Micronucleus induction by 60Co gamma-rays and fast neutrons in ataxia telangiectasia lymphocytes

References

• ANTOCCIA, A., PALLITI, F., RAGGI, T., CATENA, C., and TANZARELLA, C., 1994, Lack of effect of inhibitors of DNA synthesis/repair on the ionizing radiation-induced chromosomal damage in G2 stage of ataxia telangiectasia cells. International Journal of Radiation Biology, 66, 309–317.
   PubMed Web of Science ®Google Scholar
• BEDFORD, J. S., 1991, Sublethal damage, potentially lethal damage, and chromosomal aberrations in mammalian cells exposed to ionizing radiations. International Journal of Radiation Oncology Biology and Physics, 21, 1457–1469.
   PubMed Web of Science ®Google Scholar
• BLOCHER, D., SIGUT, D., and HANNAN, M. A., 1991, Fibroblasts from ataxia-telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rate y-irradiation as assayed by pulsed field gel electrophoresis. International Journal of Radiation Biology, 60, 791–802.
   PubMed Web of Science ®Google Scholar
• BOREHAM, D. R. and MITCHEL, R. E. J., 1991, DNA lesions that signal the induction of radioresistance and DNA repair in yeast. Radiation Research, 128, 19–28.
   PubMed Web of Science ®Google Scholar
• BREWEN, J. G. and LUIPPOLD, H. E., 1971, Radiation induced human chromosome aberrations: in vitro dose rate studies. Mutation Research, 12, 305–314.
   PubMed Web of Science ®Google Scholar
• COLE, J., ARLETT, C. F., GREEN, M. H. L., and HARCOURT, S. H., 1988, Comparative human cellular radiosensitivity: II. The survival following gamma irradiation of unstimu-lated (G0)T-lymphocytes, T-lymphocyte lines, lympho-blastoid cell lines and fibroblasts from ataxia-telangiectasia heterozygotes. International Journal of Radiation Biology, 54, 929–943.
   PubMed Web of Science ®Google Scholar
• CORNFORTH, M. N., and BEDFORD, J. S., 1985, On the nature of the defect in cells from individuals with ataxia telangiectasia. Science, 227, 1589–1591.
   PubMed Web of Science ®Google Scholar
• COQUERELLE, T. M., and WEIBEZAHN, K. F., 1981, Rejoining of DNA double-strand breaks in human fibroblasts and its impairment in one Ataxia telangiectasia and two Fanconi strains. Journal of Supramolecular Structure and Cellular Biochemistry, 17, 369–376.
   PubMedGoogle Scholar
• COQUERELLE, T. M., WEIBEZAHN, K. F., and LOCKE-HUHLE, C., 1987, Rejoining of double strand breaks in normal human and ataxia-telangiectasia fibroblasts after expo-sure to socu y-rays, 24F Am a-particles or bleomicin. International Journal of Radiation Biology, 51, 209–218. COUNTRYMAN, P. I., and HEDDLE, J. A., 1976, The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes. Mutation Research, 41, 321–332.
   Google Scholar
• Cox, R., MASSON, W. K., WEICHSELBAUM, R. R., NOVE, J., and LITTLE, J. B., 1981, The repair of potentially lethal damage in X-irradiated cultures of normal and ataxia telangiectasia human fibroblasts. InternationalJournal of Radiation Biology, 39, 357–365.
   Web of Science ®Google Scholar
• Cox, R., 1982, A cellular description of the repair defect in ataxia-telangiectasia. In: Ataxia telangiectasia. Edited by: B. A. Bridges and D. G. Harnden (Wiley, New York), pp. 141–153.
   Google Scholar
• Cox, R., DEBENHAM, P. G., MASSON, W. K., and WEBB, M. B. T., 1986, Ataxia-telangiectasia: a human mutation giving high-frequency misrepair of DNA double-strand scissions. Molecular Biology and Medicine, 3, 229–244.
