Ginger for treating nausea and vomiting: an overview of systematic reviews and meta-analyses

References

• Adel N. 2017. Overview of chemotherapy-induced nausea and vomiting and evidence-based therapies. Am J Manag Care. 23(14 Suppl):S259–S265.
   PubMedGoogle Scholar
• Al Kury LT, Mahgoub M, Howarth FC, Oz M. 2018. Natural negative allosteric modulators of 5-HT3 receptors. Molecules. 23(12):3186. doi: 10.3390/molecules23123186.
   PubMed Web of Science ®Google Scholar
• Arruda APN, Zhang Y, Gomaa H, Bergamaschi CdC, Guimaraes CC, Righesso LAR, Paglia MDG, Barberato-Filho S, Lopes LC, Ayala Melendez AP, et al. 2019. Herbal medications for anxiety, depression, pain, nausea and vomiting related to preoperative surgical patients: a systematic review and meta-analysis of randomised controlled trials. BMJ Open. 9(5):e023729. doi: 10.1136/bmjopen-2018-023729.
   PubMed Web of Science ®Google Scholar
• Atkins D, Best D, Briss PA, Eccles M, Falck-Ytter Y, Flottorp S, Guyatt GH, Harbour RT, Haugh MC, Henry D, et al. 2004. Grading quality of evidence and strength of recommendations. BMJ. 328(7454):1490. doi: 10.1136/bmj.328.7454.1490.
   PubMed Web of Science ®Google Scholar
• Baliga MS, Haniadka R, Pereira MM, D’Souza JJ, Pallaty PL, Bhat HP, Popuri S. 2011. Update on the chemopreventive effects of ginger and its phytochemicals. Crit Rev Food Sci Nutr. 51(6):499–523.,. doi: 10.1080/10408391003698669.
   PubMed Web of Science ®Google Scholar
• Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, Leeprakobboon K, Leelasettagool C. 2006. The efficacy of ginger for the prevention of postoperative nausea and vomiting: a meta-analysis. Am J Obstet Gynecol. 194(1):95–99. doi: 10.1016/j.ajog.2005.06.046.
   PubMed Web of Science ®Google Scholar
• Chang WP, Peng YX. 2019. Does the oral administration of ginger reduce chemotherapy-induced nausea and vomiting?: a meta-analysis of 10 randomized controlled trials. Cancer Nurs. 42(6):E14–E23. doi: 10.1097/NCC.0000000000000648.
   PubMed Web of Science ®Google Scholar
• Cheng Q, Feng X, Meng Q, Li Y, Chen S, Wang G, Nie K. 2020. [6]-Gingerol ameliorates cisplatin-induced pica by regulating the TPH/MAO-A/SERT/5-HT/5-HT receptor system in rats. Drug Des Devel Ther. 14:4085–4099. doi: 10.2147/DDDT.S270185.
   PubMed Web of Science ®Google Scholar
• Choi J, Lee J, Kim K, Choi H-K, Lee S-A, Lee H-J. 2022. Effects of ginger intake on chemotherapy-induced nausea and vomiting: a systematic review of randomized clinical trials. Nutrients. 14(23):4982. doi: 10.3390/nu14234982.
   PubMed Web of Science ®Google Scholar
• Crichton M, Marshall S, Marx W, McCarthy AL, Isenring E. 2019. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: a systematic review update and meta-analysis. J Acad Nutr Diet. 119(12):2055–2068. doi: 10.1016/j.jand.2019.06.009.
   PubMed Web of Science ®Google Scholar
• Dewinter G, Staelens W, Veef E, Teunkens A, Van de Velde M, Rex S. 2018. Simplified algorithm for the prevention of postoperative nausea and vomiting: a before-and-after study. Br J Anaesth. 120(1):156–163. doi: 10.1016/j.bja.2017.08.003.
   PubMed Web of Science ®Google Scholar
• Fabbri A, Parker L, Colombo C, Mosconi P, Barbara G, Frattaruolo MP, Lau E, Kroeger CM, Lunny C, Salzwedel DM, et al. 2020. Industry funding of patient and health consumer organisations: systematic review with meta-analysis. BMJ. 368:l6925. doi: 10.1136/bmj.l6925.
   PubMedGoogle Scholar
• Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM. 2019. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat Rev Dis Primers. 5(1):62. doi: 10.1038/s41572-019-0110-3.
   PubMed Web of Science ®Google Scholar
• Gaur R, Mudgal SK, Kalyani V, Athira B, Kaur N, Rulaniya S, et al. 2022. Ginger vs vitamin B6 for treating nausea and vomiting during pregnancy: a systematic review and meta-analysis. J SAFOG. 14(2):210–217. doi: 10.5005/jp-journals-10006-2040.
