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Research Article

Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (Review)

Pages 189-200 | Published online: 09 Jul 2009

References

  • Algenstaedt, P. M., Antonetti, D. A., Yaffe, M. B. and Kahn, C. R., 1997, Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+,ATPas es in muscle and heart. Journal of Biological Chemistry, 272, 23696–23702.
  • Allen, B. G. and Katz, S., 1996, Phosphorylation of cardiac junctiona l and fre e sarcoplasmic reticulum by PKC alpha, PKC beta, PKA and the Ca2+/calmodulin- dependent protein kinase. Molecular and Cellular Biochemistry, 155, 91–103.
  • Andersen, J. P., 1995, Dissection of the functional domains of the sarcoplasmic reticulum Ca2+,ATPase by site-directed mutagen- esis. Bioscience Reports, 15, 243–261.
  • Arai, M., Matsui, H. and Periasamy, M., 1994, Sarcoplasmic- reticulum gene-expression in cardiac-hypertrophy and heart-fail- ure. Circulation Research, 74, 555–564.
  • Arkin, I. T., Adams, P. D., Mackenzie, K. R., Lemmon, M. A., Brunger, A. T. and Engelman, D.M., 1994, structural organization of the pentameric transmembrane alpha-helices of phospholam- ban, a cardiac ion-channel. EMBO Journal, 13, 4757–4764.
  • Asahi, M., Kimura, Y., Kurzydlowski, R., Tada, M. and MacLennan, D.H., 1999, Transmembrane helix M6 in sarco(endo)plasmic reticulum Ca2+,ATPase forms a functional interaction site with phospholamban-Evidence for physical interactions at other sites. Journal of Biologica l Chemistry, 274, 32855–32862.
  • Asahi, M., McKenna, E., Kurzydlowski, K., Tada, M. and MacLen- nan, D. H., 2000, Physical interactions between phospholamban and sarco(endo)plasmic reticulum Ca2+,ATPases are dissociated by elevated Ca2+, but not by phospholamban phosphorylation, vanadate, or thapsigargin, and are enhanced by ATP. Journal of Biological Chemistry, 275, 15034–15038.
  • Autry, J. M. and Jones, L. R., 1997, Functional coexpression of the canine cardia c Ca2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPas e regulation. Journal of Biological Chemistry, 272, 15872–15880.
  • Baba-Aissa, F., Raeymaekers, L., Wuytack, F., Dode, L. and Casteels, R., 1998, Distribution and isoform diversity of the organellar Ca2+ pumps in the brain. Molecular and Chemical Neuropathology, 33, 199–208.
  • Baker, D. L., Hashimoto, K., Grupp, I. L., Ji, Y., Reed, T., Loukianov, E., Grupp, G., Bhagwhat, A., Hoit, B., Walsh, R., Marban, E. and Periasamy, M., 1998, Targeted overexpression of the sarcoplas- mic reticulum Ca2+, ATPase increases cardia c contractility in transgenic mouse hearts. Circulation Research, 83, 1205–1214.
  • Berridge, M., Lipp, P. and Bootman, M., 1999, Primer-Calcium signalling. Current Biology, 9, R157–R159.
  • Brody, I. A., 1969, Muscle contracture induced by exercise. A syndrome attributable to decreas ed relaxing factor. New England Journal of Medicine, 281, 187–192.
  • Burge, S. M. and Wilkinson, J. D., 1992, Darier-White Dis eas e-a review of the clinica l features in 163 patients. Journal of the American Academy of Dermatology, 27, 40–50.
  • Callen, D. F., Baker, E., Lane, S., Nancarrow, J., Thompson, A., Whitmore, S. A., MacLennan, D. H., Berger, R., Cherif, D., Jarvela, I., Peltonen, I., Sutherland, G. R. and Gardiner, R. M., 1991, Regional mapping of the Batten dis eas e locus (CLN3) to human chromosome 16p12. American Journal of Human Genet- ics, 49,1372-1377.
