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Review Articles

The Retinoblastoma Gene in Myeloid Leukaemias

Pages 43-51 | Published online: 13 Jul 2016

References

  • Cline, M. J. (1994). The molecular basis of leukemia. N. Engl. J. Med., 330, 328–336.
  • Godbout, R., Dryja, T. P., Squire, J., Gallie, B. L. and Phillips, R. A. (1983). Somatic inactivation of genes on chromosome 13 is a common event in retinoblastoma. Nature, 304, 451–453.
  • T'Ang, A., Varley, J. M., Chakraborty, S., Murphree, A. L. and Fung, Y. K. (1988). Structural rearrangement of the retinoblastoma gene in human breast carcinoma. Science, 242, 263–266.
  • Harbour, J. W., Lai, S. L., Whang Peng, J., Gazdar, A. F., Minna, J. D. and Kaye, F. J. (1988). Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science, 241, 353–357.
  • Ahuja, H. G., Jat, P. S., Foti, A., Bar, E. M. and Cline, M. J. (1991). Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia. Blood, 78, 3259–3268.
  • Lee, W. H., Bookstein, R., Hong, F., Young, L. J., Shew, J. Y. and Lee, E. Y. (1987). Human retinoblastoma susceptibility gene: cloning, identification, and sequence. Science, 235, 1394–1399.
  • Gill, R. M., Hamel, P. A., Zhe, J., Zacksenhaus, E., Gallie, B. L. and Phillips, R. A. (1994). Characterization of the human RB1 promoter and of elements involved in transcriptional regulation. Cell Growth Differ., 5, 467–474.
  • Ohtani-Fujita, N., Fujita, T., Takahashi, R., Robbins, P. D., Dryja, T. P. and Sakai, T. (1994). A silencer element in the retinoblastoma tumor-suppressor gene. Oncogene, 9, 1703–1711.
  • Savoysky, E., Mizuno, T., Sowa, Y., Watanabe, H., Sawada, J. I., Nomura, H., Ohsugi, Y., Handa, H. and Sakai, T. (1994). The retinoblastoma binding factor 1 (RBF-1) site in RB gene promoter binds preferentially E4TF1, a member of the Ets transcription factors family. Oncogene, 9 1839–1846.
  • Sakai, T., Ohtani, N., McGee, T. L., Robbins, P. D. and Dryja, T. P. (1991). Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene. Nature, 353, 83–86.
  • Ohtani, F. N., Fujita, T., Aoike, A., Osifchin, N. E., Robbins, P. D. and Sakai, T. (1993). CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene. Oncogene, 8, 1063–1067.
  • Bookstein, R., Lee, E. Y., To, H., Young, L. J., Sery, T. W., Hayes, R. C., Friedmann, T. and Lee, W. H. (1988). Human retinoblastoma susceptibility gene: genomic organization and analysis of heterozygous intragenic deletion mutants. Proc. Natl. Acad. Sci. USA, 85, 2210–2214.
  • Wiggs, J., Nordenskjold, M., Yandell, D., Rapaport, J., Grondin, V., Janson, M., Werelius, B., Petersen, R., Craft, A., Riedel, K. and et al. (1988). Prediction of the risk of hereditary retinoblastoma, using DNA polymorphisms within the retinoblastoma gene. N. Engl. J. Med., 318, 151–157.
  • Goodrich, D. W. and Lee, W. H. (1993). Molecular characterization of the retinoblastoma susceptibility gene. Biochiin. Biophys. Acta., 1155, 43–61.
  • Ludlow, J. W. and Skuse, G. R. (1995). Viral oncoprotein binding to pRB, p107, p130, and p300. Virus Res., 35, 113–121.
  • Li, Y., Graham, C., Lacy, S., Duncan, A. M. and Whyte, P. (1993). The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev., 7, 2366–2377.
  • Pardee, A. B. (1974). A restriction point for control of normal animal cell proliferation. Proc. Natl. Acad. Sci. USA, 71, 1286–1290.
