Advanced search
Publication Cover
International Journal of Radiation Biology Volume 69, 1996 - Issue 4
Submit an article Journal homepage
33
Views
59
CrossRef citations to date
0
Altmetric
Research Article

Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization

P. J. SIMPSON Chromosome Damage Group, MRC Radiation and Genome Stability Unit, Harwell, OX11 ORD, UK.
Pages 429-436 | Published online: 03 Jul 2009

References

  • BENDER, M. A., GRIGGS, H. S. and BEDFORD, J. S., 1974, Mecha-nisms of chromosomal aberration production. III. Chemicals and ionizing radiation. Mutation Research, 23, 387–402.
  • BROWN, J. M. and KOVACS, M. S., 1993, Visualisation of non-reciprocal chromosome exchanges in irradiated human fibroblasts by fluorescent in situ hybridisation. Radiation Research, 136, 71–76.
  • CHADWICK, K. H. and LEENHOUTS, H. P., 1978, The rejoining of DNA double-strand breaks and a model for the forma-tion of chromosomal rearrangements. International Journal of Radiation Biology, 33, 517–529.
  • CHADWICK, K. H. and LEENHOUTS, H. P., 1981, The Molecular Theory of Radiation Biology (Springer, Berlin).
  • GOODHEAD, D. T., 1994, Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Interna-tionalJournal of Radiation Biology, 65, 7–17.
  • GOODHEAD, D. T. and NIKJOO, H., 1989, Track-structure analysis of ultra-soft X-rays compared to high- and low-LET radiations. International Journal of Radiation Biology, 55, 513–529.
  • GOODHEAD, D. T., THACKER, J. and Cox, R., 1993, Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. InternationalJournal of Radiation Biology, 63, 543–556.
  • LEA, D. E. and CATCHESIDE, D. G., 1942, The mechanisms of the induction by radiation of chromosome aberrations in Tradescantia. Journal of Genetics, 44, 216–245.
  • LLOYD, D. C., PURROTT, R. J., DOLPHIN, G. W., BOLTON, D. and EDWARDS, A. A., 1975, The relationship between chromosome aberrations and low LET radiation dose to human lymphocytes. International Journal of Radia-tion Biology, 28, 75–90.
  • NORMAN, A. and SASAKI, M. S., 1966, Chromosome-exchange aberrations in human lymphocytes. InternationalJournal of Radiation Biology, 11, 321–328.
  • RESNICK, M. A., 1976, The repair of double-strand breaks in DNA: a model involving recombination. Journal of Theoretical Biology, 59, 97–106.
  • SAVAGE, J. R. K., 1975, Radiation-induced chromosomal aber-rations in the plant Tradescantia: dose—response curves. Radiation Botany, 15, 87–140.
  • SAVAGE, J. R. K., 1995a, The transmission of FISH-painted patterns derived from complex chromosome exchanges. Mutation Research, 347, 87–95.
  • SAVAGE, J. R. K., 1995b, Insights into sites, Mutation Research (in press).
  • SAVAGE, J. R. K., and SIMPSON, P. J., 1994a, FISH 'painting' patterns resulting from complex exchanges. Mutation Research, 312, 51–60.
  • SAVAGE, J. R. K. and SIMPSON, P. J., 1994b, On the scoring of FISH-`painted' chromosome-type exchange aberra-tions. Mutation Research, 307, 345–353.
  • SAX, K., 1940, An analysis of X-ray induced chromosomal aberrations in Tradescantia. Genetics, 25, 41–68.
  • SIMPSON, P. J. and SAVAGE, J. R. K., 1994, Identification of X-ray-induced complex aberrations using fluorescence in situ hybridization: a comparison at two doses. International Journal of Radiation Biology, 66, 629–632.
  • SIMPSON, P. J. and SAVAGE, J. R. K., 1995a, estimating the true frequency of X-ray-induced complex chromosome exchanges using fluorescence in situ hybridization. International Journal of Radiation Biology, 67, 37–45.
  • SIMPSON, P. J. and SAVAGE, J. R. K., 1995b, Detecting 'hidden' exchange events within X-ray induced aberrations using multicolour chromosome paints. Chromosome Research, 3, 69–72.
  • POWELL, S. and MCMILLAN, T. J., 1990, DNA damage and repair following treatment with ionising radiation. Radiation and Oncology, 19, 95–108.
  • TAYLOR, A. M. R., 1978, Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations. Mutation Research, 50, 407–418.
  • THACKER, J. T., Cox, R. and GOODHEAD, D. T., 1980, Do carbon soft X-rays induce exchange aberrations in cultured mammalian cells? International Journal of Radiation Biology, 38, 469–472.
  • THACKER, J. T., WILKINSON, R. E. and GOODHEAD, D. T., 1986, The induction of chromosome exchange aberrations by carbon ultrasoft X-rays in V79 hamster cells. International Journal of Radiation Biology, 49, 645–656.
  • TUCKER, J. D., RAMSEY, M. J. and MINKLER, J. L., 1993, Validation of chromosome painting as a biodosimeter in human peripheral lymphocytes following acute exposure to ionizing radiation in vitro. InternationalJournal of Radia-tion Biology, 64, 27–37.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.