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Paper

Transfer of 15N from oral lactose-ureide to lysine in normal adults

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Pages 455-462 | Published online: 06 Jul 2009

References

  • Aqvist SEG (1951): Metabolic interrelationships among amino acids studied with isotopic nitrogen. Acta Chem. Scand. 5, 1046–1073.
  • Conway JM, Bier DM, Motil KJ, Burke JF & Young VR (1980): Whole-body lysine flux in young adult men: effects of reduced total protein and of lysine intake. Am. J. Physiol. 239, E192–E200.
  • Dantzig AH, Hoskins JA, Tabas LB, Bright S, Shepard RL, Jenkins IL, Duckworth DC, Sportsman JR, Mackensen D, Rosteck PR Jr, et al. (1994): Association of intestinal peptide transport with a protein related to the cadherin superfamily. Science 264, 430–433.
  • FAO/WHO/UNU (1985): Energy and Protein Requirements, WHO Technical Report Series No. 552. Geneva: WHO. Gersovitz M, Bier D, Matthews D, Udall J, Munro H & Young VR (1980): Dynamic aspects of whole body glycine metabolism: influence of protein intake in young adult and elderly males. Metabolism 29, 1087–1094.
  • Giordano C, De Pascale C, Balestrieri C, Cittadini D & Crescenzi A (1968): Incorporation of urea 15N in amino acids of patients with chronic renal failure on low nitrogen diets. Am. J. Clin. Nutr. 21, 394–404.
  • Halliday D & McKeran RO (1975): Measurement of muscle protein synthetic rate from serial muscle biopsies and total body protein turnover in man by continuous intravenous infusion of L-[15N]lysine. Clin. Sci. Mol. Med. 49, 581–590.
  • Heine WE, Berthold HK & Klein PD (1995): A novel stable isotope breath test: 13C-labeled glycosyl ureides used as noninvasive markers of intestinal transit time. Am. J. Gastroenterol. 90, 93–98.
  • Hofmann E (1932): Ueber den abbau von Glucoseureid durch Bakterien. Biochem. Z. 253, 462–469.
  • Irving CS, Thomas MR, Marks L, Wong WW, Boutton TW & Klein PD (1986): Lysine and protein metabolism in young women. J. Clin. Invest. 77, 1321–1331.
  • Jackson AA (1983): Amino acids: essential and non- essential. Lancet ii, 1034–1037.
  • Jackson AA (1993): Chronic malnutrition: protein metabo- lism. Proc. Nutr. Soc. 52, 1–10.
  • Jackson AA (1995): Salvage of urea nitrogen and protein requirements. Proc. Nutr. Soc. 54, 535–547.
  • Jackson AA (1998): Salvage of urea-nitrogen in the large bowel: functional significance in metabolic control and adaptation. Biochem. Soc. Transact. 26, 231–237.
  • Jackson AA, Bundy R, Hounslow A, Murphy JL & Wootton SA (1999): Metabolism of lactose-[15N15N] ureide and lactose-[13C]ureide in normal adults consum- ing a diet marginally adequate in protein. Clin. Sci. 97, 547–555.
  • McCance RA & Widdowson ER (1991): The composition of foods, 5th Edition. Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food.
  • Marchini JS, Cortiella J, Hiramatsu T, Chapman TE & Young VR (1993): Requirements for indispensable amino acids in adult humans: longer term amino acid kinetic study with support for the adequacy of the Massachusetts Institute of Technology amino acid requirement pattern. Am. J. Clin. Nutr. 58, 670–683.
  • Metges CC, El-Khoury AE, Henneman L, Petzke KJ, Grant I, Bedri S, Pereira PO, Ajami AM, Fuller MF & Young VR (1999a): Availability of intestinal microbial lysine for whole body lysine homeostasis in human subjects. Am. J. Physiol. 277, E597–E607.
  • Metges CC, Petzke KJ, El-Khoury AE, Henneman L, Grant I, Bedri S, Regan MM, Fuller MF & Young VR (1999b): Incorporation of urea and ammonia nitrogen into ileal and fecal microbial proteins and plasma free amino acids in normal men and ileostomates. Am. J. Clin. Nutr. 70, 1046–1058.
