Physical activity is associated with neuromuscular and physical function in patients with multiple sclerosis independent of disease severity

References

• Thompson AJ, Baranzini SE, Geurts J, et al. Multiple sclerosis. Lancet. 2018;391:1622–1636.
   PubMed Web of Science ®Google Scholar
• Rocca MA, Battaglini M, Benedict RH, et al. Brain MRI atrophy quantification in MS: from methods to clinical application. Neurology. 2017;88:403–413.
   PubMed Web of Science ®Google Scholar
• Scott SM, Hughes AR, Galloway SD, et al. Surface EMG characteristics of people with multiple sclerosis during static contractions of the knee extensors. Clin Physiol Funct Imaging. 2011;31:11–17.
   PubMed Web of Science ®Google Scholar
• Larson RD, McCully KK, Larson DJ, et al. Bilateral differences in lower-limb performance in individuals with multiple sclerosis. J Rehabil Res Dev. 2013;50:215–222.
   PubMedGoogle Scholar
• Wens I, Dalgas U, Vandenabeele F, et al. Multiple sclerosis affects skeletal muscle characteristics. PLoS One. 2014;9:e108158.
   PubMed Web of Science ®Google Scholar
• Jorgensen M, Dalgas U, Wens I, et al. Muscle strength and power in persons with multiple sclerosis – a systematic review and meta-analysis. J Neurol Sci. 2017;376:225–241.
   PubMed Web of Science ®Google Scholar
• Broekmans T, Gijbels D, Eijnde BO, et al. The relationship between upper leg muscle strength and walking capacity in persons with multiple sclerosis. Mult Scler. 2013;19:112–119.
   PubMed Web of Science ®Google Scholar
• Sandroff BM, Sosnoff JJ, Motl RW. Physical fitness, walking performance, and gait in multiple sclerosis. J Neurol Sci. 2013;328:70–76.
   PubMed Web of Science ®Google Scholar
• Kjolhede T, Vissing K, Langeskov-Christensen D, et al. Relationship between muscle strength parameters and functional capacity in persons with mild to moderate degree multiple sclerosis. Mult Scler Relat Disord. 2015;4:151–158.
   PubMed Web of Science ®Google Scholar
• Hobart J, Lamping D, Fitzpatrick R, et al. The multiple sclerosis impact scale (MSIS-29): a new patient-based outcome measure. Brain. 2001;124:962–973.
   PubMed Web of Science ®Google Scholar
• Goldman MD, Marrie RA, Cohen JA. Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls. Mult Scler. 2008;14:383–390.
   PubMed Web of Science ®Google Scholar
• Kalron A, Achiron A, Dvir Z. Muscular and gait abnormalities in persons with early onset multiple sclerosis. J Neurol Phys Ther. 2011;35:164–169.
   PubMed Web of Science ®Google Scholar
• Burschka JM, Keune PM, Menge U, et al. An exploration of impaired walking dynamics and fatigue in multiple sclerosis. BMC Neurol. 2012;12:161.
   PubMed Web of Science ®Google Scholar
• Bethoux F. Gait disorders in multiple sclerosis. Continuum. 2013;19:1007–1022.
   PubMedGoogle Scholar
• Giovannoni G, Butzkueven H, Dhib-Jalbut S, et al. Brain health: time matters in multiple sclerosis. Mult Scler Relat Disord. 2016;9 Suppl 1:S5–S48.
   PubMed Web of Science ®Google Scholar
• Latimer-Cheung AE, Pilutti LA, Hicks AL, et al. Effects of exercise training on fitness, mobility, fatigue, and health-related quality of life among adults with multiple sclerosis: a systematic review to inform guideline development. Arch Phys Med Rehabil. 2013;94:1800–1828.
   PubMed Web of Science ®Google Scholar
• Dalgas U, Stenager E. Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis? Ther Adv Neurol Disord. 2012;5:81–95.
   PubMed Web of Science ®Google Scholar
• Sandroff BM, Klaren RE, Pilutti LA, et al. Randomized controlled trial of physical activity, cognition, and walking in multiple sclerosis. J Neurol. 2014;261:363–372.
   PubMed Web of Science ®Google Scholar
• Kinnett-Hopkins D, Adamson B, Rougeau K, et al. People with MS are less physically active than healthy controls but as active as those with other chronic diseases: an updated meta-analysis. Mult Scler Relat Disord. 2017;13:38–43.
