Lower expression of PD-1 and PD-L1 in peripheral blood from patients with chronic ITP

References

• Aslam R, Hu Y, Gebremeskel S, Segel GB, Speck ER, Guo L, et al. Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood. 2012;120(10):2127–32. doi: 10.1182/blood-2012-02-413526
   PubMed Web of Science ®Google Scholar
• Chen X, Chen S, Li C, Zhu Y, Peng B. Skewed T-cell subsets and enhanced macrophages phagocytosis in the spleen of patients with immune thrombocytopenia failing glucocorticoids. Int J Hematol. 2011;94(3):248–54. doi: 10.1007/s12185-011-0908-6
   PubMed Web of Science ®Google Scholar
• Cines DB, Cuker A, Semple JW. Pathogenesis of immune thrombocytopenia. Presse Med. 2014;43(4 Pt 2):e49–59. doi: 10.1016/j.lpm.2014.01.010
   PubMedGoogle Scholar
• McKenzie CG, Guo L, Freedman J, Semple JW. Cellular immune dysfunction in immune thrombocytopenia (ITP). Br J Haematol. 2013;163(1):10–23. doi: 10.1111/bjh.12480
   PubMed Web of Science ®Google Scholar
• Thachil J. Alternate considerations for current concepts in ITP. Hematology. 2014;19(3):163–8. doi: 10.1179/16078454137.0000000104
   PubMed Web of Science ®Google Scholar
• Zhang XL, Li YQ, Chen SH, Yang LJ, Chen S, Wu XL, et al. The feature of clonal expansion of TCR Vβ repertoire, thymic recent output function and TCRζ chain expression in patients with immune thrombocytopenic purpura. Int J Lab Hematol. 2009;31(6):639–48. doi: 10.1111/j.1751-553X.2008.01091.x
   PubMed Web of Science ®Google Scholar
• Zhang XL, Peng J, Sun JZ, Liu JJ, Guo CS, Wang ZG, et al. De novo induction of platelet-specific CD4+CD25+ regulatory T cells from CD4+CD25- cells in patients with idiopathic thrombocytopenic purpura. Blood. 2009;113(11):2568–77. doi: 10.1182/blood-2008-03-148288
   PubMed Web of Science ®Google Scholar
• Arandi N, Mirshafiey A, Jeddi-Tehrani M, Shaghaghi M, Sadeghi B, Abolhassani H, et al. Alteration in frequency and function of CD4(+)CD25(+)FOXP3(+) regulatory T cells in patients with immune thrombocytopenic purpura. Iran J Allergy Asthma Immunol. 2014;13(2):85–92.
   PubMed Web of Science ®Google Scholar
• Audia S, Samson M, Mahevas M, Ferrand C, Trad M, Ciudad M, et al. Preferential splenic CD8+ T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia. Blood. 2013;122(14):2477–86. doi: 10.1182/blood-2013-03-491415
   PubMed Web of Science ®Google Scholar
• Hu Y, Li H, Zhang L, Shan B, Xu X, Li H, et al. Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia. Hum Immunol. 2012;73(6):629–35. doi: 10.1016/j.humimm.2012.04.015
   PubMed Web of Science ®Google Scholar
• Semple JW, Provan D. The immunopathogenesis of immune thrombocytopenia: T cells still take center-stage. Curr Opin Hematol. 2012;19(5):357–62. doi: 10.1097/MOH.0b013e3283567541
   PubMed Web of Science ®Google Scholar
• Semple JW, Provan D, Garvey MB, Freedman J. Recent progress in understanding the pathogenesis of immune thrombocytopenia. Curr Opin Hematol. 2010;17(6):590–5. doi: 10.1097/MOH.0b013e32833eaef3
   PubMed Web of Science ®Google Scholar
• Song I, Kim J, Kwon K, Koo S, Jo D. Expression of CD154 (CD40L) on stimulated T lymphocytes in patients with idiopathic thrombocytopenic purpura. Hematology. 2015 Jul 17. [Epub ahead of print].
