Combined cranberry supplementation and weight loss diet in non-alcoholic fatty liver disease: a double-blind placebo-controlled randomized clinical trial

References

• Abenavoli L, Greco M, Milic N, Accattato F, Foti D, Gulletta E, Luzza F. 2017. Effect of Mediterranean diet and antioxidant formulation in non-alcoholic fatty liver disease: a randomized study. Nutrients. 9(8):870.
   Web of Science ®Google Scholar
• Abenavoli L, Milic N, Di Renzo L, Preveden T, Medić-Stojanoska M, De Lorenzo A. 2016. Metabolic aspects of adult patients with nonalcoholic fatty liver disease. World J Gastroenterol. 22(31):7006–7016.
   PubMed Web of Science ®Google Scholar
• Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O’Brien WL, Bassett DR, Schmitz KH, Emplaincourt PO, et al. 2000. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 32(9 Suppl):S498–S504.
   PubMed Web of Science ®Google Scholar
• Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, Galluzzo A, AlkaMeSy Study Group. 2010. Visceral adiposity index: a reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 33(4):920–922.
   PubMed Web of Science ®Google Scholar
• Anhê FF, Nachbar RT, Varin TV, Vilela V, Dudonné S, Pilon G, Fournier M, Lecours M-A, Desjardins Y, Roy D, et al. 2017. A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss. Mol Metab. 6(12):1563–1573.
   PubMed Web of Science ®Google Scholar
• Basu A, Betts NM, Ortiz J, Simmons B, Wu MY, Lyons TJ. 2011. Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome. Nutr Res. 31(3):190–196.
   PubMed Web of Science ®Google Scholar
• Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, Tiribelli C. 2006. The fatty liver index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol. 6(1):33.
   PubMed Web of Science ®Google Scholar
• Bellentani S, Dalle Grave R, Suppini A, Marchesini G, Network F, Fatty Liver Italian Network,. 2008. Behavior therapy for nonalcoholic fatty liver disease: the need for a multidisciplinary approach. Hepatology. 47(2):746–754.
   PubMed Web of Science ®Google Scholar
• Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F. 2013. The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol. 58(3):593–608.
   PubMed Web of Science ®Google Scholar
• Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, Grundy SM, Hobbs HH. 2004. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 40(6):1387–1395.
   PubMed Web of Science ®Google Scholar
• Byrne CD, Targher G. 2016. EASL-EASD-EASO Clinical practice guidelines for the management of non-alcoholic fatty liver disease: is universal screening appropriate? Diabetologia. 59(6):1141–1144.
   PubMed Web of Science ®Google Scholar
• Chambers BK, Camire ME. 2003. Can cranberry supplementation benefit adults with type 2 diabetes? Diabetes Care. 26(9):2695–2696.
   PubMed Web of Science ®Google Scholar
• Collin AL, Dunlap KL, Kuhn TB. 2017. Alaskan blueberries and cranberries restore glucose uptake in a type 2 diabetes model. The FASEB Journal. 31(1_supplement):970.911–970.911.
   Google Scholar
• Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ. 2009. Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol. 51(6):1061–1067.
   PubMed Web of Science ®Google Scholar
• Day C. 2002. Pathogenesis of steatohepatitis. Best Pract Res Clin Gastroenterol. 16(5):663–678.
   PubMed Web of Science ®Google Scholar
• Day CP, James OF. 1998. Steatohepatitis: a tale of two “hits”? Philadelphia(PA): Elsevier.
   Google Scholar
• Dohadwala MM, Holbrook M, Hamburg NM, Shenouda SM, Chung WB, Titas M, Kluge MA, Wang N, Palmisano J, Milbury PE, et al. 2011. Effects of cranberry juice consumption on vascular function in patients with coronary artery disease. Am J Clin Nutr. 93(5):934–940.
   PubMed Web of Science ®Google Scholar
• Eftekhari MH, Allaei M, Khosropanah S, Rajaeifard A, Sohrabi Z. 2016. Cranberry supplement and metabolic risk factors in obese and overweight females. Jentashapir J Health Res. 7(3):e37255.
   Google Scholar
• Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A. 2014. Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr. 99(3):535–542.
   PubMed Web of Science ®Google Scholar
• Fabbrini E, Sullivan S, Klein S. 2010. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 51(2):679–689.