   PubMedGoogle Scholar
• DEBENHAm, P. G., WEBB, M. B. T., JONES, N. J., and Cox, R. J., 1987, Molecular studies on the nature of the repair defect in ataxia-telangiectasia and their implications for cellular radiobiology. Cell Science Supplement, 6, 177–189.
   PubMedGoogle Scholar
• FENECH, M., and Morley, A. A., 1985, Measurement of micro-nuclei in lymphocytes. Mutation Research, 147, 29–36.
   PubMed Web of Science ®Google Scholar
• FENECH, M., 1993, The cytokinesis-block micronucleus tech-nique: a detailed description of the method and its application to genotoxicity studies in human popula-tions. Mutation Research, 285, 35–44.
   PubMed Web of Science ®Google Scholar
• GOODHEAD, D. T., 1994, Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Interna-tional Journal Radiation Biology, 65, 7–17.
   PubMed Web of Science ®Google Scholar
• HITTELMAN, W. N., and PANDITA, T. K., 1994, Possible role of chromatin alteration in the radiosensitivity of ataxia-telangiectasia. International Journal of Radiation Biology, 66, S109—S113.
   Google Scholar
• HOLLEY, W. R., and CHATTERJEE, A., 1991, The application of chemical models to cellular DNA damage. In: The Early Effects of Radiation on DNA, Vol. 54. Edited by: E. M. Fielden and P. O'Neill (Springer, Berlin), pp. 195–209.
   Google Scholar
• HUBER, R., STRENG, S., and BAUCHINGER, M., 1983, The suitability of the human lymphocyte micronucleus assay system for biological do sim e try. Mutation Research, 111, 185–193.
   PubMed Web of Science ®Google Scholar
• JONES, L. A., SCOTT, D., COWAN, R., and ROBERTS, S. A., 1995, Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations after low dose-rate irradiation. International Journal Radiation Biology, 67, 519–528.
   PubMed Web of Science ®Google Scholar
• KORMOS, C. and KOTELES, G. J., 1988, Micronuclei in X-irradiated lymphocytes. Mutation Research, 199, 31–35.
   PubMed Web of Science ®Google Scholar
• LEHMANN, A. R., and STEVEN SS., 1979, The response of ataxia-telangiectasia cells to bleomycin. Nucleic Acids Research, 6, 1953–1960.
   PubMed Web of Science ®Google Scholar
• LITTLEFIELD, L. G., SAYER, A. M., and FROME, E. L., 1989, Comparisons of dose-response parameters for radia-tion induced acentric fragments and micronuclei observed in cytokinesis arrested lymphocytes. Muta-genesis, 4, 265–270.
   Google Scholar
• Liu, N., and BRYANT, P. E., 1993, Response of ataxia telangiec-tasia cells to restriction endonuclease induced DNA double-strand breaks: I. Cytogenetic characterization. Mutagenesis, 8, 503–510.
   Google Scholar
• LLOYD, D. C., and EDWARDS, A. A., 1983, Chromosome aberra-tions in human lymphocytes: effect of radiation quality, dose and dose rate. In: Radiation-Induced Chromosome Damage in Man. Edited by: T. Ishihara and M. S. Sasaki (Liss, New York), pp. 23–49.
   Google Scholar
• MCKINNON, P. J., 1987, Ataxia-telangiectasia: an inherited disorder of ionizing-radiation sensitivity in man. Human Genetics, 75, 197–208.
   PubMed Web of Science ®Google Scholar
• MEYN, M. S., 1993, High spontaneous intrachromosomal recombination rates in ataxia-telangiectasia. Science, 260, 1327–1330.
   PubMed Web of Science ®Google Scholar
• NATARAJAN, A. T., and OBE, G., 1978, Molecular mechanisms involved in the production of chromosomal aberra-tions. I. Utilization of Neurospora endonuclease for the study of aberration production in G2 stage of the cell cycle. Mutation Research, 52, 137–149.
