724
Views
6
CrossRef citations to date
0
Altmetric
Comprehensive review

Meta-analysis of randomized controlled trials on calcium supplements and dairy products for changes in body weight and obesity indices

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, & ORCID Icon
Pages 615-631 | Received 06 Aug 2020, Accepted 24 Nov 2020, Published online: 08 Dec 2020

References

  • Abargouei AS, Janghorbani M, Salehi-Marzijarani M, Esmaillzadeh A. 2012. Effect of dairy consumption on weight and body composition in adults: a systematic review and meta-analysis of randomized controlled clinical trials. Int J Obes. 36(12):1485–1493.
  • Ades AE, Lu G, Higgins JP. 2005. The interpretation of random-effects meta-analysis in decision models. Med Decis Making. 25(6):646–654.
  • Angeles-Agdeppa I, Capanzana MV, Li-Yu J, Schollum LM, Kruger MC. 2010. High-calcium milk prevents overweight and obesity among postmenopausal women. Food Nutr Bull. 31(3):381–390.
  • Bendtsen LQ, Blaedel T, Holm JB, Lorenzen JK, Mark AB, Kiilerich P, Kristiansen K, Astrup A, Larsen LH. 2018. High intake of dairy during energy restriction does not affect energy balance or the intestinal microflora compared with low dairy intake in overweight individuals in a randomized controlled trial. Appl Physiol Nutr Metab. 43(1):1–10.
  • Bhattacharyya AK, Thera C, Anderson JT, Grande F, Keys A. 1969. Dietary calcium and fat. Effect on serum lipids and fecal excretion of cholesterol and its degradation products in man. Am J Clin Nutr. 22(9):1161–1174.
  • Booth AO, Huggins CE, Wattanapenpaiboon N, Nowson CA. 2015. Effect of increasing dietary calcium through supplements and dairy food on body weight and body composition: a meta-analysis of randomised controlled trials. Br J Nutr. 114(7):1013–1025.
  • Buchowski MS, Aslam M, Dossett C, Dorminy C, Choi L, Acra S. 2010. Effect of dairy and non-dairy calcium on fecal fat excretion in lactose digester and maldigester obese adults. Int J Obes.) 34(1):127–135.
  • Centre TNC. 2014. Review manager (RevMan). Copenhagen: The Cochrane Collaboration.
  • Chen M, Pan A, Malik VS, Hu FB. 2012. Effects of dairy intake on body weight and fat: a meta-analysis of randomized controlled trials. Am J Clin Nutr. 96(4):735–747.
  • Christensen R, Lorenzen JK, Svith CR, Bartels EM, Melanson EL, Saris WH, Tremblay A, Astrup A. 2009. Effect of calcium from dairy and dietary supplements on faecal fat excretion: a meta-analysis of randomized controlled trials. Obes Rev. 10(4):475–486.
  • Davies KM, Heaney RP, Recker RR, Lappe JM, Barger-Lux MJ, Rafferty K, Hinders S. 2000. Calcium intake and body weight. J Clin Endocrinol Metab. 85(12):4635–4638.
  • Denke MA, Fox MM, Schulte MC. 1993. Short-term dietary calcium fortification increases fecal saturated fat content and reduces serum lipids in men. J Nutr. 123(6):1047–1053.
  • DerSimonian R, Laird N. 1986. Meta-analysis in clinical trials. Control Clin Trials. 7(3):177–188.
  • European Medicines Evaluation Agency (EMEA) 2008. Guideline of clinical investigation of medicinal products for hormone replacement therapy of oestrogen deficiency symptoms in postmenopausal women.
  • Fleiss JL. 1986. Analysis of data from multiclinic trials. Control Clin Trials. 7(4):267–275.
  • Fleiss JL, Gross AJ. 1991. Meta-analysis in epidemiology, with special reference to studies of the association between exposure to environmental tobacco smoke and lung cancer: a critique. J Clin Epidemiol. 44(2):127–139.
  • Gilbert JA, Joanisse DR, Chaput JP, Miegueu P, Cianflone K, Almeras N, Tremblay A. 2011. Milk supplementation facilitates appetite control in obese women during weight loss: a randomised, single-blind, placebo-controlled trial. Br J Nutr. 105(1):133–143.
  • Godos J, Tieri M, Ghelfi F, Titta L, Marventano S, Lafranconi A, Gambera A, Alonzo E, Sciacca S, Buscemi S, et al. 2020. Dairy foods and health: an umbrella review of observational studies. Int J Food Sci Nutr. 71(2):138–151.
