854
Views
18
CrossRef citations to date
0
Altmetric
In Vitro and Animal Studies

The effect of fish oil supplementation on brain DHA and EPA content and fatty acid profile in mice

, ORCID Icon, & ORCID Icon
Pages 705-717 | Received 27 Aug 2017, Accepted 03 Dec 2017, Published online: 18 Dec 2017

References

  • Aarsetoey H, Aarsetoey R, Lindner T, Staines H, Harris WS, Nilsen DW. 2011. Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase. Lipids. 46:151–161.
  • Agren JJ, Julkunen A, Penttila I. 1992. Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column. J Lipid Res. 33:1871–1876.
  • Anderson GJ, Connor WE, Corliss JD. 1990. Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina. Pediatr Res. 27:89–97.
  • Barcelo-Coblijn G, Murphy EJ. 2009. Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. Prog Lipid Res. 48:355–374.
  • Bascoul-Colombo C, Guschina IA, Maskrey BH, Good M, O'Donnell VB, Harwood JL. 2016. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. Biochim Biophys Acta. 1861:524–537.
  • Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser B (Methodol). 57:289–300.
  • Breckenridge WC, Gombos G, Morgan IG. 1972. The lipid composition of adult rat brain synaptosomal plasma membranes. Biochim Biophys Acta. 266:695–707.
  • Burdge GC, Wright P, Jones AE, Wootton SA. 2000. A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br J Nutr. 84:781–787.
  • Carrie I, Smirnova M, Clement M, De JD, Frances H, Bourre JM. 2002. Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice. Nutr Neurosci. 5:43–52.
  • Chen CT, Green JT, Orr SK, Bazinet RP. 2008. Regulation of brain polyunsaturated fatty acid uptake and turnover. Prostaglandins Leukot Essent Fatty Acids. 79:85–91.
  • Chen CT, Liu Z, Ouellet M, Calon F, Bazinet RP. 2009. Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study. Prostaglandins Leukot Essent Fatty Acids. 80:157–163.
  • Demar JC Jr, Ma K, Chang L, Bell JM, Rapoport SI. 2005. Alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J Neurochem. 94:1063–1076.
  • Devore EE, Grodstein F, van Rooij FJ, Hofman A, Rosner B, Stampfer MJ, Witteman JC, Breteler MM. 2009. Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk. Am J Clin Nutr. 90:170–176.
  • Feart C, Samieri C, Rondeau V, Amieva H, Portet F, Dartigues JF, Scarmeas N, Barberger-Gateau P. 2009. Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. JAMA. 302:638–648.
  • Fedorova I, Salem N Jr. 2006. Omega-3 fatty acids and rodent behavior. Prostaglandins Leukot Essent Fatty Acids. 75:271–289.
  • Fenton JI, Gurzell EA, Davidson EA, Harris WS. 2016. Red blood cell PUFAs reflect the phospholipid PUFA composition of major organs. Prostaglandins Leukot Essent Fatty Acids. 112:12–23.
  • Fraser T, Tayler H, Love S. 2010. Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease. Neurochem Res. 35:503–513.
  • Gerbi A, Zerouga M, Debray M, Durand G, Chanez C, Bourre JM. 1994. Effect of fish oil diet on fatty acid composition of phospholipids of brain membranes and on kinetic properties of Na+,K(+)-ATPase isoenzymes of weaned and adult rats. J Neurochem. 62:1560–1569.
  • Guillot N, Caillet E, Laville M, Calzada C, Lagarde M, Vericel E. 2009. Increasing intakes of the long-chain omega-3 docosahexaenoic acid: effects on platelet functions and redox status in healthy men. FASEB J. 23:2909–2916.
  • Gurzell EA, Wiesinger JA, Morkam C, Hemmrich S, Harris WS, Fenton JI. 2014. Is the omega-3 index a valid marker of intestinal membrane phospholipid EPA + DHA content?. Prostaglandins Leukot Essent Fatty Acids. 91:87–96.