   Web of Science ®Google Scholar
• Xu SQ, Wang CY, Zhu XJ, Dong XY, Shi Y, Peng J, et al. Decreased indoleamine 2,3-dioxygenase expression in dendritic cells and role of indoleamine 2,3-dioxygenase-expressing dendritic cells in immune thrombocytopenia. Ann Hematol. 2012;91(10):1623–31. doi: 10.1007/s00277-012-1451-0
   PubMed Web of Science ®Google Scholar
• Fujita S, Nakanishi T, Yoshimura H, Hotta M, Nakamichi N, Tamaki T, et al. TGFβ1 and sCTLA-4 levels are increased in eltrombopag-exposed patients with ITP. Thromb Res. 2012;130(3):415–9. doi: 10.1016/j.thromres.2012.06.002
   PubMed Web of Science ®Google Scholar
• Ji X, Zhang L, Peng J, Hou M. T cell immune abnormalities in immune thrombocytopenia. J Hematol Oncol. 2014;7:72. doi: 10.1186/s13045-014-0072-6
   PubMed Web of Science ®Google Scholar
• Kiyasu J, Miyoshi H, Hirata A, Arakawa F, Ichikawa A, Niino D, et al. Expression of programmed cell death ligand 1 is associated with poor overall survival in patients with diffuse large B-cell lymphoma. Blood. 2015;126(19):2193–201. doi: 10.1182/blood-2015-02-629600
   PubMed Web of Science ®Google Scholar
• Lin AY, Lin E. Programmed death 1 blockade, an Achilles heel for MMR-deficient tumors? J Hematol Oncol. 2015;8(1):124. doi: 10.1186/s13045-015-0222-5
   PubMed Web of Science ®Google Scholar
• Shi L, Chen S, Yang L, Li Y. The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies. J Hematol Oncol. 2013;6(1):74. doi: 10.1186/1756-8722-6-74
   PubMed Web of Science ®Google Scholar
• Pavkovic M, Georgievski B, Cevreska L, Spiroski M, Efremov DG. CTLA-4 exon 1 polymorphism in patients with autoimmune blood disorders. Am J Hematol. 2003;72(2):147–9. doi: 10.1002/ajh.10278
   PubMed Web of Science ®Google Scholar
• Zhang XL, Peng J, Sun JZ, Guo CS, Yu Y, Wang ZG, et al. Modulation of immune response with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin-induced anergic T cells in chronic idiopathic thrombocytopenic purpura. J Thromb Haemost. 2008;6(1):158–65. doi: 10.1111/j.1538-7836.2007.02804.x
   PubMed Web of Science ®Google Scholar
• Schubert D, Bode C, Kenefeck R, Hou TZ, Wing JB, Kennedy A, et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat Med. 2014;20(12):1410–6. doi: 10.1038/nm.3746
   PubMed Web of Science ®Google Scholar
• Radwan ER, Goda RL. Lack of impact of cytotoxic T-lymphocyte antigen 4 gene exon 1 polymorphism on susceptibility to or clinical course of Egyptian childhood immune thrombocytopenic purpura. Clin Appl Thromb Hemost. 2015;21(4):378–82. doi: 10.1177/1076029613502254
   PubMed Web of Science ®Google Scholar
• Li H, Ge J, Zhao H, Du W, Xu J, Sui T, et al. Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with idiopathic thrombocytopenic purpura in a Chinese population. Platelets. 2011;22(1):39–44. doi: 10.3109/09537104.2010.521601
   PubMed Web of Science ®Google Scholar
• Goel G, Sun W. Advances in the management of gastrointestinal cancers—an upcoming role of immune checkpoint blockade. J Hematol Oncol. 2015;8:86. doi: 10.1186/s13045-015-0185-6
   PubMed Web of Science ®Google Scholar
• Schnorfeil FM, Lichtenegger FS, Emmerig K, Schlueter M, Neitz JS, Draenert R, et al. T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment. J Hematol Oncol. 2015;8:93. doi: 10.1186/s13045-015-0189-2
   PubMed Web of Science ®Google Scholar
• Kohnke T, Krupka C, Tischer J, Knosel T, Subklewe M. Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab. J Hematol Oncol. 2015;8(1):111. doi: 10.1186/s13045-015-0213-6
   PubMed Web of Science ®Google Scholar
• Atesoglu EB, Tarkun P, Demirsoy ET, Geduk A, Mehtap O, Batman A, et al. Soluble programmed death 1 (PD-1) is decreased in patients with immune thrombocytopenia (ITP): potential involvement of PD-1 pathway in ITP immunopathogenesis. Clin Appl Thromb Hemost. 2014; 22(3):248–51.
