161
Views
17
CrossRef citations to date
0
Altmetric
Articles

Assessment of Bcl-2 Expression as Modulator of Fas Mediated Apoptosis in Acute Leukemia

, , &
Pages 113-121 | Published online: 04 Sep 2013

References

  • Munoz, L., Aveentin, A., Villamor, N., Junca, J., Acebedo, G., Domingo, A., Rozman, M., Torres, J.P., Tormo, M. and Nomdedeu, J.F. (2003) "Immunophenotypic findings in acute leukemia with Flt3 internal Tandem duplication", Hematolo-gica 88(6), 637–645.
  • Aref, S., Salama, O., El-Tonbary, Y., Fouda, M., Menessy, A. and El-Sherbiny, M. (2002) "Land E selectins in acute myeloid leukemia: expression, clinical relevance and relation to patients outcome", Hematology 7(2), 83–87.
  • Houghton, J.A. (1999) "Apoptosis and drug response", Curr. Opin. Oncol. 11(6), 475–481.
  • Tothova, E., Fricova, M., Stecova, N., Kafkova, A. and Elbertova, A. (2002) "High expression of Bc1-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy", Neoplasma 49, 141–144.
  • Holleman, A., Den Boer, M.L., Kazemier, K.M., Janka-Schaub, G.E. and Pieters, R. (2003) "Resistance to different dases of drugs is associated with impaired apoptosis in childhood acute lymphoblastic leukemia", Blood, Epub ahead of print.
  • Peart, M.J., Tainton, KM., Ruefli, A.A., Dear, A.E., Sedelies, K.A., O'Reilly, L.A., Waterhouse, N.J., Trapani, J.A. and Johnstone, R.W. (2003) "Novel mechanism of apoptosis induced by histone deacylase inhibitors", Cancer Res. 63(15), 4460–4471.
  • Wood, CM., Goodman, EA., Vassilev, A.O. and Uckun, EM. (2003) "CD95(AP0-1 /FAS) deficiency in infant acute lymphoblastiuc leukemia: detection of novel soluble Fas splice variants", Fur. J. Haematol. 70(3), 156–171.
  • Adams, J.M. and Cory, S. (1998) "The Bc1-2 protein family. Arbiters of cell survival", Science 281(5381), 1322–1326.
  • Solary, E., Droin, N., Bettaieb, A., Corcos, L., Dimanche-Boitrel, M. and Garrido, C. (2000) "Positive and negative regulation of apoptosis pathways by cytotoxic agents in hematological malignancies", Leukemia 14(10), 1833–1849.
  • Reed, J.C. (2003) "Apoptosis- Targeted therapies for cancer", Cancer cell 3(1), 17–22.
  • Zhang, Z. and Xie, J. (2003) "Expression of Fas, FasL, Bc12 and apoptosis of bone marrow CD34+ cells in patients with myelodysplastic syndrome", Zhongguop Shi Yan Xue Ye Za Zhi 11(3), 274–277.
  • Kornblau, S., Thall, F., Estrov, Z., Walterscheid, M., Patel, S., Theriault, A., Keating, J., Kantarjian, H., Estey, E. and Andreeff, M. (1999) "The prognostic impact of Bc1-2 expression varies with cytogenetics", Clin. Cancer Res. 5(7), 1758–1766.
  • Solary, E., Bettaieb, A., Dubrez-Daloz, L. and Corcos, L. (2003) "Mitochondria as a target for inducing death of malignant hematopoietic cells", Leuk. Lymphoma 44(4), 563–574.
  • Kluck, R.M., Bossy-Wetzel, E., Green, DR. and Newmeyer, D.D. (1997) "The release of cytochrome c from mitochondria: a primary site for BcL2 regulation of apoptosis", Science 275, 1132–1136.