  • Cantilina, T., Sagara, Y., Inesi, G. and Jones, L. R., 1993, Comparative-studies of cardia c and skeletal sarcoplasmic-reticu- lum ATPas es-effect of a phospholamban antibody on enzyme activation by Ca2+. Journal of Biologica l Chemistry, 268, 17018–17025.
  • de Meis, L., 1981, The Sarcoplasmic Reticulum (New York: Wiley).
  • Dillmann, W. H., 1999, Calcium regulatory proteins and their alteration by transgenic approaches. American Journal of Cardiol-ogy, 83, 89H-91H.
  • Dode, L., De Greef, C., Mountian, I., Attard, M., Town, M. M., Casteels, R. and Wuytack, F., 1998, Structure of the human sarco/endoplasmic reticulum Ca2+,ATPase 3 gene -Promoter analysis and alternativ e splicing of the SERCA3 pre-mRNA. Journal of Biological Chemistry, 273, 13982–13994.
  • Dode, L., Wuytack, F., Kools, P. F. J., BabaAissa, F., Raeyma ekers, L., Brike, F., VanDeVen, W. J. M. and Casteels, R., 1996, cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca2+,ATPas e 3 gene. Biochemical Journal, 318, 689–699.
  • Fujii, J., Lytton, J., Tada, M. and MacLennan, D. H., 1988, Rabbit cardiac and slow-twitch muscle express the same phospholamban gene. Febs Letters, 227, 51–55.
  • Fujii, J., Ueno, A., Kitano, K., Tanaka, S., Kadoma, M. and Tada, M., 1987, Complete complementary DNA-derived amino-acid-s e- quence of canine cardia c phospholamban. Journal of Clinical Investigation, 79, 301–304.
  • Gilon, P., Arredouani, A., Gailly, P., Gromada, J. and Henquin,J. C., 1999, Uptake and releas e of Ca2+ by the endoplasmic reticulum contribute to the oscillations of the cytosolic Ca2+ concentration triggered by Ca2+ influx in the electrically excitable pancreatic B- cell. Journal of Biologica l Chemistry, 274, 20197–20205.
  • Grover, A. K., Xu, A., Samson, S. E. and Narayanan, N., 1996, Sarcoplasmic reticulum Ca2+ pump in pig coronary artery smooth muscle is regulated by a novel pathway. American Journal of Physiology- Cell Physiology, 40, C181–C187.
  • He, H. P., Giordano, F. J., HilalDandan, R., Choi, D. J., Rockman, H. A., McDonough, P. M., Bluhm, W. F., Meyer, M., Sayen, M. R., Swanson, E. and Dillmann, W.H., 1997, Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation. Journal of Clinical Investigation, 100, 380–389.
  • Hughes, G., East, J. M. and Lee, A. G., 1994, The hydrophilic domain of phospholamban inhibits the Ca2+ transport step of the Ca2+,ATPas e. Biochemical Journal, 303, 511–516.
  • Hughes, G., Starling, A. P., Sharma, R. P., East, J. M. and Lee, A. G., 1996, An investigation of the mechanism of inhibition of the Ca2+, ATPase by phospholamban. Biochemical Journal, 318, 973–979.
  • James, P., Inui, M., Tada, M., Chiesi, M. and Carafoli, E., 1989, Nature and site of phospholamban regulation of the Ca-2+ Pump of sarcoplasmic-reticulum. Nature, 342, 90–92.
  • Kao, J., Fortner, C. N., Liu, L. H., Shull, G. E. and Paul, R. J., 1999, Ablation of the SERCA3 gene alters epithelium-dependent relaxation in mouse trachea l smooth muscle. American Journal of Physiology-Lung Cellula r and Molecular Physiology, 21, L264–L270.
  • Karczewski, P., Hendrischke, T., Wolf, W. P., Morano, I., Bartel, S. and Schrader, J., 1998, Phosphorylation of phospholamban correlate s with relaxation of coronary artery induced by nitric oxide, adenosine, and prostacyclin in the pig. Journal of Cellular Biochemistry, 70, 49–59.