   PubMed Web of Science ®Google Scholar
• Faghihzadeh F, Adibi P, Rafiei R, Hekmatdoost A. 2014. Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease. Nutr Res. 34(10):837–843.
   PubMed Web of Science ®Google Scholar
• Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ. 2018. Mechanisms of NAFLD development and therapeutic strategies. Nat Med. 24(7):908–922.
   PubMed Web of Science ®Google Scholar
• García-Monzón C, Martín-Pérez E, Iacono OL, Fernández-Bermejo M, Majano PL, Apolinario A, Larrañaga E, Moreno-Otero R. 2000. Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity. J Hepatol. 33(5):716–724.
   PubMed Web of Science ®Google Scholar
• Gayoso-Diz P, Otero-González A, Rodriguez-Alvarez MX, Gude F, García F, De Francisco A, Quintela AG. 2013. Insulin resistance (HOMA-IR) cut-off values and the metabolic syndrome in a general adult population: effect of gender and age: EPIRCE cross-sectional study. BMC Endocr Disord. 13(1):47
   PubMedGoogle Scholar
• Glisan SL, Ryan C, Neilson AP, Lambert JD. 2016. Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice. J Nutr Biochem. 37:60–66.
   PubMed Web of Science ®Google Scholar
• Harrison SA, Torgerson S, Hayashi P, Ward J, Schenker S. 2003. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. 98(11):2485–2490.
   PubMed Web of Science ®Google Scholar
• Haytowitz DB, Bhagwat S. 2010. USDA database for the oxygen radical absorbance capacity (ORAC) of selected foods, Release 2. US Department of Agriculture. 10–48.
   Google Scholar
• Lee I, Chan Y, Lin C, Lee W, Sheu W. 2008. Effect of cranberry extracts on lipid profiles in subjects with type 2 diabetes. Diabet Med. 25(12):1473–1477.
   PubMed Web of Science ®Google Scholar
• Loguercio C, De ST, D’auria M, De Sio I, Federico A, Tuccillo C, Group IC. 2004. Non-alcoholic fatty liver disease: a multicentre clinical study by the Italian association for the study of the liver. Digestive and Liver Disease. 36(6):398–405.
   Web of Science ®Google Scholar
• Malekzadeh R, Poustchi H. 2011. Fibroscan for assessing liver fibrosis: an acceptable alternative for liver biopsy: fibroscan: an acceptable alternative for liver biopsy. Hepat Mon. 11(3):157–158.
   PubMed Web of Science ®Google Scholar
• Merat S, Malekzadeh R, Sohrabi MR, Sotoudeh M, Rakhshani N, Sohrabpour AA, Naserimoghadam S. 2003. Probucol in the treatment of non-alcoholic steatohepatitis: a double-blind randomized controlled study. J Hepatol. 38(4):414–418.
   PubMed Web of Science ®Google Scholar
• Morris S, Betts N, Lyons T, Basu A. 2015. Cranberries modulate postprandial metabolism in obese participants with type 2 diabetes. Faseb J. 29.(1 Meeting Abstracts).
   Web of Science ®Google Scholar
• Musso G, Gambino R, De Michieli F, Cassader M, Rizzetto M, Durazzo M, Fagà E, Silli B, Pagano G. 2003. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology. 37(4):909–916.
   PubMed Web of Science ®Google Scholar
• Novotny JA, Baer DJ, Khoo C, Gebauer SK, Charron CS. 2015. Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults. J Nutr. 145(6):1185–1193.
   PubMed Web of Science ®Google Scholar
• Ozkaya M, Cakal E, Ustun Y, Engin-Ustun Y. 2010. Effect of metformin on serum visfatin levels in patients with polycystic ovary syndrome. Fertil Steril. 93(3):880–884.
   PubMed Web of Science ®Google Scholar
• Paquette M, Medina Larqué AS, Weisnagel SJ, Desjardins Y, Marois J, Pilon G, Dudonné S, Marette A, Jacques H. 2017. Strawberry and cranberry polyphenols improve insulin sensitivity in insulin-resistant, non-diabetic adults: a parallel, double-blind, controlled and randomised clinical trial. Br J Nutr. 117(4):519–531.
