Radiosensitization Efficacy of KU-2285, RP-170 and Etanidazole at Low Radiation Doses: Assessment by in Vitro Cytokinesis-block Micronucleus Assay

References

• Brown J.M., Yu N.Y. Radiosensitization of hypoxic cells in vivo by SR-2508 at low radiation doses: a preliminary report. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 1207–1212
   PubMed Web of Science ®Google Scholar
• Brown J.M., Yu N.Y., Brown D.M., Lee W.W. SR-2508: a 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use. International Journal of Radiation Oncology, Biology and Physics 1981; 7: 695–703
   PubMed Web of Science ®Google Scholar
• Coleman C.N. Hypoxic cell radiosensitizers: expectations and progress in drug development. International Journal of Radiation Oncology, Biology and Physics 1985; 11: 323–329
   PubMed Web of Science ®Google Scholar
• Dische S. Hypoxic cell sensitizers: clinical developments. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1057–1060
   Google Scholar
• Evans J.W., Taylor Y.C., Brown J.M. The role of glutathione and DNA strand break repair in determining the shoulder of the radiation survival curve. British Journal of Cancer 1984; 49(Suppl. VI)49–53
   Google Scholar
• Fenech M., Morley A. Solutions to the kinetic problem in the micronucleus assay. Cytobios 1985; 43: 233–246
   PubMedGoogle Scholar
• Fenech M., Morley A. Cytokinesis-block micronucleus method in human lymphocytes: effect of in vivo ageing and low dose X-irradiation. Mutation Research 1986; 161: 193–198
   PubMed Web of Science ®Google Scholar
• Grdina D.J., Thames H.D., Milas L. Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range. International Journal of Radiation Oncology, Biology and Physics 1984; 10: 379–383
   PubMed Web of Science ®Google Scholar
• Hall E.J., Astor M., Biaglow J., Parham J.C. The enhanced sensitivity of mammalian cells to killing by X rays after prolonged exposure to several nitroimidazoles. International Journal of Radiation Oncology, Biology and Physics 1982; 8: 447–451
   PubMed Web of Science ®Google Scholar
• Harris J.W. Non-protein sulfhydryl content of Ehrlich ascites tumor cells exposed to hyperbaric oxygen or X-irradiation. Experimental Cell Research 1968; 50: 293–305
   PubMedGoogle Scholar
• Masunaga S., Ono K., Wandl E.O., Fushiki M., Abe M. Use of the micronucleus assay for the selective detection of radiosensitivity in BUdR-unincorporated cells after pulse-labelling of exponentially growing tumour cells. International Journal of Radiation Biology 1990; 58: 303–311
   PubMed Web of Science ®Google Scholar
• Murayama C., Suzuki A., Suzuki T., Miyata Y., Sakaguchi M., Tanabe Y., Tanaka N., Mori T. Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]-methyl-2-nitroimidazole (RP-170). International Journal of Radiation Oncology, Biology and Physics 1989; 17: 575–581
   PubMedGoogle Scholar
• Palcic B., Skarsgard L.D. Reduced oxygen enhancement ratio at low doses of ionizing radiation. Radiation Research 1984; 100: 328–339
   PubMed Web of Science ®Google Scholar
• Palcic B., Faddegon B., Skarsgard L.D. The effect of misonidazole as a hypoxic radiosensitizer at low dose. Radiation Research 1984; 100: 340–347
   PubMed Web of Science ®Google Scholar
• Révész L., Palcic B. Radiation dose dependence of the sensitization by oxygen and oxygen mimic sensitizers. Acta Radiologica Oncology 1985; 24: 209–217
   PubMed Web of Science ®Google Scholar