  • Harel M, Lund E, Gavasso S, Herbert R, Place AR. 2000. Modulation of arachidonate and docosahexaenoate in Morone chrysops larval tissues and the effect on growth and survival. Lipids. 35:1269–1280.
  • Harris WS, Thomas RM. 2010. Biological variability of blood omega-3 biomarkers. Clin Biochem. 43:338–340.
  • Harris WS, Von Schacky C. 2004. The omega-3 index: a new risk factor for death from coronary heart disease?. Prev Med. 39:212–220.
  • Hjartaker A, Lund E, Bjerve KS. 1997. Serum phospholipid fatty acid composition and habitual intake of marine foods registered by a semi-quantitative food frequency questionnaire. Eur J Clin Nutr. 51:736–742.
  • Igarashi M, DeMar JC Jr, Ma K, Chang L, Bell JM, Rapoport SI. 2007. Upregulated liver conversion of alpha-linolenic acid to docosahexaenoic acid in rats on a 15 week n-3 PUFA-deficient diet. J Lipid Res 48:152–164.
  • Innis SM. 2007. Dietary (n-3) fatty acids and brain development. J Nutr. 137:855–859.
  • Issa AM, Mojica WA, Morton SC, Traina S, Newberry SJ, Hilton LG, Garland RH, Maclean CH. 2006. The efficacy of omega-3 fatty acids on cognitive function in aging and dementia: a systematic review. Dement Geriatr Cogn Disord. 21:88–96.
  • Jakobsson A, Westerberg R, Jacobsson A. 2006. Fatty acid elongases in mammals: their regulation and roles in metabolism. Prog Lipid Res. 45:237–249.
  • Kishimoto Y, Agranoff BW, Radin NS, Burton RM. 1969. Comparison of the fatty acids of lipids of subcellular brain fractions. J Neurochem. 16:397–404.
  • Kitazawa H, Miyamoto Y, Shimamura K, Nagumo A, Tokita S. 2009. Development of a high-density assay for long-chain fatty acyl-CoA elongases. Lipids. 44:765–773.
  • Kroger E, Verreault R, Carmichael PH, Lindsay J, Julien P, Dewailly E, Ayotte P, Laurin D. 2009. Omega-3 fatty acids and risk of dementia: the Canadian Study of Health and Aging. Am J Clin Nutr. 90:184–192.
  • Lauritzen L, Brambilla P, Mazzocchi A, Harslof LB, Ciappolino V, Agostoni C. 2016. DHA effects in brain development and function. Nutrients. 8:6.
  • Lo CJ, Chiu KC, Fu M, Lo R, Helton S. 1999. Fish oil augments macrophage cyclooxygenase II (COX-2) gene expression induced by endotoxin. J Surg Res. 86:103–107.
  • Makrides M, Smithers LG, Gibson RA. 2010. Role of long-chain polyunsaturated fatty acids in neurodevelopment and growth. Nestle Nutr Workshop Ser Pediatr Program. 65:123–133. discussion 133-126.
  • Martin V, Fabelo N, Santpere G, Puig B, Marin R, Ferrer I, Diaz M. 2010. Lipid alterations in lipid rafts from Alzheimer's disease human brain cortex. J Alzheimers Dis. 19:489–502.
  • Martinez M, Mougan I. 1998. Fatty acid composition of human brain phospholipids during normal development. J Neurochem. 71:2528–2533.
  • Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. 2009. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: an in situ cerebral perfusion study. Neurochem Int. 55:476–482.
  • Panza F, Solfrizzi V, Colacicco AM, D'introno A, Capurso C, Torres F, Del Parigi A, Capurso S, Capurso A. 2004. Mediterranean diet and cognitive decline. Public Health Nutr. 7:959–963.
  • Park HG, Lawrence P, Engel MG, Kothapalli K, Brenna JT. 2016. Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). FEBS Lett. 590:3188–3194.
