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Original Article

DNA Ligands as Radioprotectors: Molecular Studies with Hoechst 33342 and Hoechst 33258

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Pages 69-81 | Received 07 Jan 1991, Accepted 18 Jun 1991, Published online: 03 Jul 2009

References

  • Bases R., Hamori I., Piazza L., Maio J., Mendez F. DNA base and strand damage in X-irradiated monkey CV-1 cells: Influence of pretreatment using small doses of radiation. International Journal of Radiation Biology 1990; 58(1)35–54
  • Blazek E.R., Peak M.J. The role of hydroxyl radical quenching in the protection by acetate and ethylenediaminetera acetate of supercoiled plasmid DNA from ionizing radiation-induced strand breakage. International Journal of Radiation Biology 1988; 53: 237–247
  • Carrondo M.A.A.F. de C.T., Coll M., Aymami J., Wang A.H.J., van der Marel G.A., van Boom J.H., Rich A. Binding of Hoechst dye to d(CGCGATATCGCG) and its influence on the conformation of the DNA fragment. Biochemistry 1989; 28: 7849–7859
  • Chaplin D.J., Durand R.E., Olive P.L. Cell selection from a murine tumour using the fluorescent probe Hoechst 33342. British Journal of Cancer 1985; 51: 569–572
  • Chaplin D.J., Olive P.L., Durand R.E. Intermittent blood flow in a murine tumour: radiobiological effects. Cancer Research 1987; 47: 597–601
  • Chen C.Z., Sutherland J.C. Gel electrophoresis method for quantitation of gamma ray induced single- and double-strand breaks in DNA irradiated in vitro. Electrophoresis 1989; 10: 318–326
  • Churchill M.E.A., Suzuki M. ‘SPKK’ motifs prefer to bind to DNA at A/T-rich sites. EMBO Journal 1989; 8(13)4189–4195
  • Cowan D.S.M., Panicucci R., McClelland R.A., Rauth A.M. Targeting Radiosensitizers to DNA by Attachment of an Intercalating Group: Nitroimidazole-Linked Phenanthridines. Radiation Research 1991; 127: 81–89
  • Cullis P.M., Symons M.C.R. Effects of direct radiation on deoxyribonucleic acids. Radiation Physics and Chemistry 1986; 27: 93–100
  • Cullis P.M., Jones G.D.D., Lea J., Symons M.C.R., Sweeney M. The effects of ionizing radiation on deoxyribonucleic acids. Part 5. The role of thiols in chemical repair. Journal of the Chemical Society. Perkin Transactions II 1987; 1907–1914
  • Cullis P.M., Symons M.C.R., Sweeney M.C., Jones G.D.D., McClymont J.D. The effects of ionizing radiation on deoxyribonucleic acid. Part 4. The role of hydrogen peroxide. Journal of Chemical Society. Perkin Transactions II 1986; 1671–1676
  • Cullis P.M., Jones G.D.D., Sweeney M.C., Symons M.C.R., Wren B.W. DNA damage in frozen aqueous solution: Sequence dependence and end groups. Free Radical Research, Communications 1989; 6: 149–152
  • Durand R.E. Use of Hoechst 33342 for cell selection from multicell systems. Journal of Histochemistry and Cytochemistry 1982; 30: 117–122
  • Gregoli S., Olast M., Bertinchamps A. Radiolytic pathways in gamma-irradiated DNA: Influence of chemical and conformational factors. Radiation Research 1982; 89: 238–258
  • Harshman K.D., Dervan P.B. Molecular recognition of B-DNA by Hoechst 33258. Nucleic Acids Research 1985; 13: 4825–4835
  • Hempel K., Mildenberger E. Determination of G-values for single and double strand break induction in plasmid DNA using agarose gel electrophoresis and a curve fitting procedure. International Journal of Rdiation Biology 1987; 52: 125–138
  • Henner W.D., Grunberg S.M., Haseltine W.A. Sites and structures of gamma-radiation-induced DNA strand breaks. Journal of Biological Chemistry 1982; 257: 11750–11754
  • Jones G.D.D., O'Neill P. The kinetics of radiation induced strand breakage in polynucleotides in the presence of oxygen: a time-resolved light-scattering study. International Journal of Radiation Biology 1990; 57: 1123–1139
  • Latt S.A., Wohlleb J.C. Optical studies of 33258 Hoechst with DNA, chromatin, and metaphase chromosomes. Chromosoma 1975; 52: 297–316
  • Lemaire D.G.E., Bothe E., Schulte-Frohlinde D. Hydroxyl radical-induced strand break formation of poly U in anoxic solution. Effect of dithiothreitol and tetranitromethane. International Journal of Radiation Biology 1987; 51: 319–330
  • Loontiens F.G., Regenfuss P., Zechel A., Dumortier L., Clegg R.M. Binding characteristics of Hoechst 33258 with calf thymus DNA Poly [d(AT)] and d (CCGGAATTCCGG); Multiple stoichiometries and determination of tight binding with a wide spectrum of site affinities. Biochemistry 1990; 29: 9029–9039
