Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations

REFERENCES

• ArnsdorfEJ, TummalaP, JacobsCR. 2009. Non-canonical Wnt signaling and N-cadherin related b-catenin signaling play a role in mechanically induced osteogenic cell fate. PLoS ONE. 4(4):e5388.
   PubMed Web of Science ®Google Scholar
• ArnsdorfE, TummalaP, KwonR, JacobsC. 2009. Mechanically induced osteogenic differentiation – the role of RhoA, ROCKII and cytoskeletal dynamics. J Cell Sci. 122(Pt 4):546–553.
   PubMed Web of Science ®Google Scholar
• BalguidA, MolA, Van VlimmerenM, BaaijensF, BoutenC. 2009. Hypoxia induces near-native mechanical properties in engineered heart valve tissue. J Am Heart Assoc. 119(2):290–297.
   Google Scholar
• Boronyak S, Smelko A, Sacks MS, Ramaswamy S. 2009. Design of a Flow-Stretch-Flexure Bioreactor for Physiologic Conditioning of Engineered Tissue. Biomedical Engineering Society Annual Fall Meeting. Pittsburgh, PA, October 7-10.
   Google Scholar
• ButcherJT, MahlerGJ, HockadayLA. 2011. Aortic valve disease and treatment: the need for naturally engineered solutions. Adv Drug Deliv Rev. 63(4-5):242–268.
   PubMed Web of Science ®Google Scholar
• CebotariS, LichtenbergA, TudoracheI, MertschingH, LeyhR, BreymannT, KallenbachK, ManiucL, BatrinacA, RepinO, MaligaO, CiubotaruA, HaverichA. 2006. Clinical application of tissue engineered human heart valve using autologous progenitor cells. Circulation. 114(1 Suppl):132–137.
   Google Scholar
• El-HamamsyI, ChesterAH, YacoubMH. 2010. Cellular regulation of the structure and function of aortic valves. J Adv Res. 1(1):5–12.
   Google Scholar
• EngelmayrGC, SalesVL, MayerJE, SacksMS. 2006. Cyclic flexure and laminar flow synergistically accelerate mesenchymal stem cell-mediated engineered tissue formation: implications for engineered heart valve tissues. Biomaterials. 27(36):6083–6095.
   PubMed Web of Science ®Google Scholar
• EngelmayrGC, SolettiL, VigmostadSC, BudilartoSG, FederspielWJ, ChandranKB, VorpDA, SacksMS. 2008. A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology. Ann Biomed Eng. 36(5):1–13.
   PubMed Web of Science ®Google Scholar
• EvegrenP, FuchsL, RevstedtJ. 2010. Wall shear stress variations in a 90-degree bifurcation in 3D pulsating flows. Med Eng Phys. 32(2):189–202.
   PubMed Web of Science ®Google Scholar
• EvegrenP, RevstedtJ, FuchsL. 2011. Pulsating flow and mass transfer in an asymmetric system of bifurcations. Comput Fluids. 49(1):46–61.
   Web of Science ®Google Scholar
• FlanaganTC, SachwehJS, FreseJ, SchnöringH, GronlohN, KochS, TolbaRH, Schmitz-RodeT, JockenhoevelS. 2009. In vivo remodelling and structural characterisation of fibrin-based tissue-engineered heart valves in the adult sheep model. Tissue Eng. 15(10):2965–2976.
   Google Scholar
• GandagliaA, BagnoA, NasoF, SpinaM, GerosaG. 2011. Cells, scaffolds and bioreactors for tissue-engineered heart valves: a journey from basic concepts to contemporary developmental innovations. Eur J Cardiothorac. 39(4):523–531.
   PubMed Web of Science ®Google Scholar
• HeX, KuDN. 1996. Pulsatile flow in the human left coronary artery bifurcation: average conditions. J Biomech Eng. 118(1):74–82.
   PubMed Web of Science ®Google Scholar
• HilfikerA, KasperC, HassR, HaverichA. 2011. Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?Arch Surg. 396(4):489–497.
   Web of Science ®Google Scholar
• JacobsCR, YellowleyCE, DavisBR, ZhouZ, CimbalaJM, DonahueHJ. 1998. Differential effect of steady versus oscillating flow on bone cells. J Biomech. 31(11):969–976.