   PubMed Web of Science ®Google Scholar
• Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA; American Society of Hematology. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood. 2011;117(16):4190–207. doi: 10.1182/blood-2010-08-302984
   PubMed Web of Science ®Google Scholar
• Shi L, Chen S, Zha X, Xu Y, Xu L, Yang L, et al. Enhancement of the TCRζ expression, polyclonal expansion, and activation of t cells from patients with acute myeloid leukemia after IL-2, IL-7, and IL-12 induction. DNA Cell Biol. 2015;34(7):481–8. doi: 10.1089/dna.2015.2810
   PubMed Web of Science ®Google Scholar
• Chen S, Zha X, Shi L, Zhou L, Yang L, Li B, et al. Upregulated TCRζ improves cytokine secretion in T cells from patients with AML. J Hematol Oncol. 2015;8:72. doi: 10.1186/s13045-015-0170-0
   PubMed Web of Science ®Google Scholar
• Grzywnowicz M, Zaleska J, Mertens D, Tomczak W, Wlasiuk P, Kosior K, et al. Programmed death-1 and its ligand are novel immunotolerant molecules expressed on leukemic B cells in chronic lymphocytic leukemia. PLoS One. 2012;7(4): e35178. doi: 10.1371/journal.pone.0035178
   PubMed Web of Science ®Google Scholar
• Liao Z, Zhou L, Wang C, He Z, Wang X, Luo X, et al. Characteristics of TCRζ, ZAP-70, and FcϵRIγ gene expression in patients with T- and NK/T-cell lymphoma. DNA Cell Biol. 2015;34(3):201–7. doi: 10.1089/dna.2014.2693
   PubMed Web of Science ®Google Scholar
• Stams WA, den Boer ML, Beverloo HB, Meijerink JP, Stigter RL, van Wering ER, et al. Sensitivity to l-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL. Blood. 2003;101(7):2743–7. doi: 10.1182/blood-2002-08-2446
   Google Scholar
• Chen S, Liu S, Xu L, Yang L, Jin Z, Ma Y, et al. The characteristic expression pattern of BMI-1 and SALL4 genes in placenta tissue and cord blood. Stem Cell Res Ther. 2013;4(2):49. doi: 10.1186/scrt199
   PubMed Web of Science ®Google Scholar
• Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–54. doi: 10.1056/NEJMoa1200690
   PubMed Web of Science ®Google Scholar
• Yu L, Zhang C, Zhang L, Shi Y, Ji X. Biomarkers for immune thrombocytopenia. Biomark Res. 2015;3:19. doi: 10.1186/s40364-015-0045-0
   PubMed Web of Science ®Google Scholar
• Zhang XM, Shan NN, Sun M, Wang X, Feng XM, Liu X, et al. Imbalanced expression of human Tim-1 and Tim-3 in peripheral blood mononuclear cells from immune thrombocytopenia patients. Int Immunopharmacol. 2014;19(1):1–4. doi: 10.1016/j.intimp.2013.12.025
   PubMed Web of Science ®Google Scholar
• Xu L, Zhang Y, Luo G, Li Y. The roles of stem cell memory T cells in hematological malignancies. J Hematol Oncol. 2015;8(1):113. doi: 10.1186/s13045-015-0214-5
   PubMed Web of Science ®Google Scholar