Mometasone furoate inhibits growth of acute leukemia cells in childhood by regulating PI3K signaling pathway

References

• Luo R, Greenberg A, Stone CD. Outcomes of clostridium difficile infection in hospitalized leukemia patients: a nationwide analysis. Infect Control Hosp Epidemiol. 2015;36(7):794–801. [PubMed: 25801085]. doi: 10.1017/ice.2015.54
   PubMed Web of Science ®Google Scholar
• Madhusoodhan PP, Carroll WL, Bhatla T. Progress and prospects in pediatric leukemia. Curr Probl Pediatr Adolesc Health Care. 2016;46(7):229–241. [PubMed: 27283082]. doi: 10.1016/j.cppeds.2016.04.003
   PubMed Web of Science ®Google Scholar
• Brethon B, Cave H, Fahd M, et al. [Infant acute leukemia]. Bull Cancer. 2016;103(3):299–311. [PubMed: 26826739]. doi: 10.1016/j.bulcan.2015.11.009
   PubMed Web of Science ®Google Scholar
• Rudant J, Lightfoot T, Urayama KY, et al. Childhood acute lymphoblastic leukemia and indicators of early immune stimulation: a childhood leukemia international consortium study. Am J Epidemiol. 2015;181(8):549–562. [PubMed: 25731888]. doi: 10.1093/aje/kwu298
   PubMed Web of Science ®Google Scholar
• Lopez-Lopez E, Gutierrez-Camino A, Bilbao-Aldaiturriaga N, et al. Pharmacogenetics of childhood acute lymphoblastic leukemia. Pharmacogenomics. 2014;15(10):1383–1398. [PubMed: 25155938]. doi: 10.2217/pgs.14.106
   PubMed Web of Science ®Google Scholar
• Rowe JM. Reasons for optimism in the therapy of acute leukemia. Best Pract Res Clin Haematol. 2015;28(2-3):69–72. PubMed: 26590761]. doi: 10.1016/j.beha.2015.10.002
   PubMed Web of Science ®Google Scholar
• Teuffel O, Kuster SP, Hunger SP, et al. Dexamethasone versus prednisone for induction therapy in childhood acute lymphoblastic leukemia: a systematic review and meta-analysis. Leukemia. 2011;25(8):1232–1238. [PubMed: 21527934]. doi: 10.1038/leu.2011.84
   PubMed Web of Science ®Google Scholar
• Lanfranconi F, Pollastri L, Ferri A, et al. Near infrared spectroscopy (NIRS) as a new non-invasive tool to detect oxidative skeletal muscle impairment in children survived to acute lymphoblastic leukaemia. PLoS One. 2014;9(6):e99282. [PubMed: 24956391]. doi: 10.1371/journal.pone.0099282
   PubMed Web of Science ®Google Scholar
• Montgomery B, Cheng HH, Drechsler J, et al. Glucocorticoids and prostate cancer treatment: friend or foe? Asian J Androl. 2014;16(3):354–358. [PubMed: 24625881]. doi: 10.4103/1008-682X.125392
   PubMed Web of Science ®Google Scholar
• Luhder F, Reichardt HM. Novel drug delivery systems tailored for improved administration of glucocorticoids. Int J Mol Sci. 2017;18(9):1836–1836. [PubMed: 28837059]. doi: 10.3390/ijms18091836
   PubMed Web of Science ®Google Scholar
• Ostenfeld EB, Erichsen R, Baron JA, et al. Preadmission glucocorticoid use and anastomotic leakage after colon and rectal cancer resections: a Danish cohort study. BMJ Open. 2015;5(9):e008045. [PubMed: 26408282]. doi: 10.1136/bmjopen-2015-008045
   PubMed Web of Science ®Google Scholar
• Pufall MA. Glucocorticoids and cancer. Adv Exp Med Biol. 2015;872:315–333. [PubMed: 5546099]. doi: 10.1007/978-1-4939-2895-8_14
   PubMed Web of Science ®Google Scholar
• Jiang L, Xu L, Xie J, et al. Inhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells. Cancer Biol Ther. 2015;16(3):466–476. [PubMed: 4622576]. doi: 10.1080/15384047.2015.1016658
   PubMed Web of Science ®Google Scholar
• Gordijn MS, Rensen N, Gemke RJ, et al. Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia. Cochrane Database Syst Rev. 2015;(8): CD008727. [PubMed: 26282194]
   PubMed Web of Science ®Google Scholar
• Valotis A, Hogger P. Significant receptor affinities of metabolites and a degradation product of mometasone furoate. Respir Res. 2004;5:1325. [PubMed: 15285788]. doi: 10.1186/1465-9921-5-7
   Web of Science ®Google Scholar
• Passali D, Spinosi MC, Crisanti A, et al. Mometasone furoate nasal spray: a systematic review. Multidiscip Respir Med. 2016;11:633, [PubMed: 27141307]. doi: 10.1186/s40248-016-0054-3
