A scoping review of current non-pharmacological treatment modalities for phantom limb pain in limb amputees

References

• Moura VL, Faurot KR, Gaylord SA, et al. Mind-body interventions for treatment of phantom limb pain in persons with amputation. Am J Phys Med Rehabil. 2012;91(8):701–714.
   PubMed Web of Science ®Google Scholar
• Padovani MT, Martins MR, Venancio A, et al. Anxiety, depression and quality of life in individuals with phantom limb pain. Acta Ortop Bras. 2015;23(2):107–110.
   PubMed Web of Science ®Google Scholar
• Collins KL, Russell HG, Schumacher PJ, et al. A review of current theories and treatments for phantom limb pain. J Clin Invest. 2018;128(6):2168–2176.
   PubMed Web of Science ®Google Scholar
• Subedi B, Grossberg GT. Phantom limb pain: mechanisms and treatment approaches. Pain Res Treat. 2011;2011:864605.
   PubMedGoogle Scholar
• O’Connor AB, Dworkin RH. Treatment of neuropathic pain: an overview of recent guidelines. Am J Med. 2009;122(10 Suppl):S22–S32.
   PubMed Web of Science ®Google Scholar
• Othman R, Mani R, Krishnamurthy I, Jayakaran P. Non-pharmacological management of phantom limb pain in lower limb amputation: a systematic review. Phys Therapy Rev. 2018;23:1–11.
   Web of Science ®Google Scholar
• Aternali A, Katz J. Recent advances in understanding and managing phantom limb pain. F1000Res. 2019;8:1167. DOI:10.12688/f1000research.19355.1.
   Google Scholar
• Richardson C, Kulkarni J. A review of the management of phantom limb pain: challenges and solutions. J Pain Res. 2017;10:1861–1870.
   PubMed Web of Science ®Google Scholar
• Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018;169(7):467–473.
   PubMed Web of Science ®Google Scholar
• Ramachandran VS, Rogers-Ramachandran D. Synaesthesia in phantom limbs induced with mirrors. Proc Biol Sci. 1996;263(1369):377–386.
   PubMed Web of Science ®Google Scholar
• Peterzell D, Rutledge L, Cone R, et al. A tripartite (triple-reflection) mirror as a rehabilitative technology for the relief of upper phantom limb pain: case studies and phenomena in non-amputees. J Pain. 2011;12:P75.
   Google Scholar
• Wilcher DG, Chernev I, Yan K. Combined mirror visual and auditory feedback therapy for upper limb phantom pain: a case report. J Med Case Rep. 2011;5:41–45.
   PubMedGoogle Scholar
• Tilak M, Isaac SA, Fletcher J, et al. Mirror therapy and transcutaneous electrical nerve stimulation for management of phantom limb pain in amputees - a single blinded randomized controlled trial. Physiother Res Int. 2016;21(2):109–115.
   PubMed Web of Science ®Google Scholar
• Darnall BD. Self-delivered home-based mirror therapy for lower limb phantom pain. Am J Phys Med Rehabil. 2009;88(1):78–81. Available from: https://www.ncbi.nlm.nih.gov/pubmed/19096290.
   PubMed Web of Science ®Google Scholar
• Mcavinue LP, Robertson IH. Individual differences in response to phantom limb movement therapy. Disabil Rehabil. 2011;33(23–24):2186–2195.
   PubMed Web of Science ®Google Scholar
• Darnall BD, Li H. Home-based self-delivered mirror therapy for phantom pain: a pilot study. J Rehabil Med. 2012;44(3):254–260.
   PubMed Web of Science ®Google Scholar
• Foell J, Bekrater-Bodmann R, Diers M, et al. Mirror therapy for phantom limb pain: brain changes and the role of body representation. Eur J Pain. 2014;18(5):729–739.
   PubMed Web of Science ®Google Scholar
• Moseley GL. Graded motor imagery for pathologic pain: a randomized controlled trial. Neurology. 2006;67(12):2129–2134.