  • Pardee, A. B., Dubrow, R., Hamlin, J. L. and Kletzien, R. F. (1978). Animal cell cycle. Annu. Rev. Biochem., 47, 715–750.
  • Weinberg, R. (1995). The retinoblastoma protein and cell cycle control. Cell, 81, 323–330.
  • Pines, J. (1995). Cyclins, CDKs and cancer. Semin. Cancer. Biol., 6, 63–72.
  • Charollais, R. H., Tiwari, S. and Thomas, N. S. (1994). Into and out of G1: the control of cell proliferation. Biochimie, 76, 887–894.
  • DeCaprio, J. A., Ludlow, J. W., Lynch, D., Furukawa, Y., Griffin, J., Piwnica Worms, H., Huang, C. M. and Livingston, D. M. (1989). The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element. Cell, 58, 1085–1095.
  • Chellappan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M. and Nevins, J. R. (1991). The E2F transcription factor is a cellular target for the RB protein. Cell, 65, 1053–1061.
  • Kim, S. J., Wagner, S., Liu, F., O'Reilly, M. A., Robbins, P. D. and Green, M. R. (1992). Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2. Nature, 358, 331–334.
  • Hamel, P. A., Phillips, R. A., Muncaster, M. and Gallie, B. L. (1993). Speculations on the roles of RB1 in tissue-specific differentiation, tumor initiation, and tumor progression. FASEB J., 7, 846–854.
  • Haas-Kogan, D. A., Kogan, S. C., Levi, D., Dazin, P., Tang, A., Fung, Y. and Israel, M. A. (1995). Inhibition of apoptosis by the retinoblastoma gene product. EMBO Journal, 14, 461–472.
  • Lee, E. Y., Chang, C. Y., Hu, N., Wang, Y. C., Lai, C. C., Herrup, K., Lee, W. H. and Bradley, A. (1992). Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature, 359, 288–294.
  • Clarke, A. R., Maandag, E. R., van Roon, M., van der Lugt, N. M., van der Valk, M., Hooper, M. L., Berns, A. and te Riele, H. (1992). Requirement for a functional Rb-1 gene in murine development. Nature, 359, 328–330.
  • Coppola, J. A., Lewis, B. A. and Cole, M. D. (1990). Increased retinoblastoma gene expression is associated with late stages of differentiation in many different cell types. Oncogene 5, 1731–1733.
  • Mistchenko, A. S., Diez, R. A., Romquin, N., Sanceau, J. and Wietzerbin, J. (1993). Interferon-gamma modulates retinoblastoma gene mRNA in monocytoid cells. Int. J. Cancer, 53, 87–90.
  • Yen, A. and Varvayanis, S. (1995). RB phosphorylation in sodium butyrate-resistant HL-60 cells: cross-resistance to retinoic acid but not vitamin D3. J. Cell. Physiol., 163, 502–509.
  • Belka, C., Greger, V., Zabel, B. and Horsthemke, B. (1991). No evidence for sequences structurally related to the RB1 gene in the human genome. Hum. Genet., 86, 401–403.
  • Lohmann, D. R., Brandt, B., Hopping, W., Passarge, E. and Horsthemke, B. (1994). Distinct RB1 gene mutations with low penetrance in hereditary retinoblastoma. Hum. Genet., 94, 349–354.
  • Blanquet, V., Turleau, C., Gross Morand, M. S., Senamaud Beaufort, C., Doz, F. and Besmond, C. (1995). Spectrum of germline mutations in the RB1 gene: a study of 232 patients with hereditary and non hereditary retinoblastoma. Hum. Mol. Genet., 4, 383–388.
  • Yee, A. S., Reichel, R., Kovesdi, I. and Nevins, J. R. (1987). Promoter interaction of the E1A-inducible factor E2F and its potential role in the formation of a multicomponent complex. EMBO J., 6, 2061–2068.
