Swine plasma peptides obtained using pepsin: In silico and in vitro properties and biological activities

References

• Alahyaribeik S, Sharifi SD, Tabandeh F, Honarbakhsh S, Ghazanfari S. 2021. Stability and cytotoxicity of DPPH inhibitory peptides derived from biodegradation of chicken feather. Protein Expr Purif. 177:105748.
   PubMed Web of Science ®Google Scholar
• AOAC. 2016. Official methods of analysis of AOAC international. 20th ed. Aluko RE, Girgih AT, He R, Malomo S, Li H, Offengenden M, Wu J. 2015. Structural and functional characterization of yellow field pea seed (Pisum sativum L.) protein-derived antihypertensive peptides. Food Res Int. 77:10–16.
   Web of Science ®Google Scholar
• Apostolidis E, Kwon Y, Shetty K. 2007. Inhibitory potential of herb, fruit, and fungal-enriched cheese against key enzymes linked to type 2 diabetes and hypertension. Innov Food Sci Emerg Technol. 8(1):46–54.
   Web of Science ®Google Scholar
• Arise RO, Yekeen AA, Ekun OE. 2016. In vitro antioxidant and α-amylase inhibitory properties of watermelon seed protein hydrolysates. EEB. 14(4):163–172.
   Google Scholar
• Bah CSF, Bekhit AEDA, Carne A, Mcconnell MA. 2013. Slaughterhouse blood: an emerging source of bioactive compounds. Compr. Rev. Food Sci. Food Saf. 12(3):314–331.
   Web of Science ®Google Scholar
• Bashir KMI, Sohn JH, Kim J-S, Choi J-S. 2020. Identification and characterization of novel antioxidant peptides from mackerel (Scomber japonicus) muscle protein hydrolysates. Food Chem. 323:126809.
   PubMed Web of Science ®Google Scholar
• Bateman A, Martin MJ, O’Donovan C, Magrane M, Alpi E, Antunes R, Bely B, Bingley M, Bonilla C, Britto R, et al. 2017. UniProt: the universal protein knowledgebase. Nucleic Acids Res. 45:D158–D169.
   PubMed Web of Science ®Google Scholar
• Bernfeld P. 1951. Enzymes of starch degradation and synthesis. Adv Enzymol Relat Areas Mol Biol. 12:380–424.
   Google Scholar
• Bhalodia NR, Nariya PB, Acharya RN, Shukla VJ. 2013. In vitro antioxidant activity of hydro alcoholic extract from the fruit pulp of Cassia fistula Linn. Ayu. 34(2):209–214.
   PubMedGoogle Scholar
• Chalamaiah M, Jyothirmayi T, Diwan PV, Dinesh Kumar B. 2015. Antioxidant activity and functional properties of enzymatic protein hydrolysates from common carp (Cyprinus carpio) roe (egg). J Food Sci Technol. 52(9):5817–5825.
   PubMed Web of Science ®Google Scholar
• Chalamaiah M, Yu W, Wu J. 2018. Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: a review. Food Chem. 245:205–222.
   PubMed Web of Science ®Google Scholar
• Chaudhary K, Kumar R, Singh S, Tuknait A, Gautam A, Mathur D, Anand P, Varshney GC, Gajendra, &, Raghava PS. 2016. A web server and mobile app for computing hemolytic potency of peptides. Sci Rep. 6:22843.
   PubMed Web of Science ®Google Scholar
• Chiarpotti MV, Longo GS, Del Popolo MG. 2021. Nanoparticles modified with cell penetrating peptides: assessing adsorption on membranes containing acidic lipids. Colloids Surf B Biointerfaces. 197:111373.
   PubMed Web of Science ®Google Scholar
• Chruszcz M, Mikolajczak K, Mank N, Majorek KA, Porebski PJ, Minor W. 2013. Serum albumins-unusual allergens. Biochim Biophys Acta. 1830(12):5375–5381.
   PubMed Web of Science ®Google Scholar
• Cox J, Mann M. 2008. MaxQuant enables high peptide identification rates, individualized ppb-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol. 26(12):1367–1372.