  • Kargacin, M. E., Ali, Z. and Kargacin, G. J., 1998, Anti-phospho-lamban and protein kinase A alter the Ca2+ s ensitivity and maximum velocity of Ca2+ uptake by the cardiac sarcoplasmic reticulum. Biochemical Journal, 331, 245–249.
  • Kimura, Y., Asahi, M., Kurzydlowski, K., Tada, M. and MacLennan, D. H., 1998, Phospholamban domain Ib mutations influence functional interactions with the Ca2+ATPas e isoform of cardia c sarcoplasmic reticulum. Journal of Biological Chemistry, 273, 1423814241.
  • Kimura, Y., Kurzydlowski, K., Tada, M. and MacLennan, D. H., 1996, Phospholamban regulates the Ca2+,ATPase through intramem- brane interactions. Journal of Biological Chemistry, 271, 21726–21731.
  • Kimura, Y., Kurzydlowski, K., Tada, M. and MacLennan, D. H., 1997, Phospholamban inhibitory function is activated by depolymeriza- tion. Journal of Biological Chemistry, 272, 15061–15064.
  • Klebl, B. M., Ayoub, A. T. and Pette, D., 1998, Protein oxidation, tyrosine nitration, and inactivation of sarcoplasmic reticulum Ca2+,ATPase in low-frequency stimulated rabbit muscle. Febs Letters, 422, 381–384.
  • Lacabaratz-Porret, C., Corvazier, E., Kovacs, T., Bobe, R., Bredoux, R., Launay, S., Papp, B. and Enouf, J., 1998, Platelet sarco/ endoplasmic reticulum Ca(2+)ATPas e isoform 3b and Rap 1b: interrelation and regulation in physiopathology. Biochemical Journal, 332, 173–181.
  • Lee, M. G., Xu, X., Zeng, W. Z., Diaz, J., Kuo, T. H., Wuytack, F., Raeymaekers, L. and Muallem, S., 1997, Polarized expression of Ca2+ pumps in pancreatic and salivary gland cells-Role in initiation and propagation of [Ca2+](i) waves. Journal of Biological Chemistry, 272, 15771–15776.
  • Levine, B. A., Patchell, V. B., Sharma, P., Gao, Y., Bigelow, D. J., Yao, Q., Goh, S., Colyer, J., Drago, G. A. and Perry, S. V., 1999, Sites on the cytoplasmic region of phospholamban involved in interaction with the calcium-activated ATPas e of the sarcoplasmic reticulum. E uropean Journal of Biochemistry, 264, 905–913.
  • Liu, L. H., Paul, R. J., Sutliff, R. L., Miller, M. L., Lorenz, J. N., Pun, R. Y. K., Duffy, J.J., Doetschman, T., Kimura, Y., MacLennan, D. H., Hoying, J. B. and Shull, G. E ., 1997, Defective endothelium- dependent relaxation of vascular smooth muscle and endothelial cell Ca2+ signaling in mice lacking sarco(endo)plasmic reticulum Ca2+,ATPase isoform 3. Journal of Biologica l Chemistry, 272, 30538- 30545.
  • Loukianov, E., Ji, Y., Grupp, I. L., Kirkpatrick, D. L., Baker, D. L., Loukianova, T., Grupp,G., Lytton, J., Walsh, R. A. and Periasamy, M., 1998, Enhanced myocardial contractility and increased Ca2+ transport function in transgenic hearts expressing the east-twitch skeletal muscle sarcoplasmic reticulum Ca2+,ATPas e. Circulation Research, 83, 889–897.
  • Luo, W. S., Chu, G. X., Sato, Y., Zhou, Z. P., Kadambi, V. J. and Kranias, E. G., 1998, Transgenic approaches to define the functional role of dual site phospholamban phosphorylation. Journal of Biologica l Chemistry, 278, 4734–4739.
  • Lytton, J., Westlin, M., Burk, S. E., Shull, G. E. and MacLennan, D. H., 1992, Functional comparisons between isoforms of the sarcoplasmic or endoplasmic-reticulum family of calcium pumps. Journal of Biological Chemistry, 267, 14483–14489.