   PubMed Web of Science ®Google Scholar
• Brunelli S, Morone G, Iosa M, et al. Efficacy of progressive muscle relaxation, mental imagery, and phantom exercise training on phantom limb: a randomized controlled trial. Arch Phys Med Rehabil. 2015;96(2):181–187.
   PubMed Web of Science ®Google Scholar
• Beaumont G, Mercier C, Michon PE, et al. Decreasing phantom limb pain through observation of action and imagery: a case series. Pain Med. 2011;12(2):289–299.
   PubMed Web of Science ®Google Scholar
• Jiang G, Yin X, Li C, et al. The plasticity of brain gray matter and white matter following lower limb amputation. Neural Plast. 2015;2015:823110–823185.
   Web of Science ®Google Scholar
• Mulvey MR, Radford HE, Fawkner HJ, et al. Transcutaneous electrical nerve stimulation for phantom pain and stump pain in adult amputees. Pain Pract. 2013;13(4):289–296.
   PubMed Web of Science ®Google Scholar
• Giuffrida O, Simpson L, Halligan PW. Contralateral stimulation, using TENS, of phantom limb pain: two confirmatory cases. Pain Med. 2010;11(1):133–141.
   PubMed Web of Science ®Google Scholar
• Gilmore CA, Ilfeld BM, Rosenow JM, et al. Percutaneous 60-day peripheral nerve stimulation implant provides sustained relief of chronic pain following amputation: 12-month follow-up of a randomized, double-blind, placebo-controlled trial. Reg Anesth Pain Med. 2020;45(1):44–51.
   Web of Science ®Google Scholar
• Rauck RL, Cohen SP, Gilmore CA, et al. Treatment of post-amputation pain with peripheral nerve stimulation. Neuromodulation. 2014;17(2):188–197.
   PubMed Web of Science ®Google Scholar
• Soin A, Syed Shah N, Fang Z. High-frequency electrical nerve block for postamputation pain: a pilot study. Neuromodulation. 2015;18(3):197–206.
   PubMedGoogle Scholar
• Cornish P, Wall C. Successful peripheral neuromodulation for phantom limb pain. Pain Med. 2015;16(4):761–764.
   PubMed Web of Science ®Google Scholar
• Bocci R, De Carolis G, Ferrucci R, et al. Cerebellar transcranial direct current stimulation (ctDCS) ameliorates phantom limb pain and non-painful phantom limb sensations. Cerebellum. 2019;18(3):527–535.
   PubMed Web of Science ®Google Scholar
• Bolognini N, Spandri V, Olgiati E, et al. Long-term analgesic effects of transcranial direct current stimulation of the motor cortex on phantom limb and stump pain: a case report. J Pain Symptom Manage. 2013;46(4):e1–e4.
   PubMed Web of Science ®Google Scholar
• Kikkert S, Mezue M, O’Shea J, et al. Neural basis of induced phantom limb pain relief. Ann Neurol. 2019;85(1):59–73.
   PubMed Web of Science ®Google Scholar
• De Caridi G, Massara M, Serra R, et al. Spinal cord stimulation therapy for the treatment of concomitant phantom limb pain and critical limb ischemia. Ann Vasc Surg. 2016;32:131.e11–e14.
   Web of Science ®Google Scholar
• Lee PM, So Y, Park JM, et al. Spinal cauda equina stimulation for alternative location of spinal cord stimulation in intractable phantom limb pain syndrome: a case report. Korean J Pain. 2016;29(2):123–128.
   PubMed Web of Science ®Google Scholar
• Shawver C, McCallin J, Guthmiller KA. Case series of dorsal root ganglion stimulation for refractory phantom limb pain in combat injured veteran amputees. Pain Med. 2018;19:818–905.
   Google Scholar
• Bunch JR, Goldstein HV, Hurley RW. Complete coverage of phantom limb and stump pain with constant current SCS system: a case report and review of the literature. Pain Pract. 2015;15(1):E20–E26.
   PubMed Web of Science ®Google Scholar
• Poveda DS, Montero FS, Guardo LA, et al. Spinal cord stimulation in phantom upper limb syndrome. Case report. Neuromodulation. 2019;22:296–584.