   PubMed Web of Science ®Google Scholar
• Croglio MP, Commins SP, McGill SK. 2021. Isolated gastrointestinal alpha-gal meat allergy is a cause for gastrointestinal distress without anaphylaxis. Gastroenterology. 160(6):2178–2180.e1.
   PubMed Web of Science ®Google Scholar
• Daroit DJ, Brandelli A. 2021. In vivo bioactivities of food protein-derived peptides – a current review. Curr Opin Food Sci. 39:120–129.
   Web of Science ®Google Scholar
• Derakhshankhah H, Jafari S. 2018. Cell penetrating peptides: a concise review with emphasis on biomedical applications. Biomed Pharmacother. 108:1090–1096.
   PubMed Web of Science ®Google Scholar
• Deveci E, Cayan F, Tel-Caya G, Duru ME. 2021. Inhibitory activities of medicinal mushrooms on a-amylase and a-glucosidase-enzymes related to type 2 diabetes. S Afr J Bot. 137:19–23.
   Web of Science ®Google Scholar
• Dimitrov I, Flower DR, Doytchinova I. 2013. AllerTOP-a server for in silico prediction of allergens. BMC Bioinformatics. 14(Suppl 6):S4.
   PubMed Web of Science ®Google Scholar
• Di Pierro G, O’Keeffe MB, Poyarkov A, Lomolino G, FitzGerald RJ. 2014. Antioxidant activity of bovine casein hydrolysates produced by Ficus carica L.-derived proteinase. Food Chem. 156:305–311.
   PubMed Web of Science ®Google Scholar
• Elavarasan K, Shamasundar BA. 2014. Angiotensin I-converting enzyme inhibitory activity of protein hydrolysates prepared from three freshwater carps (Catla catla, Labeo rohita and Cirrhinus mrigala) using Flavorzyme. Int J Food Sci Technol. 49(5):1344–1350.
   Web of Science ®Google Scholar
• Fu Y, Liu J, Zhang W, Waehrens SS, Tøstesen M, Hansen ET, Bredie WLP, Lametsch R. 2020. Exopeptidase treatment combined with Maillard reaction modification of protein hydrolysates derived from porcine muscle and plasma: structure–taste relationship. Food Chem. 306:125613.
   PubMed Web of Science ®Google Scholar
• Gee Yap P, Yuen Gan C. 2020. In vivo challenges of anti-diabetic peptide therapeutics: Gastrointestinal stability, toxicity and allergenicity. Trends Food Sci. Technol. 105:161–175.
   Web of Science ®Google Scholar
• Gomes B, Augusto MT, Felício MR, Hollmann A, Franco OL, Gonçalves S, Santos NC. 2018. Designing improved active peptides for therapeutic approaches against infectious diseases. Biotechnol Adv. 36(2):415–429.
   PubMed Web of Science ®Google Scholar
• Gupta S, Kapoor P, Chaudhary K, Gautam A, Kumar R, Raghava GPS, Open Source Drug Discovery Consortium. 2013. In silico approach for predicting toxicity of peptides and proteins. PLOS One. 8(9):e73957.
   PubMed Web of Science ®Google Scholar
• Halim NRA, Yusof HM, Sarbon NM. 2016. Functional and bioactive properties of fish protein hydolysates and peptides: a comprehensive review. Trends Food Sci Technol. 51:24–33.
   Web of Science ®Google Scholar
• Holton TA, Pollastri G, Shields DC, Mooney C. 2013. CPPpred: prediction of cell penetrating peptides. Bioinformatics. 29(23):3094–3096.
   PubMed Web of Science ®Google Scholar
• Hoyle NT, Merritt JH. 1994. Quality of fish protein hydrolysates from Herring (Clupea harengus). J Food Sci. 59:1–4.
   Web of Science ®Google Scholar
• Hu, H., Yang, X., Wang, T., Li, L., Wu, Y., Zhou, y., You, L. Purification and identification of antioxidant peptides from round scad (Decapterus maruadsi) hydrolysates by consecutive chromatography and electrospray ionization-mass spectrometry. Food Chem. Toxicol. 135:110882.
