271
Views
10
CrossRef citations to date
0
Altmetric
Papers

Bile acids as possible human carcinogens: new tricks from an old dog

Pages 116-125 | Published online: 21 Sep 2009

References

  • Axelson M, Mork B, Sjovall J. Occurrence of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood. J Lipid Res 1988; 29: 629–641
  • Bajpai M, Liu J, Geng X, Souza RF, Amenta PS, Das KM. Repeated exposure to acid and bile selectively induces colonic phenotype expression in a heterogeneous Barrett's epithelial cell line. Lab Invest 2008; 88: 643–651
  • Baker PR, Wilton JC, Jones CE, Stenzel DJ, Watson N, Smith GJ. Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells. Br J Cancer 1992; 65: 566–572
  • Baron JA, Beach MD, Mandel JS, Stolk RU, Haile RW, Sandler RS, Rothstein R, Summers RW, Snover DC, Beck GJ, Bond JH, Greenberg ER. Calcium supplements for the prevention of colorectal adenomas. The New England Journal of Medicine 1999; 340: 101–107
  • Bayerdorffer E, Mannes GA, Richter WO, Ochsenkuhn T, Wiebecke B, Kopcke W, Paumgartner G. Increased serum deoxycholic acid levels in men with colorectal adenomas. Gastroenterology 1993; 104: 145–151
  • Berkhout M, Roelofs HM, Friederich P, van Schaik A, Gosens MJ, Marian B, Pool-Zobel BL, van Krieken JH, Peters WH, Nagengast FM. Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: A pilot study. Transl Res 2007; 150: 147–149
  • Bernstein H, Bernstein C, Payne CM, Dvorakova K, Garewal H. Bile acids as carcinogens in human gastrointestinal cancers. Mutat Res 2005; 589: 47–65
  • Calvet X, Ponce J. Gastroesophageal reflux disease: Epidemiology, diagnosis and treatment. Gastroenterol Hepatol 2006; 29(Suppl 3)23–30
  • Chaplin MF. Bile acids, fibre and colon cancer: The story unfolds. J R Soc Health 1998; 118: 53–61
  • Chen KH, Mukaisho K, Sugihara H, Araki Y, Yamamoto G, Hattori T. High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. Cancer Sci 2007; 98: 1683–1688
  • Cook JW, Hazelwood GA. Conversion of a bile acid into a hydrocarbon derived from 1,2-benzanthracene. Chemical Industry Reviews. 1933; 11: 758–759
  • Costarelli V, Sanders TA. Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women. Br J Nutr 2001; 86: 471–477
  • Costarelli V, Sanders TA. Plasma bile acids and risk of breast cancer. IARC Sci Publ 2002; 156: 305–306
  • Csendes A, Burdiles P. Scientific foundations for medical treatment based on modifying diet, lifestyle habits, and patient attitudes in chronic gastroesophageal reflux disease. Cir Esp 2007; 81: 64–69
  • Deschner EE, Cohen BI, Raicht RF. Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation. Digestion 1981; 21: 290–296
  • Dore MP, Maragkoudakis E, Fraley K, Pedroni A, Tadeu V, Realdi G, Graham DY, Delitala G, Malaty HM. Diet, lifestyle and gender in gastro-esophageal reflux disease. Dig Dis Sci 2008; 53: 2027–2032
  • Flynn C, Montrose DC, Swank DL, Nakanishi M, Ilsley JN, Rosenberg DW. Deoxycholic acid promotes the growth of colonic aberrant crypt foci. Mol Carcinogen 2007; 46: 60–70
  • Gibson T. The Anatomy of Humane Bodies2nd ed. Flesher, London 1684
  • Hofmann AF. Enterohepatic circulation of bile acids and biliary lipid secretion. Minerva Med 1977; 68: 3011–3017