  • Heaney RP. 2003. Normalizing calcium intake: projected population effects for body weight. J Nutr. 133(1):268S–270S.
  • Heaney RP, Davies KM, Barger-Lux MJ. 2002. Calcium and weight: clinical studies. J Am Coll Nutr. 21(2):152S–155S.
  • Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, Savovic J, Schulz KF, Weeks L, Sterne JA, Cochrane Statistical Methods Group 2011. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 343:d5928.
  • Higgins JP, Thomas J. 2019a. Cochrane handbook for systematic reviews of interventions 6.0 ver, Chapter 6. Wiley-Blackwell, John Wiley & Sons.
  • Higgins JP, Thomas J. 2019b. Cochrane handbook for systematic reviews of interventions 6.0 ver, Chapter 10. Chichester (UK): Wiley-Blackwell.
  • Higgins JP, Thompson SG. 2002. Quantifying heterogeneity in a meta-analysis. Stat Med. 21(11):1539–1558.
  • Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J. 2006. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods. 11(2):193–206.
  • Jacobsen R, Lorenzen JK, Toubro S, Krog-Mikkelsen I, Astrup A. 2005. Effect of short-term high dietary calcium intake on 24-h energy expenditure, fat oxidation, and fecal fat excretion. Int J Obes. 29(3):292–301.
  • Jakobsen JC, Wetterslev J, Winkel P, Lange T, Gluud C. 2014. Thresholds for statistical and clinical significance in systematic reviews with meta-analytic methods. BMC Med Res Methodol. 14:120
  • Jones KW, Eller LK, Parnell JA, Doyle-Baker PK, Edwards AL, Reimer RA. 2013. Effect of a dairy- and calcium-rich diet on weight loss and appetite during energy restriction in overweight and obese adults: a randomized trial. Eur J Clin Nutr. 67(4):371–376.
  • Josse AR, Atkinson SA, Tarnopolsky MA, Phillips SM. 2011. Increased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal women. J Nutr. 141(9):1626–1634.
  • BMJ Best Practice. 2019. Study design search filters. https://bestpractice.bmj.com/info/toolkit/learn-ebm/study-design-search-filters/
  • Higgins J, Thomas J. 2019c. Cochrane handbook for systematic reviews of interventions 6.0 ver, Chapter 8. Chichester (UK): Wiley-Blackwell.
  • Kratz M, Baars T, Guyenet S. 2013. The relationship between high-fat dairy consumption and obesity, cardiovascular, and metabolic disease. Eur J Nutr. 52(1):1–24.
  • Kukuljan S, Nowson CA, Sanders K, Daly RM. 2009. Effects of resistance exercise and fortified milk on skeletal muscle mass, muscle size, and functional performance in middle-aged and older men: an 18-mo randomized controlled trial. J Appl Physiol. 107(6):1864–1873.
  • Li P, Fan C, Lu Y, Qi K. 2016. Effects of calcium supplementation on body weight: a meta-analysis. Am J Clin Nutr. 104(5):1263–1273.
  • Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 6(7):e1000100
  • Moeyaert M, Ugille M, Natasha Beretvas S, Ferron J, Bunuan R, Van den Noortgate W. 2017. Methods for dealing with multiple outcomes in meta-analysis: a comparison between averaging effect sizes, robust variance estimation and multilevel meta-analysis. Inter J Soc Res Methodol. 20(6):559–572.
  • McCarron DA, Morris CD, Henry HJ, Stanton JL. 1984. Blood pressure and nutrient intake in the United States. Science. 224(4656):1392–1398.
  • Naggara O, Raymond J, Guilbert F, Altman DG. 2011. The problem of subgroup analyses: an example from a trial on ruptured intracranial aneurysms. AJNR Am J Neuroradiol. 32(4):633–636.
  • Newberry SJ, Chung M, Shekelle PG, Booth MS, Liu JL, Maher AR, Motala A, Cui M, Perry T, Shanman R. 2014. Vitamin D and calcium: a systematic review of health outcomes (Update). Evid Rep Technol Assess (Full Rep). 217:1–929.
  • Newgard CB. 2012. Interplay between lipids and branched-chain amino acids in development of insulin resistance. Cell Metab. 15(5):606–614.
  • Onakpoya IJ, Perry R, Zhang J, Ernst E. 2011. Efficacy of calcium supplementation for management of overweight and obesity: systematic review of randomized clinical trials. Nutr Rev. 69(6):335–343.
