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Original Articles

Regional Entrepreneurial Opportunities in the Biotech Industry: Exploring the Transition from Award-Winning Nascent Entrepreneurs to Real Start-Ups

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Pages 1708-1734 | Received 01 Jan 2011, Accepted 01 Nov 2011, Published online: 15 Jan 2013

References

  • Aharonson, B., Baum, J. & Feldman, M. (2007) Desperately seeking spillovers? Increasing returns, industrial organization and the location of new entrants in geographic and technological space, Industrial and Corporate Change, 16(1), pp. 89–130. doi: 10.1093/icc/dtl034
  • Almeida, P. & Kogut, B. (1999) Localization of knowledge and the mobility of engineers in regional networks, Management Science, 45(7), pp. 905–917. doi: 10.1287/mnsc.45.7.905
  • Anselin, L., Varga, A. & Acs, Z. (1997) Local geographic spillovers between university research and high technology innovations, Journal of Urban Economics, 42(3), pp. 422–448. doi: 10.1006/juec.1997.2032
  • Armington, C. & Acs, Z. (2002) The determinants of regional variation in new firm formation, Regional Studies, 36(1), pp. 33–45. doi: 10.1080/00343400120099843
  • Arrow, K. (1962) The economic implications of learning by doing, The Review of Economic Studies, 29(3), pp. 155–173. doi: 10.2307/2295952
  • Arundel, A. & Geuna, A. (2004) Proximity and the use of public science by innovative European firms, Economics of Innovation and New Technology, 13(6), pp. 559–580. doi: 10.1080/1043859092000234311
  • Audretsch, D. & Feldman, M. (1996) R&D spillovers and the geography of innovation and production, American Economic Review, 86(3), pp. 630–640.
  • Audretsch, D. & Fritsch, M. (1994) The geography of firm births in Germany, Regional Studies, 28(4), pp. 359–365. doi: 10.1080/00343409412331348326
  • Audretsch, D. & Keilbach, M. (2007) The localisation of entrepreneurship capital: Evidence from Germany, Papers in Regional Science, 86(3), pp. 351–365. doi: 10.1111/j.1435-5957.2007.00131.x
  • Audretsch, D., Keilbach, M. & Lehmann, E. (2006) Entrepreneurship and Economic Growth (New York: Oxford University Press).
  • BBSR (Bundesinstitut fuer Bau-, Stadt-, und Raumforschung) (2009) Indikatoren, Karten und Graphiken zur Raum- und Stadtentwicklung in Deutschland und in Europa (INKAR) (Bonn: BBSR).
  • Beaudry, C. & Schiffauerova, A. (2009) Who's right, Marshall or Jacobs? The localization versus urbanization debate, Research Policy, 38(2), pp. 318–337. doi: 10.1016/j.respol.2008.11.010
  • BMBF (Federal Ministry for Education and Research) (2010) Die Deutsche Biotechnologie-Branche 2010 (Berlin: BMBF).
  • BMWi (Bundesministerium fuer Wirtschaft und Technologie) (2007) 40 Mio. Euro fuer Technologiegruendungen aus der Wissenschaft, Pressemitteilung 26.11.2007 (Berlin: BMWi).
  • Bozeman, B. (2000) Technology transfer and public policy: A review of research and theory, Research Policy, 29(4–5), pp. 627–655. doi: 10.1016/S0048-7333(99)00093-1
  • Breschi, S. & Lissoni, F. (2001) Knowledge spillovers and local innovation systems: A critical survey, Industrial and Corporate Change, 10(4), pp. 975–1005. doi: 10.1093/icc/10.4.975
  • Brixy, U. & Hessels, J. (2010) Human Capital and Start-up Success of Nascent Entrepreneurs, EIM Research Report H201013, Erasmus University, Rotterdam.
  • Brixy, U., Hundt, C. & Sternberg, R. (2010) Global Entrepreneurship Monitor. Unternehmensgruendungen im weltweiten Vergleich, Laenderbericht Deutschland 2009, Hannover and Nuernberg.