   PubMed Web of Science ®Google Scholar
• KleinstreuerC. 2006. Biofluid Dynamics: Principles and Selected Applications. CRC Press. Boca Raton, Florida. 1st Ed. p. 197–205.
   Google Scholar
• KorakianitisT, ShiY. 2006a. A concentrated parameter model for the human cardiovascular system including heart valve dynamics and atrioventricular interaction. Med Eng Phys. 28(7):613–628.
   PubMed Web of Science ®Google Scholar
• KorakianitisT, ShiY. 2006b. Numerical simulation of cardiovascular dynamics with healthy and diseased heart valves. J Biomech. 39(11):1964–1982.
   PubMed Web of Science ®Google Scholar
• LeeK, LeeH, KimM, KimH, JungG, HurS, TaeH. 2009. Cilostazol inhibits high glucose- and angiotensin II-induced type 1 plasminogen activator inhibitor expression in artery wall and neointimal region after vascular injury. Atherosclerosis. 207(2):391–398.
   PubMed Web of Science ®Google Scholar
• LiYJ, BatraNN, YouL, MeierSC, CoeIA, YellowleyCE, JacobsCR. 2004. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. 22(6):1283–1289.
   PubMed Web of Science ®Google Scholar
• LichtenbergA, BreymannT, CebotariS, HaverichA. 2006. Cell seeded tissue engineered cardiac valves based on allograft and xenograft scaffolds. Prog Pediatr Cardiol. 21(2):211–217.
   Google Scholar
• LotzJ, MeierC, LeppertA, GalanskiM. 2002. Cardiovascular flow measurement with phase contrast MR imaging: basic facts and implementation. Radiographics. 22(3):651–671.
   PubMed Web of Science ®Google Scholar
• NeuenschwanderS, HoerstrupSP. 2004. Heart valve tissue engineering. Transpl Immunol. 12(3–4):359–365.
   PubMed Web of Science ®Google Scholar
• PerryTE, KaushalS, SutherlandFWH, GuleserianKJ, BischoffJ, SacksM, MayerJE. 2003. Bone marrow as a cell source for tissue engineering heart valves. Ann Thorac Surg. 75(3):761–767.
   PubMed Web of Science ®Google Scholar
• Ramaswamy S, Boronyak S, Sacks MS. 2008. Design and evaluation of a new flow-stretch-flexure bioreactor for mechanical conditioning of engineered heart valve tissues in the physiological range. The TERMIS-NA 2008 Annual Conference & Exposition. San Diego, CA. December 7–10.
   Google Scholar
• Ramaswamy S, Boronyak S, Engelmayr GC, Schmidt DE, El-Kurdi M, Sacks MS. 2011. Flow-stretch-flexure bioreactor (US patent application #: 12/959,906) September 1st 2011; USA.
   Google Scholar
• RamaswamyS, BoronyakS, SchmidtDE, HobsonC, HolmesA, SacksMS. 2012. A novel bioreactor for the study of physiological fluid induced stresses for heart valve tissue engineering (Unpublished work).
   Google Scholar
• Ramaswamy S, Boronyak S, Schmidt D, Sacks MS. 2009. Design of a novel curved tube flow-stretch-flexure bioreactor for mechanistic studies in heart valve tissue engineering. Society for Biomaterials, 2009 Annual meeting and exposition. San Antonio, TX. April 22–25.
   Google Scholar
• RamaswamyS, GottliebD, EngelmayrGC, Jr, AikawaE, SchmidtDE, Gaitan-LeonDM, SalesVL, MayerJE, Jr, SacksMS. 2010. The role of organ level conditioning on the promotion of engineered heart valve tissue development in-vitro using mesenchymal stem cells. Biomaterials. 31(6):1114–1125.
   PubMed Web of Science ®Google Scholar
• Ramaswamy S, Schmidt D, Boronyak S, Sacks MS. 2009. Flow patterns under combined flexural states for engineered heart valve tissue development. Biomedical Engineering Society Annual Fall Meeting, Pittsburgh, PA. October 7–10.
   Google Scholar
• RatnerBD, HuffmanAS, SchoenFJ, LemonsJE. 2008. An introduction to materials in medicine. Elsevier Academic Press, San Diego, California. 2nd Ed p. 260–79.
