179
Views
18
CrossRef citations to date
0
Altmetric
Original

Quercetin is bioavailable from a single ingestion of grape juice

, , &
Pages 391-398 | Published online: 06 Jul 2009

References

  • Arts ICW, Sesink ALA, Faassen-Peters M, Hollman PCH. The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br J Nutr 2004; 91: 841–847
  • Bitsch R, Netzel M, Frank T, Strass G, Bitsch I. Bioavailability and biokinetics of anthocyanins from red grape juice and red wine. J Biomed Biotechnol 2004; 5: 293–298
  • Cermak R, Landgraf S, Wolffram S. The bioavailability of quercetin in pigs depends on the glycoside moiety and on dietary factors. J Nutr 2003; 133: 2802–2807
  • Cheynier V, Rigaud J. HPLC separation and characterization of flavonols in the skins of Vitis vinifera var. Cinsault. Am J Enol Vitic 1986; 37: 248–252
  • Crozier A, Lean MEJ, McDonald MS, Black C. Quantitative analysis of the flavonoid content of commercial tomates, onions, lettuce and celery. J Agric Food Chem 1997; 45: 590–595
  • Day AJ, Mellon F, Barron D, Sarrazin G, Morgan MRA, Williamson G. Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free Radic Res 2001; 35: 941–952
  • Demrow HS, Slane PR, Folts JD. Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 1995; 91: 1182–1188
  • Dupont MS, Bennet RN, Mellon FA, Williamson G. Polyphenols from alcoholic apple cider are absorbed, metabolized and excreted by humans. J Nutr 2002; 132: 172–175
  • Erlund I, Alfthan G, Siren H, Ariniemi K, Aro A. Validated method for the quantification of quercetin plasma using high-performance liquid chromatography with electrochemical detection. J Chomatogr B 1999; 727: 179–189
  • Erlund K, Silaste ML, Alfthan G, Rantala M, Kesäniemi YA, Aro A. Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables. Eur J Clin Nutr 2002; 56: 891–898
  • Erlund K, Marniemi J, Hakala P, Alfthan G, Meririnne E, Aro A. Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations. Eur J Clin Nutr 2003; 57: 37–42
  • Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 2003; 36: 79–87
  • Häkkinen, S. 2000. Flavonols and phenolic acids in berries and berry products. PhD Thesis, Department of Clinical Nutrition and Department of Physiology, Kuopio University, Finland.
  • Hertog MGL, Hollman PCH, Venema DP. Optimization of a quantitative HPLC determination of potentially anticarcinogenic flavonoides in vegetables and fruits. J Agric Food Chem 1992; 40: 1591–1598
  • Hertog MGL, Hollman PCH, van de Putte B. Content of potentially anticarcinogenic flavonoids in tea, infusions, wines, and fruit juices. J Agric Food Chem 1993; 41: 1242–1246
  • Hollman PCH, Trijp JMP, Buysman MNCP, Gaag MS, Mengelers MJB, de Vries JHM, Katan MB. Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man. FEBS Lett 1997; 418: 152–156
  • Honsho S, Sugiyama A, Takahara A, Satoh Y, Nakamura Y, Hashimoto K. A red wine vinegar beverage can inhibit the rennin-angiotensin system: experimental evidence in vivo. Biol Pharm Bull 2005; 28: 1208–1210
  • Huxley RR, Neil H. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. Eur J Clin Nutr 2003; 57: 904–908
  • Jung, K-J, Wallig, MA, Singletary, KW. 2005. Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett, 233:279–288.
  • Manach C, Morand C, Crespy V, Demigne C, Texier O, Regerat F, Remesy C. Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett 1998; 426: 331–336
  • Manach C, Williamson G, Morand C, Scalbert A, Rémésy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailibility studies. Am J Clin Nutr 2005; 81: 230S–242S
  • McAnlis GT, McEneny J, Pearce J, Young IS. Absorption and antioxidant effects of quercetin from onions, in man. Eur J Clin Nutr 1999; 53: 92–96
  • Meng X, Maliakal P, Lu H, Lee MJ, Yang CS. Urinary and plasma levels of resveratrol and quercetin in humans, mice and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 2004; 52: 935–942
  • Németh K, Plumb GW, Berrin J-G, Juge N, Jacob R, Naim HY, Williamson G, Swallow DM, Kroon PA. Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur J Nutr 2003; 42: 29–42
  • Neuhouser ML. Dietary flavonoids and cancer risk: Evidence from human population studies. Nutr Cancer 2004; 50: 1–7
  • O'Byrne DJ, Devaraj S, Grundy SM, Jialal I. Comparison of the antioxidant effects of Concord grape juice flavonoids and alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin Nutr 2002; 76: 1367–1374
  • Park Y K, Park E, Kim JS, Kang MH. Daily grape juice consumption reduces oxidative DNA damage and plasma free radical levels in healthy Koreans. Mutat Res 2003; 529: 77–86
  • Radtke J, Linseisen J, Wolfram G. Fasting plasma concentrations of selected flavonoids as markers of their ordinary dietary intake. Eur J Nutr 2002; 41: 203–209
  • Serafini M, Bugianesi R, Salucci M, Azzini E, Raguzzini A, Maiani G. Effect of acute ingestion of fresh and stored lettuce (Lactuca sativa) on plasma total antioxidant capacity and antioxidant levels in human subjects. Br J Nutr 2002; 88: 615–623
  • de Vries JHM, Hollman PCH, Meyboom S, Buysman MNCP, Zock PL, van Staveren WA, Katan MB. Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempherol as biomarkers for dietary intake. Am J Clin Nutr 1998; 68: 60–65
  • de Vries JHM, Hollman PCH, Meyboom S, Buysman MNCP, Zock PL, van Staveren WA, Katan MB. Plasma concentrations and urinary excretion of the antioxidant flavonols quercetin and kaempherol as biomarkers for dietary intake. Am J Clin Nutr 2001a; 131: 745–748
  • de Vries JHM, Hollman PCH, van Amersfoort I, Olthof MR, Katan MB. Red wine is a poor source of bioavailable flavonol in men. J Nutr 2001b; 131: 745–748

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.