  • MacLennan, D. H. and Green, N. M., 2000, Structura l biology-Pumping ions. Nature, 405, 633–634.
  • MacLennan, D. H., Brandl, C. J., Korczak, B. and Green, N. M., 1985, Amino-acid sequence of a Ca2+ + Mg2-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence. Nature, 316, 696–700.
  • MacLennan, D. H., Rice, W. J. and Green, N. M., 1997a, The mechanism of Ca2+ transport by sarco(endo)plasmic reticulum Ca2+,ATPases. Journal of Biological Chemistry, 272, 28815–28818.
  • MacLennan, D. H., Rice, W. J. and Odermatt, A., 1997b, Structure/function analysis of the Ca2+ binding and translocation domain of SERCA1 and the role in Brody diseas e of the ATP2A1 gene encoding SERCA1. Annals of the New York Academy of Science, Na/K-ATPas e and Related Transport ATPas es, 834, 175–185.
  • Martonosi, A. N., 1995, The structure and interactions of Ca2+, ATPase. Bioscience Reports, 15, 263–281.
  • McIntosh, D.B., 2000, Portrait of a P-type pump Nature Structural Biology, 7, 532–535.
  • Mùller, J. V., Juul, B. and leMaire, M., 1996, Structura l organization, ion transport, and energy transduction of P-type ATPas es. Biochimica et Biophysica Acta-Reviews on Biomembranes, 1286, 1–51.
  • Morris, G. L., Cheng, H. C., Colyer, J. and Wang, J. H., 1991, Phospholamban regulation of cardia c sarcoplasmic-reticulum (Ca2+,Mg2+)-ATPas e-mechanism of regulation and site of monoclonal-antibody interaction. Journal of Biological Chemistry, 266, 11270–11275.
  • Mountian, I., Manolopoulos, V. G., De Smedt, H., Parys, J. B., Missia en, L. and Wuytack, F., 1999, Expression patterns of sarco/ endoplasmic reticulum Ca2+,ATPas e and inositol 1,4,5-trispho- sphate receptor isoforms in vascular endothelial cells. Cell Calcium, 25, 371–380.
  • Odermatt, A., Barton, K., Khanna, V. K., Mathieu, J., Escolar, D., Kuntz er, T., Karpati, G. and MacLennan, D. H., 2000, The mutation of Pro(789) to Leu reduces the activity of the fast-twitch skeleta l muscle sarco(endo)plasmic reticulum Ca2+ ATPas e (SERCA1)and is associated with Brody dis ease. Human Genetics, 106, 482–491.
  • Odermatt, A., Becker, S., Khanna, V. K., Kurzydlowski, K., Leisner, E., Pette, D. and MacLennan, D. H., 1998, Sarcolipin regulates the activity of SERCA1, the fast-twitch skeleta l muscle sarcoplasmic reticulum Ca2+,ATPas e. Journal of Biological Chemistry, 273, 12360–12369.
  • Odermatt, A., Kurzydlowski, K. and MacLennan, D. H., 1996a, The V-max of the Ca2+,ATPas e of cardia c sarcoplasmic reticulum (SERCA2a) is not altered by Ca2+/Calmodulin dependent phosphorylation or by interaction with phospholamban. Journal of Biological Chemistry, 271, 14206–14213.
  • Odermatt, A., Taschner, P. E. M., Khanna, V. K., Busch, H. F. M., Karpati, G., Jablecki, C. K., Breuning, M. H. and MacLennan, D. H., 1996b, Mutations in the gene-encoding SERCA1, the fast- twitch skeletal muscle sarcoplasmic reticulum Ca2+ ATPas e, are associated with Brody dis eas e. Nature Genetics, 14, 191–194.