   Google Scholar
• Eldabe S, Burger K, Moser H, et al. Dorsal Root Ganglion (DRG) stimulation in the treatment of phantom limb pain (PLP). Neuromodulation. 2015;18(7):610–616.
   PubMed Web of Science ®Google Scholar
• Naidu H, Henley M, Muquit S, et al. A retrospective review of clinical outcome following spinal cord stimulation in phantom limb pain (deafferentation pain): impact of new spinal target selection method on clinical outcome. Neuromodulation 2013;16:e171.
   Google Scholar
• Taylor N. DRG stimulation prevents the development of post-amputation pain: two cases. Neuromodulation. 2019;22:563.
   Google Scholar
• Schneider S, Koller T, Meichtry A, et al. The effect of two-point discrimination training by individuals with lower limb amputation on phantom limb phenomena. Physiotherapy 2015;101:e1349–e1349.
   Google Scholar
• Wakolbinger R, Diers M, Hruby LA, et al. Home-based tactile discrimination training reduces phantom limb pain. Pain Pract. 2018;18(6):709–715.
   PubMed Web of Science ®Google Scholar
• De Nunzio AM, Schweisfurth MA, Ge N, et al. Relieving phantom limb pain with multimodal sensory-motor training. J Neural Eng. 2018;15(6):066022–066022.
   PubMed Web of Science ®Google Scholar
• Dietrich C, Nehrdich S, Seifert S, et al. Leg prosthesis with somatosensory feedback reduces phantom limb pain and increases functionality. Front Neurol. 2018;9:270.
   PubMed Web of Science ®Google Scholar
• Chau B, Phelan I, Ta P, et al. Immersive virtual reality therapy with myoelectric control for treatment-resistant phantom limb pain: case report. Innov Clin Neurosci. 2017;14(7–8):3–7.
   PubMedGoogle Scholar
• Ta PA, Chi B, Chau BL. Poster 318: treatment of phantom limb pain in recent amputee with virtual reality mirror therapy: a case report. PM&R. 2018;10:S105–S106.
   Google Scholar
• Heckman J, Hartman E, Meredith L, et al. A novel augmented reality treatment option for phantom limb pain: a case report. PM&R. 2013;5:S143–S143.
   Google Scholar
• Murray CD, Patchick EL, Caillette F, et al. Can immersive virtual reality reduce phantom limb pain? Stud Health Technol Inform. 2006;119:407–412.
   PubMedGoogle Scholar
• Kulkarni J, Pettifer S, Turner S, et al. An investigation into the effects of a virtual reality system on phantom limb pain: a pilot study. Brit J pain 2019;14:204946371985991–204946371985997.
   Web of Science ®Google Scholar
• Rothgangel A, Braun S, Winkens B, et al. Traditional and augmented reality mirror therapy for patients with chronic phantom limb pain (PACT study): results of a three-group, multicentre single-blind randomized controlled trial. Clin Rehabil. 2018;32(12):1591–1608.
   PubMed Web of Science ®Google Scholar
• Shapiro F. Efficacy of the eye movement desensitization procedure in the treatment of traumatic memories. J Traum Stress. 1989;2(2):199–223.
   Google Scholar
• Tesarz J, Leisner S, Gerhardt A, et al. Effects of Eye Movement Desensitization and Reprocessing (EMDR) treatment in chronic pain patients: a systematic review. Pain Med. 2014;15(2):247–263.
   PubMed Web of Science ®Google Scholar
• Russell MC. Treating traumatic amputation-related phantom limb pain. Clin Case Stud. 2008;7(2):136–153.
   Google Scholar
• Schneider J, Hofmann A, Rost C, et al. EMDR in the treatment of chronic phantom limb pain. Pain Med. 2008;9(1):76–82.
   PubMed Web of Science ®Google Scholar
• de Roos C, Veenstra MA, de Jongh A, et al. Treatment of chronic phantom limb pain using a trauma-focused psychological approach. Pain Res Manag. 2010;15(2):65–71.
   PubMed Web of Science ®Google Scholar
• Sinici E. Evaluation of EMDR therapy efficacy in treatment of phantom limb pain. Dusunen Adam. 2016;29:349–358.