   Web of Science ®Google Scholar
• Kim DH, Lee HJ, Park CW, et al. The clinical efficacy of mometasone furoate in multi-lamellar emulsion for eczema: A double-blinded crossover study. Ann Dermatol. 2013;25(1):17–22. [PubMed: 23467551]. doi: 10.5021/ad.2013.25.1.17
   PubMed Web of Science ®Google Scholar
• Meltzer EO, Baena-Cagnani CE, Gates D, et al. Relieving nasal congestion in children with seasonal and perennial allergic rhinitis: efficacy and safety studies of mometasone furoate nasal spray. World Allergy Organ J. 2013;6(1):1. [PubMed: 23663488]. doi: 10.1186/1939-4551-6-5
   PubMedGoogle Scholar
• Silveira AB, Laranjeira AB, Rodrigues GO, et al. PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia. Oncotarget. 2015;6(15):13105–13118. [PubMed: 25869207]. doi: 10.18632/oncotarget.3524
   PubMedGoogle Scholar
• Xue L, Li C, Wang Y, et al. Single nucleotide polymorphisms in non-coding region of the glucocorticoid receptor gene and prednisone response in childhood acute lymphoblastic leukemia. Leuk Lymphoma. 2015;56(6):1704–1709. [PubMed: 25644744]. doi: 10.3109/10428194.2014.951848
   PubMed Web of Science ®Google Scholar
• Liang YN, Tang YL, Ke ZY, et al. MiR-124 contributes to glucocorticoid resistance in acute lymphoblastic leukemia by promoting proliferation, inhibiting apoptosis and targeting the glucocorticoid receptor. J Steroid Biochem Mol Biol. 2017;172:62–68. [PubMed: 28578002]. doi: 10.1016/j.jsbmb.2017.05.014
   PubMed Web of Science ®Google Scholar
• Rodriguez-Martinez CE, Sossa-Briceno MP, Vladimir Lemos E. Cost-effectiveness analysis of mometasone furoate versus beclomethasone dipropionate for the treatment of pediatric allergic rhinitis in Colombia. Adv Ther. 2015;32(3):254–269. doi: 10.1007/s12325-015-0192-6
   PubMed Web of Science ®Google Scholar
• Mielcarek M, Furlong T, Storer BE, et al. Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial. Haematologica. 2015;100(6):842–848. doi: 10.3324/haematol.2014.118471
   PubMed Web of Science ®Google Scholar
• Krasselt M, Baerwald C. Efficacy and safety of modified-release prednisone in patients with rheumatoid arthritis. Drug Des Devel Ther. 2016;10:1047–1058. doi: 10.2147/DDDT.S87792
   PubMed Web of Science ®Google Scholar
• Ramsey LB, Janke LJ, Payton MAet al. Antileukemic efficacy of continuous vs discontinuous dexamethasone in murine models of acute lymphoblastic leukemia. PloS one. 2015;10(8):e0135134. doi: 10.1371/journal.pone.0135134
   PubMed Web of Science ®Google Scholar
• Zeng M, Li ZY, Ma J, et al. Clarithromycin and dexamethasone show similar anti-inflammatory effects on distinct phenotypic chronic rhinosinusitis: an explant model study. BMC Immunol.. 2015;16:1. doi: 10.1186/s12865-015-0096-x
   PubMed Web of Science ®Google Scholar
• Deng X, Tu Z, Xiong M, et al. Wnt5a and CCL25 promote adult T-cell acute lymphoblastic leukemia cell migration, invasion and metastasis. Oncotarget. 2017;8(24):39033–39047. [PubMed: 28380463].
   PubMedGoogle Scholar
• Calverley PM, Rennard S, Nelson HS, et al. One-year treatment with mometasone furoate in chronic obstructive pulmonary disease. Respir Res. 2008;9:765. [PubMed: 19014549]. doi: 10.1186/1465-9921-9-73
   Web of Science ®Google Scholar
• D’Urzo A, Karpel JP, Busse WW, et al. Efficacy and safety of mometasone furoate administered once-daily in the evening in patients with persistent asthma dependent on inhaled corticosteroids. Curr Med Res Opin. 2005;21(8):1281–1289. [PubMed: 16083538]. doi: 10.1185/030079905X56402
   PubMed Web of Science ®Google Scholar
• Bijsmans IT, Guercini C, Ramos Pittol JM, et al. The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression. Sci Rep. 2015;5:710. [PubMed: 4572934]. doi: 10.1038/srep14086
   Web of Science ®Google Scholar
• Corazza M, Virgili A, Toni G, et al. Mometasone furoate in the treatment of vulvar lichen sclerosus: could its formulation influence efficacy, tolerability and adherence to treatment? J Dermatolog Treat. 2017;4:1–5. [PubMed: 28753097].