• Sasai K., Fushiki M., Yukawa Y., Suyama S., Iwai H., Shibamoto Y., Nishimoto S., Takahashi M., Abe M. In vivo radiosensitizing activity of a new fluorinated hypoxic cell radiosensitizer, KU-2285, in combination with radiation dose fractionation. International Journal of Radiation Oncology, Biology and Physics 1991a; 21: 1231–1234
   PubMedGoogle Scholar
• Sasai K., Nishimoto S., Shimokawa K., Hisanaga Y., Kitakabu Y., Shibamoto Y., Zhou L., Wang J., Takahashi M., Kagiya T., Abe M. A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer. International Journal of Radiation Oncology, Biology and Physics 1991b; 20: 1249–1254
   PubMed Web of Science ®Google Scholar
• Sasai K., Shibamoto Y., Takahashi M., Abe M., Wang J., Zhou L., Nishimoto S., Kagiya T. A new, potent 2-nitroimidazole nucleoside hypoxic cell radiosensitizer, RP-170. Japanese Journal of Cancer Research 1989; 80: 1113–1118
   Google Scholar
• Sasai K., Shibamoto Y., Takahashi M., Ito T., Nishimoto S., Abe M. Pharmacokinetics of 2-nitroimidazole hypoxic cell radiosensitizers in rodent peripheral nervous tissue. International Journal of Radiation Biology 1990; 57: 971–980
   PubMed Web of Science ®Google Scholar
• Shibamoto Y., Nishimoto S., Mi F., Sasai K., Kagiya T., Abe M. Evaluation of various types of new hypoxic cell sensitizers using the EMT6 single cellspheroid-solid tumour system. International Journal of Radiation Biology 1987; 52: 347–357
   Web of Science ®Google Scholar
• Shibamoto Y., Nishimoto S., Shimokawa K., Hisanaga Y., Zhou L., Wang J., Sasai K., Takahashi M., Abe M., Kagiya T. Characteristics of fluorinated nitroazoles as hypoxic cell radiosensitizers. International Journal of Radiation Oncology, Biology and Physics 1989; 16: 1045–1048
   PubMed Web of Science ®Google Scholar
• Shibamoto Y., Ono K., Takahashi M., Kano E., Hori H., Shibata T., Inayama S., Abe M. An in vitro and in vivo screening system for new hypoxic cell radio-sensitizers using EMT6 cells. Japanese Journal of Cancer Research (Gann) 1986; 77: 1027–1033
   PubMedGoogle Scholar
• Shibamoto Y., Sasai K., Sakaguchi M., Tamulevicius P., Kitakabu Y., Streffer C., Abe M. Evaluation of a new 2-nitroimidazole nucleoside analogue, RK-28 as a radiosensitizer for clinical use. International Journal of Radiation Biology 1991a; 59: 105–115
   PubMed Web of Science ®Google Scholar
• Shibamoto Y., Streffer C., Fuhrmann C., Budach V. Tumor radiosensitivity prediction by the cytokinesis-block micronucleus assay. Radiation Research 1991b; 128: 293–300
   PubMed Web of Science ®Google Scholar
• Skarsgard L.D., Harrison I., Durand R.E., Palcic B. Radiosensitization of hypoxic cells at low doses. International Journal of Radiation Oncology, Biology and Physics 1986; 12: 1075–1078
   PubMedGoogle Scholar
• Stratford I.J., Adams G.E., Hardy C., Hoe S., O'Neill P., Sheldon P.W. Thiol reactive nitroimidazoles: radiosensitization studies in vitro and in vivo. International Journal of Radiation Biology 1984; 46: 731–745
   Web of Science ®Google Scholar
• Taylor Y.C., Brown J.M. Radiosensitization in multifraction schedules. II. Greater sensitization by 2-nitroimidazoles than by oxygen. Radiation Research 1987; 112: 134–145
   Google Scholar
• Wandl E.O., Ono K., Kain R., Herbsthofer T., Hienert G., Höbarth K. Linear correlation between surviving fraction and the micronucleus frequency. International Journal of Radiation Biology 1989; 56: 771–775
   PubMed Web of Science ®Google Scholar