  • Molecular Cloning: A Laboratory Manual, T. Maniatis, E.F. Fritsch, J. Sambrooke. Cold Spring Harbour Press, New York 1982
  • Martin R.F., Holmes N. Use of an 125I-labelled DNA ligand to probe DNA structure. Nature 1983; 302: 452–454
  • Martin R.F., Murray V., D'Cunha G., Pardee M., Kampouris E., Haigh A., Kelly, Hodgson G.S. Radiation sensitization by an iodine-labelled DNA ligand. International Journal of Radiation Biology 1990; 57: 939–946
  • Maxam A.M., Gilbert W. Sequencing end-labelled DNA with base-specific chemical cleavages. Methods of Enzymology 1980; 65: 499–560
  • Murray V., Martin R.F. The sequence specificity of 125I-labelled Hoechst 33258 in intact human cells. Journal of Molecular Biology 1988a; 201: 437–442
  • Murray V., Martin R.F. The sequence specificity of 125I-labelled Hoechst 33258 damage in six closely related sequences. Journal of Molecular Biology 1988b; 203: 63–73
  • McGowan P.F., Hurst R.E., Bass R.A., Wilcox L.J., Hemstreet G.P., Postier R.G. Equilibrium binding of Hoechst 33258 and Hoechst 33342 fluorochromes with rat colorectal cells. Journal of Histochemistry and Cytochemistry 1988; 36: 757–762
  • Olive P.L., Chaplin D.J., Durand R.E. Pharmacokinetics binding and distribution of Hoechst 33342 in spheroids and murine tumours. British Journal of Cancer 1985; 52: 739–739
  • Parkinson J.A., Barber J., Douglas K.T., Rosamund J., Sharples D. Nuclear magnetic resonance probing of binding interactions used by minor groove binding DNA-directed ligands: Assignment of the binding site of Hoechst 33258 on the self-complementary oligonucleotide, d(CGCGAATTCGCG). Journal of Chemical Society Chemical Communications 1989; 1023–1025
  • Pjura P.E., Grezeskowiak K., Dickerson R.E. Binding of Hoechst 33258 to the minor groove of B-DNA. Journal of Molecular Biology 1987; 197: 257–271
  • Roberts P.B., Anderson R.F., Wilson W.R. Hypoxia-selective radiosensitization of mammalian cells by nitracrine, an electron-affinic DNA intercalator. International Journal of Radiation Biology 1987; 51: 652–652
  • Searle M.S., Embrey K.J. Sequence-specific interaction of Hoechst 33258 with the minor groove of an adenine-tract DNA duplex studied in solution by 1H NMR spectroscopy. Nucleic Acids Research 1990; 18(13)3753–3762
  • Siemann D.W., Keng P.C. Characterization of radiation resistant hypoxic cell subpopulations in KHT sarcomas. (ii) Cell sorting. British Journal of Cancer 1988; 58: 296–296
  • Skov K.A. Modification of radiation by metal complexes: A review with emphasis of nonplatinum studies. Radiation Research 1987; 112: 217–242
  • Smith P.J., Anderson C.O. Modification of the radiation sensitivity of human tumour cells by a bisbenzimidazole derivative. International Journal of Radiation Biology 1984; 46: 331–344
  • Smoluk G.D., Fahey R.C., Ward J.F. Equilibrium dialysis of the binding of radioprotector compounds to DNA. Radiation Research 1986; 107: 194–204
  • Smoluk G.D., Fahey R.C., Ward J.F. Interaction of glutathione and other low molecular weight thiols with DNA: Evidence for counterion condensation and co-ion depletion near DNA. Radiation Research 1988; 114: 3–10
  • Stubbe J., Kozarich J.W. Mechanisms of bleomcyin-induced DNA degradation. Chemical Reviews 1987; 87: 1107–1136
  • Teng M., Usman N., Frederick C.A., Wang A.H.J. The molecular structure of the complex of Hoechst 33258 and the DNA dodecamer d(CGCGAATTCGCG)2. Nucleic Acid Research 1988; 16: 2671–2690
  • Van Touw J.H., Verberne J.B., Reter J., Loman H. Radiation-induced strand breaks in phiX 174 replicative from DNA: and improved experimental and theoretical approach. International Journal of Radiation Biology 1985; 48: 567–578
  • Whillans D.W., Adams G.E. Electron affinic sensitization VI: Pulse radiolysis and ESR comparison of some 2- and 5-nitroimidazoles. Radiation Research 1975; 62: 407–421
  • Young S.D., Hill R.P. Radiation sensitivity of tumour cells strand in vitro or in vivo with the benzimidazole fluoroscence Hoechst 33342. British Journal of Cancer 1989; 60: 715–721
  • Zimmer C., Wahnert U. Nonintercalating DNA-binding ligands: Specificity of the interaction and their use as tools in biophysical, biochemical and biological investigations of the genetic material. Progress in Biophysics Molecular Biology 1986; 47: 31–112

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