In vitro rejoining of double-strand breaks in cellular DNA by factors present in extracts of HeLa cells

References

• ABOUSSERHRA, A., BIGGERSTAFF, M., SHIVJI, M. K. K., VILPO, J. A., MONCOLLIN, V., PODUST, V. N., PROTIC, M., HUEBSCHER, U., EGLI; J.-M. and WOOD, R. D., 1995, Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell, 80, 859–868.
   Google Scholar
• AUSUBEL, F. M., BRENT, R., KINGSTON, R. E., MOORE, D. D., SEIDMAN, J. G., SMITH, J. A. and STRUHL, K., 1989, DNA—protein interactions. In Current Protocols in Mole-cular Biology (New York, NY: Wiley), pp. 12.0.3-1.9.
   Google Scholar
• BADIE, C., ILIAKIS, G., FORAY, N., ALSBEIH, G., PANTELIAS, G. E., OKAYASU, R., CHEONG, N., RUSSELL, N. S., BEGG, A. C., ARLETT, C. F. and MALAISE, E. P., 1995, Defective repair of DNA double-strand breaks and chromosome damage in fibroblasts from radiosensitive leukemia patient. Cancer Research, 55, 1232–1234.
   PubMed Web of Science ®Google Scholar
• BASES, R., HAMORI, I., PAZZA, L., Mmo, J. and MENDEZ, F., 1990, DNA base and strand damage in X-irradiated monkey CV-1 cells: influence of pretreatment using small doses of radiation. International Journal of Radiation Biology, 58, 35–54.
   PubMed Web of Science ®Google Scholar
• BLUNT, T., FINNIE, N. J., TACCIOLI, G. E., SMITH, G. C. M., DEMENGEOT, J., GOTTLIEB, T. M., MIZUTA, R., VARGHESE, A. J., ALT, F. W., JEGGO, P. A. and JACKSON, S. P., 1995, Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine SCID mutation. Cell, 80, 813–823.
   Google Scholar
• DAR, M. E. and JORGENSEN, T. J., 1995, Deletions at short direct repeats and base substitutions are characteristic muta-tions for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system. Nucleic Acids Research, 23, 3224–3230.
   PubMed Web of Science ®Google Scholar
• DE JONG, J. H. R., VERMEULEN, W., KLEIN, B. and HOEIJMAKERS, H. J., 1983, Microinjection of human cell extracts corrects xeroderma pigmentosum defect. EMBO Journal, 2, 637–641.
   Google Scholar
• DERBYSHIRE, M. K., EPSTEIN, L. H., YOUNG, C. S. H., MUNZ, P. L. and FISHEL, R. 1994, Nonhomologous recombination in human cells. Molecular and Cellular Biology, 14, 156–169.
   Google Scholar
• FAIRMAN, M. P., JOHNSON, A. P. and THACKER, J., 1992, Multiple components are involved in the efficient joining of double stranded DNA breaks in human cell extracts. Nucleic Acids Research, 20, 4145–4152.
   PubMed Web of Science ®Google Scholar
• FANG, W. -H. and MODRICH, P., 1993, Human strand-specific mismatch repair occurs by a bi-directional mechanism similar to that of the bacterial reaction. Journal of Biological Chemistry, 268, 11838–11844.
   Google Scholar
• FRANKENBERG-SCHWAGER, M., 1990, Induction, repair and biolo-gical relevance of radiation-induced DNA lesions in eukaryotic cells. Radiation and Environmental Biophysics, 29, 273–292.
   PubMed Web of Science ®Google Scholar
• GANGULY, T. and 'Twos, G., 1995, A cell-free assay using cyto-plasmic cell extracts to study rejoining of radiation-induced DNA double-strand breaks in human cell nuclei. InternationalJournal of Radiation Biology, 68, 447–458.
   Google Scholar
• GETTS, R. and STAMATO, T. D., 1994, Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. Journal of Biological Chemistry, 269, 15981–15984.
   PubMed Web of Science ®Google Scholar
• GIARD, D. J., AARONSON, S. A., TODARO, G. J., ARNSTEIN, p., KERSEY, J. H., Dosix, H. and PARKS, W. P., 1973, In vitro cultiva-tion of human tumors: establishment of cell lines derived from a series of solid tumors. Journal of the National Cancer Institute, 51, 1417–1423.