  • Odermatt, A., Taschner, P. E. M., Scherer, S. W., Beatty, B., Khanna, V. K., Cornblath, D. R., Chaudhry, V., Yee, W. C., Schrank, B., Karpati, G., Breuning, M. H., Knoers, N. and MacLennan, D. H., 1997, Characterization of the gene encoding human sarcolipin (SLN) a proteolipid associated with SERCA1: absence of structural mutations in five patients with Brody dis ease. Genomics, 45, 541–553.
  • Ogawa, H., Stokes, D. L., Sasabe, H. and Toyoshima, C., 1998, Structure of the Ca2+ pump of sarcoplasmic reticulum: a view along the lipid bilayer at 9-AÊ resolution. Biophysical Journal, 75, 41–52.
  • Osada, M., Netticadan, T., Tamura, K. and Dhalla, N. S., 1998, Modification of ischemia-reperfusion-induced changes in cardia c sarcoplasmic reticulum by preconditioning. American Journal of Physiology-Heart and Circulatory Physiology, 43, H2025–H2034.
  • Periasamy, M., Reed, T. D., Liu, L. H., Ji, Y., Loukianov, E., Paul, R.J., Nieman, M.L., Riddle, T., Duffy, J. J., Doetschman, T., Lorenz, J. N. and Shull,G. E., 1999, Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plas- mic reticulum Ca2+,ATPase isoform 2 (SERCA2) gene. Journal of Biological Chemistry, 274, 2556–2562.
  • Pernollet, M. G., Lantoine, F. and Devynck, M. A., 1996, Nitric oxide inhibits ATP-dependent Ca2+ uptake into platelet membrane vesicles. Biochemical and Biophysical Research Communica- tions, 222, 780–785.
  • Poch, E., Leach, S., Snape, S., Cacic, T., MacLennan, D. H. and Lytton, J., 1998, Functional characterization of alternatively spliced human SERCA3 transcripts. American Journal of Physiol- ogy-Cell Physiology, 44, C1449–C1458.
  • Pollesello, P., Annila, A. and Ovaska, M., 1999, Structure of the 1-36 amino-termina l fragment of human phospholamban by nuclear magnetic resonance and modeling of the phospholamban pentamer. Biophysical Journal, 76, 1784–1795.
  • Reddy, L. G., Jones, L. R., Cala, S. E., O’Brian,J. J., Tatulian, S. A. and Stokes, D. L., 1995, Functional reconstitution of recombinant phospholamban with rabbit skeletal Ca2+,ATPase. Journal of Biological Chemistry, 270, 9390–9397.
  • Reddy, L. G., Jones, L. R., Pace, R. C. and Stokes, D. L., 1996, Purified, reconstitute d cardiac Ca2+,ATPase is regulated by phospholamban but not by direct phosphorylation with Ca2+/ calmodulin-dependent protein kinas e. Journal of Biological Chem- istry, 271, 14964–14970.
  • Rooney, E. and Meldolesi, J., 1996, The endoplasmic reticulum in PC12 cells-Evidence for a mosaic of domains differently specializ ed in Ca2+ handling. Journal of Biological Chemistry, 271, 29304–29311.
  • Ruiz-Perez, V. L., Carter, S. A., Healy, E ., Todd, C., Rees, J. L.,
  • Steijlen, P. M., Carmicha el, A. J., Lewis, H. M., Hohl, D., Itin, P., Vahlquist, A., Gobello, T., Mazzanti, C., Reggazini, R., Nagy, G., Munro, C. S. and Strachan, T., 1999, ATP2A2 mutations in Darier’s disease: variant cutaneous phenotypes are associated with miss ense mutations, but neuropsychiatric features are indepen- dent of mutation class. Human Molecular Genetics, 8, 1621-1630. Sakuntabhai, A., Ruiz-Perez, V., Carter, S., Jacobs en, N., Burge, S., Monk, S., Smith, M., Munro, C. S., O’Donovan, M., Craddock, N., Kucherlapati, R., Rees, J. L., Owen, M., Lathrop, G. M., Monaco, A. P., Strachan, T. and Hovnanian, A., 1999, Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nature Genetics, 21, 271–277.
