Ancient wheat and health: a legend or the reality? A review on KAMUT khorasan wheat

References

• Abdel-Aal el SM, Rabalski I. 2008. Bioactive compounds and their antioxidant capacity in selected primitive and modern wheat species. Open Agric J. 2:7–14.
   Google Scholar
• Abdel-Aal el SM, Young JC, Rabalski I, Hucl P, Fregeau-Reid J. 2007. Identification and quantification of seed carotenoids in selected wheat species. J Agric Food Chem. 55:787–794.
   PubMed Web of Science ®Google Scholar
• Abdel-Aal el SM, Young JC, Wood PJ, Rabalski I, Hucl P, Falk D, Fregeau-Reid J. 2002. Einkorn: a potential candidate for developing high lutein wheat. Cereal Chem. 79:455–457.
   Web of Science ®Google Scholar
• Angioloni A, Collar C. 2011. Nutritional and functional added value of oat, Kamut, spelt, rye and buckwheat versus common wheat in breadmaking. J Sci Food Agric. 91:1283–1292.
   PubMed Web of Science ®Google Scholar
• Balestra F, Laghi L, Saa DT, Gianotti A, Rocculi P, Pinnavaia G. 2015. Physico-chemical and metabolomic characterization of KAMUT® Khorasan and durum wheat fermented dough. Food Chem. 187:451–459.
   PubMed Web of Science ®Google Scholar
• Benedetti S, Primiterra M, Tagliamonte MC, Carnevali A, Gianotti A, Bordoni A, Canestrari F. 2012. Counteraction of oxidative damage in the rat liver by an ancient grain (Kamut brand khorasan wheat). Nutrition. 28:436–441.
   PubMed Web of Science ®Google Scholar
• Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. 2013. No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 145:320–328. e323.
   PubMed Web of Science ®Google Scholar
• Bordoni A, Capozzi F. 2014. Foodomics for healthy nutrition. Curr Opin Clin Nutr Metab Care. 17:418–424.
   PubMed Web of Science ®Google Scholar
• Canavari M, Lombardi P, Spadoni R. 2009. Evaluation of the potential interest of Italian retail distribution chains for kamut-based products. J Food Prod Mark. 16:39–59.
   Google Scholar
• Carini E, Curti E, Vittadini E. 2010. Effect of long-term storage on water status and physicochemical properties of nutritionally enhanced tortillas. Food Biophys. 5:300–308.
   Web of Science ®Google Scholar
• Carnevali A, Gianotti A, Benedetti S, Tagliamonte MC, Primiterra M, Laghi L, Danesi F, Valli V, Ndaghijimana M, Capozzi F, et al. 2014. Role of Kamut® brand khorasan wheat in the counteraction of non-celiac wheat sensitivity and oxidative damage. Food Res Int. 63:218–226.
   Web of Science ®Google Scholar
• Carvalho DO, Curto AF, Guido LF. 2015. Determination of phenolic content in different barley varieties and corresponding malts by liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry. Antioxidants (Basel). 4:563–576.
   PubMedGoogle Scholar
• Chandi GK, Lok CW, Jie NY, Seetharaman K. 2015. Functionality of Kamut and Millet flours in macro wire cut cookie systems. J Food Sci Technol Mys. 52:556–561.
   Web of Science ®Google Scholar
• Coda R, Rizzello CG, Pinto D, Gobbetti M. 2012. Selected lactic acid bacteria synthesize antioxidant peptides during sourdough fermentation of cereal flours. Appl Environ Microb. 78:1087–1096.
   PubMed Web of Science ®Google Scholar
• Colomba MS, Gregorini A. 2012. Are ancient durum wheats less toxic to celiac patients? A study of α-gliadin from Graziella Ra and Kamut. Sci World J. 2012:837416.
   Web of Science ®Google Scholar
• Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, Almeida M, Quinquis B, Levenez F, Galleron N, Gougis S, et al. 2013. Dietary intervention impact on gut microbial gene richness. Nature. 500:585–588.
   PubMed Web of Science ®Google Scholar
• Curtis BC. 2002. Wheat in the world. [cited 2016 Feb 19]. Available from: http://www.fao.org/docrep/006/y4011e/y4011e04.htm.