   PubMed Web of Science ®Google Scholar
• HENNER, W. D., GRUNBERG, S. M. and HAsETTINE, W. A., 1982, Sites and structure of y radiation-induced DNA strand breaks. Journal of Biological Chemistry, 257, 11750–11754.
   PubMed Web of Science ®Google Scholar
• HENNER, W. D., RODRIGUEZ, L. G., HECHT, S. M. and HASELTINE, W. A., 1983, Gamma-ray induced deoxyribonucleic acid strand breaks. Journal of Biological Chemistry, 258, 711–713.
   PubMed Web of Science ®Google Scholar
• ILIAKIS, G. E., CICILIONI, O. and METZGER, L., 1991b, Measure-ment of DNA double-strand breaks in CHO cells at various stages of the cell cycle using pulsed field gel electrophoresis: calibrations by means of 251 decay. International Journal of Radiation Biology, 59, 343–357.
   PubMed Web of Science ®Google Scholar
• ILIAKIS, G., 1991, The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells. BioEssays, 13, 641–648.
   PubMed Web of Science ®Google Scholar
• ILIAKIS, G., METZGER, L., DENKO, N., and STAMATO, T., 1991a, Detection of DNA double-strand breaks in synchro-nous cultures of CHO cells by means of asymmetric field inversion gel electrophoresis. InternationalJournal of Radiation Biology, 59, 321–341.
   PubMed Web of Science ®Google Scholar
• JEGGO, P. A., 1990, Studies on mammalian mutants defective in radiation-induced DNA lesions in eukaryotic cells. Mutation Research, 239,1–16.
   PubMed Web of Science ®Google Scholar
• KIRCHGESSNER, C. U., PATIL, C. K., EVANS, J. W., CUOMO, C. A., FRIED, L. M., CARTER, T., ()ETTINGER, M. A. and BRowN, J. M., 1995, DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science (Washington), 267, 1178–1182.
   Google Scholar
• LEES-MILLER, S. P., GODBOUT, R., CHAN, D. W., WEINFIELD, M., DAY, R. S., III, BARRON, G. M. and ALLALUNIS-TURNER., 1995, Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science (Washington), 267, 1183–1185.
   Google Scholar
• LIEBER, M., SMITH, B., SZAKAL, A., NELSON-REES, W. and TODARO, G., 1976, A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. International Journal of Cancer, 17, 62–70.
   Google Scholar
• LINDAHL, T. and BARNES, D. E., 1992, Mammalian DNA ligases. Annual Review of Biochemistry, 63, 251–281.
   Google Scholar
• LeEmucti, M., RYDBERG, B. and COOPER, P. K., 1994, DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. II. Probing indivi-dual Notl fragments by hybridization. Radiation Research, 139, 142–151.
   PubMed Web of Science ®Google Scholar
• LOPEZ, B. S., CORTEGGIANI, E., BERTRAND-MERCAT, P. and COFFEY, J., 1992, Directional recombination is initiated at a double strand break in human nuclear extracts. Nucleic Acids Research, 20, 501–506.
   Google Scholar
• METZGER, L. and hums, G., 1991, Kinetics of DNA double-strand break repair throughout the cell cycle as assayed by pulsed field gel electrophoresis in CHO cells. Inter-nationalJournal of Radiation Biology, 59, 1325–1339.
   PubMed Web of Science ®Google Scholar
• NtcotAs, A. L., MuNz, P. L. and YOUNG, C. S. H., 1995,A modified single-strand annealing model best explains the joining of DNA double-strand breaks in mammalian cells and cell extracts. Nucleic Acids Research, 23, 1036–1043.
   PubMed Web of Science ®Google Scholar
• NICOLAS, A. L. and YOUNG, C. S. H., 1994, Characterization of DNA end joining in a mammalian cell nuclear extract: junction formation is accompanied by nucleotide loss, which is limited and uniform but not site specific. Molecular and Cellular Biology, 14, 170–180.
   PubMed Web of Science ®Google Scholar
• NISHIDA, C., CHOI, S. -Y., Kim, J., KEENEY, J. and LINN, S., 1988, DNA polymerases plus hela or human fibroblast cell-free extracts complement permeabilized xeroderma pigmentosum (XP) fibroblasts: application for puri-fication of XP correcting factors. In Mechanisms and Consequences of DNA Damage Processing, edited by E.C. Friedberg and P. C. Hanawalt (New York: Liss) pp. 337–341.