   Google Scholar
• Rostaminejad A, Behnammoghadam M, Rostaminejad M, et al. Efficacy of eye movement desensitization and reprocessing on the phantom limb pain of patients with amputations within a 24-month follow-up. Int J Rehabil Res. 2017;40:209–214.
   PubMed Web of Science ®Google Scholar
• Barker A, Jalinous R, Freeston I. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985;325(8437):1106–1107.
   Google Scholar
• Hallett M. Transcranial magnetic stimulation: a primer. Neuron. 2007;55(2):187–199.
   PubMed Web of Science ®Google Scholar
• Lee J-H, Byun J-H, Choe Y-R, et al. Successful treatment of phantom limb pain by 1 Hz repetitive transcranial magnetic stimulation over affected supplementary motor complex: a case report. Ann Rehabil Med. 2015;39(4):630–633.
   PubMedGoogle Scholar
• Malavera M, García R, Quiros J, et al. Effects of transcranial magnetic stimulation in the treatment of phantom limb pain in landmine/INS;victims: a randomized clinical trial. J Neurol Sci. 2013;333:e534.
   Google Scholar
• Malavera A, Silva FA, Fregni F, et al. Repetitive transcranial magnetic stimulation for phantom limb pain in land mine victims: a double-blinded, randomized, sham-controlled trial. J Pain. 2016;17(8):911–918.
   PubMed Web of Science ®Google Scholar
• Vickers AJ, Cronin AM, Maschino AC, et al. Chronic pain individual patient data meta-analysis. Arch Intern Med. 2012;172(19):1444–1453.
   PubMedGoogle Scholar
• Davies A. Acupuncture treatment of phantom limb pain and phantom limb sensation in a primary care setting. Acupunct Med. 2013;31(1):101–104.
   PubMed Web of Science ®Google Scholar
• Kotlyar A, Brener R, Lis M. Use of Yamamoto new scalp acupuncture for treatment of chronic. Severe Phantom Leg Pain. 2012;24(2):123–128.
   Google Scholar
• Jacobs MB, Niemtzow RC. Treatment of phantom limb pain with laser and needle auricular acupuncture: a case report. Med Acupunct. 2011;23(1):57–60.
   Google Scholar
• Tseng C-C, Chen P-Y, Lee Y-C. Successful treatment of phantom limb pain and phantom limb sensation in the traumatic amputee using scalp acupuncture. Acupunct Med. 2014;32(4):356–358.
   PubMed Web of Science ®Google Scholar
• Trevelyan EG, Turner WA, Summerfield-Mann L, et al. Acupuncture for the treatment of phantom limb syndrome in lower limb amputees: a randomised controlled feasibility study. Trials. 2016;17(1):519.
   PubMedGoogle Scholar
• Silva-Filho R, Oliveira P, Baroni MC. Auriculotherapy as an alternative method for the treatment of phantom pain in amputees. J Altern Complement Med. 2019;25:A11–A12.
   Google Scholar
• Shealy CN. Percutaneous radiofrequency denervation of spinal facets. Treatment for chronic back pain and sciatica. J Neurosurg. 1975;43(4):448–451.
   PubMed Web of Science ®Google Scholar
• Lloyd J, Barnard JD, Glynn C. Cryoanalgesia: a new approach to pain relief. Lancet. 1976;308:932–934.
   Google Scholar
• Leggett LE, Soril LJ, Lorenzetti DL, et al. Radiofrequency ablation for chronic low back pain: a systematic review of randomized controlled trials. Pain Res Manag. 2014;19(5):e146–e153.
   PubMed Web of Science ®Google Scholar
• Sperry BP, Cheney CW, Conger A, et al. Cooled radiofrequency ablation of a large sciatic neuroma at the infrapiriformis foramen for recalcitrant phantom limb pain in a below-knee amputee. Pain Med. 2021;22:223–226.
   Google Scholar
• West M, Wu H. Pulsed radiofrequency ablation for residual and phantom limb pain: a case series. Pain Pract. 2010;10(5):485–491.