   PubMed Web of Science ®Google Scholar
• NATARAJAN, A. T., and OBE, G., 1984, Molecular mechanisms involved in the production of chromosomal aberra-tions. III. Restriction endonucleases. Chromosoma, 90, 120–127.
   PubMed Web of Science ®Google Scholar
• NATARAJAN, A. T., and MEYERS, M., 1979, Chromosomal radio-sensitivity of ataxia telangiectasia cells at different cell cycle stages. Human Genetics, 52, 127–132.
   PubMed Web of Science ®Google Scholar
• Netherlands Commission on Radiation Dosimetry, 1986, NCS Report 2. Code of practice for the dosimetry of high-energy photon beams. Netherlands Commission on Radiation Dosimetry, Bilthove, The Netherlands).
   Google Scholar
• NEARY, G. J., 1965, Chromosome aberrations and the theory of RBE. 1. General considerations. International Journal of Radiation Biology, 9, 477–503.
   Web of Science ®Google Scholar
• OBE, G., JOHANNES, C., and SCHULTE-EROHLINDE, D., 1992, Review. DNA double strand breaks induced by sparsely ionizing radiation and endonucleases as critical lesions for cell death, chromosomal aberrations, mutations and oncogenic transformation. Mutagenesis, 7, 3–12.
   PubMed Web of Science ®Google Scholar
• PEAK, M. J., WANG, L., HILL, C. K., and PEAK, J. G., 1991, Comparison of repair of DNA double-strand breaks caused by neutron or gamma radiation in cultured human cells. International Journal of Radiation Biology, 60, 891–898.
   PubMed Web of Science ®Google Scholar
• POWELL, S., WHITAKER, S., PEACOCK, J., and MCMILLAN, T. J., 1993, Ataxia-telangiectasia: an investigation of the repair defect in the cell line AT5BIVA by plasmid recon-struction. Mutation Research, 294, 9–20.
   PubMed Web of Science ®Google Scholar
• PROSSER, J. S., MOQUET, J. E., LLOYD, D. C., and EDWARDS, A. A., 1988, Radiation induction of micronuclei in human lymphocytes. Mutation Research, 199, 37–45.
   PubMed Web of Science ®Google Scholar
• PURROTT, R. J., and REEDER, E., 1976, The effect of changes in dose rate on the yield of chromosome aberrations in human lymphocytes exposed to gamma radiation. Mutation Research, 35, 437–444.
   PubMed Web of Science ®Google Scholar
• RAMALHO, A., SUNJEVARIC, I., and NATARAJAN, A. T., 1988, Use of the frequencies of micronuclei as quantitative indica-tors of X-ray-induced chromosomal aberrations in human peripheral blood lymphocytes: comparison of two methods. Mutation Research, 207, 141–146.
   PubMed Web of Science ®Google Scholar
• SANFORD, K. K., and PARSHAD, R., 1990, Detection of cancer-prone individuals using cytogenetic response to X-rays. In: Chromosomal Aberrations. Edited by: G. Obe and A. J. Natarajan (Springer, Berlin), pp. 113–120.
   Google Scholar
• SCOTT, D., SHARPE, H., BATCHELOR, A. L., EVANS, H. J., and PAPWORTH, D. G., 1969, Radiation-induced chromo-some damage in human peripheral blood lymphocytes in vitro. I. RBE and dose-rate studies with fast neutrons. Mutation Research, 8, 367–381.
   PubMedGoogle Scholar
• SCOTT, D., SHARPE, H. B. A., BATCHELOR, A. L., EVANS, H. J., and PAPWORTH, D. G., 1970, Radiation-induced chromo-some damage in human peripheral blood lymphocytes in vitro. II. RBE and dose rate studies with 60 _0 u gamma and X-rays. Mutation Research, 9, 225–237.
   PubMedGoogle Scholar
• SCOTT, D., SPREADBOROUGH, A. R., and ROBERTS, S. A., 1994, Radiation induced G2 delay and spontaneous chromosome aberrations in A-T homozygotes. Inter-national Journal of Radiation Biology, 66, S157—S163.