   Google Scholar
• Ghayur MN, Gilani AH. 2005. Pharmacological basis for the medicinal use of ginger in gastrointestinal disorders. Dig Dis Sci. 50(10):1889–1897. doi: 10.1007/s10620-005-2957-2.
   PubMed Web of Science ®Google Scholar
• Giacosa A, Morazzoni P, Bombardelli E, Riva A, Bianchi Porro G, Rondanelli M. 2015. Can nausea and vomiting be treated with ginger extract? Eur Rev Med Pharmacol Sci. 19:1291–1296.
   PubMed Web of Science ®Google Scholar
• Gonlachanvit S, Chen YH, Hasler WL, Sun WM, Owyang C. 2003. Ginger reduces hyperglycemia-evoked gastric dysrhythmias in healthy humans: possible role of endogenous prostaglandins. J Pharmacol Exp Ther. 307(3):1098–1103. doi: 10.1124/jpet.103.053421.
   PubMed Web of Science ®Google Scholar
• Gress K, Urits I, Viswanath O, Urman RD. 2020. Clinical and economic burden of postoperative nausea and vomiting: analysis of existing cost data. Best Pract Res Clin Anaesthesiol. 34(4):681–686. doi: 10.1016/j.bpa.2020.07.003.
   PubMed Web of Science ®Google Scholar
• Griffiths JD, Gyte GM, Popham PA, Williams K, Paranjothy S, Broughton HK, Brown HC, Thomas J. 2021. Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section. Cochrane Database Syst Rev. 5(5):Cd007579. doi: 10.1002/14651858.CD007579.pub3.
   PubMedGoogle Scholar
• Heckroth M, Luckett RT, Moser C, Parajuli D, Abell TL. 2021. Nausea and vomiting in 2021: a comprehensive update. J Clin Gastroenterol. 55(4):279–299. doi: 10.1097/MCG.0000000000001485.
   PubMed Web of Science ®Google Scholar
• Ho KY, Lam KKW, Chung JOK, Xia W, Cheung AT, Ho LK, Chiu SY, Chan GCF, Li HCW. 2019. Systematic review of the effectiveness of complementary and alternative medicine on nausea and vomiting in children with cancer: a study protocol. BMJ Open. 9(10):e031834. doi: 10.1136/bmjopen-2019-031834.
   PubMed Web of Science ®Google Scholar
• Hu Y, Amoah AN, Zhang H, Fu R, Qiu Y, Cao Y, Sun Y, Chen H, Liu Y, Lyu Q, et al. 2022. Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis. J Matern Fetal Neona. 35(1):187–196. doi: 10.1080/14767058.2020.1712714.
   PubMed Web of Science ®Google Scholar
• Hunt H, Pollock A, Campbell P, Estcourt L, Brunton G. 2018. An introduction to overviews of reviews: planning a relevant research question and objective for an overview. Syst Rev. 7(1):39. doi: 10.1186/s13643-018-0695-8.
   PubMed Web of Science ®Google Scholar
• Kalava A, Darji SJ, Kalstein A, Yarmush JM, SchianodiCola J, Weinberg J. 2013. Efficacy of ginger on intraoperative and postoperative nausea and vomiting in elective cesarean section patients. Eur J Obstet Gynecol Reprod Biol. 169(2):184–188. doi: 10.1016/j.ejogrb.2013.02.014.
   PubMed Web of Science ®Google Scholar
• Kim S-D, Kwag E-B, Yang M-X, Yoo H-S. 2022. Efficacy and safety of ginger on the side effects of chemotherapy in breast cancer patients: systematic review and meta-analysis. Int J Mol Sci. 23(19):11267. doi: 10.3390/ijms231911267.
   PubMed Web of Science ®Google Scholar
• Lacy BE, Parkman HP, Camilleri M. 2018. Chronic nausea and vomiting: evaluation and treatment. Am J Gastroenterol. 113(5):647–659. doi: 10.1038/s41395-018-0039-2.
   PubMed Web of Science ®Google Scholar
• Lete I, Allué J. 2016. The effectiveness of ginger in the prevention of nausea and vomiting during pregnancy and chemotherapy. Integr Med Insights. 11:11–17. doi: 10.4137/IMI.S36273.
   PubMedGoogle Scholar
• Lohning AE, Marx W, Isenring L. 2016. In silico investigation into the interactions between murine 5-HT3 receptor and the principle active compounds of ginger (Zingiber officinale). J Mol Graph Model. 70:315–327. doi: 10.1016/j.jmgm.2016.10.008.