  • Carter, N., Gartner, W. & Reynolds, P. (1996) Exploring start-up event sequences, Journal of Business Venturing, 11(3), pp. 151–166. doi: 10.1016/0883-9026(95)00129-8
  • Combes, P. (2000) Economic structure and local growth: France, 1984–1993, Journal of Urban Economics, 47(3), pp. 329–355. doi: 10.1006/juec.1999.2143
  • Commission of the European Communities (2005) The activities of the European Union for small and medium-sized enterprises (SMEs) SME Envoy Report, Commission Staff Working Paper, Brussels. Available at ftp://ftp.cordis.europa.eu/pub/incubators/docs/sme_envoy_report_2005_en.pdf (accessed 12 December 2012).
  • Cooper, R. (1990) Stage-gate systems: A new tool for managing new products, Business Horizons, 33(3), pp. 44–54. doi: 10.1016/0007-6813(90)90040-I
  • Corolleur, F., Mangematin, V. & Torre, E. (2003) French biotech start-ups and biotech clusters in France: The importance of geographic proximity, in: Fuchs, G. & Luib, B. (Eds) Biotechnology in Comparative Perspective: Growth and Regional Concentration, pp. 221–257 (London: Routledge).
  • Delmar, F. & Davidsson, P. (2000) Where do they come from? Prevalence and characteristics of nascent entrepreneurs, Entrepreneurship & Regional Development, 12(1), pp. 1–23. doi: 10.1080/089856200283063
  • Diochon, M., Menzies, T. & Gasse, Y. (2003) Canadian nascent entrepreneurs’ start-up efforts: Outcomes and individual influences on sustainability, Journal of Small Business and Entrepreneurship, 18(1), pp. 53–73. doi: 10.1080/08276331.2005.10593332
  • Diochon, M., Menzies, T. & Gasse, Y. (2007) Attributions and success in new venture creation among Canadian nascent entrepreneurs, Journal of Small Business and Entrepreneurship, 20(4), pp. 335–350. doi: 10.1080/08276331.2007.10593404
  • Dippe, A. & Mueller, T. (2005) Unternehmensgruendungen und ihre Unterstuetzung durch Gruendungswettbewerbe, in: Gemuenden, H., Salomo, S. & Mueller, T. (Ed) Entrepreneurial Excellence: Unternehmertum, Unternehmerische Kompetenz und Wachstum Junger Unternehmen, pp. 293–327 (Wiesbaden: Deutscher Universitaetsverlag).
  • Dohse, D. (2000) Technology policy and the regions: The case of the BioRegio contest, Research Policy, 29(9), pp. 1111–1133. doi: 10.1016/S0048-7333(99)00077-3
  • Egeln, J., Gottschalk, S., Rammer, C. & Spielkamp, A. (2002) Spinoff-Gruendungen aus der oeffentlichen Forschung in Deutschland (Baden-Baden: Nomos).
  • Eickelpasch, A. & Fritsch, M. (2005) Contest for cooperation: A new approach in German innovation policy, Research Policy, 34(8), pp. 1269–1282. doi: 10.1016/j.respol.2005.02.009
  • Engel, D. & Fier, A. (2001) Does R&D infrastructure attract high-tech start-ups?, in: Fischer, M. M. & Froehlich, J. (Ed) Knowledge, Complexity and Innovation Systems, 1 (Advances in Spatial Science Series), pp. 402–419 (Berlin: Springer).
