Methotrexate-induced mucositis in acute leukemia patients is not associated with the MTHFR 677T allele in Mexico

References

• Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, Rozen R. A candidate risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111–113.
   Google Scholar
• van der Put NM, Gabreels F, Stevens EM, Smeitink JA, Trijbels FJ, Eskes TK, van den Heuvel LP, Blom HJ. A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk factor for neural-tube defects? Am J Hum Genet 1998;62:1044–1051.
   PubMed Web of Science ®Google Scholar
• Ulrich CM, Yasui Y, Storb R, Schubert MM, Wagner JL, Bigler J, Ariail KS, Keener CL, Liu H, Farm FM, Potter JD. Pharmacogenetics of methotrexate: Toxicity among marrow transplantation patients varies with the methylenetetrahydro-folate reductase C677T polymorphism. Blood 2001;98: 231–234.
   PubMed Web of Science ®Google Scholar
• Robien K, Schubert MM, Bruemmer B, Lloid ME, Potter JD, Ulrich CM. Predictors of oral mucositis in patients receiving hematopoietic stem cell transplants for chronic myelogenous leukemia. J Clin Oncol 2004;22:1268–1275.
   PubMed Web of Science ®Google Scholar
• Robien K, Schubert MM, Chay T, Bigler J, Storb R, Yasui Y, Potter JD, Ulrich CM. Methylenetetrahydrofolate reductase and thymidilate synthase genotypes modify oral mucositis severity following hematpopoietic stem cell transplantation. Bone Marrow Transplant 2006;37:799–800.
   PubMed Web of Science ®Google Scholar
• Shimasaki N, Mori T, Samejima H, Sato R, Shimada H, Yahagi N, Toni C, Yoshihara H, Tanigawara Y, Takahashi T, Kosaki K. Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lym-phoblastic leukemia or lymphoma. J Pediatr Hematol Oncol 2006;28: 64–68.
   PubMed Web of Science ®Google Scholar
• Chiusolo P, Reddiconto G, Casorelli I, Laurenti L, Sora F, Mele L, Annino L, Leone G, Sica S. Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate. Ann Oncol 2002;13: 1915–1918.
   PubMed Web of Science ®Google Scholar
• Rivas F, Jr, Ortiz M, Rodarte K, Esparza A, Lopez B, Aguilar C, Olivares N, Rivas F, Polimorfismos MTHFR. en leucemia linfoblistica aguda. Gen Biomed Mol 2005;5:12.
   Google Scholar
• Gonzalez-Herrera L, Garcia-Escalante G, Castillo-Zapata I, Canto-Herrera J, Ceballos-Quintal J, Pinto-Escalante D, Diaz-Rubio F, Del Angel RM, Orozco-Orozco L. Frequency of the thermolabile variant C677T in the MTHFR gene and lack of association with neural tube defects in the state of Yucata, Mexicon. Clin Genet 2002;62:394–398.
   PubMed Web of Science ®Google Scholar
• Davalos IP, Olivares N, Castillo MT, Cantu JM, Ibarra B, Sandoval L, Moran MC, Gallegos MP, Chakraborty R, Rivas F. The C677T polymorphism of the methylenetetrahydrofo-late reductase gene in Mexican mestizo neural-tube defect parents, control mestizo and native populations. Ann Genet 2000;43:89–92.
   PubMedGoogle Scholar
• Galaviz-Hernández C, Sierra-Ramírez JA, Sánchez-Urbina R, Martínez-Salazar MG, Izquierdo-González I, Camacho-Molina A, García-Cavazos R. Frecuencia de la mutación MTHFR C677T en población abierta de Tehuacán, Puebla. Gen Biomed Mol 2005;5:7,
   Google Scholar
• Mena-Ramirez JP, Dávalos IP, Gámez JI, González L, Muñioz-Valle F, Vásquez del Mercado M, Martínez G, Sandoval LR, Rangel-Villalobos H, Casillas-Ávila M, Salazar-Páramo M. Polimorfismos A1298C y C677T del gen de la enzima metilenotetrahidrofolato reductasa en pacientes con artritis reumatoide, Abstract GP07. XXX Congreso Nacional de Genética Humana. (Last visited: 07/14/2006) www.respy-n.uanl.mx/especiales/2006/ee-05-2006/carteles/genetica_de_-poblaciones.htm
   Google Scholar
• Delgado-Enciso I, Martínez-Garza SG, Rojas-Martínez A, Ortiz López R, Bosques-Padilla F, Calderón-Garcidueñas AL, Zarate-Gömez M, Barrera-Saldaña HA. Mutación 677T del gen MTHFR en adenomas y cáncer colorrectal en una muestra de la población del noreste de México. Resultados preliminares Rev Gastroenterol Mex 2001;66:32–37.