   PubMed Web of Science ®Google Scholar
• Lu C, Chen X, Yan X, He J, Nie Z. 2022. The preventive and relieving effects of ginger on postoperative nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials. Int J Nurs Stud. 125:104094. doi: 10.1016/j.ijnurstu.2021.104094.
   PubMed Web of Science ®Google Scholar
• Lu T-T, Lu C-C, Li M-X, Ke L-X, Cai H, Yang K-H. 2022. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: a methodological investigation with evidence map. J Integr Med. 20(3):213–220. doi: 10.1016/j.joim.2022.02.003.
   PubMedGoogle Scholar
• Ma Z-J, Wang H-J, Ma X-J, Li Y, Yang H-J, Li H, Su J-R, Zhang C-E, Huang L-Q. 2020. Modulation of gut microbiota and intestinal barrier function during alleviation of antibiotic-associated diarrhea with Rhizoma Zingiber officinale (Ginger) extract. Food Funct. 11(12):10839–10851. doi: 10.1039/d0fo01536a.
   PubMed Web of Science ®Google Scholar
• Marx W, Ried K, McCarthy AL, Vitetta L, Sali A, McKavanagh D, Isenring L. 2017. Ginger-Mechanism of action in chemotherapy-induced nausea and vomiting: a review. Crit Rev Food Sci Nutr. 57(1):141–146. doi: 10.1080/10408398.2013.865590.
   PubMed Web of Science ®Google Scholar
• Micklefield GH, Redeker Y, Meister V, Jung O, Greving I, May B. 1999. Effects of ginger on gastroduodenal motility. Int J Clin Pharmacol Ther. 37(7):341–346.
   PubMed Web of Science ®Google Scholar
• Moher D, Hopewell S, Schulz KF, Montori V, Gøtzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG. 2010. CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. BMJ. 340(mar23 1):c869–c869. doi: 10.1136/bmj.c869.
   PubMed Web of Science ®Google Scholar
• Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. 2009. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 339(jul21 1):b2535–b2535. doi: 10.1136/bmj.b2535.
   PubMed Web of Science ®Google Scholar
• Napadow V, Sheehan JD, Kim J, Lacount LT, Park K, Kaptchuk TJ, Rosen BR, Kuo B. 2013. The brain circuitry underlying the temporal evolution of nausea in humans. Cereb Cortex. 23(4):806–813. doi: 10.1093/cercor/bhs073.
   PubMed Web of Science ®Google Scholar
• Navari RM, Aapro M. 2016. Antiemetic prophylaxis for chemotherapy-induced nausea and vomiting. N Engl J Med. 374(14):1356–1367. doi: 10.1056/NEJMra1515442.
   PubMed Web of Science ®Google Scholar
• Ng TL, Hutton B, Clemons M. 2015. Chemotherapy-induced nausea and vomiting: time for more emphasis on nausea? Oncologist. 20(6):576–583. doi: 10.1634/theoncologist.2014-0438.
   PubMed Web of Science ®Google Scholar
• Nicholson BD. 2017. Economic and clinical burden of opioid-induced nausea and vomiting. Postgrad Med. 129(1):111–117. doi: 10.1080/00325481.2017.1243004.
   PubMed Web of Science ®Google Scholar
• Palatty PL, Haniadka R, Valder B, Arora R, Baliga MS. 2013. Ginger in the prevention of nausea and vomiting: a review. Crit Rev Food Sci Nutr. 53(7):659–669. doi: 10.1080/10408398.2011.553751.
   PubMed Web of Science ®Google Scholar
• Pieper D, Antoine S-L, Mathes T, Neugebauer EAM, Eikermann M. 2014. Systematic review finds overlapping reviews were not mentioned in every other overview. J Clin Epidemiol. 67(4):368–375. doi: 10.1016/j.jclinepi.2013.11.007.
   PubMed Web of Science ®Google Scholar
• Pollock M, Fernandes RM, Newton AS, Scott SD, Hartling L. 2019. A decision tool to help researchers make decisions about including systematic reviews in overviews of reviews of healthcare interventions. Syst Rev. 8(1):29. doi: 10.1186/s13643-018-0768-8.
   PubMedGoogle Scholar
• Qiu L, Cai J, Mei A, Wang X, Zhou Z, Sun J. 2023. Predictors of postoperative nausea and vomiting after same-day surgery: a retrospective study. Clin Ther. 45(3):210–217. doi: 10.1016/j.clinthera.2023.01.013.
