The cardiovascular benefits of indiscriminate supplementation of omega-3 fatty acids; meta-analysis and decision-making approach

References

• Anderson KM, Wilson PW, Odell PM, Kannel WB. 1991. An updated coronary risk profile. A statement for health professionals. Circulation. 83:356–362.
   PubMed Web of Science ®Google Scholar
• Bang HO, Dyerberg J. 1980. Lipid metabolism and ischemic heart disease in Greenland Eskimos. In: Draper H editor. Advances in nutrition research. New York: Plenum Press; p. 1–22.
   Google Scholar
• Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L. 2014. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med. 160:398–406.
   PubMed Web of Science ®Google Scholar
• Colussi G, Catena C, Novello M, Bertin N, Sechi LA. 2017. Impact of omega-3 polyunsaturated fatty acids on vascular function and blood pressure: relevance for cardiovascular outcomes. Nutr Metab Cardiovasc Dis. 27:191–200.
   PubMed Web of Science ®Google Scholar
• Connor WE, Connor SL. 2005. n-3 Fatty acids from fish and plants: primary and secondary prevention of cardiovascular disease. In: Bendich A, Deckelbaum RJ editors, Preventive nutrition. The comprehensive guide for health professionals. 3rd ed. Totowa (NJ): Humana Press; p. 221–244.
   Google Scholar
• Cowie MR, Cure S, Bianic F, McGuire A, Goodall G, Tavazzi L. 2011. Cost-effectiveness of highly purified omega-3 polyunsaturated fatty acid ethyl esters in the treatment of chronic heart failure: results of Markov modelling in a UK setting. Eur J Heart Fail. 13:681–689.
   PubMed Web of Science ®Google Scholar
• Djousse L, Gaziano JM, Buring JE, Lee IM. 2011. Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. Am J Clin Nutr. 93:143–150.
   PubMed Web of Science ®Google Scholar
• Dotan Y, Lichtenberg D, Pinchuk I. 2009. No evidence supports vitamin E indiscriminate supplementation. Biofactors. 35:469–473.
   PubMed Web of Science ®Google Scholar
• Dotan Y, Pinchuk I, Lichtenberg D, Leshno M. 2009. Decision analysis supports the paradigm that indiscriminate supplementation of vitamin E does more harm than good. Arterioscl Throm Vasc. 29:1304–1309.
   PubMed Web of Science ®Google Scholar
• Eussen SRBM, Geleijnse JM, Giltay EJ, Rompelberg CJM, Klungel OH, Kromhout D. 2012. Effects of n-3 fatty acids on major cardiovascular events in statin users and non-users with a history of myocardial infarction. Eur Heart J. 33:1582–1588.
   PubMed Web of Science ®Google Scholar
• Franke C, Demmelmair H, Decsi T, Campoy C, Cruz M, Molina-Font JA, Mueller K, Koletzko B. 2010. Influence of fish oil or folate supplementation on the time course of plasma redox markers during pregnancy. Br J Nutr. 103:1648–1656.
   PubMed Web of Science ®Google Scholar
• Galan P, Kesse-Guyot E, Czernichow S, Briancon S, Blacher J, Hercberg S. (SU.FOL.OM3 Collaborative Group). 2010. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. Brit Med J. 341:c6273.
   PubMed Web of Science ®Google Scholar
• GISSI-HF investigators. 2008. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 372:1223–1230.
   PubMed Web of Science ®Google Scholar
• GISSI-Prevenzione Investigators. 1999. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354:447–455.
   PubMed Web of Science ®Google Scholar
• Guevel MR, Sirot V, Volatier JL, Leblanc JC. 2008. A risk-benefit analysis of French high fish consumption: a QALY approach. Risk Anal. 28:37–48.
   PubMed Web of Science ®Google Scholar
• Kromhout D, Giltay EJ, Geleijnse JM. (Alpha Omega Trial Group). 2010. n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med. 363:2015–2026.
   PubMed Web of Science ®Google Scholar
• Leslie MA, Cohen DJA, Liddle DM, Robinson LE, Ma DWL. 2015. A review of the effect of omega-3 polyunsaturated fatty acids on blood triacylglycerol levels in normolipidemic and borderline hyperlipidemic individuals. Lipids Health Dis. 14:53.
   PubMed Web of Science ®Google Scholar
• Liu T, Korantzopoulos P, Shehata M, Li GP, Wang XZ, Kaul S. 2011. Prevention of atrial fibrillation with omega-3 fatty acids: a meta-analysis of randomised clinical trials. Heart. 97:1034–1040.