   Google Scholar
• SacksMS, David MerrymanW, SchmidtDE. 2009. On the biomechanics of heart valve function. J Biomech. 42(12):1804–1824.
   PubMed Web of Science ®Google Scholar
• SacksMS, SchoenFJ, MayerJE. 2009. Bioengineering challenges for heart valve tissue engineering. Annu Rev Biomed Eng. 11:289–313.
   PubMed Web of Science ®Google Scholar
• SacksMS, YoganathanAP. 2007. Heart valve function: a biomechanical perspective. Phil Trans R Soc Lond Biol Sci. 362(1484):1369–1391.
   PubMed Web of Science ®Google Scholar
• SalesVL, MettlerBA, EngelmayrGC, AikawaE, BischoffJ, MartinDP, ExarhopoulosA, MosesMA, SchoenFJ, SacksMS, MayerJE. 2010. Endothelial progenitor cells as a sole source for ex vivo seeding of tissue-engineered heart valves. Circulation. 16(1):257–267.
   Google Scholar
• SchmidtD, AchermannJ, OdermattB, BreymannC, MolA, GenoniM, ZundG, HoerstrupSP. 2007. Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source. Circulation. 116(11 Suppl):I64–I70.
   PubMed Web of Science ®Google Scholar
• SchmidtD, DijkmanPE, Driessen-MolA, StengerR, MarianiC, PuolakkaA, RissanenM, DeichmannT, OdermattB, WeberB et al., 2010. Minimally-invasive implantation of living tissue engineered heart valves: a comprehensive approach from autologous vascular cells to stem cells. J Am Coll Cardiol. 56(6):510–520.
   PubMed Web of Science ®Google Scholar
• SchmidtD, MolA, OdermattB, NeuenschwanderS, BreymannC, GössiM, GenoniM, ZundG, HoerstrupSP. 2006. Engineering of biologically active living heart valve leaflets using human umbilical cord-derived progenitor cells. Tissue Eng. 12(11):3223–3232.
   PubMedGoogle Scholar
• SchoenFJ. 2008. Evolving concepts of cardiac valve dynamics the continuum of development, functional structure, pathobiology and tissue engineering. Circulation. 118(18):1864–1880.
   PubMed Web of Science ®Google Scholar
• SiepeM, AkhyariP, LichtenbergA, SchlensakC, BeyersdorfF. 2008. Stem cells used for cardiovascular tissue engineering. Eur J Cardiothoracic Surg. 34(2):242–247.
   PubMed Web of Science ®Google Scholar
• SodianR, HoerstrupSP, SperlingJS, DaebritzSH, MartinDP, SchoenFJ, VacantiJP, MayerJE. 2000. Tissue engineering of heart valves: in vitro experience. Ann Thorac Surg. 70:140–144.
   PubMed Web of Science ®Google Scholar
• SticklerP, De VisscherG, MesureL, FamaeyN, MartinD, CampbellJH, Van OosterwyckH, MeurisB, FlamengW. 2010. Cyclically stretching developing tissue in vivo enhances mechanical strength and organization of vascular grafts. Acta Biomater. 6(7):2448–2456.
   PubMed Web of Science ®Google Scholar
• StockUA, SakamotoT, HatsuokaS, MartinDP, NagashimaM, MoranAM, MosesMA, KhalilPN, SchoenFJ, VacantiJP, MayerJE. 2000. Patch augmentation of the pulmonary artery with bioabsorbable polymers and autologous cell seeding. J Thorac Cardiov Sur. 120(6):1158–1167.
   PubMed Web of Science ®Google Scholar
• SutherlandFW, PerryTE, YuY, SherwoodMC, RabkinE, MasudaY, GarciaAG, McLellanDL, EngelmayrGC, SacksMS, SchoenFJ, MayerJE. 2005. From stem cells to viable autologous semilunar heart valve. Circulation. 111(21):2783–2791.
   PubMed Web of Science ®Google Scholar
• YeattsAB, FisherJP. 2011. Bone tissue engineering bioreactors: dynamic culture and the influence of shear stress. Bone. 48(2):171–181.
   PubMed Web of Science ®Google Scholar