Exploring the anticancer properties of the gum of Ferula gummosa: impact on cytotoxicity, caspase 3/7 activity and apoptosis, and gene expression in SW-480 cells

References

• Alilou M, Dibwe DF, Schwaiger S, Khodami M, Troppmair J, Awale S, Stuppner H. 2020. Antiausterity activity of secondary metabolites from the roots of Ferula hezarlalehzarica against the PANC-1 human pancreatic cancer cell line. J Nat Prod. 83(4):1099–1106. doi: 10.1021/acs.jnatprod.9b01109.
   PubMed Web of Science ®Google Scholar
• Amiri MS, Taghavizadeh Yazdi ME, Rahnama M. 2021. Medicinal plants and phytotherapy in Iran: glorious history, current status and future prospects. Plant Sci Today. 8(1):95–111. doi: 10.14719/pst.2021.8.1.926.
   Web of Science ®Google Scholar
• Birkett MA, Campbell CA, Chamberlain K, Guerrieri E, Hick AJ, Martin JL, Matthes M, Napier JA, Pattersson J, Pickett JA, et al. 2000. New roles for cis-jasmone as an insect semiochemical and in plant defense. Proc Natl Acad Sci U S A. 97(16):9329–9334. doi: 10.1073/pnas.160241697.
   PubMed Web of Science ®Google Scholar
• Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394–424. doi: 10.3322/caac.21492.
   PubMed Web of Science ®Google Scholar
• Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH. 2013. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 14:1–9. doi:10.1186/1471-2121-14-32.
   PubMedGoogle Scholar
• Caponio GR, Lippolis T, Tutino V, Gigante I, De Nunzio V, Milella RA, Gasparro M, Notarnicola M. 2022. Nutraceuticals: focus on anti-inflammatory, anti-cancer, antioxidant properties in gastrointestinal tract. Antioxidants. 11(7):1274. doi: 10.3390/antiox11071274.
   Web of Science ®Google Scholar
• Choudhari S, Khokhar W, Jabre I, Reddy AS, Byrne LJ, Wilson CM, Syed NH. 2019. Alternative splicing and protein diversity: plants versus animals. Front Plant Sci. 10:708. doi:10.3389/fpls.2019.00708.
   PubMed Web of Science ®Google Scholar
• Gharaei R, Akrami H, Heidari S, Asadi MH, Jalili A. 2013. The suppression effect of Ferula gummosa Boiss. extracts on cell proliferation through apoptosis induction in gastric cancer cell line. Eur J Integr Med. 5(3):241–247. doi: 10.1016/j.eujim.2013.01.002.
   Web of Science ®Google Scholar
• Grada A, Otero-Vinas M, Prieto-Castrillo F, Obagi Z, Falanga V. 2017. Research techniques made simple: analysis of collective cell migration using the wound healing assay. J Invest Dermatol. 137(2):e11–e16. doi: 10.1016/j.jid.2016.11.020.
   PubMed Web of Science ®Google Scholar
• Gudarzi H, Salimi M, Irian S, Amanzadeh A, Mostafapour Kandelous H, Azadmanesh K, Salimi M. 2015. Ethanolic extract of Ferula gummosa is cytotoxic against cancer cells by inducing apoptosis and cell cycle arrest. Nat Prod Res. 29(6):546–550. doi: 10.1080/14786419.2014.951854.
   PubMed Web of Science ®Google Scholar
• Hossain MS, Karuniawati H, Jairoun AA, Urbi Z, Ooi DJ, John A, Lim YC, Kibria KMK, Mohiuddin AKM, Ming LC, et al. 2022. Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers Basel. 14(7):1732. doi: 10.3390/cancers14071732.
   PubMed Web of Science ®Google Scholar
• Kooti W, Daraei N. 2017. A review of the antioxidant activity of celery (Apium graveolens L). J Evid Based Complementary Altern Med. 22(4):1029–1034. doi: 10.1177/2156587217717415.
   PubMedGoogle Scholar
• Mahboubi M. 2016. Ferula gummosa, a traditional medicine with novel applications. J Diet Suppl. 13(6):700–718. doi: 10.3109/19390211.2016.1157715.
   PubMedGoogle Scholar
• Mandegary A, Sayyah M, Heidari MR. 2004. Antinociceptive and anti-inflammatory activity of the seed and root extracts of Ferula gummosa Boiss in mice and rats. Daru. 12(2):58–62.
   Google Scholar
• Mirzaaghaei S, Akrami H, Asadi MH, Mahdiuni H. 2014. Ferula gummosa Boiss flower and leaf extracts inhibit angiogenesis in vitro. Indian J Cancer. 51(4):615–620. doi: 10.4103/0019-509x.175323.
   PubMed Web of Science ®Google Scholar
• Mohammadhosseini M, Venditti A, Sarker SD, Nahar L, Akbarzadeh A. 2019. The genus Ferula: Ethnobotany, phytochemistry and bioactivities–A review. Ind Crops Prod. 129:350–394. doi:10.1016/j.indcrop.2018.12.012.
   Web of Science ®Google Scholar
• Mousavi-Kouhi SM, Beyk-Khormizi A, Amiri MS, Mashreghi M, Hashemzadeh A, Mohammadzadeh V, Alavi F, Mottaghipisheh J, Sarafraz Ardakani MR, Taghavizadeh Yazdi ME. 2023. Plant gel-mediated synthesis of gold-coated nanoceria using Ferula gummosa: characterization and estimation of its cellular toxicity toward breast cancer cell lines. J Funct Biomater. 14:332. doi:10.3390/jfb14070332.
   PubMed Web of Science ®Google Scholar
• Oyeyemi IT, Yekeen OM, Odusina PO, Ologun TM, Ogbaide OM, Olaleye OI, Bakare AA. 2015. Genotoxicity and antigenotoxicity study of aqueous and hydro-methanol extracts of Spondias mombin L., Nymphaea lotus L. and Luffa cylindrical L. using animal bioassays. Interdiscip Toxicol. 8(4):184–192. doi: 10.1515/intox-2015-0028.
   PubMedGoogle Scholar
• Pfeffer CM, Singh AT. 2018. Apoptosis: a target for anticancer therapy. Int J Mol Sci. 19(2):448. doi: 10.3390/ijms19020448.
   PubMed Web of Science ®Google Scholar
• Schreuders EH, Ruco A, Rabeneck L, Schoen RE, Sung JJ, Young GP, Kuipers EJ. 2015. Colorectal cancer screening: a global overview of existing programmes. Gut. 64(10):1637–1649. doi: 10.1136/gutjnl-2014-309086.
   PubMed Web of Science ®Google Scholar
• Sun H, Gong TT, Xia Y, Wen ZY, Zhao LG, Zhao YH, Wu QJ. 2021. Diet and ovarian cancer risk: an umbrella review of systematic reviews and meta-analyses of cohort studies. Clin Nutr. 40(4):1682–1690. doi: 10.1016/j.clnu.2020.11.032.
   PubMed Web of Science ®Google Scholar
• Walsh JG, Cullen SP, Sheridan C, Lüthi AU, Gerner C, Martin SJ. 2008. Executioner caspase-3 and caspase-7 are functionally distinct proteases. Proc Natl Acad Sci U S A. 105(35):12815–12819. doi: 10.1073/pnas.0707715105.
   PubMed Web of Science ®Google Scholar