  • Wang, D., Freeman, G.J., Levine, H., Ritz, J. and Robertson, M.J. (1997) "Role of CD40 and CD95 (Apo—Fas) antigens in the apoptosis of human B-cell malignancies", Br. J. Hematol. 97(2), 409–419.
  • Timmer, T., de Vries, E.G. and de Jong, S. (2002) "Fas receptor-mediated apoptosis: a clinical application?", J. Pathol. 196(2), 125–134.
  • Urbaniak-Kujda, D., Jazwiec, B., Tomaszewska-Toporska, B., Wolowiec, D., Kapelko-Slowik, K. and Kuliczkowski, K. (2002) "Expression of Fas receptror and soluble Fas ligand (sFasL) concentration in acute leukemia", Pol. Arch. Med. Wewn. 108(3), 873–878.
  • Lewis, N.R., Pallis, M. and Russel, N.H. (2000) "Fas receptor-Fas ligand system is independent of both CD-34 status and chemosensitivity in acute myeloid leukemia", Exp. Hematol. 28, 535–542.
  • Salomons, G.S., Brady, H.J., Verwijs-Janssen, M., Van Den Berg, J.D., Hart, A.A., Van Den Berg, H., Behrendt, H., Hablen, K. and Smets, L.A. (1997) "The Bax/alpha Bc1-2 ratio modulates the response to dexamethazone in leukemic cells and is highly variable in childhood acute leukemia", Int. J. Cancer 71(6), 959–965.
  • Bene, M.C., Castoldi, G., Knapp, W., Ludwing, W.D., Matutes, E. and Orfao, A. (1995) "European group for immunological classification of acute leukemias", Leukemia 9(10), 1783–1786.
  • Nagafuji, K., Shibuya, T., Harada, M., Mizuno, S., Takenaka, K., Miyamyoto, H., Okamura, T., Gondo, H. and Niho, Y. (1995) "Functional expression of Fas antigen (CD95) on hematopiotic progenitor cells", Blood 86(3), 883–889.
  • Schmid, I., Uittenbogaart, C.H. and Giorgi, J.V. (1991) "A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification", Cytometry 12(3), 274–285.
  • Campos, L., Rouault, J., Sabido, O., Oriol, E, Roubi, N., Vasselon, C., Archimbaud, E., Magaud, J.P. and Guyotat, D. (1993) "High expression of Bc12 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy", Blood 81(11), 3091–3096.
  • Bradbury, D.A. and Russell, N.H. (1995) "Comparative quantitive expression of Bc1-2 by normal and leukemic myeloid cells", Br. J. Haematol. 91(2), 374–379.
  • Karawajew, L., Wuchter, C., Ruppert, V., Drexler, H., Gruss, H.J., Dorken, B. and Ludwig, W.D. (1997) "Differential CD95 expression and function in T and B lineage acute lympho-blastic leukemia cells", Leukemia 11(8), 1245–1252.
  • Prokop, A., Wieder, T., Sturm, I., Essmanm, F., Seeger, K., Wuchter, C., Ludwig, W.D., Henze, G. and Dorken, B. (2000) "Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the bax /bc1-2 ratio", Leukemia 14(9), 1606–1613.
  • Hunter, J., Bond, B.L. and Parslow, T. (1996) "Function dissection of the human Bd-2 protein. Sequence requirements for inhibition of apoptosis", Mol. Cell Biol. 16(3), 877–883.
  • Kohler, T., Schill, C., Deininger, M.W., Krahl, R., Borchert, S., Hasenclever, D., Leiblein, S., Wagner, O. and Niederwieser, D. (2002) "High Bad, and Bax mRNA expression correlates with negative outcome in acute myeloid leukemia (AML)", Leukemia 16(1), 22–29.
  • Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J.P. and Korsmeyer, S.J. (1990) "De-regulated Bc1-2 gene expression selectively prolongs the survival of growth factor deprived haemopioetic cell lines", J. Immunol. 144(9), 3602–3610.