   Google Scholar
• Danesi F, Valli V, Elementi S, D’Antuono LF. 2014. The agronomic techniques as determinants of the phenolic content and the biological antioxidant effect of palm-tree kale. Food Nutr Sci. 5:1–7.
   Google Scholar
• Di Silvestro R, Di Loreto A, Marotti I, Bosi S, Bregola V, Gianotti A, Quinn R, Dinelli G. 2014. Effects of flour storage and heat generated during milling on starch, dietary fiber and polyphenols in stoneground flours from two durum-type wheats. Int J Food Sci Technol. 49:2230–2236.
   Web of Science ®Google Scholar
• Dinelli G, Carretero AS, Di Silvestro R, Marotti I, Fu SP, Benedettelli S, Ghiselli L, Gutierrez AF. 2009. Determination of phenolic compounds in modern and old varieties of durum wheat using liquid chromatography coupled with time-of-flight mass spectrometry. J Chromatogr A. 1216:7229–7240.
   PubMed Web of Science ®Google Scholar
• Gawlik-Dziki U, Swieca M, Dziki D. 2012. Comparison of phenolic acids profile and antioxidant potential of six varieties of spelt (Triticum spelta L.). J Agric Food Chem. 60:4603–4612.
   PubMed Web of Science ®Google Scholar
• Gélinas P, McKinnon C, Gagnon F. 2016. Fructans, water-soluble fiber and fermentable sugars in bread and pasta made with ancient and modern wheat. Int J Food Sci Technol. 51:555–564.
   Web of Science ®Google Scholar
• Giacco R, Della Pepa G, Luongo D, Riccardi G. 2011. Whole grain intake in relation to body weight: from epidemiological evidence to clinical trials. Nutr Metab Cardiovasc Dis. 21:901–908.
   PubMed Web of Science ®Google Scholar
• Gianotti A, Danesi F, Verardo V, Serrazanetti DI, Valli V, Russo A, Riciputi Y, Tossani N, Caboni MF, Guerzoni ME, Bordoni A. 2011. Role of cereal type and processing in whole grain in vivo protection from oxidative stress. Front Biosci (Landmark Ed). 16:1609–1618.
   PubMed Web of Science ®Google Scholar
• Gil A, Ortega RM, Maldonado J. 2011. Wholegrain cereals and bread: a duet of the Mediterranean diet for the prevention of chronic diseases. Public Health Nutr. 14:2316–2322.
   PubMed Web of Science ®Google Scholar
• Gregorini A, Colomba M, Ellis HJ, Ciclitira PJ. 2009. Immunogenicity characterization of two ancient wheat α-gliadin peptides related to coeliac disease. Nutrients. 1:276–290.
   PubMed Web of Science ®Google Scholar
• Halmos EP, Power VA, Shepherd SJ, Gibson PR, Muir JG. 2014. A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology. 146:67–75.
   PubMed Web of Science ®Google Scholar
• Hidalgo A, Brandolini A, Pompei C, Piscozzi R. 2006. Carotenoids and tocols of einkorn wheat (Triticum monococcum ssp monococcum L.). J Cereal Sci. 44:182–193.
   Web of Science ®Google Scholar
• Hidalgo A, Brusco M, Plizzari L, Brandolini A. 2013. Polyphenol oxidase, alpha-amylase and beta-amylase activities of Triticum monococcum, Triticum turgidum and Triticum aestivum: a two-year study. J Cereal Sci. 58:51–58.
   Web of Science ®Google Scholar
• Holmer A, Hausner H, Reinbach HC, Bredie WL, Wendin K. 2012. Acceptance of Nordic snack bars in children aged 8–11 years. Food Nutr Res. 56:10484.
   Web of Science ®Google Scholar
• Inomata N. 2009. Wheat allergy. Curr Opin Allergy Clin Immunol. 9:238–243.
   PubMed Web of Science ®Google Scholar
• Kitts DD, Weiler K. 2003. Bioactive proteins and peptides from food sources. Applications of bioprocesses used in isolation and recovery. Curr Pharm Des. 9:1309–1323.