  • Feldman, M. (2001) The entrepreneurial event revisited: Firm formation in a regional context, Industrial and Corporate Change, 10(4), pp. 861–891. doi: 10.1093/icc/10.4.861
  • Figueiredo, O., Guimarães, P. & Woodward, D. (2002) Home-field advantage: Location decisions of Portuguese entrepreneurs, Journal of Urban Economics, 52(2), pp. 341–361. doi: 10.1016/S0094-1190(02)00006-2
  • Fontana, R., Geuna, A. & Matt, M. (2006) Factors affecting university–industry R&D projects: The importance of searching, screening and signalling, Research Policy, 35(2), pp. 309–323. doi: 10.1016/j.respol.2005.12.001
  • Fritsch, M. & Mueller, P. (2007) The persistence of regional new business formation-activity over time: Assessing the potential of policy promotion programs, Journal of Evolutionary Economics, 17(3), pp. 299–315. doi: 10.1007/s00191-007-0056-6
  • Fritsch, M. & Slavtchev, V. (2007) Universities and innovation in space, Industry and Innovation, 14(2), pp. 201–218. doi: 10.1080/13662710701253466
  • Geroski, P. (1995) What do we know about entry?, International Journal of Industrial Organization, 13(4), pp. 421–440. doi: 10.1016/0167-7187(95)00498-X
  • Glaeser, E., Kerr, W. & Ponzetto, G. (2010a) Clusters of entrepreneurship, Journal of Urban Economics, 67(1), pp. 150–168. doi: 10.1016/j.jue.2009.09.008
  • Glaeser, E., Rosenthal, S. & Strange, W. (2010b) Urban economics and entrepreneurship, Journal of Urban Economics, 67(1), pp. 1–14. doi: 10.1016/j.jue.2009.10.005
  • Grupp, H., Legler, H., Jungmittag, A. & Schmoch, U. (2000) Hochtechnologie 2000: Neudefinition der Hochtechnologie fuer die Berichterstattung zur technologischen Leistungsfaehigkeit Deutschlands (Karlsruhe: ISI/NIW).
  • Hall, B., Link, A. & Scott, J. (2003) Universities as research partners, Review of Economics and Statistics, 85(2), pp. 485–491. doi: 10.1162/rest.2003.85.2.485
  • Henderson, J. (1982) The impact of government policies on urban concentration, Journal of Urban Economics, 12(3), pp. 280–303. doi: 10.1016/0094-1190(82)90019-5
  • Henderson, V. & Becker, R. (2000) Political economy and city sizes and formation, Journal of Urban Economics, 48(4), pp. 453–484. doi: 10.1006/juec.2000.2176
  • Isard, W. (1956) Location and Space-Economy: A General Theory Relating to Industrial Location, Market Areas, Land Use, Trade and Urban Structure (CambridgeMA: MIT Press).
  • Jacobs, J. (1969) The Economy of Cities (New York: Random House).
  • Jaffe, A., Trajtenberg, M. & Henderson, R. (1993) Geographic localization of knowledge spillovers as evidenced by patent citations, Quarterly Journal of Economics, 108(3), pp. 577–598. doi: 10.2307/2118401
  • Johnston, P., Parker, S. & Wijbenga, F. (2006) Nascent entrepreneurship research: Achievements and opportunities, Small Business Economics, 27(1), pp. 1–4. doi: 10.1007/s11187-006-9004-3
  • Kerlen, C. & Prescher, S. (2010) Gruendungswettbewerbe als Instrument der Gruendungsfoerderung (Berlin: IIT).
  • Kessler, A. & Frank, H. (2009) Nascent entrepreneurship in a longitudinal perspective: The impact of person, environment, resources and the founding process on the decision to start business activities, International Small Business Journal, 27(6), pp. 720–742. doi: 10.1177/0266242609344363
  • Malmberg, A. & Maskell, P. (1997) Towards an explanation of regional specialization and industry agglomeration, European Planning Studies, 5(1), pp. 25–42. doi: 10.1080/09654319708720382
  • Markman, G., Phan, P., Balkin, D. & Gianiodis, P. (2005) Entrepreneurship and university-based technology transfer, Journal of Business Venturing, 20(2), pp. 241–263. doi: 10.1016/j.jbusvent.2003.12.003
  • Marshall, A. (1920) Principles of Economics, 8th ed., reprinted 1962 (London: Macmillan)
  • Metzger, G., Niefert, M. & Licht, G. (2008) High-Tech Gruendungen in Deutschland—Trends, Strukturen, Potenziale (Mannheim: Centre for European Economic Research).
  • Miller, F. (2004) Schneller zum besseren Medikament, Fraunhofer Magazin, 3, pp. 8–12.
