16
Views
20
CrossRef citations to date
0
Altmetric
Original Article

DNA Instability, Paternal Irradiation and Leukaemia in Children Around Sellafield

Pages 581-595 | Received 14 Jan 1991, Accepted 22 Apr 1991, Published online: 03 Jul 2009

References

  • Abrahamson S. Childhood leukaemia at Sellafield—a genetically transmitted disease?. RERF Update 1990; 3–4, Spring issue
  • Baverstock K.F. Abnormal distribution of double-strand breaks in DNA after direct action of ionising energy. International Journal of Radiation Biology 1985; 47: 369–374
  • Blocher D., Pohlit W. DNA double strand breaks in Ehrlich ascites tumour cells at low doses of X-rays. II. Can cell death be attributed to double strand breaks?. International Journal of Radiation Biology 1982; 42: 329–338
  • Blocher D., Nusse M., Bryant P.E. Kinetics of double strand break repair in the DNA of X-irradiated synchronized mammalian cells. International Journal of Radiation Biology 1983; 43: 579–584
  • Boer J.G. de, Drobetsky E.A., Grosovsky A.J., Mazur M., Glickman B.W. The Chinese hamster APRT gene as a mutational target. Its sequence and an analysis of direct and inverted repeats. Mutation Research 1989; 226: 239–244
  • Chiu S., Friedman L.R., Oleinick N.L. The fate of DNA-protein crosslinks formed in γ-irradiated metaphase cells. International Journal of Radiation Biology 1990; 58: 235–247
  • Comings D.E. A general theory of carcinogenesis. Proceedings of the National Academy of Sciences, USA 1973; 70: 3324–3328
  • Corry P.M., Cole A. Double strand rejoining in mammalian DNA. Nature New Biology 1973; 245: 100–101
  • Den Dunnen J.T., Grootscholten P.M., Bakker E., Blonden L.A.J., Ginjaar H.B., Wapenaar M.C., Paassen H.M.B. Van, Broeckhoven C. van, Pearson P.L., Ommen G.J.B. van. Topography of the Duchenne muscular dystrophy (DMD) gene: FIGE and cDNA analysis of 194 cases reveals 115 deletions and 13 duplications. American Journal of Human Genetics 1989; 45: 835–847
  • Evans J.H. Leukaemia and radiation. Nature 1990; 345: 16–18
  • Gardner M.J., Snee M.P., Hall A.J., Powell C.A., Downs S., Terrell J.D. Results of a case-control study of leukaemia and lymphoma among young people near Sellafield nuclear plant in West Cumbria. British Medical Journal 1990; 300: 423–428
  • Goodhead D.T. Relationship of microdosimetric techniques to applications in biological systems. The Dosimetry of Ionising Radiations, K.R. Kase, B.E. Bjarngard, F.H. Attix. Academic Press, New York & Orlando 1987; 2: 1–89
  • Greaves M.F. Speculations on the cause of childhood acute lymphoblastic leukaemia. Leukaemia 1988; 2: 120–125
  • Greaves M.F. The Sellafield childhood leukaemia clusters: are germline mutations responsible?. Leukaemia 1990; 4: 391–396
  • ICRU. Microdosimetry Report of the International Commission on Radiation Units. 1983, No. 36
  • Johnson D.K., Russel E.H., Rinchick E.M. Molecular mapping within the mouse albino-deletion complex. Proceedings of the National Academy of Sciences, USA 1989; 86: 8862–8866
  • Knudson A.G. Mutation and cancer: statistical study of retinoblastoma. Proceedings of the National Academy of Sciences, USA 1971; 68: 820–823
  • Lehmann A.R., Stevens S. The production and repair of double strand breaks in cells from normal humans and from patients with ataxia telangiectasia. Biochimica et Biophysica Acta 1977; 474: 49–60
  • Lewin B. Genes IV. Oxford University Press, Oxford 1990
  • Lindahl T., Nyberg B. Rate of depurination of native deoxyribonucleic acid. Biochemistry 1972; 11: 3610–3621
  • Little M.P. A comparison between the risks of childhood leukaemia from parental exposure to radiation in the Sellafield workforce and those displayed among the Japanese bomb survivors. Journal of Radiological Protection 1990; 10: 185–198