   PubMed Web of Science ®Google Scholar
• Ludvigsson JF, Leffler DA, Bai JC, Biagi F, Fasano A, Green PHR, Hadjivassiliou M, Kaukinen K, Kelly CP, Leonard JN, Lundin KE, et al. 2013. The Oslo definitions for coeliac disease and related terms. Gut. 62:43–52.
   PubMed Web of Science ®Google Scholar
• Maki KC, Phillips AK. 2015. Dietary substitutions for refined carbohydrate that show promise for reducing risk of type 2 diabetes in men and women. J Nutr. 145:159–163.
   PubMed Web of Science ®Google Scholar
• Marotti I, Bregola V, Aloisio I, Di Gioia D, Bosi S, Di Silvestro R, Quinn R, Dinelli G. 2012. Prebiotic effect of soluble fibres from modern and old durum-type wheat varieties on Lactobacillus and Bifidobacterium strains. J Sci Food Agric. 92:2133–2140.
   PubMed Web of Science ®Google Scholar
• Martucci S, Biagi F, Di Sabatino A, Corazza GR. 2002. Celiac disease. Digest Liver Dis. 34:S150–S153.
   Google Scholar
• Molberg O, Uhlen AK, Jensen T, Flaete NS, Fleckenstein B, Arentz-Hansen H, Raki M, Lundin KE, Sollid LM. 2005. Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease. Gastroenterology. 128:393–401.
   PubMed Web of Science ®Google Scholar
• Pasqualone A, Piergiovanni AR, Caponio F, Paradiso VM, Summo C, Simeone R. 2011. Evaluation of the technological characteristics and bread-making quality of alternative wheat cereals in comparison with common and durum wheat. Food Sci Technol Int. 17:135–142.
   PubMed Web of Science ®Google Scholar
• Pedersen HA, Laursen B, Mortensen A, Fomsgaard IS. 2011. Bread from common cereal cultivars contains an important array of neglected bioactive benzoxazinoids. Food Chem. 127:1814–1820.
   Web of Science ®Google Scholar
• Penagini F, Dilillo D, Meneghin F, Mameli C, Fabiano V, Zuccotti GV. 2013. Gluten-free diet in children: an approach to a nutritionally adequate and balanced diet. Nutrients. 5:4553–4565.
   PubMed Web of Science ®Google Scholar
• Piergiovanni AR, Simeone R, Pasqualone A. 2009. Composition of whole and refined meals of Kamut under southern Italian conditions. Chem Eng Trans. 17:891–896.
   Google Scholar
• Quinn RM. 1999. Kamut®: ancient grain, new cereal. In: Perspectives on new crops and new uses. Alexandria: ASHS Press. p. 182–183.
   Google Scholar
• Sahyoun NR, Jacques PF, Zhang XLL, Juan WY, McKeown NM. 2006. Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr. 83:124–131.
   PubMed Web of Science ®Google Scholar
• Scazzina F, Del Rio D, Serventi L, Carini E, Vittadini E. 2008. Development of nutritionally enhanced tortillas. Food Biophys. 3:235–240.
   Web of Science ®Google Scholar
• Serventi L, Carini E, Curti E, Vittadini E. 2009. Effect of formulation on physicochemical properties and water status of nutritionally enhanced tortillas. J Sci Food Agric. 89:73–79.
   Web of Science ®Google Scholar
• Shewry PR, Hey S. 2015. Do “ancient” wheat species differ from modern bread wheat in their contents of bioactive components? J Cereal Sci. 65:236–243.
   Web of Science ®Google Scholar
• Slavin JL, Jacobs D, Marquart L. 2001. Grain processing and nutrition. Crit Rev Biotechnol. 21:49–66.
   PubMed Web of Science ®Google Scholar
• Sofi F, Whittaker A, Cesari F, Gori AM, Fiorillo C, Becatti M, Marotti I, Dinelli G, Casini A, Abbate R, Gensini GF, Benedettelli S. 2013. Characterization of Khorasan wheat (Kamut) and impact of a replacement diet on cardiovascular risk factors: cross-over dietary intervention study. Eur J Clin Nutr. 67:190–195.
   PubMed Web of Science ®Google Scholar
• Sofi F, Whittaker A, Gori AM, Cesari F, Surrenti E, Abbate R, Gensini GF, Benedettelli S, Casini A. 2014. Effect of Triticum turgidum subsp. turanicum wheat on irritable bowel syndrome: a double-blinded randomised dietary intervention trial. Br J Nutr. 111:1992–1999.