   PubMed Web of Science ®Google Scholar
• Hyun C-K, Shin H-K. 2000. Utilization of bovine blood plasma proteins for the production of angiotensin I converting enzyme inhibitory peptides. Process Biochem. 36(1–2):65–71.
   Web of Science ®Google Scholar
• Iacumin L, Manzano M, Stella S, Comi G. 2017. Fate of the microbial population and the physico-chemical parameters of “Sanganel” a typical blood sausages of the Friuli, a north-east region of Italy. Food Microbiol. 63:84–91.
   PubMed Web of Science ®Google Scholar
• Iwaniak A, Darewicz M, Mogut D, Minkiewicz P. 2019. Elucidation of the role of in silico methodologies in approaches to studying bioactive peptides derived from foods. J Funct Foods. 61:103486.
   Web of Science ®Google Scholar
• Karami Z, Akbari-Adergani B. 2019. Bioactive food derived peptides: a review on correlation between structure of bioactive peptides and their functional properties. J Food Sci Technol. 56(2):535–547.
   PubMed Web of Science ®Google Scholar
• Khan MM, Nina Filipczak N, Torchilin VP. 2020. Cell penetrating peptides: a versatile vector for co-delivery of drug andgenes in cancer. J Control Release. 330:1220–1228.
   PubMed Web of Science ®Google Scholar
• Kim GC, Cheon DH, Lee Y. 2021. Challenge to overcome current limitations of cell-penetrating peptides. Biochim Biophys Acta Proteins Proteom. 1869(4):140604.
   PubMed Web of Science ®Google Scholar
• Kristoffersen KA, Liland KH, Böcker U, Wubshet SG, Lindberg D, Horn SJ, Afseth NK. 2019. FTIR-based hierarchical modeling for prediction of average molecular weights of protein hydrolysates. Talanta. 205(1):120084.
   PubMedGoogle Scholar
• Ladics GS. 2008. Current codex guidelines for assessment of potential protein allergenicity. Food Chem Toxicol. 46(Suppl 10):S20–S23.
   PubMed Web of Science ®Google Scholar
• Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227(5259):680–685.
   PubMed Web of Science ®Google Scholar
• Lafarga T, Wilm M, Wynne K, Hayes M. 2016. Bioactive hydrolysates from bovine blood globulins: generation, characterisation, and in silico prediction of toxicity and allergenicity. J Funct Foods. 24:142–155.
   Web of Science ®Google Scholar
• Lassoued I, Mora L, Nasri R, Aydi M, Toldrá F, Aristoy MC, Barkia A, Nasri M. 2015. Characterization, antioxidative and ACE inhibitory properties of hydrolysates obtained from thornback ray (Raja clavata) muscle. J Proteomics. 128:458–468.
   PubMed Web of Science ®Google Scholar
• Layer P, Zinsmeister AR, Dimagno EP. 1986. Effects of decreasing intraluminal amylase activity on starch digestion and postplandial gastrointestinal function in humans. Gastroenterology. 91(1):41–48.
   PubMed Web of Science ®Google Scholar
• Li C, Huang Z, Dong L, Liu X. 2018. Improvement of enzymological properties of pepsin by chemical modification with chitooligosaccharides. Int J Biol Macromol. 118(Pt A):216–227.
   PubMedGoogle Scholar
• López-Pedrouso M, Borrajo P, Pateiro M, Lorenzo JM, Franco D. 2020. Antioxidant activity and peptidomic analysis of porcine liver hydrolysates using alcalase, bromelain, flavourzyme and papain enzymes. Food Res Int. 137:109389.
   PubMed Web of Science ®Google Scholar
• Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem. 193(1):265–275.
   PubMed Web of Science ®Google Scholar
• Marques TR, Lopes L, Pereira S, Simão AA, Ramos VDO, Braga MA, Duarte A, Donizete C. 2014. Inibição de enzimas digestivas por pellets de lúpulo (Humulus lupulus L.). Braz J Biosci. 12:183–187.
   Google Scholar
• Sauter M, Strieker M, Kleist C, Wischnjow A, Daniel V, Altmann A, Haberkorn U, Mier W. 2020. Improving antibody-based therapies by chemical engineering of antibodies with multimeric cell-penetrating peptides for elevated intracellular delivery. J Control Release. 322:200–208.