   PubMedGoogle Scholar
• Lacasana-Navarro M, Galvan-Portillo M, Chen J, Lopez-Cervantes M, Lopez-Carrillo L. Methylenetetrahydrofolate reductase 677C > T polymorphism and gastric cancer susceptibility in Mexico. Eur J Cancer 2006;42:528–533.
   PubMed Web of Science ®Google Scholar
• Izquierdo González I, Galaviz Hernández G, Fierros Adame M, Pérez Cosio C, Sierra Ramírez JA, Martinez Salazar MG, Sanchez Urbina R, Garcia Cavazos R. Estudio de las mutaciones MTHFR C677T y G1691A de factor V de Leiden en pacientes con preeclampsia y eclampsia, Abstract GP10. XXIX Congreso Nacional de Genética Humana. (Last visited: 07/13/2006) www.respyn.uanl.mx/especiales/2005/ee-05-2005/carteles/genetica_de_poblaciones.htm
   Google Scholar
• Gueant-Rodriguez RNI, Gueant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, Chabi NW, Sanni A, Anello G, Bosco P, Romano C, Amouzou E, Arrieta HR, Sanchez BE, Romano A, Herbeth B, Guilland JC, Mutchinick OM. Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: A comparative study in Mexican, West African and European populations. Am J Clin Nutr 2006;83: 701–707.
   PubMed Web of Science ®Google Scholar
• Torres-Sanchez L, Chen J, Diaz-Sanchez Y, Palomeque C, Bottiglieri T, Lopez-Cervantes M, Lopez-Carrillo L. Dietary and genetic determinants of homocysteine levels among Mexican women of reproductive age. Eur J Clin Nutr 2006;60:691–697.
   PubMed Web of Science ®Google Scholar
• Ruiz-Arguelles GJ, Garcés-Eisele J, Reyes-Nüñez V, Ramírez-Cisneros F. Primary thrombophilia in Mexico II: Factor V G1691A (Leiden), prothrombin G20210A and methylenete-trahydrofolate reductase C677T polymorphism in thrombo-philic Mexican mestizos. Am J Hematol 2001;66:28–31.
   PubMed Web of Science ®Google Scholar
• Mutchinick OM, Lopez MA, Luna L, Waxman J, Babinsky VE. High prevalence of the thermolabile methylenetetrahy-drofolate reductase variant in Mexico: A country with a very high prevalence of neural tube defects. Mol Genet Metab 1999;68:461–467.
   Google Scholar
• Rivera GK, Raimondi SC, Hancock ML, Behm FG, Pui CH, Abromowitch M, Mirro J, Jr, Ochs JS, Look AT, Williams DL. Improved outcome in childhood acute lymphoblastic leukae-mia with reinforced early treatment and rotational combi-nation chemotherapy. Lancet 1991;337:61–66.
   Google Scholar
• Kluijtmans LAJ, van den Heuvel LPWJ, Boers GHJ, Frosst P, Stevens EMB, van Oost BA, den Heijer M, Trijbels FMJ, Rozen R, Blom HJ. Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methy-lentetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 1996;58:35–41.
   PubMed Web of Science ®Google Scholar
• McGuire DB, Peterson DE, Muller S, Owen DC, Slemmons MF, Schubert MM. The 20 item oral mucositis index: Reliability and validity in bone marrow and stem cell transplant patients. Cancer Invest 2002;20:893–903.
   PubMed Web of Science ®Google Scholar
• Gilks WR, Thomas A, Spiegelhalter DJ. A language and program for complex Bayesian modeling. Statistician 1994;43:169–178.
   Google Scholar
• Spiegelhalter DJ, Thomas A, Best N, Lunn D. 1.4.1 user manual MRC biostatistics unit. Cambridge: Institute of Public Health; 2004.
   Google Scholar
• Congdon P. Bayesian statistical modelling. Chichester: John Wiley & Sons; 2001.