  • Beltinger, C., Kurz, E., Bohler, T., Schrappe, M., Ludwig, W. and Debatin, K.M. (1998) "CD95 (Apo-1 Fas) Mutation in childhood T- lineage acute lymphoblastic leukemia", Blood 91(10), 3943–3951.
  • Dirks, W., Schone, S., Uphoff, C., Quentmeier, H., Pradella, S. and Drexler, H.G. (1997) "Expression and function of CD95 (Fas / Apo-1) in leukemia-Lymphoma tumors lines", Br. J. Hematol. 96(3), 584–593.
  • Komada, Y., Zhou, Y.W., Zhang, X.L., Xue, H.L., Sakataku, H. and Sakurai, M. (1995) "Fas receptor (CD95) mediate apoptosis is induced in leukemic cells interning GIB compartment of the cell cycle", Blood 86(10), 3848–3860.
  • Komada, Y. and Sakurai, M. (1997) "Fas receptor (CD95)-mediated apoptosis in leukemic cells", Leuk. Lymphoma 25(1-2), 9–21.
  • Takahashi, H., Kobayashi, H., Hashimotoy-Mastsou, S. and Lizukah, A. (1995) "Interferon 'y dependent stimulation of Fas antigen in 5V40-transformed human keratinocytes: modulation of the apoptotic process by protein kinase", Clin. J. Investig. Dermatol. 105(6), 810–815.
  • Molica, S., Mannella, A., Dattilo, A., Levato, D., Iuliano, F., Peta, A., Consartino, C. and Magro, S. (1996) "Differential expression of BcL-2 oncoprotein and Fas antigen on normal blood and leukemic bone marrow cells. A flow cytometric analysis", Hematologica 81, 302–309.
  • Wesselborg, S., Engels, I.H., Rossmann, E., Los, M. and Schulze-Osthoff, K. (1999) "Anticancer drugs induce caspase-8/FLICE activation and apoptosis in the absence of CD95 receptor/ligand interaction", Blood 93, 3053–3063.
  • Newton, K. and Strasser, A. (2000) "Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implication for cancer therapy", J. Exp. Med. 191, 195–200.
  • Liu, T., Raetz, E., Moos, P.J., Perkins, S.L., Bruggers, C.S., Smith, E and Carroll, W.L. (2002) "Diversity of the apoptotic response to chemotherapy in childhood leukemia", Leukemia 16, 223–232.
  • McMullin, J., Lillman, S., Hann, I. and Behm, E (2000) "Cytomorphology of childhood lymphoblastic leukemia prospective study of 2000 patients", Br. J. Hematol. 81(2000), 52.
  • Guedez, L., Suresh, A., Tung, E and Zucali, J. (1996) "Quantitation of resistance to cytosine arabinoside by myeloid leukemic cells expressing Bc1-2", Fur. J. Hematol. 57(2), 149–156.
  • Peters, A.M., Kohfink, B., Martin, H., Griesinger, F., Wormann, B., Gahr, M. and Roesler, J. (1999) "Defective apoptosis due to point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease", Exp. Hematol. 27(5), 868–874.
  • Louie, F., Raspardori, D. and Rondell, D. (1998) "Bc1-2 expression does not correlate with patient out come in pediatric acute myelogenous leukemia", Leuk. Res. 22, 81— 87.
  • Karakas, T., Maurer, U., Weidman, E., Meithing, C., Hoelzer, D. and Bergman, L. (1998) "High expression of bc1-2 mRNA as a determinant of poor prognosis in AML", Ann. oncol. 9(2), 159–165.
  • Filipits, M., Stranzl, T., Pohl, G., Heinzl, H., Jager, U., Geissler, K., Fonatsch, C., Haas, A., Lechner, K. and Pirker, R. (2000) "Durg resistance factors in acute myeloid leukemia: a comparative analysis", Leukemia 14(1), 68–76.
