In Vitro and in Vivo Studies Using BW12C: Toxicity, Haemoglobin Modification and Effects on the Radiosensitivity of Normal Marrow and RIF-1 Tumours in Mice

References

• van den Aardweg G.J.M.J., Hopewell J.W., Barnes D.W.H., Sansome J.M., Nethersell A.B.W. Modification of the radiation response of pig skin by manipulation of tissue oxygen tension using anaesthetics and administration of BW12C. International Journal of Radiation Oncology, Biology, Physics 1989; 16: 1191–1194
   PubMed Web of Science ®Google Scholar
• van den Aardweg G.J.M.J., Hopewell J.W., Adams G.E., Barnes D.W.H., Sansome J.M., Stratford I.J., Nethersell A.B.W. Protection of the pig epidermis against radiation-induced damage by the infusion of BW12C. International Journal of Radiation Biology 1991; 59: 1039–1051
   PubMed Web of Science ®Google Scholar
• Adams G.E., Stratford I.J., Nethersell A.B.W., White R.D. Induction of severe tumour hypoxia by modifiers of the oxygen affinity of haemoglobin. International Journal of Radiation Oncology, Biology, Physics 1989; 16: 1179–1182
   PubMed Web of Science ®Google Scholar
• Adams G.E., Barnes D.W.H., du Boulay C., Loutit J.F., Cole S., Sheldon P.W., Stratford I.J., van den Aardweg G.J.M.J., Hopewell J.W., White R.D., Kneen G., Nethersell A.B.W., Edwards J.C. Induction of hypoxia in normal and malignant tissues by changing the oxygen affinity of haemoglobin—implications for therapy. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1299–1302
   PubMed Web of Science ®Google Scholar
• Allalunis M.J., Chapman J.D., Turner A.R. Identification of a hypoxic population of bone marrow cells. International Journal of Radiation Oncology, Biology Physics 1983; 9: 227–232
   PubMed Web of Science ®Google Scholar
• Beddell C.R., Goodford P.J., Kneen G., White R.D., Wilkinson S., Wootton R. Substituted benzaldehydes designed to increase the oxygen affinity of human haemoglobin and inhibit the sickling of sickle crythrocytes. British Journal of Pharmacology 1984; 82: 397–407
   PubMed Web of Science ®Google Scholar
• Brown J.M., Twentyman P.R., Zamvil S.S. Response of the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay and tumour control) chemotherapeutic agents and activated macrophages. Journal of the National Cancer Institute 1980; 64: 605–611
   PubMedGoogle Scholar
• Cole S., Robbins L. Manipulation of oxygenation in a human tumour xenograft with BW12C or hydralazine: effects on responses to radiation and to the bioreductive cytotoxicity of misonidazole or RSU-1069. Radiotherapy and Oncology 1989; 16: 235–243
   PubMed Web of Science ®Google Scholar
• Fitzharris P., McLean A.E.M., Sparks R.G., Weatherly B.C., White R.D., Wootton R. The effects in volunteers of BW12C, a compound designed to left-shift the blood-oxygen saturation curve. British Journal of Pharmacology 1985; 19: 471–481
   Google Scholar
• Hendry J.H., Lord B.I. The analysis of the early and late response to cytotoxic insults in the haemopoietic cell hierarchy. Cytotoxic Insult to Tissue, C.S. Potten, J.H. Hendry. Churchill Livingstone, London 1983; 1–66
   Google Scholar
• Honess D.J., Bleehen N.M. Sensitivity of normal mouse marrow and RIF-1 tumour to hyperthermia combined with cyclophosphamide or BCNU: a lack of therapeutic gain. British Journal of Cancer 1982; 46: 236–248
   PubMedGoogle Scholar
• Honess D.J., White R.D., Nethersell A.B.W., Bleehen N.M. Effects of the manipulation of oxyhaemoglobin status by BW12C on tumor thermosensitivity and on blood flow in tumor and normal tissues in mice. International Journal of Radiation Oncology, Biology, Physics 1989; 16: 1187–1190
   PubMed Web of Science ®Google Scholar
• Keidan A.J., White R.D., Huehns E.R., Franklin I.M., Joy M., Stuart J. Effect of BW12C on oxygen affinity of haemoglobin in sickle-cell disease. Lancet April, 1986; 831–834, 12th
   PubMedGoogle Scholar
• Kennedy K.A. Hypoxic cells as specific targets for chemotherapy. Anticancer Drug Design 1987; 2: 181–194
   PubMed Web of Science ®Google Scholar
• Ramsay J.R.S., Bleehen N.M., Dennis I., Workman P., Ward R., Falk S.J., Bedford P., Wootton R., Nethersell A.B.W. Phase I study of BW12C in combination with mitomycin C in patients with advanced gastrointestinal cancer. International Journal of Radiation Oncology, Biology, Physics 1991, in press
   Google Scholar
• Rockwell S.C., Kallman R.F., Fajardo L.F. Characteristics of a serially transplanted mouse mammary tumor and its tissue-culture-adapted derivative. Journal of the National Cancer Institute 1972; 49: 735–747
   PubMedGoogle Scholar
• Sartorelli A. Therapeutic attack of hypoxic cells of solid tumours: presidential address. Cancer Research 1988; 48: 775–778
   PubMedGoogle Scholar
• Stevens G., Hill S.A., Joiner M.C., Joiner B., Johns H., Williams K., Nethersell A.B.W., Denekamp J. The effect of BW12C on the radiosensitivity and necrosis of murine normal tissues and tumours. Radiotherapy and Oncology 1991, submitted.
   PubMedGoogle Scholar
• Stratford I.J., O'Neill P., Sheldon P.W., Silver A.R.J., Walling J.M., Adams G.E. RSU-1069, a nitroimidazole containing an aziridine group: bioreduction greatly increases cytotoxicity under hypoxic conditions. Biochemical Pharmacology 1986; 36: 105–109
   Google Scholar
• Twentyman P.R., Brown J.M., Gray J.W., Franko A.J., Scoles M.A., Kallman R.F. A new mouse model tumour system (RIF-1) for comparison of end-point studies. Journal of the National Cancer Institute 1980; 64: 595–604
   PubMedGoogle Scholar
• Urano M., Nesumi N., Ando K., Koike S., Ohnuma N. Repair of potentially lethal radiation damage in a spontaneous animal tumour in vivo. Radiological Research and Radiotherapy (IAEA Vienna) 1977; 2: 212–219
   Google Scholar
• Zeman E.M., Brown J.M., Lemmon M.J., Hirst V.K., Lee W.W. SR4233: a new bioreductive agent with a high selective toxicity for hypoxic mammalian cells. International Journal of Radiation Oncology, Biology, Physics 1986; 12: 1239–1242
   PubMed Web of Science ®Google Scholar