   Google Scholar
• Hernández JL, Weir BS. A disequilibrium approach to Hardy—Weinberg testing. Biometrics 1989;45:53–70.
   PubMed Web of Science ®Google Scholar
• Hessner MJ, Luhm RA, Pearson SL, Endean DJ, Friedman KD, Montgomery RR. Prevalence of the prothrombin G20210A, factor V G1691A (Leiden) and methylenetetrahy-drofolate reductase (MTHFR) C677T in seven different populations determined by multiplex allele-specific PCR. Thromb Haemost 1999;81:733–738.
   PubMed Web of Science ®Google Scholar
• Franco RF, Simoes BP, Tone LG, Gabellini SM, Zago MA, Falcao RR The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol 2001;115:616–618.
   PubMed Web of Science ®Google Scholar
• Skibola CF, Smith MT, Kane E, Roman E, Rollinson S, Cartwright RA, Morgan G. Polymorphisms in the methylene-tetrahydrofolate reductase gene are associated with suscepti-bility to acute leukemia in adults. Proc Natl Acad Sci USA 1999;96:12810–12815.
   Google Scholar
• Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. United Kingdom childhood cancer study investigators: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA 2001;98:4004–4009.
   PubMed Web of Science ®Google Scholar
• Franco RF, Simoes BP, Tone LG, Gabellini SM, Zago MA, Falcao RR The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukemia. Br J Haematol 2001;115:616–618.
   PubMed Web of Science ®Google Scholar
• Gemmati D, Ongaro A, Scapoli GL, Della Porta M, Tognazzo S, Serino ML, Di Bona E, Rodeghiero F, Gilli G, Reverberi R, Caruso A, Pasello M, Pellati A, De Mattei M. Common gene polymorphisms in the metabolic folate and methylation pathway and the risk of acute lymphoblastic leukemia and non-Hodgkin's lymphoma in adults. Cancer Epidemiol Biomarkers Prey 2004;13:787–794.
   Google Scholar
• Balta G, Yuksek N, Ozyurek E, Ertem U, Hicsonmez G, Altay C, Gurgey A. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Am J Hematol 2003;73: 154–160.
   PubMed Web of Science ®Google Scholar
• Schnakenberg E, Mehles A, Cario G, Rehe K, Seidemann K, Schlegelberger B, Elsner HA, Welte KH, Schrappe M, Stanulla M. Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population. BMC Med Genet 2005;6:23.
   PubMed Web of Science ®Google Scholar
• Aplenc R, Thompson J, Han P, La M, Zhao H, Lange B, Rebbeck T. Methylenetetrahydrofolate reductase polymorph-isms and therapy response in pediatric acute lymphoblastic leukemia. Cancer Res 2005;65:2482–2487.
   Google Scholar
• Chiusolo P, Reddiconto G, Casorelli I, Laurenti L, Sora F, Mele L, Annino L, Leone G, Sica S. Preponderance of methylenetetrahydrofolate reductase C677T homozygosity among leukemia patients intolerant to methotrexate. Ann Oncol 2002;13: 1915–1918.
   PubMed Web of Science ®Google Scholar
• Ruiz-Argüelles GJ, López-Martínez B, Cruz-Cruz D, Reyes-Aulis MB. Primary thrombophilia in Mexico III. A prospective study of the sticky platelet syndrome. Chin Appl Thromb Hemost 2002;8:273–277.
   PubMed Web of Science ®Google Scholar
• Ruiz-Argüelles GJ, López-Martínez B, Valdés-Tapia P, Gómez-Rangel JD, Reyes-Núñez V, Garcés-Eisele J. Primary thrombophilia in Mexico V: A comprehensive prospective study indicates that most cases are multifactorial. Am J Hematol 2005;78:21–26.
   PubMed Web of Science ®Google Scholar
• Kapiszewska M, Kalemba M, Wojciech U, Milewicz T. Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B-12 concentrations and methylenetetrahydrofolate reductase poly-morphisms. A pilot study. J Nutr Biochem 2005;8:467–478.
   Web of Science ®Google Scholar
• Lobato-Mendizábal E, Ruiz-Argüelles GJ, Marín-López A. Leukaemia and nutrition I. Malnutrition is an adverse prognostic factor in the outcome of treatment of patients with standard-risk acute lymphoblastic leukaemia. Leuk Res 1989;13:899–906.
   Google Scholar