  • Lyon M.F., Papworth D.G., Phillips R.J.S. Dose-rate and mutation frequency after irradiation of mouse spermatogonia. Nature New Biology 1972; 238: 101–104
  • Meistrich M.L., van Beek M.E.A.B. Radiation sensitivity of the human testis. Advances in Radiation Biology 1990; 14: 227–268
  • Monesi V. Spermatogenesis and spermatozoa. Reproduction in Mammals, vol. 1: Germ Cells and Fertilisation, C.R. Austin, R.V. Short. Cambridge University Press, Cambridge 1972; 46–84
  • Moolgavkar S.H., Knudson A.G. Mutation and cancer: a model for human carcinogenesis. Journal of the National Cancer Institute 1981; 66: 1037–1052
  • Neel J.V., Schull W.J., Awa A.A., Satoh C., Kato H., Otake M., Yoshimoto Y. The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humans. American Journal of Human Genetics 1990; 46: 1053–1072
  • Nomura T. Parental exposure to X-rays and chemicals induces heritable tumours and anomalies in mice. Nature 1982; 296: 575–577
  • Ramakrishnan N., Chiu S., Oleinick N.L. Yield of DNA-protein crosslinks in γ-irradiated Chinese hamster cells. Cancer Research 1987; 47: 2032–2035
  • Rooij D.G. de. Proliferation and differentiation of undifferentiated spermatogonial cells in the mammalian testis. Stem Cells: their Identification and Characterisation, C.S. Potten. Churchill Livingstone, Edinburgh 1983; 89–117
  • Ruppert S., Müller G., Kwon B., Schütz G. Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO Journal 1988; 7: 2715–2722
  • Russell W.L. Evidence from mice concerning the nature of the mutation process. Genetics Today, S.J. Geerts. Pergamon, Oxford 1964; 257–264
  • Russell W.L. Studies in mammalian radiation genetics. Nucleonics 1965; 23: 53–62
  • Russell W.L., Kelly E.M. Specific locus mutation frequencies induced in mouse spermatogonia at very low radiation dose rates. Genetics 1976; 83: S66–S66, (abs)
  • Russell W.L., Russell L.B., Kelly E.M. Radiation dose rate and mutation frequency. Science 1958; 128: 1546–1550
  • Russell L.B., Russell W.L., Kelly E.M. Analysis of the albino-locus region of the mouse. I. Origin and viability. Genetics 1979; 91: 127–139
  • Sankaranarayanan K. Genetic Effects of Ionising Radiation in Multicellelur Eukaryotes and the Assessment of Genetic Radiation Hazards in Man. Elsevier, Amsterdam 1982
  • Searle A.G. Mutation induction in mice. Advances in Radiation Biology 1974; 4: 131–207
  • Searle A.G. Evidence from mammalian studies on genetic effects of low level irradiation. Low Dose Radiation: the Biological Basis of Risk Assessment, K.F. Baverstock, J.W. Stather. Taylor & Francis, London 1989; 123–137
  • Selby P.J. Experimental induction of dominant mutations in mammals by ionising radiations and chemicals. Issues and Reviews in Teratology 1990; 5: 181–253
  • UNSCEAR. Sources, Effects and Risks of Ionising Radiation. United Nations, New York 1988, United Nations Scientific Committee on the Effects of Atomic Radiation
  • Vilenchik M.M. Spontaneous DNA damage and repair. Mechanisms of DNA Damage and Repair. Biological Centre of the Academy of Sciences, Pushchino 1971; 266–267
  • Vilenchik M.M. DNA Instability and Late Radiation Effect. Energoatomizdat, Moscow 1987
  • Ward J.F. DNA damage produced by ionising radiation in mammalian cells: identities, mechanisms of formation and repairability. Progress in Nucleic Acid Research and Molecular Biology 1988; 35: 95–125
  • Wilkins R.J. Genomic imprinting and carcinogenesis. Lancet 1988; 1: 239–331
  • Yoshimoto Y., Neel J.V., Schull W.J., Kato H., Soda M., Eto R., Mabuchi K. Malignant tumours during the first two decades of life in the offspring of atomic bomb survivors. American Journal of Human Genetics 1990; 46: 1041–1052

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.