  • Paggi, M. G., de Fabritis, P., Bonetto, F., Amadio, L., Santarelli, G., Spadea, A., Gentile, F. P., Floridi, A. and Felsani, A. (1995). The retinoblastoma gene product in acute myeloid leukemia: A possible involvement in promyelocytic leukemia. Cancer Res., 55, 4552–4556.
  • Chen, Y. C., Chen, P. J., Yeh, S. H., Tien, H. F., Wang, C. H., Tang, J. L. and Hong, R. L. (1990). Deletion of the human retinoblastoma gene in primary leukemias. Blood 76, 2060–2064.
  • Jamal, R., Gale, R. E., Thomas, N. S. B. and Linch, D. C. (1996). The retinoblastoma gene in acute myeloid leukaemia: Analysis of gene rearrangements, protein expression and disease outcome. Br. J. Haematol. (In press).
  • Tang, J. L., Yeh, S. H., Chen, P. J., Lin, M. T., Tien, H. F. and Chen, Y. C. (1992). Inactivation of the retinoblastoma gene in acute myelogenous leukaemia. Br. J. Haematol 82, 502–507.
  • Weide, R., Parviz, B., Pfluger, K. H. and Havemann, K. (1993). Altered expression of the human retinoblastoma gene in monocytic leukaemias. Br. J. Haematol., 83, 428–432.
  • Zhu, Y. M., Bradbury, D. and Russell, N. (1994a). Decreased retinoblastoma protein expression in acute myeloblastic leukaemia is associated with the autonomous proliferation of clonogenic blasts. Br. J. Haematol., 86, 533–539.
  • Kornblau, S. M., Xu, H. J., Zhang, W., Hu, S. X., Beran, M., Smith, T. L., Hester, J., Estey, E., Benedict, W. F. and Deisseroth, A. B. (1994). Levels of retinoblastoma protein expression in newly diagnosed acute myelogenous leukemia. Blood, 84, 256–261.
  • Jamal, R., Gale, R. E., Thomas, N. S. B. and Linch, D. C. (1994). Analysis of RB1 gene rearrangements in patients with acute myeloid leukaemia. Br. J. Haematol., 86, Suppl 1, 9.
  • Zhu, Y. M., Bradbury, D. A., Keith, F. J. and Russell, N. (1994b). Absence of retinoblastoma protein expression results in autocrine production of interleukin-6 and promotes the autonomous growth of acute myeloid leukemia blast cells. Leukemia, 8, 1982–1988.
  • Lugo, T. G., Pendergast, A. M., Muller, A. J. and Witte, O. N. (1990). Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science, 247, 1079–1082.
  • Towatari, M., Adachi, K., Kato, H. and Saito, H. (1991). Absence of the human retinoblastoma gene product in the megakaryoblastic crisis of chronic myelogenous leukemia. Blood, 78, 2178–2181.
  • Furukawa, Y., DeCaprio, J. A., Belvin, M. and Griffin, J. D. (1991). Heterogeneous expression of the product of the retinoblastoma susceptibility gene in primary human leukemia cells. Oncogene, 6, 1343–1346.
  • Gaidano, G., Guerrasio, A., Serra, A., Rege Cambrin, G. and Saglio, G. (1994). Molecular mechanisms of tumor progression in chronic myeloproliferative disorders. Leukemia, 8, Suppl 1, S27–29.
  • Silly, H., Chase, A., Mills, K. I., Apfelbeck, U., Sormann, S., Goldman, J. M. and Cross, N. C. (1994). No evidence for microsatellite instability or consistent loss of heterozygosity at selected loci in chronic myeloid leukaemia blast crisis. Leukemia, 8, 1923–1928.
  • Blick, M., Romero, P., Talpaz, M., Kurzrock, R., Shtalrid, M., Andersson, B., Trujillo, J., Beran, M. and Gutterman, J. (1987). Molecular characteristics of chronic myelogenous leukemia in blast crisis. Cancer Genet. Cytogenet., 27, 349–56.