  • Sasaki, T., Inui, M., Kimura, Y., Kuzuya, T. and Tada, M., 1992, Molecula r mechanism of regulation of Ca2+ pump ATPase by phospholamban in cardia c sarcoplasmic-reticulum-effects of synthetic phospholamban peptides on Ca2+ pump ATPase. Journal of Biological Chemistry, 267, 1674–1679.
  • Schoneich, C., Viner, R. I., Farmington, D. A. and Bigelow, D. J., 1999, Age-related chemical modification of the skeleta l muscle sarcoplasmic reticulum Ca-ATPase of the rat. Mechanisms of Ageing and Development, 107, 221–231.
  • Simmerman, H. K. B. and Jones, L. R., 1998, Phospholamban: protein structure, mechanism of action, and role in cardiac function. Physiologica l Reviews, 78, 921–947
  • Simmerman, H. K. B., Collins, J. H., Theibert, J. L., Wegener, A. D. and Jones, L.R., 1986, Sequence-analysis of phospholamban-identifica tion of phosphorylation sites and 2 major structura l domains. Journal of Biological Chemistry, 261, 3333–3341.
  • Simmerman, H. K. B., Kobayashi, Y. M., Autry, J. M. and Jones, L. R., 1996, A leucine zipper stabiliz es the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure. Journal of Biological Chemistry, 271, 5941–5946.
  • Soulie, S., Neumann, J. M., Berthomieu, C., Mùller, J. V., le Maire, M. and Forge V., 1999, NMR conformational study of the sixth transmembrane segment of sarcoplasmic reticulum Ca2+,AT- Pas e. Biochemistry, 38, 5813–5821.
  • Starling, A. P., Hughes, G., Sharma, R. P., East, J. M. and Lee, A. G., 1995, The hydrophilic domain of phospholamban inhibits the Ca2+, ATPase-the importance of the method of assay. Biochemical and Biophysical Res earch Communications, 215, 1067–1070.
  • Stokes, D. L. and Green, N. M., 2000, Modeling a dehalogenase fold into the 8-AÊ density map for Ca2+,ATPase defines a new domain structure. Biophysical Journal, 78, 1765–1776.
  • Sudbrak, R., Brown, J., Dobson-Stone, C., Carter, S., Ramser, J., White, J., Healy, E., Dissanayake, M., Larregue, M., Perruss el, M., Lehrach, H., Munro, C. S., Strachan, T., Burge, S., Hovnanian, A. and Monaco, A. P., 2000, Hailey-Hailey dis eas e is caus ed by mutations in ATP2C1 encoding a novel Ca2+ pump. Human Molecular Genetics, 9, 1131–1140.
  • Tada, M. and Toyofuku, T., 1998, Molecular regulation of phospho- lamban function and expression. Trends in Cardiovascular Medicine, 8, 330–340.
  • Thomas, A. P., Bird, G. S. J., Hajnoczky, G., RobbGaspers, L. D. and Putney, J. W., 1996, Spatial and temporal aspects of cellula r calcium signaling. Fas eb Journal, 10, 1505–1517.
  • Toyofuku, T., Kurzydlowski, K., Tada, M. and MacLennan, D. H., 1993, Identification of regions in the Ca2+,ATPas e of sarcoplas- mic-reticulum that affect functiona l association with phospholam- ban. Journal of Biological Chemistry, 268, 2809–2815.
  • Toyofuku, T., Kurzydlowski, K., Tada, M. and MacLennan, D. H., 1994a, Amino-acids Lys-Asp-Asp-Lys-Pro-Val(402) in the Ca2+, ATPas e of cardia c sarcoplasmic-reticulum are critica l for func- tional association with phospholamban. Journal of Biological Chemistry, 269, 22929–22932.
  • Toyofuku, T., Kurzydlowski, K., Tada, M. and MacLennan, D. H., 1994b, Amino-acids Glu(2) to Ile(18) in the cytoplasmic domain of phospholamban are ess ential for functional association with the Ca2+,ATPas e of sarcoplasmic-reticulum. Journal of Biological Chemistry, 269, 3088–3094.