  • Hofmann AF. Bile acids: The good, the bad, and the ugly. News Physiol Sci 1999a; 14: 24–29
  • Hofmann AF. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med 1999b; 159: 2647–2658
  • Hsing AW, Gao YT, Han TQ, Rashid A, Sakoda LC, Wang BS, Shen MC, Zhang BH, Niwa S, Chen J, Fraumeni JF., Jr. Gallstones and the risk of biliary tract cancer: A population-based study in China. Br J Cancer 2007; 97: 1577–1582
  • Jansen PL. Endogenous bile acids as carcinogens. J Hepatol 2007; 47: 434–435
  • Javitt NB, Budai K, Miller DG, Cahan AC, Raju U, Levitz M. Breast–gut connection: Origin of chenodeoxycholic acid in breast cyst fluid. Lancet 1994; 343: 633–635
  • Jenkins GJ, Harries K, Doak SH, Wilmes A, Griffiths AP, Baxter JN, Parry JM. The bile acid deoxycholic acid (DCA) at neutral pH activates NF-kappaB and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis 2004; 25: 317–323
  • Kauer WK, Peters JH, DeMeester TR, Feussner H, Ireland AP, Stein HJ, Siewert RJ. Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease. Surgery 1997; 122: 874–881
  • Kondo K. Duodenogastric reflux and gastric stump carcinoma. Gastric Cancer 2002; 5: 16–22
  • Korn WM. Prevention and management of early esophageal cancer. Curr Treat Options Oncol 2004; 5: 405–416
  • Kulkarni MS, Heidepriem PM, Yielding KL. Production by lithocholic acid of DNA strand breaks in L1210 cells. Cancer Res 1980; 40: 2666–2669
  • Lam KD, Phan JT, Garcia RT, Trinh H, Nguyen H, Nguyen K, Triadafilopoulos G, Vutien P, Nguyen L, Nguyen MH. Low proportion of Barrett's esophagus in Asian Americans. Am J Gastroenterol 2008; 103: 1625–1630
  • Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev 2009; 89: 147–191
  • Liebig J. Animal Chemistry or Chemistry in its Applications to Physiology and Pathology2nd ed. Taylor and Watton, London 1843
  • Micozzi MS, Carter CL, Albanes D, Taylor PR, Licitra LM. Bowel function and breast cancer in US women. Am J Public Health 1989; 79: 73–75
  • Ouatu-Lascar R, Fitzgerald RC, Triadafilopoulos G. Differentiation and proliferation in Barrett's esophagus and the effects of acid suppression. Gastroenterology 1999; 17: 327–335
  • Owen RW, Henly PJ, Thompson MH, Hill MJ. Steroids and cancer: Faecal bile acid screening for early detection of cancer risk. J Steroid Biochem 1986; 24: 391–394
  • Papatestas AE, Panvelliwalla D, Tartter PI, Miller S, Pertsemlidis D, Aufses AH., Jr. Fecal steroid metabolites and breast cancer risk. Cancer 1982; 49: 1201–1205
  • Park JY, Park BK, Ko JS, Bang S, Song SY, Chung JB. Bile acid analysis in biliary tract cancer. Yonsei Med J 2006; 47: 817–825
  • Petrakis NL, King EB. Cytological abnormalities in nipple aspirates of breast fluid from women with severe constipation. Lancet 1981; 2: 1203–1204
  • Raju U, Levitz M, Javitt NB. Bile acids in human breast cyst fluid: The identification of lithocholic acid. J Clin Endocrinol Metab 1990; 70: 1030–1034
  • Rodrigo L, Riestra S. Diet and colon cancer. Rev Esp Enferm Dig 2007; 99: 183–189
  • Ross RK, Hartnett NM, Bernstein L, Henderson BE. Epidemiology of adenocarcinomas of the small intestine: Is bile a small bowel carcinogen?. Br J Cancer 1991; 63: 143–145
  • Salemans JM, Nagengast FM, Tangerman A, van Schaik A, Hopman WP, de Haan AF, Jansen JB. Effect of ageing on postprandial conjugated and unconjugated serum bile acid levels in healthy subjects. Eur J Clin Invest 1993; 23: 192–198