   PubMed Web of Science ®Google Scholar
• Wilkes D, Ganceres N, Solanki D, et al. Pulsed radiofrequency treatment of lower extremity phantom limb pain. Clin J Pain. 2008;24(8):736–739.
   PubMed Web of Science ®Google Scholar
• Prologo J, Gilliland C, Michael M, et al. Percutaneous image-guided cryoablation for the treatment of phantom limb pain in amputees: a pilot study. J Vasc Interv Radiol. 2017;28:24–34.e4.
   PubMed Web of Science ®Google Scholar
• Imani F, Gharaei H, Rezvani M. Pulsed radiofrequency of lumbar dorsal root ganglion for chronic postamputation phantom pain. Anesth Pain Med. 2012;1(3):194–197.
   PubMedGoogle Scholar
• Dumanian GA, Ko JH, O’Shaughnessy KD, et al. Targeted reinnervation for transhumeral amputees: current surgical technique and update on results. Plast Reconstr Surg. 2009;124(3):863–869.
   PubMed Web of Science ®Google Scholar
• Mioton LM, Dumanian GA, Shah N, et al. Targeted muscle reinnervation improves residual limb pain, phantom limb pain, and limb function: a prospective study of 33 major limb amputees. 2020;478:2161–2167.
   Google Scholar
• Alexander JH, Jordan SW, West JM, et al. Targeted muscle reinnervation in oncologic amputees: early experience of a novel institutional protocol. J Surg Oncol. 2019;120(3):348–358.
   PubMed Web of Science ®Google Scholar
• Chang BL, Attinger CE, Akbari CM, et al. Targeted muscle reinnervation reduces pain and improves ambulation in patients undergoing below-knee amputation: a single-institution matched cohort study. J Vasc Surg. 2020;72(1):e30–e31.
   Web of Science ®Google Scholar
• Valerio IL, Dumanian GA, Jordan SW, et al. Preemptive treatment of phantom and residual limb pain with targeted muscle reinnervation at the time of major limb amputation. J Am Coll Surg. 2019;228(3):217–226.
   PubMed Web of Science ®Google Scholar
• Huang C-Y, Yang R-S, Kuo T-S, et al. Phantom limb pain treated by far infrared ray. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:1589–1591.
   PubMedGoogle Scholar
• Huang C-Y, Hsu K-H, Chen J-H, et al. Treating severe phantom limb pain by applying far infrared ray to ‘phantom limb’. J Formos Med Assoc. 2016;115(3):215–216.
   PubMed Web of Science ®Google Scholar
• Murphy DP, Haywood SA, Soares JI. Poster 415: treatment of phantom limb pain with calmare scrambler therapy: a case report. PM&R. 2017;9(9S1):S264.
   Google Scholar
• Fabbri L, Pirotti SP, Rosati M, et al. Phantom limb pain successfully treated with scrambler therapy. Minerva Anestesiol. 2018;84(5):642–643.
   PubMed Web of Science ®Google Scholar
• Contract D, Caruso D. Poster 394 treatment of recalcitrant phantom limb pain with alpha-stimulation®: a case report. PM&R. 2016;8(9S):S290.
   Google Scholar
• Lyrakos GN, Batistaki C, Spinaris B, et al. T428 Treatment of chronic phantom limb pain using a CBT-focused psychological approach, a case study. Eur J Pain Suppl. 2011;5:72–73.
   Google Scholar
• Brown CA, Lido C. Reflexology treatment for patients with lower limb amputations and phantom limb pain-an exploratory pilot study. Complement Ther Clin Pract. 2008;14(2):124–131.
   PubMedGoogle Scholar
• Tung ML, Murphy IC, Griffin SC, et al. Observation of limb movements reduces phantom limb pain in bilateral amputees. Ann Clin Transl Neurol. 2014;1(9):633–638.
   PubMed Web of Science ®Google Scholar
• Van Stan JH, Dijkers MP, Whyte J, et al. The rehabilitation treatment specification system: implications for improvements in research design, reporting, replication, and synthesis. Arch Phys Med Rehabil. 2019;100(1):146–155.
   PubMed Web of Science ®Google Scholar