758
Views
8
CrossRef citations to date
0
Altmetric
PAPERS

Polyethylenimine of various molecular weights as adjuvant for transfection mediated by cationic liposomes

, & , PhD
Pages 249-263 | Received 22 Jul 2008, Published online: 09 Jul 2009

References

  • Mulligan RC. The basic science of gene therapy. Science 1993; 260: 926–932
  • Penacho N, Filipe A, Simoes S, Pedroso de Lima MC. Transferrin-associated lipoplexes as gene delivery systems: Relevance of mode of preparation and biophysical properties. J Membr Biol 2008; 221: 141–152
  • da Cruz MT, Cardoso AL, de Almeida LP, Simoes S, de Lima MC. Tf-lipoplex-mediated NGF gene transfer to the CNS: Neuronal protection and recovery in an excitotoxic model of brain injury. Gene Ther 2005; 12: 1242–1252
  • da Cruz MT, Simoes S, de Lima MC. Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons. Exp Neurol 2004; 187: 65–75
  • Neves SS, Sarmento-Ribeiro AB, Simoes SP, Pedroso de Lima MC. Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: Mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy. Biochim Biophys Acta 2006; 1758: 1703–1712
  • Simoes S, Slepushkin V, Pires P, Gaspar R, de Lima MP, Duzgunes N. Mechanisms of gene transfer mediated by lipoplexes associated with targeting ligands or pH-sensitive peptides. Gene Ther 1999; 6: 1798–1807
  • Simoes S, Slepushkin V, Gaspar R, Pedroso de Lima MC, Duzgunes N. Successful transfection of lymphocytes by ternary lipoplexes. Biosci Rep 1999; 19: 601–609
  • Cardoso AL, Simoes S, de Almeida LP, Pelisek J, Culmsee C, Wagner E, Pedroso de Lima MC. siRNA delivery by a transferrin-associated lipid-based vector: A non-viral strategy to mediate gene silencing. J Gene Med 2007; 9: 170–183
  • Lampela P, Soininen P, Urtti A, Mannisto PT, Raasmaja A. Synergism in gene delivery by small PEIs and three different nonviral vectors. Int J Pharm 2004; 270: 175–184
  • Lampela P, Elomaa M, Ruponen M, Urtti A, Mannisto PT, Raasmaja A. Different synergistic roles of small polyethylenimine and Dosper in gene delivery. J Control Release 2003; 88: 173–183
  • Lampela P, Raisanen J, Mannisto PT, Yla-Herttuala S, Raasmaja A. The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures. J Gene Med 2002; 4: 205–214
  • Lee CH, Ni YH, Chen CC, Chou C, Chang FH. Synergistic effect of polyethylenimine and cationic liposomes in nucleic acid delivery to human cancer cells. Biochim Biophys Acta 2003; 1611: 55–62
  • Boussif O, Lezoualc'h F, Zanta MA, Mergny MD, Scherman D, Demeneix B, Behr JP. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: Polyethylenimine. Proc Natl Acad Sci USA 1995; 92: 7297–7301
  • Behr JP. Gene transfer with synthetic cationic amphiphiles: Prospects for gene therapy. Bioconjug Chem 1994; 5: 382–389
  • Godbey WT, Barry MA, Saggau P, Wu KK, Mikos AG. Poly(ethylenimine)-mediated transfection: A new paradigm for gene delivery. J Biomed Mater Res 2000; 51: 321–328
  • Godbey WT, Wu KK, Mikos AG. Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc Natl Acad Sci USA 1999; 96: 5177–5181
  • Pollard H, Remy JS, Loussouarn G, Demolombe S, Behr JP, Escande D. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J Biol Chem 1998; 273: 7507–7511
  • Pinnaduwage P, Schmitt L, Huang L. Use of a quaternary ammonium detergent in liposome mediated DNA transfection of mouse L-cells. Biochim Biophys Acta 1989; 985: 33–37
  • Tranchant I, Thompson B, Nicolazzi C, Mignet N, Scherman D. Physicochemical optimisation of plasmid delivery by cationic lipids. J Gene Med 2004; 6(Suppl. 1)S24–35
  • Maitani Y, Igarashi S, Sato M, Hattori Y. Cationic liposome (DC-Chol/DOPE = 1:2) and a modified ethanol injection method to prepare liposomes, increased gene expression. Int J Pharm 2007; 342: 33–39
  • Domazou AS, Luisi PL. Size distribution of spontaneously formed liposomes by the alcohol injection method. J Liposome Res 2002; 12: 205–220
  • Kunath K, von Harpe A, Fischer D, Petersen H, Bickel U, Voigt K, Kissel T. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: Comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J Control Release 2003; 89: 113–125
  • Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, New York 1989
  • Saenger W. Principles of nuclei structure. Springer Verlag, New York 1984
  • Batzri S, Korn ED. Single bilayer liposomes prepared without sonication. Biochim Biophys Acta 1973; 298: 1015–1019
  • Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res 2002; 62: 6831–6836
  • Lendemans DG, Myschik J, Hook S, Rades T. Immuno-stimulating complexes prepared by ethanol injection. J Pharm Pharmacol 2005; 56: 729–734
  • Sedmak JJ, Grossberg SE. A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250. Anal Biochem 1977; 79: 544–552