   PubMed Web of Science ®Google Scholar
• Qiu X, Wang C. 2016. Literature searches in the conduct of systematic reviews and evaluations. Shanghai Arch Psychiatry. 28(3):154–159. doi: 10.11919/j.issn.1002-0829.215008.
   PubMedGoogle Scholar
• Razvi Y, Chan S, McFarlane T, McKenzie E, Zaki P, DeAngelis C, Pidduck W, Bushehri A, Chow E, Jerzak KJ, et al. 2019. ASCO, NCCN, MASCC/ESMO: a comparison of antiemetic guidelines for the treatment of chemotherapy-induced nausea and vomiting in adult patients. Support Care Cancer. 27(1):87–95. doi: 10.1007/s00520-018-4464-y.
   PubMed Web of Science ®Google Scholar
• Schulz KF, Altman DG, Moher D; CONSORT Group. 2010. CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med. 152(11):726–732. doi: 10.7326/0003-4819-152-11-201006010-00232.
   PubMed Web of Science ®Google Scholar
• Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, Moher D, Tugwell P, Welch V, Kristjansson E, et al. 2017. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 358:j4008. doi: 10.1136/bmj.j4008.
   PubMed Web of Science ®Google Scholar
• Sun X, Zhou X, Yu Y, Liu H. 2018. Exploring reporting quality of systematic reviews and Meta-analyses on nursing interventions in patients with Alzheimer’s disease before and after PRISMA introduction. BMC Med Res Methodol. 18(1):154. doi: 10.1186/s12874-018-0622-7.
   PubMedGoogle Scholar
• Tan M-Y, Shu S-H, Liu R-L, Zhao Q. 2023. The efficacy and safety of complementary and alternative medicine in the treatment of nausea and vomiting during pregnancy: a systematic review and meta-analysis. Front Public Health. 11:1108756. doi: 10.3389/fpubh.2023.1108756.
   PubMed Web of Science ®Google Scholar
• Thomson M, Corbin R, Leung L. 2014. Effects of ginger for nausea and vomiting in early pregnancy: a meta-analysis. J Am Board Fam Med. 27(1):115–122. doi: 10.3122/jabfm.2014.01.130167.
   PubMed Web of Science ®Google Scholar
• Tian L, Qian W, Qian Q, Zhang W, Cai X. 2020. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 74(2):353–370. doi: 10.1007/s11418-019-01372-x.
   PubMed Web of Science ®Google Scholar
• Tóth B, Lantos T, Hegyi P, Viola R, Vasas A, Benkő R, Gyöngyi Z, Vincze Á, Csécsei P, Mikó A, et al. 2018. Ginger (Zingiber officinale): an alternative for the prevention of postoperative nausea and vomiting. A meta-analysis. Phytomedicine. 50:8–18. doi: 10.1016/j.phymed.2018.09.007.
   PubMed Web of Science ®Google Scholar
• Viljoen E, Visser J, Koen N, Musekiwa A. 2014. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting. Nutr J. 13(1):20. doi: 10.1186/1475-2891-13-20.
   PubMedGoogle Scholar
• Wang P, Wang R, Zhu Y, Sang S. 2017. Interindividual variability in metabolism of [6]-shogaol by gut microbiota. J Agric Food Chem. 65(44):9618–9625. doi: 10.1021/acs.jafc.7b02850.
   PubMed Web of Science ®Google Scholar
• Xie R, Xia Y, Chen Y, Li H, Shang H, Kuang X, Xia L, Guo Y. 2020. The RIGHT Extension Statement for Traditional Chinese Medicine: development, recommendations, and explanation. Pharmacol Res. 160:105178. doi: 10.1016/j.phrs.2020.105178.
   PubMed Web of Science ®Google Scholar
• Zhang X, Tan R, Lam WC, Yao L, Wang X, Cheng CW, Liu F, Chan JC, Aixinjueluo Q, Lau CT, et al. 2020. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Extension for Chinese Herbal Medicines 2020 (PRISMA-CHM 2020). Am J Chin Med. 48(6):1279–1313. doi: 10.1142/S0192415X20500639.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhao R, Wang D, Wang L, Zhang Q, Wei S, Lu F, Peng W, Wu C. 2021. Ginger (Zingiber officinale Rosc.) and its bioactive components are potential resources for health beneficial agents. Phytother Res. 35(2):711–742. doi: 10.1002/ptr.6858.
   PubMed Web of Science ®Google Scholar
• Zhu W, Dai Y, Huang M, Li J. 2021. Efficacy of ginger in preventing postoperative nausea and vomiting: a systematic review and meta-analysis. J Nurs Scholarsh. 53(6):671–679. doi: 10.1111/jnu.12691.
   PubMed Web of Science ®Google Scholar