  • Millward DJ & Jackson AA (2004): Protein/energy ratios of current diets in developed and developing countries compared with a safe protein/energy ratio: implications for recommended protein and amino acid intakes. Public Health Nutr. 7, 387–405.
  • Millward DJ, Forrester T, Ah-Sing E, Yeboah N, Gibson N, Badaloo A, Boyne M, Reade M, Persaud C & Jackson AA (2000): The transfer of 15N from urea to lysine in the human infant. Br. J. Nutr. 83, 505–512.
  • Moran BJ & Jackson AA (1990a): 15N-urea metabolism in the functioning human colon: luminal hydrolysis and mucosal permeability. Gut 31, 454–457.
  • Moran BJ & Jackson AA (1990b): Metabolism of 15N- labelled urea in the functioning and defunctioned human colon. Clin. Sci. 79, 253–258.
  • Murphy JL, Wootton SA, Bond SA & Jackson AA (1991): The energy content of stools in normal healthy controls and patients with cystic fibrosis. Arch. Dis. Child 66, 495–500.
  • Stephen AM & Cummings JH (1980): The microbial contribution to human faecal mass. J. Med. Microbiol. 13, 45–56.
  • Niiyama M, Deguchi E, Kagota K & Namioka S (1979): Appearance of 15N-labeled intestinal microbial amino acids in the venous blood of the pig colon. Am. J. Vet. Res. 40, 716–718.
  • Nissim I, Yudkoff M, Yang W, Terwilliger T & Segal S (1981): Rapid gas chromatograph-mass spectrometric analysis of [15N]urea: application to human metabolic studies. Clin. Chim. Acta 109, 295–304.
  • Nissim I, Yudkoff M & Segal S (1983): A model for determination of total body protein synthesis based upon compartmental analysis of the plasma [15N]glycine decay curve. Metabolism 32, 646–653.
  • Persaud C (1983): Studies of [15 N]Alanine Metabolism in Man: Estimation of Whole Body Protein Turnover Rates, Alanine Flux, de novo Synthesis of Alanine and Alanine Contribution to Urinary Ammonia. M.Sc. Thesis, Uni- versity of the West Indies.
  • Petzke KJ, Grigorov JG, Korkushko OV, Semesko TG & Metges CC (1998): Incorporation of urea nitrogen into fecal protein and plasma protein amino acids in elderly human volunteers after ingestion of lactic acid bacteria. Z. Ernahrunswiss 37, 368–375.
  • Tanaka N, Kubo K & Shirak K (1980): A pilot study on protein metabolism in the Papua New Guinea High- landers. J. Nutr. Sci. 26, 247–259.
  • Torrallardona D, Harris CI, Coates ME & Fuller MF (1996a): Microbial amino acid synthesis and utilization in rats: incorporation of 15N from 15NH4Cl into lysine in the tissues of germ-free and conventional rats. Br J Nutr 76, 689–700.
  • Torrallardona D, Harris CI & Fuller MF (1996b): Microbial amino acid synthesis and utilization in rats: the role of coprophagy. Br. J. Nutr. 76, 701–709.
  • Walser M & Bodenlos LJ (1959): Urea metabolism in man. J. Clin. Invest. 38, 1617–1626.
  • Waterlow JC (1967): Lysine turnover in man measured by intravenous infusion of L-[U-14C]lysine. Clin. Sci. 33, 507–515.
  • Wrong OM, Vince AJ & Waterlow JC (1985): The contribu- tion of endogenous urea to faecal ammonia in man determined by 15N-labelling of plasma urea. Clin. Sci. 68, 193–199.
  • Wutzke KD, Heine WE, Plath C, Leitzmann P, Radke M, Mohr C, Richter I, Gulzow HU & Hobusch D (1997): Evaluation of oro-coecal transit time: a comparison of the lactose-[13C, 15N]ureide 13CO2 and the lactulose H2- breath test in humans. Eur. J. Clin. Nutr. 51, 11–19.
  • Yang RD, Matthews DE, Bier DM, Wen ZM & Young VR (1986): Response of alanine metabolism in humans to manipulation of dietary protein and energy intakes. Am. J. Physiol. 250, E39–E46.
  • Ziegler TR, Fernandez-Estivariz C, Gu LH, Bazargan N, Umeakunne K, Wallace TM, Diaz EE, Rosado KE, Pascal RR, Galloway JR, Wilcox JN & Leader LM (2002): Distribution of the H /peptide transporter PepT1 in human intestine: up-regulated expression in colonic mucosa of patients with short-bowel syndrome. Am. J. Clin. Nutr. 75, 922–930.

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