   Web of Science ®Google Scholar
• SCOTT, D., SPREADBOROUGH, A. R., JONES, L. A., ROBERTS, S. A., and MOORE, C. J., 1996, Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition. Radiation Research, 145, 3–16.
   PubMed Web of Science ®Google Scholar
• TAYLOR, A. M. R., HARNDEN, D. G., ARLETT, C. F., HARCOURT, S. A., LEHMANN, A. R., STEVENS, S., and BRIDGES, B. A., 1975, Ataxia telangiectasia: a human mutation with abnor-mal radiosensitivity. Nature, 258, 427–429.
   PubMed Web of Science ®Google Scholar
• TAYLOR, A. M. R., METCALFE, J. A., OXFORD, J. M., and HARNDEN, D. G., 1976, Is chromatid-type damage in ataxia telangiectasia after irradiation at Go a conse-quence of defective repair? Nature, 260, 441–443.
   Google Scholar
• TAYLOR, A. M. R., 1978, Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations. Mutation Research, 50, 407–418.
   PubMed Web of Science ®Google Scholar
• TAYLOR, A. M. R., METCALFE, J. A., and MCCONVILLE, C. M., 1989, Increased radiosensitivity and the basic defect in ataxia telangiectasia. InternationalJournal Radiation Biology, 56, 677–684.
   PubMed Web of Science ®Google Scholar
• TAYLOR, A. M. R., BYRD, P. J., MCCONVILLE, C. M. and THACKER, S., 1994, Genetic and cellular features of ataxia-telangiectasia. International Journal of Radiation Biology, 65, 65–70.
   Google Scholar
• THIERENS, H., VRAL, A. and DE RIDDER, L., 1991, Biological dosimetry using the micronucleus assay for lympho-cytes: interindividual differences in dose-response. Health Physics, 61, 623–630.
   PubMed Web of Science ®Google Scholar
• VAN DER SCHANS, G. P., PATERSON, M. C., and CROSS, W. G., 1983, DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma-rays. International Journal of Radiation Biology, 44, 75–85.
   Web of Science ®Google Scholar
• VIRSIK, R. P., and HARDER, D., 1980, Recovery kinetics of radiation induced chromosome aberrations in human Go lymphocytes. Radiation Environmental Biophysics, 18, 221–238.
   PubMed Web of Science ®Google Scholar
• VRAL, A., THIERENS, H., and DE RIDDER, L., 1992, Study of dose rate and split dose effects on the in vitro micronucleus yield in human lymphocytes exposed to X-rays. Inter-national Journal of Radiation Biology, 61, 777–784.
   PubMed Web of Science ®Google Scholar
• VRAL, A., VERHAEGEN, F., THIERENS, H., and DE RIDDER, L., 1994a, Micronuclei induced by fast neutrons versus Co y-rays in human peripheral blood lymphocytes. Interna-tional Journal of Radiation Biology, 65, 321–328.
   PubMed Web of Science ®Google Scholar
• VRAL, A., VERHAEGEN, F., THIERENS, H., and DE RIDDER, L., 1994b, The in vitro cytokinesis-block micronucleus assay: a detailed description of an improved slide preparation technique for the automated detection of micronuclei in human lymphocytes. Mutagenesis, 9, 439–443.
   PubMed Web of Science ®Google Scholar
• WEST, G. M. L., SCOTT, D., and PEACOCK, J. H., 1994, Normal cell radiosensitivity: clinical application in predicting response to radiotherapy and cancer predisposition. International Journal of Radiation Biology, 66, 231–234.
   PubMed Web of Science ®Google Scholar
• WEST, G. M. L., ELYAN, S. A. G., BERRY, P., COWAN, R., and SCOTT, D., 1995, A comparison of the radiosensitivity of lymphocytes from normal donors, cancer patients, individuals with ataxia-telangiectasia (A-T) and A-T heterozygotes. International Journal of Radiation Biology, 68, 197–203.
   PubMed Web of Science ®Google Scholar