   Google Scholar
• Greive KA, Barnes TM. Bioequivalence of 0.1% mometasone furoate lotion to 0.1% mometasone furoate hydrogel. Australas J Dermatol. 2016;57(2):e39–e45. [PubMed: 25545549]. doi: 10.1111/ajd.12275
   PubMed Web of Science ®Google Scholar
• Mei JM, Niu CS. Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2/Bax and caspase-3 activation. Neurol Sci. 2014;35(8):1275–1280. [PubMed: 24633814]. doi: 10.1007/s10072-014-1700-1
   PubMed Web of Science ®Google Scholar
• Zhang G, Zhang Z, Yang J. DNA tetrahedron delivery enhances doxorubicin-induced apoptosis of HT-29 colon cancer cells. Nanoscale Res Lett. 2017;12(1):717. [PubMed: 28812246].
   Google Scholar
• Cirillo N, Morgan DJ, Pedicillo MC, et al. Characterisation of the cancer-associated glucocorticoid system: key role of 11beta-hydroxysteroid dehydrogenase type 2. Br J Cancer. 2017;117(7):984–993. [PubMed: 28797028]. doi: 10.1038/bjc.2017.243
   PubMed Web of Science ®Google Scholar
• Smith LK, Cidlowski JA. Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes. Prog Brain Res. 2010;182:1–30. [PubMed: 20541659]. doi: 10.1016/S0079-6123(10)82001-1
   PubMed Web of Science ®Google Scholar
• Harr MW, Rong Y, Bootman MD, et al. Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors. J Biol Chem. 2009;284(46):31860–31871. [PubMed: 19776014]. doi: 10.1074/jbc.M109.005579
   PubMed Web of Science ®Google Scholar
• Zhou ZW, Li XX, He ZX, et al. Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells. Drug Des Devel Ther. 2015;9:1511–1554. [PubMed: 25834399]. doi: 10.2147/DDDT.S75976
   PubMed Web of Science ®Google Scholar
• Akinleye A, Avvaru P, Furqan M, et al. Phosphatidylinositol 3-kinase (PI3K) inhibitors as cancer therapeutics. J Hematol Oncol. 2013;6(1):88. [PubMed: 24261963]. doi: 10.1186/1756-8722-6-88
   PubMedGoogle Scholar
• Khan KH, Wong M, Rihawi K, et al. Hyperglycemia and phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) inhibitors in phase I trials: incidence, predictive factors, and management. Oncologist. 2016;21(7):855–860. [PubMed: 27151652]. doi: 10.1634/theoncologist.2015-0248
   PubMed Web of Science ®Google Scholar
• Zhang L, Huo X, Liao Y, et al. Zeylenone, a naturally occurring cyclohexene oxide, inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways. Sci Rep. 2017;7(1):58. [PubMed: 28490807]. doi: 10.1038/s41598-017-00100-3
   PubMedGoogle Scholar
• Halacli SO, Dogan AL. FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells. Oncol Lett. 2015;9(3):1482–1488. [PubMed: 25663935]. doi: 10.3892/ol.2015.2885
   PubMed Web of Science ®Google Scholar
• Liu W, Ren H, Ren J, et al. The role of EGFR/PI3 K/Akt/cyclinD1 signaling pathway in acquired middle ear cholesteatoma. Mediators Inflamm. 2013;2013:651207. [PubMed: 24311896].
   PubMed Web of Science ®Google Scholar
• Zhao S, Yi M, Yuan Y, et al. Expression of AKAP95, Cx43, CyclinE1 and CyclinD1 in esophageal cancer and their association with the clinical and pathological parameters. Int J Clin Exp Med. 2015;8(5):7324–7332. [PubMed: 26221272].
   PubMed Web of Science ®Google Scholar
• Cheng R, Liu YJ, Cui JW, et al. Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells. Oncotarget. 2017;8(18):30252–30264. [PubMed: 28415819].
   PubMedGoogle Scholar
• Zadeh MA H, Amin EM, Hoareau-Aveilla C, et al. Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance. Mol Oncol. 2015;9(1):167–178. [PubMed: 25224594]. doi: 10.1016/j.molonc.2014.07.017
   PubMed Web of Science ®Google Scholar
• Chetty C, Lakka SS, Bhoopathi P, et al. MMP-2 alters VEGF expression via αVβ3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. Int J Cancer. 2010;127(5):1081–1095. [PubMed: 20027628]. doi: 10.1002/ijc.25134
   PubMed Web of Science ®Google Scholar