   PubMed Web of Science ®Google Scholar
• Macchia A, Grancelli H, Varini S, Nul D, Laffaye N, Mariani J, Ferrante D, et al. 2013. Omega-3 fatty acids for the prevention of recurrent symptomatic atrial fibrillation: results of the FORWARD (randomized trial to assess efficacy of PUFA for the maintenance of sinus rhythm in persistent atrial fibrillation) trial. J Am Coll Cardiol. 61:463–468.
   PubMed Web of Science ®Google Scholar
• Marventano S, Kolacz P, Castellano S, Galvano F, Buscemi S, Mistretta A, Grosso G. 2015. A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: does the ratio really matter? Int J Food Sci Nutr. 201566:611–622.
   PubMed Web of Science ®Google Scholar
• Metcalf RG, James MJ, Gibson RA, Edwards JRM, Stubberfield J, Stuklis R, Roberts-Thomson K, et al. 2007. Effects of fish-oil supplementation on myocardial fatty acids in humans. Am J Clin Nutr. 85:1222–1228.
   PubMed Web of Science ®Google Scholar
• Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. 2005. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 142:37–46.
   PubMed Web of Science ®Google Scholar
• Milte CM, Coates AM, Buckley JD, Hill AM, Howe PRC. 2008. Dose-dependent effects of docosahexaenoic acid-rich fish oil on erythrocyte docosahexaenoic acid and blood lipid levels. Brit J Nutr. 99:1083–1088.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG. 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 6:e1000097.
   PubMed Web of Science ®Google Scholar
• Mozaffarian D, Marchioli R, Macchia A, Silletta MG, Ferrazzi P, Gardner TJ, Latini R, Libby P, Lombardi F, O’Gara PT, et al. 2012. Fish oil and postoperative atrial fibrillation. The omega-3 fatty acids for prevention of post-operative atrial fibrillation (OPERA) randomized trial. JAMA. 308:2001–2011.
   PubMed Web of Science ®Google Scholar
• Nicholson T, Khademi H, Moghadasian MH. 2013. The role of marine n-3 fatty acids in improving cardiovascular health: a review. Food Funct. 4:357–365.
   PubMed Web of Science ®Google Scholar
• ORIGIN Trial Investigators. 2012. n–3 Fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med. 367:309–318.
   PubMed Web of Science ®Google Scholar
• Rauch B, Schiele R, Schneider S, Frank D, Victor N, Gohlke H, Gottwik M, Steinbeck G, Del Castillo U, Sack R, et al. 2010. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation. 122:2152–2159.
   PubMed Web of Science ®Google Scholar
• Rizos EC, Ntzani EE, Bika E, Kostapanos MS, Elisaf MS. 2012. Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis. JAMA. 308:1024–1033.
   PubMed Web of Science ®Google Scholar
• The Risk and Prevention Study Collaborative Group. 2013. n − 3 Fatty acids in patients with multiple cardiovascular risk factors. New Engl J Med. 368:1800–1808.
   PubMed Web of Science ®Google Scholar
• Sesso HD, Chen RS, L'italien GJ, Lapuerta P, Lee WC, Glynn RJ. 2003. Blood pressure lowering and life expectancy based on a markov model of cardiovascular events. Hypertension. 42:885–890.
   PubMed Web of Science ®Google Scholar
• Siscovick DS, Barringer TA, Fretts AM, Wu JHY, Lichtenstein AH, Costello RB, Kris-Etherton PM, Jacobson TA, Engler MB, Alger HM, et al. 2017. Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease: a science advisory from the American Heart Association. Circulation. 135:e867–e884.
   PubMed Web of Science ®Google Scholar
• Sutton AJ, Abrams KR, Jones DR, Sheldon TA, Song F. 2000. Methods for meta-analysis in medical research. Chichester: Wiley.
   Google Scholar
• Tur JA, Bibiloni MM, Sureda A, Pons A. 2012. Dietary sources of omega 3 fatty acids: public health risks and benefits. Brit J Nutr. 107:S23–S52.
   PubMed Web of Science ®Google Scholar
• Weinstein MC, Coxson PG, Williams LW, Pass TM, Stason WB. 1987. Forecasting coronary heart disease incidence, mortality, and cost: the coronary heart disease policy model. Am J Public Health. 77:1417–1426.
   PubMed Web of Science ®Google Scholar
• Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida Hitoshi, Itakura H, et al. 2007. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet. 369:1090–1098. http://newhope.com/supply-news-amp-analysis/goed-disputes-jama-omega-3-meta-analysis
   PubMed Web of Science ®Google Scholar