   PubMed Web of Science ®Google Scholar
• Spaenij-Dekking L, Kooy-Winkelaar Y, van Veelen P, Drijfhout JW, Jonker H, van Soest L, Smulders MJ, Bosch D, Gilissen LJ, Koning F. 2005. Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients. Gastroenterology. 129:797–806.
   PubMed Web of Science ®Google Scholar
• Šuligoj T, Gregorini A, Colomba M, Ellis HJ, Ciclitira PJ. 2013. Evaluation of the safety of ancient strains of wheat in celiac disease reveals heterogeneous small intestinal T cell responses suggestive of celiac toxicity. Clin Nutr. 32:1043–1049.
   PubMed Web of Science ®Google Scholar
• Sumczynski D, Bubelova Z, Sneyd J, Erb-Weber S, Mlcek J. 2015. Total phenolics, flavonoids, antioxidant activity, crude fibre and digestibility in non-traditional wheat flakes and muesli. Food Chem. 174:319–325.
   PubMed Web of Science ®Google Scholar
• Taneyo Saa D, Turroni S, Serrazanetti DI, Rampelli S, Maccaferri S, Candela M, Severgnini M, Simonettie E, Brigidib P, Gianotti A. 2014. Impact of Kamut® Khorasan on gut microbiota and metabolome in healthy volunteers. Food Res Int. 63:227–232.
   Web of Science ®Google Scholar
• Tovoli F, Masi C, Guidetti E, Negrini G, Paterini P, Bolondi L. 2015. Clinical and diagnostic aspects of gluten related disorders. World J Clin Cases. 3:275–284.
   PubMedGoogle Scholar
• Truswell AS. 2002. Cereal grains and coronary heart disease. Eur J Clin Nutr. 56:1–14.
   PubMed Web of Science ®Google Scholar
• Valerii MC, Ricci C, Spisni E, Di Silvestro R, De Fazio L, Cavazza E, Lanzini A, Campieri M, Dalpiaz A, Pavan B, Volta U, Dinelli G. 2015. Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources. Food Chem. 176:167–174.
   PubMed Web of Science ®Google Scholar
• Valli V, Danesi F, Gianotti A, Di Nunzio M, Taneyo Saa DL, Bordoni A. 2016. Antioxidative and anti-inflammatory effect of in vitro digested cookies baked using different types of flours and fermentation methods. Food Res Int. 88:256–262.
   Web of Science ®Google Scholar
• van den Broeck HC, de Jong HC, Salentijn EMJ, Dekking L, Bosch D, Hamer RJ, Gilissen LJ, van der Meer IM, Smulders MJ. 2010. Presence of celiac disease epitopes in modern and old hexaploid wheat varieties: wheat breeding may have contributed to increased prevalence of celiac disease. Theor Appl Genet. 121:1527–1539.
   PubMed Web of Science ®Google Scholar
• Whittaker A, Dinu M, Cesari F, Gori AM, Fiorillo C, Becatti M, Casini A, Marcucci R, Benedettelli S, Sofi F. 2016. A khorasan wheat-based replacement diet improves risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized crossover trial. Eur J Nutr. [Epub ahead of print]. doi: 10.1007/s00394-016-1168-2.
   PubMedGoogle Scholar
• Whittaker A, Sofi F, Luisi ML, Rafanelli E, Fiorillo C, Becatti M, Abbate R, Casini A, Gensini GF, Benedettelli S. 2015. An organic khorasan wheat-based replacement diet improves risk profile of patients with acute coronary syndrome: a randomized crossover trial. Nutrients. 7:3401–3415.
   PubMed Web of Science ®Google Scholar
• Wijngaard HH, Arendt EK. 2006. Buckwheat. Cereal Chem. 83:391–401.
   Web of Science ®Google Scholar
• Wiwart M, Suchowilska E, Kandler W, Sulyok M, Groenwald P, Krska R. 2013. Can Polish wheat (Triticum polonicum L.) be an interesting gene source for breeding wheat cultivars with increased resistance to Fusarium head blight? Genet Resour Crop Evol. 60:2359–2373.
   Web of Science ®Google Scholar