   PubMed Web of Science ®Google Scholar
• Casey B, Coote S, Galvin R, et al. Objective physical activity levels in people with multiple sclerosis: meta-analysis. Scand J Med Sci Sports. 2018;28:1960–1969.
   PubMed Web of Science ®Google Scholar
• Klaren RE, Motl RW, Dlugonski D, et al. Objectively quantified physical activity in persons with multiple sclerosis. Arch Phys Med Rehabil. 2013;94:2342–2348.
   PubMed Web of Science ®Google Scholar
• Streber R, Peters S, Pfeifer K. Systematic review of correlates and determinants of physical activity in persons with multiple sclerosis. Arch Phys Med Rehabil. 2016;97:633–645.
   PubMed Web of Science ®Google Scholar
• Gijbels D, Alders G, Van Hoof E, et al. Predicting habitual walking performance in multiple sclerosis: relevance of capacity and self-report measures. Mult Scler. 2010;16:618–626.
   PubMed Web of Science ®Google Scholar
• Sandroff BM, Dlugonski D, Pilutti LA, et al. Physical activity is associated with cognitive processing speed in persons with multiple sclerosis. Mult Scler Relat Disord. 2014;3:123–128.
   PubMed Web of Science ®Google Scholar
• Kahraman T, Savci S, Coskuner-Poyraz E, et al. Determinants of physical activity in minimally impaired people with multiple sclerosis. Clin Neurol Neurosurg. 2015;138:20–24.
   PubMed Web of Science ®Google Scholar
• Ketelhut NB, Kindred JH, Pimentel RE, et al. Functional factors that are important correlates to physical activity in people with multiple sclerosis: a pilot study. Disabil Rehabil. 2018;40:2416–2423.
   PubMed Web of Science ®Google Scholar
• Cederberg KL, Motl RW, McAuley E. Physical activity, sedentary behavior, and physical function in older adults with multiple sclerosis. J Aging Phys Act. 2018;26:177–182.
   PubMed Web of Science ®Google Scholar
• McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001;50:121–127.
   PubMed Web of Science ®Google Scholar
• Møller AB, Bibby BM, Skjerbæk AG, et al. Validity and variability of the 5-repetition sit-to-stand test in patients with multiple sclerosis. Disabil Rehabil. 2012;34:2251–2258.
   PubMed Web of Science ®Google Scholar
• Kieseier BC, Pozzilli C. Assessing walking disability in multiple sclerosis. Mult Scler. 2012;18:914–924.
   PubMed Web of Science ®Google Scholar
• Light KE, Bebrman AL, Thigpen M, et al. The 2-minute walk test: a tool for evaluating walking endurance in clients with Parkinson's disease. J Neurol Phys Ther. 1997;21:136–139.
   Google Scholar
• Gijbels D, Eijnde BO, Feys P. Comparison of the 2- and 6-minute walk test in multiple sclerosis. Mult Scler. 2011;17:1269–1272.
   PubMed Web of Science ®Google Scholar
• Jaric S. Muscle strength testing: use of normalisation for body size. Sports Med. 2002;32:615–631.
   PubMed Web of Science ®Google Scholar
• Maffiuletti NA, Aagaard P, Blazevich AJ, et al. Rate of force development: physiological and methodological considerations. Eur J Appl Physiol. 2016;116:1091–1116.
   PubMed Web of Science ®Google Scholar
• Schneller MB, Bentsen P, Nielsen G, et al. Measuring children's physical activity: compliance using skin-taped accelerometers. Med Sci Sports Exerc. 2017;49:1261–1269.
   PubMed Web of Science ®Google Scholar
• Sandroff BM, Klaren RE, Motl RW. Relationships among physical inactivity, deconditioning, and walking impairment in persons with multiple sclerosis. J Neurol Phys Ther. 2015;39:103–110.
   PubMed Web of Science ®Google Scholar
• Sandroff BM, Riskin BJ, Agiovlasitis S, et al. Accelerometer cut-points derived during over-ground walking in persons with mild, moderate, and severe multiple sclerosis. J Neurol Sci. 2014;340:50–57.
   PubMed Web of Science ®Google Scholar
• Langeskov-Christensen D, Feys P, Baert I, et al. Performed and perceived walking ability in relation to the expanded disability status scale in persons with multiple sclerosis. J Neurol Sci. 2017;382:131–136.
   PubMed Web of Science ®Google Scholar