   Google Scholar
• NORTH, p., GANESH, A. and THACKER, J., 1990, The rejoining of double-strand breaks in DNA by human cell extracts. Nucleic Acids Research, 18, 6205–6210.
   PubMed Web of Science ®Google Scholar
• PAINTER, R. B., 1980, The role of DNA damage and repair in cell killing induced by ionizing radiation. In Radiation Biology in Cancer Research, edited by R. E. Meyn and H. R. Withers (New York, NY: Raven), pp. 59–68.
   Google Scholar
• PFEIFFER, P. and VIELMETTER, W., 1988. Joining of nonhomolo-gous DNA double strand breaks in vitro. Nucleic Acids Research, 16, 907–924.
   PubMed Web of Science ®Google Scholar
• RATHMELL, W. K. and CHU, G. A., 1994, DNA end-binding factor involved in double strand break repair and V(D)J recombination. Molecular and Cellular Biology, 14, 4741–4748.
   PubMed Web of Science ®Google Scholar
• RESNICK, M. A. and MARTIN, P., 1976, The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Molecular and General Genetics, 143, 119–129.
   PubMedGoogle Scholar
• RESNICK, M. A., ZGAGA, Z., HEITER, P., WESTMORELAND, J., FOGEL, S. and NILSSON-TILLGREN, T., 1992, Recombinational repair of diverged DNAs: a study of homoeologous chromosomes and mammalian YACs in yeast. Molecular and General Genetics, 234, 65–73.
   Google Scholar
• ROTH, D., and WILSON, J., 1988, Illegitimate recombination in mammalian cells. In Genetic Recombination, edited by R. Kucherlapati and G. R. Smith (Washington: American Society of Microbiology), chapter 21, pp. 621–653.
   Google Scholar
• SMIDER, V., RATHMELL, W. K., LIEBER, M. R. and CHU, G., 1994, Restoration of X-ray resistance and V(D)J recombina-tion in mutant cells by Ku cDNA. Science, 266, 288–291.
   PubMed Web of Science ®Google Scholar
• STILLMAN, B., 1989, Initiation of eukaryotic DNA replication in vitro. Annual Review of Cell Biology, 5, 197–245.
   PubMedGoogle Scholar
• TACCIOLI, G., GOTTLIEB, T. M., BLUN TT., PRIESTIA A., DEMENGEOT, J., MIZUTA, R., LEHMANN, A., ALT, F. W., JACKSON, S. P. and JEGGO, P. A., 1994, Ku-80: product of XRCC5 gene and its role in DNA repair and V(D)J recombination. Science (Washington), 265, 1442–1445.
   Google Scholar
• THODE, S., SCHAFER, A., PFEIFFER, P. and VIELMETTER, W., 1990,A novel pathway of DNA end-to-end joining. Cell, 60, 921–928.
   PubMed Web of Science ®Google Scholar
• VAN GENT, D. C., MGBLANE, J. F., RAMSDEN, D. A., SADOFSKV, M. J., HEssE, J. E. and GELLERT, M., 1995, Initiation of V(D)J recombination in a cell-free system. Cell, 81, 925–934.
   PubMed Web of Science ®Google Scholar
• WAGA, S., BAUER, G. and STILLMAN, B. 1994, Reconstitution of complete 5V40 DNA replication with purified replication facto rs. Journal of Biological Chemistry, 269, 10923–10934.
   PubMed Web of Science ®Google Scholar
• WANG, Y, HGQ, M. S., CHENG, X. and Rums, G., 1995, Regula-tion of DNA replication in irradiated cells by trans-acting factors. Radiation Research, 142, 169–175.
   PubMed Web of Science ®Google Scholar
• WARD, J. F., 1990, The yield of DNA double-strand breaks pro-duced intracellularly by ionizing radiation: a review. Inter-national Journal of Radiation Biology, 57, 1141–1150.
   PubMed Web of Science ®Google Scholar
• WINTERS, T. A., WEINFIELD, M. and JORGENSEN, T. J., 1992, Human, HeLa cell enzymes that remove phosphogly-colate 2 -end groups from DNA. Nucleic Acids Research, 20, 2573–2580.
   PubMed Web of Science ®Google Scholar
• WOOD, R. D., ROBINS, P. and LINDAHL, T., 1988, Complementa-tion of the Xeroderma Pigmentosum DNA repair defect in cell-free extracts. Cell, 53, 97–106.
   PubMed Web of Science ®Google Scholar