   PubMed Web of Science ®Google Scholar
• Milan ZB, Boskovic M, Ivanovic J, Janjic J, Dokmanovic M, Markovic R, Tatjana B. 2014. Bioactive peptides from meat and their influence on human health. Tehnol Mesa. 55(1):8–21.
   Google Scholar
• Mooney C, Haslam NJ, Pollastri G, Shields DC. 2012. Towards the improved discovery and design of functional peptides: common features of diverse classes permit generalized prediction of bioactivity. PLOS One. 7(10):e45012.
   PubMed Web of Science ®Google Scholar
• Najafian L, Babji AS. 2014. Production of bioactive peptides using enzymatic hydrolysis and identification antioxidative peptides from Patin (Pangasius sutchi) sarcoplasmic protein hydolysate. J Funct Foods. 9:280–289.
   Web of Science ®Google Scholar
• Norris R, Fitzgerald RJ. 2013. Antihypertensive peptides from food proteins. In: Hernandez-Ledezma B, Hseih B (Eds.), Bioactive food peptides in health and disease (pp. 45-72). Croatia: In Tech.
   Google Scholar
• Oboh G, Ademiluyi AO, Faloye YM. 2011. Effect of combination on the antioxidant and inhibitory properties of tropical pepper varieties against α-amylase and α-glucosidase activities in vitro. J Med Food. 14(10):1152–1158.
   PubMed Web of Science ®Google Scholar
• Olusanya R, James J, Mic-Braimoh IM, Korode E, Nike R, Osemwegie O. 2019. In vitro angiotesin-1-converting enzyme, α-amylase and α-glucosidase inhibitory and antioxidant activities of Luffa cylindrical (L.) M. Roem seed protein hydrolysate. Heliyon. 5(5):e01634.
   PubMed Web of Science ®Google Scholar
• Olusola AO, Ekun OE, David TI, Olorunfemi OE, Oyewale MB. 2018. Moringa oleifera seed protein hydrolysates: kinetics of α-amylase inhibition and antioxidant potentials. J Med Med Sci. 7:190–201.
   Google Scholar
• Pal GK, Suresh PV. 2017. Physico-chemical characteristics and fibril-forming capacity of carp swim bladder collagens and exploration of their potential bioactive peptides by in silico approaches. Int J Biol Macromol. 101:304–313.
   PubMed Web of Science ®Google Scholar
• Pereira JA, Dionísio L, Patarata L, Matos TJS. 2015. Effect of packaging technology on microbiological and sensory quality of a cooked blood sausage, Morcela de Arroz, from Monchique region of Portugal. Meat Sci. 101:33–41.
   PubMed Web of Science ®Google Scholar
• Pérez-Gálvez R, Almécija MC, Espejo FJ, Guadix EM, Guadix A. 2011. Bi-objective optimisation of the enzymatic hydrolysis of porcine blood protein. Biochem. Eng. J. 53(3):305–310.
   Web of Science ®Google Scholar
• Raftery RM, Walsh DP, Blokpoel Ferreras L, Mencía Castaño I, Chen G, LeMoine M, Osman G, Shakesheff KM, Dixon JE, O'Brien FJ. 2019. Highly versatile cell-penetrating peptide loaded scaffold for efficient and localised gene delivery to multiple cell types: from development to application in tissue engineering. Biomaterials. 216:119277.
   PubMed Web of Science ®Google Scholar
• Raghavan S, Kristinsson HG. 2009. ACE-inhibitory activity of tilapia protein hydrolysates. Food Chem. 117(4):582–588.
   Web of Science ®Google Scholar
• Roy A, Nair S, Sen N, Soni N, Madhusudhan MS. 2017. In silico methods for design of biological therapeutics. Methods. 131:33–65.
   PubMed Web of Science ®Google Scholar
• Ryan JT, Ross RP, Bolton D, Fitzgerald GF, Stanton C. 2011. Bioactive peptides from muscle sources: meat and fish. Nutrients. 3(9):765–791.