  • Laura, F., Raspadori, D., Rondelli, D., Uentura, M.A., Fiacchini, M., Visani, G., Forconi, E and Tura, S. (1997) "High BcL-2 expression in acute myeloid leukemia is associated with CD34 positivity and complete remission rate", Leukemia 11(12), 2075–2083.
  • Sedky, H., El-Genedy, H., Abdel-Ghaffar, A., Wahba, M. and Bashat, G. (2002) "Expression of BcL-2, CD98 and DNA ploidy in acute leukemia and their prognostic relevance", Egypt. J. Hematol. 27(1), 47–64.
  • Carter, B.Z., Kornblau, S.M., Tsao, T., Wang, R.Y., Schober, W.D., Milella, M., Sung, HG., Reed, J.C. and Andreeff, M. (2003) "Caspase independent cell death in AML: caspase-inhibition in vitro with pan-caspase inhibitors or in vivo by X1AP or surivin does not affect cell survival or prognosis", Blood, Eup a head of print.
  • Ruiz-Ruiz, C., Robledo, G., Cano, E., Redondo, J.M. and Lopez-Rivas, A. (2003) "Characterization of P53 mediated up regulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells", Biol. Chem. 278(34), 31667–31675.
  • Debatin, K.M. and Krammer, PH. (1997) "Resistance to Apo 1(CD95) induced apoptosis in TALL is determined by a Bc12 independent anti-apoptotic program", Leukemia 9(5), 815–820.
  • Munker, R., Lubbert, M., Yonehara, S., Tuchnitz, A., Mertelsmann, R. and Wilmanns, W. (1995) "Expression of the Fas antigen on primary human leukemia cells", Ann. Hematol. 70(1), 15–17.
  • Wuchter, C., Karawajew, L., Ruppert, V, Buchner, T., Schochc, C., Haferlach, T., Ratei, R. and ludwing, W.D. (1999) "Clinical significance of CD95, Bc1-2 and Box expression in adult de novo acute myeloid leukemia in context of P-glycoprotein function maturation stage and cytogenetics", Leukemia 13(12), 1943–1953.
  • Uckun, F.M., Yang, Z., Sather, H., Steinherz, P., Nachman, J., Bostrom, B., Crotly, L., Sarquis, M., Ek, O., Zeren, T., Tubergren, D., Reaman, G. and Gaynon, P (1997) "Cellular expression of antiapoptotic Bc1-2 oncoprotein in newly diagnosed childhood acute lymphoblastic leukemia", Blood 89(10), 3769–3777.
  • Min, Y, Lees, S., Lee, J.W., Chong, S.Y., Hahn, J.S. and Ko, Y.W. (1996) "Expression of Fas antigen in acute myeloid leukemia is associated with therapeutic response to chemotherapy", Br. J. Hematol. 93(4), 928–930.
  • Muller, M., Wilder, S., Bannasch, D., Israeli, D., Lehlbach, K., Li-Weber, M., Fridman, S.L., Galle, P.R., Stremmel, W., Oren, M. and Krammer, PH. (1998) "P53 activates the CD95 (apo-1 /Fas) gene in response to DNA damage by anti cancer drugs", J. Exp. Med. 188(11), 2033–2045.
  • El Habshy, S., Imam, M. and El-kholy, N. (2002) "Bc1-2 gene expression in childhood acute lymphoblastic leukemia, relationship with apoptosis, clinicobiological features, and treatment outcome", Egypt J. Hematol. 27(1), 19–31.
  • Salomons, G.S., Smets, L.A., Verwijs-Janssen, M., Hart, A.A.M., Haartmann, E.G., Kaspers, G.I.L., Van Wering, E.R., Van Der Does-Van Den Berg, A. and Kamps, W.A. (1999) "BcL-2 family members in childhood acute lymphoblastic leukemia: relationships with features at presentation, in vitro and in vivo drug response and long-term clinical outcome", Leukemia 131, 574–1580.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.