  • Palacios C, Bertran JJ, Rios RE, Soltero S. 2011. No effects of low and high consumption of dairy products and calcium supplements on body composition and serum lipids in Puerto Rican obese adults. Nutrition. 27(5):520–525.
  • Parikh SJ, Yanovski JA. 2003. Calcium intake and adiposity. Am J Clin Nutr. 77(2):281–287.
  • Pearce N. 2011. Epidemiology in a changing world: variation, causation and ubiquitous risk factors. Int J Epidemiol. 40(2):503–512.
  • Pereira MA, Jacobs DR, Jr., Van Horn L, Slattery ML, Kartashov AI, Ludwig DS. 2002. Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA. 287(16):2081–2089.
  • Reid IR, Ames R, Mason B, Bolland MJ, Bacon CJ, Reid HE, Kyle C, Gamble GD, Grey A, Horne A. 2010. Effects of calcium supplementation on lipids, blood pressure, and body composition in healthy older men: a randomized controlled trial. Am J Clin Nutr. 91(1):131–139.
  • Rohatgi A. 2017. WebPlotDigitizer [Internet]. Austin, Texas, USA.
  • Rosado JL, Garcia OP, Ronquillo D, Hervert-Hernández D, Caamaño MDC, Martínez G, Gutiérrez J, García S. 2011. Intake of milk with added micronutrients increases the effectiveness of an energy-restricted diet to reduce body weight: a randomized controlled clinical trial in Mexican women. J Am Diet Assoc. 111(10):1507–1516.
  • Rucker G, Cates CJ, Schwarzer G. 2017. Methods for including information from multi-arm trials in pairwise meta-analysis. Res Synth Methods. 8(4):392–403.
  • Ruiz-Canela M, Toledo E, Clish CB, Hruby A, Liang L, Salas-Salvadó J, Razquin C, Corella D, Estruch R, Ros E, et al. 2016. Plasma branched-chain amino acids and incident cardiovascular disease in the PREDIMED Trial. Clin Chem. 62(4):582–592.
  • Rural Development Administration NRRDI 2006. Food composition table, 7th ed. Suwon, Korea.
  • Shahkhalili Y, Murset C, Meirim I, Duruz E, Guinchard S, Cavadini C, Acheson K. 2001. Calcium supplementation of chocolate: effect on cocoa butter digestibility and blood lipids in humans. Am J Clin Nutr. 73(2):246–252.
  • Shalileh M, Shidfar F, Haghani H, Eghtesadi S, Heydari I. 2010. The influence of calcium supplement on body composition, weight loss and insulin resistance in obese adults receiving low calorie diet. J Res Med Sci. 15(4):191–201.
  • Shi H, Dirienzo D, Zemel MB. 2001. Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy-restricted aP2-agouti transgenic mice. Faseb J. 15(2):291–293.
  • Smilowitz JT, Wiest MM, Teegarden D, Zemel MB, German JB, Van Loan MD. 2011. Dietary fat and not calcium supplementation or dairy product consumption is associated with changes in anthropometrics during a randomized, placebo-controlled energy-restriction trial. Nutr Metab (Lond)). 8(1):67.
  • Stancliffe RA, Thorpe T, Zemel MB. 2011. Dairy attentuates oxidative and inflammatory stress in metabolic syndrome. Am J Clin Nutr. 94(2):422–430.
  • Stonehouse W, Wycherley T, Luscombe-Marsh N, Taylor P, Brinkworth G, Riley M. 2016. Dairy Intake Enhances Body Weight and Composition Changes during Energy Restriction in 18-50-Year-Old Adults-A Meta-Analysis of Randomized Controlled Trials. Nutrients. 8(7):394.
  • Subih HS, Zueter Z, Obeidat BM, Al-Qudah MA, Janakat S, Hammoh F, Sharkas G, Bawadi HA. 2018. A high weekly dose of cholecalciferol and calcium supplement enhances weight loss and improves health biomarkers in obese women. Nutr Res. 59:53–64.
  • Sun X, Zemel MB. 2004. Role of uncoupling protein 2 (UCP2) expression and 1alpha, 25-dihydroxyvitamin D3 in modulating adipocyte apoptosis. FASEB J. 18(12):1430–1432.
  • Tanaka S, Uenishi K, Ishida H, Takami Y, Hosoi T, Kadowaki T, Orimo H, Ohashi Y. 2014. A randomized intervention trial of 24-wk dairy consumption on waist circumference, blood pressure, and fasting blood sugar and lipids in Japanese men with metabolic syndrome. Journal of Nutritional Science and Vitaminology J Nutr Sci Vitaminol. 60(5):305–312.