  • Pawlosky RJ, Hibbeln JR, Novotny JA, Salem N Jr. 2001. Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res. 42:1257–1265.
  • Pickens CA, Lane-Elliot A, Comstock SS, Fenton JI. 2016. Altered saturated and monounsaturated plasma phospholipid fatty acid profiles in adult males with colon adenomas. Cancer Epidemiol Biomarkers Prev. 25:498–506.
  • Rose HG, Oklander M. 1965. Improved procedure for the extraction of lipids from human erythrocytes. J Lipid Res. 6:428–431.
  • Sargent JR, Coupland K, Wilson R. 1994. Nervonic acid and demyelinating disease. Med Hypotheses. 42:237–242.
  • Serini S, Calviello G. 2016. Reduction of oxidative/nitrosative stress in brain and its involvement in the neuroprotective effect of n-3 PUFA in Alzheimer's disease. Curr Alzheimer Res. 13:123–134.
  • Shaikh SR. 2012. Biophysical and biochemical mechanisms by which dietary N-3 polyunsaturated fatty acids from fish oil disrupt membrane lipid rafts. J Nutr Biochem. 23:101–105.
  • Simopoulos AP. 1999. Essential fatty acids in health and chronic disease. Am J Clin Nutr. 70:560S–569S.
  • Simopoulos AP. 2008. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp Biol Med (Maywood). 233:674–688.
  • Slater SJ, Kelly MB, Taddeo FJ, Ho C, Rubin E, Stubbs CD. 1994. The modulation of protein kinase C activity by membrane lipid bilayer structure. J Biol Chem. 269:4866–4871.
  • Solfrizzi V, Frisardi V, Capurso C, D'introno A, Colacicco AM, Vendemiale G, Capurso A, Panza F. 2010. Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms. Ageing Res Rev. 9:184–199.
  • Sugasini D, Thomas R, Yalagala PCR, Tai LM, Subbaiah PV. 2017. Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice. Sci Rep. 7:11263.
  • Svennerholm L, Vanier MT. 1973. The distribution of lipids in the human nervous system. IV. Fatty acid composition of major sphingolipids of human infant brain. Brain Res. 55:413–423.
  • Team RC. 2015. R: A Language and environment for stastical computing. http://wwwr-projectorg/
  • Turk HF, Chapkin RS. 2013. Membrane lipid raft organization is uniquely modified by n-3 polyunsaturated fatty acids. Prostaglandins Leukot Essent Fatty Acids. 88:43–47.
  • Uauy R, Dangour AD. 2006. Nutrition in brain development and aging: role of essential fatty acids. Nutr Rev. 64:S24–S33. discussion S72-91.
  • Von Schacky C. 2011. The Omega-3 Index as a risk factor for cardiovascular diseases. Prostaglandins Other Lipid Mediat. 96:94–98.
  • Whelan J. 2008. (n-6) and (n-3) Polyunsaturated fatty acids and the aging brain: food for thought. J Nutr. 138:2521–2522.
  • Yu H, Bi Y, Ma W, He L, Yuan L, Feng J, Xiao R. 2010. Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice. Int J Dev Neurosci. 28:271–276.
  • Yurko-Mauro K, McCarthy D, Rom D, Nelson EB, Ryan AS, Blackwell A, Salem N Jr, Stedman M, MIDAS Investigators. 2010. Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline. Alzheimers Dement. 6:456–464.
  • Zarate R, El Jaber-Vazdekis N, Tejera N, Perez JA, Rodriguez C. 2017. Significance of long chain polyunsaturated fatty acids in human health. Clin Transl Med. 6:25
  • Zerouga M, Jenski LJ, Stillwell W. 1995. Comparison of phosphatidylcholines containing one or two docosahexaenoic acyl chains on properties of phospholipid monolayers and bilayers. Biochim Biophys Acta. 1236:266–272.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.