  • Toyoshima, C., Nakasako, M., Nomura, H. and Ogawa, H., 2000, Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 AÊ resolution. Nature, 405, 647–655.
  • Varadi, A., Lebel, L., Hashim, Y., Mehta, Z., Ashcroft, S. J. H. and Turner, R., 1999, Sequence variants of the sarco(endo)plasmic reticulum Ca2+, transport ATPas e 3 gene (SERCA3) in Cauca- sian Type II diabetic patients (UH Prospective Diabetes Study 48). Diabetologia, 42, 1240–1243.
  • Verboomen, H., Mertens, L., Eggermont, J., Wuytack, F. and VandenBosch, L., 1995, Modulation of SERCA2 activity: regulated splicing and interaction with phospholamban. Bioscience Reports, 15, 307–315.
  • Verboomen, H., Wuytack, F., Desmedt, H., Himpens, B. and Casteels, R., 1992, Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospho- lamban. Biochemical Journal, 286, 591–595.
  • Viner, R. I., Farmington, D. A., Huhmer, A. F. R., Bigelow, D. J. and Scenic, C., 1996, Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca- ATPas e of rat skeletal muscle during aging: a peroxynitrite-mediated process? Febs Letters, 379, 286–290.
  • Wankerl, M. and Schwartz, K., 1995, Calcium-transport proteins in the nonfailing and failing heart-gene-expression and function. Journal of Molecular Medicine, 73, 487–496.
  • Worley, J. F., McIntyre, M. S., Spencer, B., Mertz, R. J., Roe, M. W. and Dukes, I. D., 1994, Endoplasmic-reticulum calcium store regulates membrane- potential in mous e islet beta-cells. Journal of Biologica l Chemistry, 269, 14359–14362.
  • Wuytack, F., Dode, L., BabaAissa, F. and Raeymaekers, L., 1995, The SE RCA3-type of organellar Ca2+ pumps. Bioscience Reports, 15, 299–306.
  • Xu, A. D. and Narayanan, N., 1999, Ca2+/calmodulin-dependent phosphorylation of the Ca2+, ATPase, uncoupled from phospho- lamban, stimulates Ca2+,pumping in native cardia c sarcoplasmic reticulum. Biochemical and Biophysical Research Communica- tions, 258, 66–72.
  • Xu, A., Hawkins, C. and Narayanan, N., 1993, Phosphorylation and activation of the Ca2+,pumping ATPas e of cardia c sarcoplasmic- reticulum by Ca2+/calmodulin-dependent protein-kinase. Journal of Biologica l Chemistry, 268, 8394–8397.
  • Zhai, J., Schmidt, A. G., Hoit, B. D., Kimura, Y., MacLennan, D. H. and Kranias, E. G., 2000, Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo. Journal of Biological Chemistry, 275, 10538–10544.
  • Zhang, P. J., Toyoshima, C., Yonekura, K., Green, N. M. and Stokes, D. L., 1998, Structure of the calcium pump from sarcoplasmic reticulum at 8-AÊ resolution. Nature, 392, 835–839.
  • Zhang, Y. L., Fujii, J., Phillips, M. S., Chen, H. S., Karpati, G., Yee, W. C., Schrank, B., Cornblath, D. R., Boylan, K. B. and MacLennan, D. H., 1995, Characterization of cDNA and genomic DNA encoding SERCA1, the Ca2+,ATPase of human fast-twitch skeletal muscle sarcoplasmic reticulum, and its elimination as a candidate gene for Brody dis eas e. Genomics, 30, 415–424.
  • Zvaritch, E., Backx, P. H., Jirik, F., Kimura, Y., de Leon, S., Schmidt, A. G., Hoit, B. D., Lester, J. W., Kranias, E. G. and MacLennan, D. H., 2000, The transgenic express ion of highly inhibitory mono- meric forms of phospholamban in mous e heart impairs cardia c contractility. Journal of Biological Chemistry, 275, 14985–14991.

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