   PubMed Web of Science ®Google Scholar
• Saadi S, Saari N, Anwar F, Hamid AA, Ghazali M. 2015. Recent advances in food biopeptides: production, biological functionalities and therapeutic applications. Biotechnol Adv. 33(1):80–116.
   PubMed Web of Science ®Google Scholar
• Sagawa N, Inomata N, Suzuki K, Sano S, Watanabe Y, Aihara M. 2021. Pork-cat syndrome caused by ingestion of beef intestines in an 8-year-old child. Allergol Int. 70(3):395–397.
   PubMedGoogle Scholar
• Saha S, Raghava GPS. 2006. AlgPred: Prediction of allergenic proteins and mapping of IgE epitopes. Nucleic Acids Res. 34(Web Server issue):W202–W209.
   PubMed Web of Science ®Google Scholar
• Shahidi F, Zhong Y. 2008. Bioactive Peptides. J AOAC Int. 91(4):914–931.
   PubMed Web of Science ®Google Scholar
• Sun Q, Luo Y. 2011. Porcine hemoglobin hydrolysate prepared with pepsin: antioxidant activities and their mechanisms. Int. J. Food Prop. 14(4):840–853.
   Web of Science ®Google Scholar
• Sun Q, Luo Y, Shen H, Hu X. 2011a. Effects of pH, temperature and enzyme to substrate ratio on the antioxidant activity of porcine hemoglobin hydrolysate prepared with pepsin. J. Food Biochem. 35(1):44–61.
   Web of Science ®Google Scholar
• Sun Q, Shen H, Luo Y. 2011b. Antioxidant activity of hydrolysates and peptide fractions derived from porcine hemoglobin. J Food Sci Technol. 48(1):53–60.
   PubMed Web of Science ®Google Scholar
• Tavano OL. 2013. Protein hydrolysis using proteases: an important tool for food biotechnology. J Mol Catal B Enzym. 90:1–11.
   Web of Science ®Google Scholar
• Thybaud V, Kasper P, Sobol Z, Elhajouji A, Fellows M, Guerard M, Lynch AM, Sutter A, Tanir JY. 2016. Genotoxicity assessment of peptide/protein-related biotherapeutics: points to consider before testing. Mutagenesis. 31(4):375–384.
   PubMed Web of Science ®Google Scholar
• Toldrá F, Mora L, Reig M. 2016. New insights into meat by-product utilization. Meat Sci. 120:54–59.
   PubMed Web of Science ®Google Scholar
• Vale N, Duarte D, Silva S, Correia AS, Costa B, Gouveia MJ, Ferreira A. 2020. Cell-penetrating peptides in oncologic pharmacotherapy: a review. Pharmacol Res. 162:105231.
   PubMed Web of Science ®Google Scholar
• Wilson JM, Platts-Mills TAE. 2018. Meat allergy and allergens. Mol Immunol. 100:107–112.
   PubMed Web of Science ®Google Scholar
• Wojeicchowski JP, Liandra G, Siqueira DA, De Lacerda LG, Schnitzler E, Demiate IM. 2018. Physicochemical, structural and thermal properties of oxidized, acetylated and dual-modified common bean. Food Sci Technol. 38(2):318–327.
   Web of Science ®Google Scholar
• Wu H, Chen H, Shiau C. 2003. Free amino acids and peptides as related to antioxidant properties in protein hydrolysates of mackerel (Scomber austriasicus). Food Res. Int. 36(9–10):949–957.
   Web of Science ®Google Scholar
• Xu X, Cao R, He L, Yang N. 2009. Antioxidant activity of hydrolysates derived from porcine plasma. J Sci Food Agric. 89(11):1897–1903.
   Web of Science ®Google Scholar
• Xu Y, Zhang X, Wang N, Pei X, Guo Y, Wang J, Barth S, Yu F, Lee SJ, He H, et al. 2020. Cell-penetrating peptide enhanced insulin buccal absorption. Int J Pharm. 584:119469.
   PubMedGoogle Scholar
• Zhou F, He S, Sun H, Wang Y, Zhang Y. 2021. Advances in epitope mapping technologies for food protein allergens: a review. Trends Food Sci Technol. 107:226–239.
   Web of Science ®Google Scholar