  • Dhingra, K., Talpaz, M., Kantarjian, H., Ku, S., Rothberg, J., Gutterman, J. U. and Kurzrock, R. (1991). Appearance of acute leukemia-associated P190BCR-ABL in chronic myelogenous leukemia may correlate with disease progression. Leukemia 5, 191–5.
  • Cline, M. J., Jat, P. S. and Foti, A. (1992). Molecular mechanisms in the evolution of chronic myelocytic leukemia. Leuk. Lymphoma., 7, 283–287.
  • Wetzler, M., Talpaz, M., Estrov, Z. and Kurzrock, R. (1993). CML: mechanisms of disease initiation and progression. Leuk. Lymphoma., 1, 47–50.
  • Presti, J. J., Reuter, V. E., Galan, T., Fair, W. R. and Cordon, C. C. (1991). Molecular genetic alterations in superficial and locally advanced human bladder cancer. Cancer Res., 51, 5405–5409.
  • Cairns, P., Proctor, A. J. and Knowles, M. A. (1991). Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma. Oncogene, 6, 2305–2309.
  • Xu, H. J., Cairns, P., Hu, S. X., Knowles, M. A. and Benedict, W. F. (1993). Loss of RB protein expression in primary bladder cancer correlates with loss of heterozygosity at the RB locus and tumor progression. Int. J. Cancer, 53, 781–784.
  • Cance, W. G., Brennan, M. F., Dudas, M. E., Huang, C. M. and Cordon, C. C. (1990). Altered expression of the retinoblastoma gene product in human sarcomas. N. Engl. J. Med., 323, 1457–1462.
  • Pietilainen, T., Lipponen, P., Aaltomaa, S., Eskelinen, M., Kosma, V. M. and Syrjanen, K. (1995). Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival. Eur. J. Cancer Part A: General Topics, 31, 329–333.
  • Kornblau, S. M., Xu, H. J., del Giglio, A., Hu, S. X., Zhang, W., Calvert, L., Beran, M., Estey, E., Andreeff, M., Trujillo, J. and et al. (1992). Clinical implications of decreased retinoblastoma protein expression in acute myelogenous leukemia. Cancer Res., 52, 4587–4590.
  • Kornblau, S. M., Xu, H. J., Hu, S. X., Estey, E., Benedict, W. F. and Deisseroth, A. B. (1995). Low and maximally phosphorylated levels of the retinoblastoma (RB) protein confer poor prognosis at diagnosis in newly diagnosed acute myelogenous leukemia: A prospective study. Blood, 86, Suppl 1, 599a.
  • Weide, R., Parviz, B., Pfluger, K. H., Koppler, H., Wormann, B., Zuhlsdorf, M. and Havemann, K. (1995). The role of decreased retinoblastoma protein expression in acute myelomonocytic and monoblastic leukemias. Leuk. Lymphoma., 17, 135–137.
  • Wheatley, K., Burnett, A., Goldstone, A., Hann, I., Stevens, R., Rees, J. and Gray, R. (1995). A simple, robust and highly predictive prognostic index for the determination of risk directed therapy in acute myeloid leukaemia (AML) derived from the United Kingdom Medical Research Council (MRC) AML10 trial. Blood, 86, Suppl 1, 598a.
  • Hockenberry, D., Nunez, G., Platt, F. M., McKearn, J. P. and Korsmeyer, S. J. (1990). Bcl-2 is an inner mitochondrial membrane protein that blocks programme cell death. Nature, 348, 334–336.
  • El-Deiry, W., Harper, J., O'Connor, P., Velculescu, V., Canman, C., Jackman, J., Pietenpol, J., Burrell, M., Hill, D., Wang, Y., Wiman, K., Mercer, W., Kastan, M., Kohn, K., Elledge, S., Kinzler, K. and Vogelstein, B. (1994). WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res., 54, 1169–1174.

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