241: comparison of LICAM(C), DTPA and DFOA in rats, hamsters and mice. International Journal of Radiation Biology 1986; 49: 449–462
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  • Volf V., Taylor D.M., Brandau W., Schlenker P. The effect of pure LICAM(C) on the retention of plutonium-238 in mice and rats. International Journal of Radiation Biology 1986; 50: 205–211
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