  • Konopka K, Pretzer E, Felgner PL, Duzgunes N. Human immunodeficiency virus type-1 (HIV-1) infection increases the sensitivity of macrophages and THP-1 cells to cytotoxicity by cationic liposomes. Biochim Biophys Acta 1996; 1312: 186–196
  • Kim TW, Kim YJ, Chung H, Kwon IC, Sung HC, Jeong SY. The role of non-ionic surfactants on cationic lipid mediated gene transfer. J Control Release 2002; 82: 455–465
  • Harvie P, Wong FM, Bally MB. Use of poly(ethylene glycol)-lipid conjugates to regulate the surface attributes and transfection activity of lipid-DNA particles. J Pharm Sci 2000; 89: 652–663
  • da Cruz MT, Simoes S, Pires PP, Nir S, de Lima MC. Kinetic analysis of the initial steps involved in lipoplex – cell interactions: Effect of various factors that influence transfection activity. Biochim Biophys Acta 2001; 1510: 136–151
  • Birchall JC, Kellaway IW, Mills SN. Physico-chemical characterisation and transfection efficiency of lipid-based gene delivery complexes. Int J Pharm 1999; 183: 195–207
  • Chin JH, Goldstein DB. Effects of low concentrations of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes. Mol Pharmacol 1977; 13: 435–441
  • Bailey AL, Sullivan SM. Efficient encapsulation of DNA plasmids in small neutral liposomes induced by ethanol and calcium. Biochim Biophys Acta 2000; 1468: 239–252
  • Anji, A, Shaik, KA, Kumari, M. 2003. Effect of ethanol on lipid-mediated transfection of primary cortical neurons. Ann NY Acad Sci 993:95–102; discussion 123–104.
  • Chanturiya A, Leikina E, Zimmerberg J, Chernomordik LV. Short-chain alcohols promote an early stage of membrane hemifusion. Biophys J 1999; 77: 2035–2045
  • Zuhorn IS, Bakowsky U, Polushkin E, Visser WH, Stuart MC, Engberts JB, Hoekstra D. Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency. Mol Ther 2005; 11: 801–810
  • Shi F, Wasungu L, Nomden A, Stuart MC, Polushkin E, Engberts JB, Hoekstra D. Interference of poly(ethylene glycol)-lipid analogues with cationic-lipid-mediated delivery of oligonucleotides; role of lipid exchangeability and non-lamellar transitions. Biochem J 2002; 366: 333–341
  • Rivest V, Phivilay A, Julien C, Belanger S, Tremblay C, Emond V, Calon F. Novel liposomal formulation for targeted gene delivery. Pharm Res 2007; 24: 981–990
  • Thomas M, Klibanov AM. Non-viral gene therapy: Polycation-mediated DNA delivery. Appl Microbiol Biotechnol 2003; 62: 27–34
  • Garcia L, Bunuales M, Duzgunes N, Tros de Ilarduya C. Serum-resistant lipopolyplexes for gene delivery to liver tumour cells. Eur J Pharm Biopharm 2007; 67: 58–66
  • Neu M, Fischer D, Kissel T. Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med 2005; 7: 992–1009
  • Petersen H, Kunath K, Martin AL, Stolnik S, Roberts CJ, Davies MC, Kissel T. Star-shaped poly(ethylene glycol)-block-polyethylenimine copolymers enhance DNA condensation of low molecular weight polyethylenimines. Biomacromolecules 2002; 3: 926–936
  • Fattal E, Couvreur P, Dubernet C. Smart” delivery of antisense oligonucleotides by anionic pH-sensitive liposomes. Adv Drug Deliv Rev 2004; 56: 931–946
  • van der Aa MA, Huth US, Hafele SY, Schubert R, Oosting RS, Mastrobattista E, Hennink WE, Peschka-Suss R, Koning GA, Crommelin DJ. Cellular uptake of cationic polymer-DNA complexes via caveolae plays a pivotal role in gene transfection in COS-7 cells. Pharm Res 2007; 24: 1590–1598
  • Rejman J, Conese M, Hoekstra D. Gene transfer by means of lipo- and polyplexes: Role of clathrin and caveolae-mediated endocytosis. J Liposome Res 2006; 16: 237–247
  • Forrest ML, Pack DW. On the kinetics of polyplex endocytic trafficking: implications for gene delivery vector design. Mol Ther 2002; 6: 57–66
  • Bieber T, Meissner W, Kostin S, Niemann A, Elsasser HP. Intracellular route and transcriptional competence of polyethylenimine-DNA complexes. J Control Release 2002; 82: 441–454
  • Masotti A, Moretti F, Mancini F, Russo G, Di Lauro N, Checchia P, Marianecci C, Carafa M, Santucci E, Ortaggi G. Physicochemical and biological study of selected hydrophobic polyethylenimine-based polycationic liposomes and their complexes with DNA. Bioorg Med Chem 2007; 15: 1504–1515
  • Kheirolomoom A, Ferrara KW. Cholesterol transport from liposomal delivery vehicles. Biomaterials 2007; 28: 4311–4320
  • Rosa M, Penacho N, Simoes S, Lima MC, Lindman B, Miguel MG. DNA pre-condensation with an amino acid-based cationic amphiphile. A viable approach for liposome-based gene delivery. Mol Membr Biol 2008; 25: 23–34
  • Elouahabi A, Ruysschaert JM. Formation and intracellular trafficking of lipoplexes and polyplexes. Mol Ther 2005; 11: 336–347

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.