   PubMed Web of Science ®Google Scholar
• Peixoto TC, Moura EG, de Oliveira E, Soares PN, Guarda DS, Bernardino DN, Ai XX, Rodrigues V. d S T, de Souza GR, da Silva AJR, et al. 2018. Cranberry (Vaccinium macrocarpon) extract treatment improves triglyceridemia, liver cholesterol, liver steatosis, oxidative damage and corticosteronemia in rats rendered obese by high fat diet. Eur J Nutr. 57(5):1829–1844.
   PubMed Web of Science ®Google Scholar
• Petta S, Muratore C, Craxi A. 2009. Non-alcoholic fatty liver disease pathogenesis: the present and the future. Dig Liver Dis. 41(9):615–625.
   PubMedGoogle Scholar
• Pierantonelli I, Svegliati-Baroni G. 2019. Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH. Transplantation. 103(1):e1–e13.
   PubMed Web of Science ®Google Scholar
• Ruel G, Lapointe A, Pomerleau S, Couture P, Lemieux S, Lamarche B, Couillard C. 2013. Evidence that cranberry juice may improve augmentation index in overweight men. Nutr Res. 33(1):41–49.
   PubMed Web of Science ®Google Scholar
• Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, Mullen KD, Cooper JN, Sheridan MJ. 2002. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 123(3):745–750.
   PubMed Web of Science ®Google Scholar
• Salomone F, Godos J, Zelber-Sagi S. 2016. Natural antioxidants for non-alcoholic fatty liver disease: molecular targets and clinical perspectives . Liver Int. 36(1):5–20.
   PubMed Web of Science ®Google Scholar
• Salomone F, Ivancovsky-Wajcman D, Fliss-Isakov N, Webb M, Grosso G, Godos J, Galvano F, Shibolet O, Kariv R, Zelber-Sagi S. 2020. Higher phenolic acid intake independently associates with lower prevalence of insulin resistance and non-alcoholic fatty liver disease. JHEP Rep. 2(2):100069
   PubMedGoogle Scholar
• Salomone F, Micek A, Godos J. 2018. simple scores of fibrosis and mortality in patients with NAFLD: a systematic review with meta-analysis. J Compos Sci. 7(8):219.
   Google Scholar
• Sanna C, Rosso C, Marietti M, Bugianesi E. 2016. Non-alcoholic fatty liver disease and extra-hepatic cancers. Int J Mol Sci. 17(5):717.
   PubMed Web of Science ®Google Scholar
• Shidfar F, Heydari I, Hajimiresmaiel SJ, Hosseini S, Shidfar S, Amiri F. 2012. The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and paraoxonase-1 activity in type 2 diabetic male patients. J Res Med Sci. 17(4):355–360.
   PubMed Web of Science ®Google Scholar
• Shimizu K, Ono M, Imoto A, Nagayama H, Tetsumura N, Terada T, Tomita K, Nishinaka T. 2019. Cranberry attenuates progression of non-alcoholic fatty liver disease induced by high-fat diet in mice. Biol Pharm Bull. 42(8):1295–1302.
   PubMed Web of Science ®Google Scholar
• Slavin JL, Lloyd B. 2012. Health benefits of fruits and vegetables. Adv Nutr. 3(4):506–516.
   PubMed Web of Science ®Google Scholar
• Thimóteo NSB, Scavuzzi BM, Simão ANC, Dichi I. 2017. The impact of cranberry (Vaccinium macrocarpon) and cranberry products on each component of the metabolic syndrome: a review. Nutrire. 42(1):25.
   Google Scholar
• Yilmaz Y. 2012. Review article: is non-alcoholic fatty liver disease a spectrum, or are steatosis and non-alcoholic steatohepatitis distinct conditions? Aliment Pharmacol Ther. 36(9):815–823.
   PubMed Web of Science ®Google Scholar
• Zare Javid A, Maghsoumi-Norouzabad L, Ashrafzadeh E, Yousefimanesh HA, Zakerkish M, Ahmadi Angali K, Ravanbakhsh M, Babaei H. 2018. Impact of cranberry juice enriched with omega-3 fatty acids adjunct with nonsurgical periodontal treatment on metabolic control and periodontal status in type 2 patients with diabetes with periodontal disease. J Am Coll Nutr. 37(1):71–79.
   PubMed Web of Science ®Google Scholar