  • Thomas DT, Wideman L, Lovelady CA. 2010. Effects of calcium and resistance exercise on body composition in overweight premenopausal women. J Am Coll Nutr. 29(6):604–611.
  • Torres MR, Sanjuliani AF. 2013. Effects of weight loss from a high-calcium energy-reduced diet on biomarkers of inflammatory stress, fibrinolysis, and endothelial function in obese subjects. Nutrition. 29(1):143–151.
  • Trowman R, Dumville JC, Hahn S, Torgerson DJ. 2006. A systematic review of the effects of calcium supplementation on body weight. Br J Nutr. 95(6):1033–1038.
  • US Department of Health and Human Services. 2008. Guidance for Industry: Recommendations for clinical evaluation.
  • Van Loan MD, Keim NL, Adams SH, Souza E, Woodhouse LR, Thomas A, Witbracht M, Gertz ER, Piccolo B, Bremer AA, et al. 2011. Dairy Foods in a moderate energy restricted diet do not enhance central fat, weight, and intra-abdominal adipose tissue losses nor reduce adipocyte size or inflammatory markers in overweight and obese adults: a controlled feeding Study. J Obes. 2011:989657.
  • Varenna M, Binelli L, Casari S, Zucchi F, Sinigaglia L. 2007. Effects of dietary calcium intake on body weight and prevalence of osteoporosis in early postmenopausal women. Am J Clin Nutr. 86(3):639–644.
  • Welberg JW, Monkelbaan JF, de Vries EG, Muskiet FA, Cats A, Oremus ET, Boersma-van Ek W, van Rijsbergen H, van der Meer R, Mulder NH. 1994. Effects of supplemental dietary calcium on quantitative and qualitative fecal fat excretion in man. Ann Nutr Metab. 38(4):185–191.
  • Wennersberg MH, Smedman A, Turpeinen AM, Retterstol K, Tengblad S, Lipre E, Aro A, Mutanen P, Seljeflot I, Basu S, et al. 2009. Dairy products and metabolic effects in overweight men and women: results from a 6-mo intervention study. Am J Clin Nutr. 90(4):960–968.
  • WHO 2020. Obesity and overweight (Fact sheet No. 311). Geneva, Switzerland: World Health Organization.
  • Xue B, Greenberg AG, Kraemer FB, Zemel MB. 2001. Mechanism of intracellular calcium ([Ca2+]i) inhibition of lipolysis in human adipocytes. Faseb J. 15(13):2527–2529.
  • Xue B, Moustaid N, Wilkison WO, Zemel MB. 1998. The agouti gene product inhibits lipolysis in human adipocytes via a Ca2+-dependent mechanism. FASEB J. 12(13):1391–1396.
  • Yanovski JA, Parikh SJ, Yanoff LB, Denkinger BI, Calis KA, Reynolds JC, Sebring NG, McHugh T. 2009. Effects of calcium supplementation on body weight and adiposity in overweight and obese adults: a randomized trial. Ann Intern Med. 150(12):821–829. W145-6.
  • Zemel MB. 1998. Nutritional and endocrine modulation of intracellular calcium: implications in obesity, insulin resistance and hypertension. Mol Cell Biochem. 188(1-2):129–136.
  • Zemel MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E. 2005. Dairy augmentation of total and central fat loss in obese subjects. Int J Obes. 29(4):391–397.
  • Zemel MB, Shi H, Greer B, Dirienzo D, Zemel PC. 2000. Regulation of adiposity by dietary calcium. FASEB J. 14(9):1132–1138.
  • Zemel MS, Geng X. 2001. Effects of calcium-fortified breakfast cereal on adiposity in a transgenic mice. Faseb J. 15:A598. [Abstract 480.7].
  • Zemel MT, Zemel P, et al. 2002. Dietary calcium and dairy products accelerate weight and fat loss during energy restriction in obese adults. Am J Clin Nutr. 75 (Suppl):342S.
  • Zhou J, Zhao LJ, Watson P, Zhang Q, Lappe JM. 2010. The effect of calcium and vitamin D supplementation on obesity in postmenopausal women: secondary analysis for a large-scale, placebo controlled, double-blind, 4-year longitudinal clinical trial. Nutr Metab (Lond)). 7(1):62.
  • Zhu W, Cai D, Wang Y, Lin N, Hu Q, Qi Y, Ma S, Amarasekara S. 2013. Calcium plus vitamin D3 supplementation facilitated fat loss in overweight and obese college students with very-low calcium consumption: a randomized controlled trial. Nutr J. 12(1):8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.