  • Minniti, M. (2005) Entrepreneurship and network externalities, Journal of Economic Behavior and Organization, 57(1), pp. 1–27. doi: 10.1016/j.jebo.2004.10.002
  • Mueller, P. (2006) Entrepreneurship in the region: Breeding ground for nascent entrepreneurs?, Small Business Economics, 27(1), pp. 41–58. doi: 10.1007/s11187-006-6951-7
  • Niefert, M., Metzger, G., Heger, D. & Licht, G. (2006) Hightech-Gruendungen in Deutschland: Trends und Entwicklungsperspektiven, Zentrum fuer Europaeische Wirtschaftsforschung ZEW, Mannheim.
  • Parker, S. & Belghitar, Y. (2006) What happens to nascent entrepreneurs? An econometric analysis of the PSED, Small Business Economics, 27(1), pp. 81–101. doi: 10.1007/s11187-006-9003-4
  • Reynolds, P. (1997) Who starts new firms? Preliminary explorations of firms-in-gestation, Small Business Economics, 9(5), pp. 449–462. doi: 10.1023/A:1007935726528
  • Reynolds, P. & Miller, B. (1992) New firm gestation: Conception, birth and implications for research, Journal of Business Venturing, 7(5), pp. 405–417. doi: 10.1016/0883-9026(92)90016-K
  • Romer, P. (1986) Increasing returns and long-run growth, Journal of Political Economy, 94(5), pp. 1002–1037. doi: 10.1086/261420
  • Saxenian, A. (1991) The origins and dynamics of production networks in Silicon Valley, Research Policy, 20(5), pp. 423–437. doi: 10.1016/0048-7333(91)90067-Z
  • Schwartz, M. & Hornych, C. (2010) Cooperation patterns of incubator firms and the impact of incubator specialization: Empirical evidence from Germany, Technovation, 30(9–10), pp. 485–495. doi: 10.1016/j.technovation.2010.05.001
  • Sternberg, R. & Wennekers, S. (2005) Determinants and effects of new business creation using global entrepreneurship monitor data, Small Business Economics, 24(3), pp. 193–203. doi: 10.1007/s11187-005-1974-z
  • Storey, D. & Tether, B. (1998) Public policy measures to support new technology-based firms in the European Union, Research Policy, 26(9), pp. 1037–1057. doi: 10.1016/S0048-7333(97)00058-9
  • Stuart, T. & Sorenson, O. (2003) The geography of opportunity: Spatial heterogeneity in founding rates and the performance of biotechnology, Research Policy, 32(2), pp. 229–253. doi: 10.1016/S0048-7333(02)00098-7
  • Van Gelderen, M., Bosma, N. & Thurik, R. (2001) Setting up a Business in the Netherlands: Who Starts, Who Gives Up, Who is Still Trying, ERIM Reports Series Research in Management, ERS-2001-15-STR, Erasmus University, Rotterdam.
  • VFA (Verband Forschender Arzneimittelhersteller e.V.) (2010) Forschungs- und Biotech-Standort Deutschland, vfa-Positionspapier, vfa, Berlin.
  • Wagner, J. (2004) Nascent Entrepreneurs, IZA Discussion Paper Series No. DP 1293, Institute for the Study of Labor, Bonn.
  • Wagner, J. (2008) Nascent and infant entrepreneurs in Germany. Evidence from the regional entrepreneurship monitor (REM), in: Merz, J. & Schulte, R. (Ed) Neue Ansaetze der Mittelstandsforschung, pp. 395–411 (Berlin: Lit-Verlag).
  • Wagner, J. & Sternberg, R. (2004) Start-up activities, individual characteristics, and the regional milieu: Lessons for entrepreneurship support policy from German micro data, The Annals of Regional Science, 38(2), pp. 219–240. doi: 10.1007/s00168-004-0193-x
  • Zucker, L., Darby, M. & Brewer, M. (1998) Intellectual human capital and the birth of US biotechnology enterprises, American Economic Review, 88(1), pp. 290–306.

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