  • Schweitzer EJ, Bass BL, Batzri S, Harmon JW. Bile acid accumulation by rabbit esophageal mucosa. Dig Dis Sci 1986; 31: 1105–1113
  • Setchell KDR, Ives JA, Cashmore GC, Lawson AM. On the homogeneity of stools with respect to bile acid composition and normal day-to-day variations: a detailed qualitative and quantitative study using capillary column gas chromatography-mass spectrometry. Clinical Chimica Acta 1987; 162: 157–175
  • Sharma V, Chauhan VS, Nath G, Kumar A, Shukla VK. Role of bile bacteria in gallbladder carcinoma. Hepatogastroenterology 2007; 54: 1622–1625
  • Sjovall J. Fifty years with bile acids and steroids in health and disease. Lipids 2004; 39: 703–722
  • Spigelman AD, Williams CB, Talbot IC, Domizio P, Phillips RK. Upper gastrointestinal cancer in patients with familial adenomatous polyposis. Lancet 1989; 2: 783–785
  • Stamp DH. Three hypotheses linking bile to carcinogenesis in the gastrointestinal tract: Certain bile salts have properties that may be used to complement chemotherapy. Med Hypotheses 2002; 59: 398–405
  • Sung MW, Roh JL, Park BJ, Park SW, Kwon TK, Lee SJ, Kim KH. Bile acid induces cyclo-oxygenase-2 expression in cultured human pharyngeal cells: A possible mechanism of carcinogenesis in the upper aerodigestive tract by laryngopharyngeal reflux. Laryngoscope 2003; 113: 1059–1063
  • Thao TD, Ryu HC, Yoo SH, Rhee DK. Antibacterial and anti-atrophic effects of a highly soluble, acid stable UDCA formula in Helicobacter pylori-induced gastritis. Biochem Pharmacol 2008; 75: 2135–2146
  • Triadafilopoulos G. Acid and bile reflux in Barrett's esophagus: A tale of two evils. Gastroenterology 2001; 121: 1502–1506
  • Tucker ON, Dannenberg AJ, Yang EK, Fahey 3rd TJ. Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines. Carcinogenesis 2004; 25: 419–423
  • Van Tassel RL, MacDonald DK, Wilkins TD. Production of a fecal mutagen by Bacteroides spp. Infect Immun 1982; 37: 975–980
  • Vemulapalli R. Diet and lifestyle modifications in the management of gastroesophageal reflux disease. Nutr Clin Pract 2008; 23: 293–298
  • Wang YD, Chen WD, Moore DD, Huang W. FXR: A metabolic regulator and cell protector. Cell Res 2008; 18: 1087–1095
  • Weisburger JH. Lifestyle, health and disease prevention: the underlying mechanisms. Eur J Cancer Prev 2002; 11(Suppl 2)S1–S7
  • Wu Z, Lu Y, Wang B, Liu C, Wang ZR. Effects of bile acids on proliferation and ultrastructural alteration of pancreatic cancer cell lines. World J Gastroenterol 2003; 9: 2759–2763
  • Yee SB, Song YS, Jeong SH, Lee HS, Seo SY, Kim JH, Suh H, Kim ND, Yoo YH. A novel chenodeoxycholic derivative HS-1200 enhances radiation-induced apoptosis in MCF-7 cells. Oncol Rep 2007; 17: 919–923
  • Yui S, Kanamoto R, Saeki T. Deoxycholic acid can induce apoptosis in the human colon cancer cell line HCT116 in the absence of Bax. Nutr Cancer 2008; 60: 91–96
  • Zhang F, Altorki NK, Wu YC, Soslow RA, Subbaramaiah K, Dannenberg AJ. Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: Evidence for involvement of bile acids. Gastroenterology 2001; 121: 1391–1399

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.